Risk of cardiovascular, cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease
Identifieur interne : 000095 ( Pmc/Corpus ); précédent : 000094; suivant : 000096Risk of cardiovascular, cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease
Auteurs : Stefano Ballestri ; Amedeo Lonardo ; Stefano Bonapace ; Christopher D. Byrne ; Paola Loria ; Giovanni TargherSource :
- World Journal of Gastroenterology : WJG [ 1007-9327 ] ; 2014.
Abstract
Non-alcoholic fatty liver disease (NAFLD) has emerged as a public health problem of epidemic proportions worldwide. Accumulating clinical and epidemiological evidence indicates that NAFLD is not only associated with liver-related morbidity and mortality but also with an increased risk of coronary heart disease (CHD), abnormalities of cardiac function and structure (
Url:
DOI: 10.3748/wjg.v20.i7.1724
PubMed: 24587651
PubMed Central: 3930972
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PMC:3930972Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Risk of cardiovascular, cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease</title>
<author><name sortKey="Ballestri, Stefano" sort="Ballestri, Stefano" uniqKey="Ballestri S" first="Stefano" last="Ballestri">Stefano Ballestri</name>
</author>
<author><name sortKey="Lonardo, Amedeo" sort="Lonardo, Amedeo" uniqKey="Lonardo A" first="Amedeo" last="Lonardo">Amedeo Lonardo</name>
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<author><name sortKey="Bonapace, Stefano" sort="Bonapace, Stefano" uniqKey="Bonapace S" first="Stefano" last="Bonapace">Stefano Bonapace</name>
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<author><name sortKey="Byrne, Christopher D" sort="Byrne, Christopher D" uniqKey="Byrne C" first="Christopher D" last="Byrne">Christopher D. Byrne</name>
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<author><name sortKey="Loria, Paola" sort="Loria, Paola" uniqKey="Loria P" first="Paola" last="Loria">Paola Loria</name>
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<author><name sortKey="Targher, Giovanni" sort="Targher, Giovanni" uniqKey="Targher G" first="Giovanni" last="Targher">Giovanni Targher</name>
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<author><name sortKey="Lonardo, Amedeo" sort="Lonardo, Amedeo" uniqKey="Lonardo A" first="Amedeo" last="Lonardo">Amedeo Lonardo</name>
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<author><name sortKey="Byrne, Christopher D" sort="Byrne, Christopher D" uniqKey="Byrne C" first="Christopher D" last="Byrne">Christopher D. Byrne</name>
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<author><name sortKey="Loria, Paola" sort="Loria, Paola" uniqKey="Loria P" first="Paola" last="Loria">Paola Loria</name>
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<author><name sortKey="Targher, Giovanni" sort="Targher, Giovanni" uniqKey="Targher G" first="Giovanni" last="Targher">Giovanni Targher</name>
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<series><title level="j">World Journal of Gastroenterology : WJG</title>
<idno type="ISSN">1007-9327</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><p>Non-alcoholic fatty liver disease (NAFLD) has emerged as a public health problem of epidemic proportions worldwide. Accumulating clinical and epidemiological evidence indicates that NAFLD is not only associated with liver-related morbidity and mortality but also with an increased risk of coronary heart disease (CHD), abnormalities of cardiac function and structure (<italic>e.g</italic>
., left ventricular dysfunction and hypertrophy, and heart failure), valvular heart disease (<italic>e.g</italic>
., aortic valve sclerosis) and arrhythmias (<italic>e.g</italic>
., atrial fibrillation). Experimental evidence suggests that NAFLD itself, especially in its more severe forms, exacerbates systemic/hepatic insulin resistance, causes atherogenic dyslipidemia, and releases a variety of pro-inflammatory, pro-coagulant and pro-fibrogenic mediators that may play important roles in the pathophysiology of cardiac and arrhythmic complications. Collectively, these findings suggest that patients with NAFLD may benefit from more intensive surveillance and early treatment interventions to decrease the risk for CHD and other cardiac/arrhythmic complications. The purpose of this clinical review is to summarize the rapidly expanding body of evidence that supports a strong association between NAFLD and cardiovascular, cardiac and arrhythmic complications, to briefly examine the putative biological mechanisms underlying this association, and to discuss some of the current treatment options that may influence both NAFLD and its related cardiac and arrhythmic complications.</p>
</div>
</front>
</TEI>
<pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Gastroenterol</journal-id>
<journal-id journal-id-type="iso-abbrev">World J. Gastroenterol</journal-id>
<journal-id journal-id-type="publisher-id">WJG</journal-id>
