The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research.
Identifieur interne : 000036 ( PubMed/Corpus ); précédent : 000035; suivant : 000037The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research.
Auteurs : Joseline Ratnam ; Barbara Zdrazil ; Daniela Digles ; Emiliano Cuadrado-Rodriguez ; Jean-Marc Neefs ; Hannah Tipney ; Ronald Siebes ; Andra Waagmeester ; Glyn Bradley ; Chau Han Chau ; Lars Richter ; Jose Brea ; Chris T. Evelo ; Edgar Jacoby ; Stefan Senger ; Maria Isabel Loza ; Gerhard F. Ecker ; Christine ChichesterSource :
- PloS one [ 1932-6203 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- methods : Drug Discovery.
- organization & administration : Drug Discovery.
- statistics & numerical data : Drug Discovery.
- Databases as Topic, Software.
Abstract
Integration of open access, curated, high-quality information from multiple disciplines in the Life and Biomedical Sciences provides a holistic understanding of the domain. Additionally, the effective linking of diverse data sources can unearth hidden relationships and guide potential research strategies. However, given the lack of consistency between descriptors and identifiers used in different resources and the absence of a simple mechanism to link them, gathering and combining relevant, comprehensive information from diverse databases remains a challenge. The Open Pharmacological Concepts Triple Store (Open PHACTS) is an Innovative Medicines Initiative project that uses semantic web technology approaches to enable scientists to easily access and process data from multiple sources to solve real-world drug discovery problems. The project draws together sources of publicly-available pharmacological, physicochemical and biomolecular data, represents it in a stable infrastructure and provides well-defined information exploration and retrieval methods. Here, we highlight the utility of this platform in conjunction with workflow tools to solve pharmacological research questions that require interoperability between target, compound, and pathway data. Use cases presented herein cover 1) the comprehensive identification of chemical matter for a dopamine receptor drug discovery program 2) the identification of compounds active against all targets in the Epidermal growth factor receptor (ErbB) signaling pathway that have a relevance to disease and 3) the evaluation of established targets in the Vitamin D metabolism pathway to aid novel Vitamin D analogue design. The example workflows presented illustrate how the Open PHACTS Discovery Platform can be used to exploit existing knowledge and generate new hypotheses in the process of drug discovery.
DOI: 10.1371/journal.pone.0115460
PubMed: 25522365
Links to Exploration step
pubmed:25522365Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research.</title><author><name sortKey="Ratnam, Joseline" sort="Ratnam, Joseline" uniqKey="Ratnam J" first="Joseline" last="Ratnam">Joseline Ratnam</name><affiliation><nlm:affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Zdrazil, Barbara" sort="Zdrazil, Barbara" uniqKey="Zdrazil B" first="Barbara" last="Zdrazil">Barbara Zdrazil</name><affiliation><nlm:affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Digles, Daniela" sort="Digles, Daniela" uniqKey="Digles D" first="Daniela" last="Digles">Daniela Digles</name><affiliation><nlm:affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Cuadrado Rodriguez, Emiliano" sort="Cuadrado Rodriguez, Emiliano" uniqKey="Cuadrado Rodriguez E" first="Emiliano" last="Cuadrado-Rodriguez">Emiliano Cuadrado-Rodriguez</name><affiliation><nlm:affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Neefs, Jean Marc" sort="Neefs, Jean Marc" uniqKey="Neefs J" first="Jean-Marc" last="Neefs">Jean-Marc Neefs</name><affiliation><nlm:affiliation>Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Tipney, Hannah" sort="Tipney, Hannah" uniqKey="Tipney H" first="Hannah" last="Tipney">Hannah Tipney</name><affiliation><nlm:affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Siebes, Ronald" sort="Siebes, Ronald" uniqKey="Siebes R" first="Ronald" last="Siebes">Ronald Siebes</name><affiliation><nlm:affiliation>Vrije Universiteit, Faculty of Sciences, division of Math. and Computer Science, De Boelelaan 1081a, 1081 HV Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Waagmeester, Andra" sort="Waagmeester, Andra" uniqKey="Waagmeester A" first="Andra" last="Waagmeester">Andra Waagmeester</name><affiliation><nlm:affiliation>Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bradley, Glyn" sort="Bradley, Glyn" uniqKey="Bradley G" first="Glyn" last="Bradley">Glyn Bradley</name><affiliation><nlm:affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Chau, Chau Han" sort="Chau, Chau Han" uniqKey="Chau C" first="Chau Han" last="Chau">Chau Han Chau</name><affiliation><nlm:affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Richter, Lars" sort="Richter, Lars" uniqKey="Richter L" first="Lars" last="Richter">Lars Richter</name><affiliation><nlm:affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Brea, Jose" sort="Brea, Jose" uniqKey="Brea J" first="Jose" last="Brea">Jose Brea</name><affiliation><nlm:affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Evelo, Chris