Androstenetriol and androstenediol. Protection against lethal radiation and restoration of immunity after radiation injury.
Identifieur interne : 000183 ( PubMed/Corpus ); précédent : 000182; suivant : 000184Androstenetriol and androstenediol. Protection against lethal radiation and restoration of immunity after radiation injury.
Auteurs : R M Loria ; D H Conrad ; T. Huff ; H. Carter ; D. Ben-NathanSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2000.
English descriptors
- KwdEn :
- Anabolic Agents (pharmacology), Anabolic Agents (therapeutic use), Androstenediol (immunology), Androstenediol (pharmacology), Androstenediol (therapeutic use), Animals, Immunity (drug effects), Male, Mice, Mice, Inbred C57BL, Neuroimmunomodulation, Radiation Injuries (immunology), Radiation Injuries (prevention & control).
- MESH :
- chemical , immunology : Androstenediol.
- chemical , pharmacology : Anabolic Agents, Androstenediol.
- chemical , therapeutic use : Anabolic Agents, Androstenediol.
- drug effects : Immunity.
- immunology : Radiation Injuries.
- prevention & control : Radiation Injuries.
- Animals, Male, Mice, Mice, Inbred C57BL, Neuroimmunomodulation.
Abstract
Androstenetriol (AET) and Androstenediol (AED) upregulate host immunity, leading to increased resistance against infections. AET augments IL-2, IL-3, IFN gamma levels, and counteracts hydrocortisone immune suppression. AET and AED at a dose of 0.75 mg/- and 8.0 mg/25-g mouse, protected 60 and 70%, respectively, of C57/BL/6J mice irradiated with a lethal dose. These hormones also protected mice irradiated with 6 Gy and infected with a coxsackievirus B4 LD50. AET significantly increased spleen lymphocyte numbers at 7, 14, and 21 days after a 6-Gy exposure. Fluorescent activated cell-sorter analysis of irradiated mice, spleen, and bone marrow showed that AET significantly augmented the myeloid precursor markers, CD11b/Mac-1, and B220 (pan B), as well as the absolute numbers of CD4+/CD8+ cells over the 21 days of testing. Overall, the data are consistent with AET/AED inducing a more rapid recovery of all hematopoietic precursors from the small number of surviving stem cells.
PubMed: 11268417
Links to Exploration step
pubmed:11268417Le document en format XML
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Carter</name></author><author><name sortKey="Ben Nathan, D" sort="Ben Nathan, D" uniqKey="Ben Nathan D" first="D" last="Ben-Nathan">D. Ben-Nathan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:11268417</idno><idno type="pmid">11268417</idno><idno type="wicri:Area/PubMed/Corpus">000183</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000183</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Androstenetriol and androstenediol. Protection against lethal radiation and restoration of immunity after radiation injury.</title><author><name sortKey="Loria, R M" sort="Loria, R M" uniqKey="Loria R" first="R M" last="Loria">R M Loria</name><affiliation><nlm:affiliation>Department of Microbiology, Immunology and Pathology, Commonwealth University of Virginia, Medical College of Virginia, Richmond, VA 23298-0678, USA. Loria@hsc.vcu.edu</nlm:affiliation></affiliation></author><author><name sortKey="Conrad, D H" sort="Conrad, D H" uniqKey="Conrad D" first="D H" last="Conrad">D H Conrad</name></author><author><name sortKey="Huff, T" sort="Huff, T" uniqKey="Huff T" first="T" last="Huff">T. Huff</name></author><author><name sortKey="Carter, H" sort="Carter, H" uniqKey="Carter H" first="H" last="Carter">H. Carter</name></author><author><name sortKey="Ben Nathan, D" sort="Ben Nathan, D" uniqKey="Ben Nathan D" first="D" last="Ben-Nathan">D. Ben-Nathan</name></author></analytic><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anabolic Agents (pharmacology)</term><term>Anabolic Agents (therapeutic use)</term><term>Androstenediol (immunology)</term><term>Androstenediol (pharmacology)</term><term>Androstenediol (therapeutic use)</term><term>Animals</term><term>Immunity (drug effects)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Neuroimmunomodulation</term><term>Radiation Injuries (immunology)</term><term>Radiation Injuries (prevention & control)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Androstenediol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anabolic Agents</term><term>Androstenediol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anabolic Agents</term><term>Androstenediol</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immunity</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Radiation Injuries</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Radiation