<journal-title-group><journal-title>World Journal of Gastroenterology : WJG</journal-title>
</journal-title-group>
<issn pub-type="ppub">1007-9327</issn>
<publisher><publisher-name>Baishideng Publishing Group Co., Limited</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24587651</article-id>
<article-id pub-id-type="pmc">3930972</article-id>
<article-id pub-id-type="other">jWJG.v20.i7.pg1724</article-id>
<article-id pub-id-type="doi">10.3748/wjg.v20.i7.1724</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Topic Highlight</subject>
</subj-group>
</article-categories>
<title-group><article-title>Risk of cardiovascular, cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Ballestri</surname>
<given-names>Stefano</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lonardo</surname>
<given-names>Amedeo</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Bonapace</surname>
<given-names>Stefano</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Byrne</surname>
<given-names>Christopher D</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Loria</surname>
<given-names>Paola</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Targher</surname>
<given-names>Giovanni</given-names>
</name>
</contrib>
<aff>Stefano Ballestri, Division of Internal Medicine, Pavullo Hospital, 41026 Pavullo, Italy</aff>
<aff>Stefano Ballestri, Amedeo Lonardo, Paola Loria, Department of Biomedical, Metabolic and Neural Sciences, Division of Internal Medicine NOCSAE, University of Modena and Reggio Emilia and Azienda USL, Baggiovara, 41126 Modena, Italy</aff>
<aff>Stefano Bonapace, Division of Cardiology, “Sacro Cuore” Hospital, 37024 Negrar, Italy</aff>
<aff>Christopher D Byrne, Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton SO16 6YD, United Kingdom</aff>
<aff>Giovanni Targher, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy</aff>
</contrib-group>
<author-notes><fn><p>Author contributions: Targher G conceived the hypothesis and the outline of the manuscript; Ballestri S, Lonardo A and Targher G researched the data, analyzed the data and wrote the manuscript; Bonapace S, Byrne CD and Loria P contributed to discussion and reviewed/edited the manuscript.</p>
<p>Correspondence to: Giovanni Targher, MD, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata, Piazzale A. Stefani 1, 37126 Verona, Italy. <email>giovanni.targher@univr.it</email>
</p>
<p>Telephone: +39-45-8123748 Fax: +39-45-8027314</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>21</day>
<month>2</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>21</day>
<month>2</month>
<year>2014</year>
</pub-date>
<volume>20</volume>
<issue>7</issue>
<fpage>1724</fpage>
<lpage>1745</lpage>
<history><date date-type="received"><day>30</day>
<month>9</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>30</day>
<month>10</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>18</day>
<month>11</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>©2014 Baishideng Publishing Group Co., Limited. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><p>Non-alcoholic fatty liver disease (NAFLD) has emerged as a public health problem of epidemic proportions worldwide. Accumulating clinical and epidemiological evidence indicates that NAFLD is not only associated with liver-related morbidity and mortality but also with an increased risk of coronary heart disease (CHD), abnormalities of cardiac function and structure (<italic>e.g</italic>
., left ventricular dysfunction and hypertrophy, and heart failure), valvular heart disease (<italic>e.g</italic>
., aortic valve sclerosis) and arrhythmias (<italic>e.g</italic>
., atrial fibrillation). Experimental evidence suggests that NAFLD itself, especially in its more severe forms, exacerbates systemic/hepatic insulin resistance, causes atherogenic dyslipidemia, and releases a variety of pro-inflammatory, pro-coagulant and pro-fibrogenic mediators that may play important roles in the pathophysiology of cardiac and arrhythmic complications. Collectively, these findings suggest that patients with NAFLD may benefit from more intensive surveillance and early treatment interventions to decrease the risk for CHD and other cardiac/arrhythmic complications. The purpose of this clinical review is to summarize the rapidly expanding body of evidence that supports a strong association between NAFLD and cardiovascular, cardiac and arrhythmic complications, to briefly examine the putative biological mechanisms underlying this association, and to discuss some of the current treatment options that may influence both NAFLD and its related cardiac and arrhythmic complications.</p>
</abstract>
<kwd-group><kwd>Non-alcoholic fatty liver disease</kwd>
<kwd>Cardiovascular disease</kwd>
<kwd>Cardiac complications</kwd>
<kwd>Coronary heart disease</kwd>
<kwd>Myocardial dysfunction</kwd>
<kwd>Valvular heart disease</kwd>
<kwd>Arrhythmias</kwd>
<kwd>Arrhythmic complications</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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