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AP-1 and NF- B stimulated by carbachol in human neuroblastoma SH-SY5Y cells are differentially sensitive to inhibition by lithium

Identifieur interne : 001832 ( Main/Merge ); précédent : 001831; suivant : 001833

AP-1 and NF- B stimulated by carbachol in human neuroblastoma SH-SY5Y cells are differentially sensitive to inhibition by lithium

Auteurs : Richard S. Jope [États-Unis] ; Ling Song [États-Unis]

Source :

Molecular Brain Research [ 0169-328X ] ; 1997.

RBID : ISTEX:BBE29F0F5F7C2820DC6174F25854186EF9A370C4

English descriptors

Entity :
- org : Sparks Center, University of Michigan.
- pers : B. Fig, B. Inhibition, B. Ro, B.V. Keywords, Brain Research, M. Pretreatment, M.J. Iadarola, R.S. Jope, Research, Richard S. Jope, S. Jope, S.K. Fisher, Ždata.
- place : AL, Birmingham, SY.
KwdEn :
- AP-1, Bipolar disorder, Cholinergic stimulation, EMSA, IP3, Lithium, NAME, NF- B, PMA, Transcription factor.
Teeft :
- Activation, Anova, Atropine, Binding activity, Carbachol, Carbachol stimulation, Cholinergic, Cholinergic stimulation, Differential effect, Differentially sensitive, Emsa, Gene expression, High concentration, Human neuroblastoma cell, Inhibitory effect, Initial spike, Inositol, Intracellular, Intracellular calcium, Jope, Kinase, Licl, Lithium, Molecular brain research, Muscarinic, Neuroblastoma, Neuronal model system, Nuclear extract, Pertussis toxin, Phosphoinositide, Phosphoinositide hydrolysis, Phosphoinositide signal transduction system, Pretreatment, Protein kinase, Receptor, Signal transduction, Signal transduction system, Specific gene, Specific manner, Therapeutic concentration, Therapeutic effect, Transcription, Transcription factor, Transcription factor activation, Transduction.

Abstract

Abstract: In order to identify potential actions of lithium, the primary therapeutic agent for bipolar affective disorder, on processes regulating gene expression, its effects on two transcription factors, AP-1 and NF- B, were measured in human neuroblastoma SH-SY5Y cells. The cholinergic agonist carbachol concentration-dependently stimulated AP-1 (EC50 2M) and NF-B (EC50 14M). Pretreatment for 24hwith a therapeutically relevant concentration of lithium (1mM) substantially inhibited (30-35) carbachol-stimulation AP-1 but not NF- B. Inhibition of carbachol-induced AP-1 was directly related to the concentration of lithium (1-20mM). Besides being differentially sensitive to inhibition by lithium, activation of AP-1 and NF-B demonstrated different carbachol EC50 concentrations, and carbachol-induced activation of AP-1, but not NF-B, was inhibited by treating cells with Ni2+, which blocks receptor-mediated calcium influx. These findings demonstrate that one mechanism by which lithium can influence the expression of specific genes is through the selective modulation of signaling processes which emanate from cholinergic receptor stimulation.

Url:

https://api.istex.fr/ark:/67375/6H6-3DW8G95J-B/fulltext.pdf

DOI: 10.1016/S0169-328X(97)00183-6

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ISTEX:BBE29F0F5F7C2820DC6174F25854186EF9A370C4

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: In order to identify potential actions of lithium, the primary therapeutic agent for bipolar affective disorder, on processes regulating gene expression, its effects on two transcription factors, AP-1 and NF- B, were measured in human neuroblastoma SH-SY5Y cells. The cholinergic agonist carbachol concentration-dependently stimulated AP-1 (EC50 2M) and NF-B (EC50 14M). Pretreatment for 24hwith a therapeutically relevant concentration of lithium (1mM) substantially inhibited (30-35) carbachol-stimulation AP-1 but not NF- B. Inhibition of carbachol-induced AP-1 was directly related to the concentration of lithium (1-20mM). Besides being differentially sensitive to inhibition by lithium, activation of AP-1 and NF-B demonstrated different carbachol EC50 concentrations, and carbachol-induced activation of AP-1, but not NF-B, was inhibited by treating cells with Ni2+, which blocks receptor-mediated calcium influx. These findings demonstrate that one mechanism by which lithium can influence the expression of specific genes is through the selective modulation of signaling processes which emanate from cholinergic receptor stimulation.</div>
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AP-1 and NF- B stimulated by carbachol in human neuroblastoma SH-SY5Y cells are differentially sensitive to inhibition by lithium

AP-1 and NF- B stimulated by carbachol in human neuroblastoma SH-SY5Y cells are differentially sensitive to inhibition by lithium

Source :

English descriptors

Abstract

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