Injuries</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Neuroimmunomodulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Androstenetriol (AET) and Androstenediol (AED) upregulate host immunity, leading to increased resistance against infections. AET augments IL-2, IL-3, IFN gamma levels, and counteracts hydrocortisone immune suppression. AET and AED at a dose of 0.75 mg/- and 8.0 mg/25-g mouse, protected 60 and 70%, respectively, of C57/BL/6J mice irradiated with a lethal dose. These hormones also protected mice irradiated with 6 Gy and infected with a coxsackievirus B4 LD50. AET significantly increased spleen lymphocyte numbers at 7, 14, and 21 days after a 6-Gy exposure. Fluorescent activated cell-sorter analysis of irradiated mice, spleen, and bone marrow showed that AET significantly augmented the myeloid precursor markers, CD11b/Mac-1, and B220 (pan B), as well as the absolute numbers of CD4+/CD8+ cells over the 21 days of testing. Overall, the data are consistent with AET/AED inducing a more rapid recovery of all hematopoietic precursors from the small number of surviving stem cells.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">11268417</PMID><DateCreated><Year>2001</Year><Month>03</Month><Day>27</Day></DateCreated><DateCompleted><Year>2001</Year><Month>04</Month><Day>19</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0077-8923</ISSN><JournalIssue CitedMedium="Print"><Volume>917</Volume><PubDate><Year>2000</Year></PubDate></JournalIssue><Title>Annals of the New York Academy of Sciences</Title><ISOAbbreviation>Ann. N. Y. Acad. Sci.</ISOAbbreviation></Journal><ArticleTitle>Androstenetriol and androstenediol. Protection against lethal radiation and restoration of immunity after radiation injury.</ArticleTitle><Pagination><MedlinePgn>860-7</MedlinePgn></Pagination><Abstract><AbstractText>Androstenetriol (AET) and Androstenediol (AED) upregulate host immunity, leading to increased resistance against infections. AET augments IL-2, IL-3, IFN gamma levels, and counteracts hydrocortisone immune suppression. AET and AED at a dose of 0.75 mg/- and 8.0 mg/25-g mouse, protected 60 and 70%, respectively, of C57/BL/6J mice irradiated with a lethal dose. These hormones also protected mice irradiated with 6 Gy and infected with a coxsackievirus B4 LD50. AET significantly increased spleen lymphocyte numbers at 7, 14, and 21 days after a 6-Gy exposure. Fluorescent activated cell-sorter analysis of irradiated mice, spleen, and bone marrow showed that AET significantly augmented the myeloid precursor markers, CD11b/Mac-1, and B220 (pan B), as well as the absolute numbers of CD4+/CD8+ cells over the 21 days of testing. Overall, the data are consistent with AET/AED inducing a more rapid recovery of all hematopoietic precursors from the small number of surviving stem cells.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Loria</LastName><ForeName>R M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Immunology and Pathology, Commonwealth University of Virginia, Medical College of Virginia, Richmond, VA 23298-0678, USA. Loria@hsc.vcu.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conrad</LastName><ForeName>D H</ForeName><Initials>DH</Initials></Author><Author ValidYN="Y"><LastName>Huff</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Carter</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Ben-Nathan</LastName><ForeName>D</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann N Y Acad Sci</MedlineTA><NlmUniqueID>7506858</NlmUniqueID><ISSNLinking>0077-8923</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D045930">Anabolic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>95PS51EMXY</RegistryNumber><NameOfSubstance UI="D015114">Androstenediol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D045930">Anabolic Agents</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015114">Androstenediol</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000276">immunology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007109">Immunity</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051379">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008810">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015213">Neuroimmunomodulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011832">Radiation Injuries</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000276">immunology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>3</Month><Day>28</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>4</Month><Day>21</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>3</Month><Day>28</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11268417</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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