T" sort="Evelo, Chris T" uniqKey="Evelo C" first="Chris T" last="Evelo">Chris T. Evelo</name><affiliation><nlm:affiliation>Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Jacoby, Edgar" sort="Jacoby, Edgar" uniqKey="Jacoby E" first="Edgar" last="Jacoby">Edgar Jacoby</name><affiliation><nlm:affiliation>Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Senger, Stefan" sort="Senger, Stefan" uniqKey="Senger S" first="Stefan" last="Senger">Stefan Senger</name><affiliation><nlm:affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Loza, Maria Isabel" sort="Loza, Maria Isabel" uniqKey="Loza M" first="Maria Isabel" last="Loza">Maria Isabel Loza</name><affiliation><nlm:affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ecker, Gerhard F" sort="Ecker, Gerhard F" uniqKey="Ecker G" first="Gerhard F" last="Ecker">Gerhard F. Ecker</name><affiliation><nlm:affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Chichester, Christine" sort="Chichester, Christine" uniqKey="Chichester C" first="Christine" last="Chichester">Christine Chichester</name><affiliation><nlm:affiliation>Swiss Institute of Bioinformatics, CALIPHO Group, CMU - Rue Michel-Servet 1, 1211 Geneva 4, Switzerland.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25522365</idno><idno type="pmid">25522365</idno><idno type="doi">10.1371/journal.pone.0115460</idno><idno type="wicri:Area/PubMed/Corpus">000036</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research.</title><author><name sortKey="Ratnam, Joseline" sort="Ratnam, Joseline" uniqKey="Ratnam J" first="Joseline" last="Ratnam">Joseline Ratnam</name><affiliation><nlm:affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Zdrazil, Barbara" sort="Zdrazil, Barbara" uniqKey="Zdrazil B" first="Barbara" last="Zdrazil">Barbara Zdrazil</name><affiliation><nlm:affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Digles, Daniela" sort="Digles, Daniela" uniqKey="Digles D" first="Daniela" last="Digles">Daniela Digles</name><affiliation><nlm:affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Cuadrado Rodriguez, Emiliano" sort="Cuadrado Rodriguez, Emiliano" uniqKey="Cuadrado Rodriguez E" first="Emiliano" last="Cuadrado-Rodriguez">Emiliano Cuadrado-Rodriguez</name><affiliation><nlm:affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Neefs, Jean Marc" sort="Neefs, Jean Marc" uniqKey="Neefs J" first="Jean-Marc" last="Neefs">Jean-Marc Neefs</name><affiliation><nlm:affiliation>Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Tipney, Hannah" sort="Tipney, Hannah" uniqKey="Tipney H" first="Hannah" last="Tipney">Hannah Tipney</name><affiliation><nlm:affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Siebes, Ronald" sort="Siebes, Ronald" uniqKey="Siebes R" first="Ronald" last="Siebes">Ronald Siebes</name><affiliation><nlm:affiliation>Vrije Universiteit, Faculty of Sciences, division of Math. and Computer Science, De Boelelaan 1081a, 1081 HV Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Waagmeester, Andra" sort="Waagmeester, Andra" uniqKey="Waagmeester A" first="Andra" last="Waagmeester">Andra Waagmeester</name><affiliation><nlm:affiliation>Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bradley, Glyn" sort="Bradley, Glyn" uniqKey="Bradley G" first="Glyn" last="Bradley">Glyn Bradley</name><affiliation><nlm:affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Chau, Chau Han" sort="Chau, Chau Han" uniqKey="Chau C" first="Chau Han" last="Chau">Chau Han Chau</name><affiliation><nlm:affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Richter, Lars" sort="Richter, Lars" uniqKey="Richter L" first="Lars" last="Richter">Lars Richter</name><affiliation><nlm:affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Brea, Jose" sort="Brea, Jose" uniqKey="Brea J" first="Jose" last="Brea">Jose Brea</name><affiliation><nlm:affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Evelo, Chris T" sort="Evelo, Chris T" uniqKey="Evelo C" first="Chris T" last="Evelo">Chris T. Evelo</name><affiliation><nlm:affiliation>Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Jacoby, Edgar" sort="Jacoby, Edgar" uniqKey="Jacoby E" first="Edgar" last="Jacoby">Edgar Jacoby</name><affiliation><nlm:affiliation>Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Senger, Stefan" sort="Senger, Stefan" uniqKey="Senger S" first="Stefan" last="Senger">Stefan Senger</name><affiliation><nlm:affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Loza, Maria Isabel" sort="Loza, Maria Isabel" uniqKey="Loza M" first="Maria Isabel" last="Loza">Maria Isabel Loza</name><affiliation><nlm:affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ecker, Gerhard F" sort="Ecker, Gerhard F" uniqKey="Ecker G" first="Gerhard F" last="Ecker">Gerhard F. Ecker</name><affiliation><nlm:affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Chichester, Christine" sort="Chichester, Christine" uniqKey="Chichester C" first="Christine" last="Chichester">Christine Chichester</name><affiliation><nlm:affiliation>Swiss Institute of Bioinformatics, CALIPHO Group, CMU - Rue Michel-Servet 1, 1211 Geneva 4, Switzerland.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Databases as Topic</term><term>Drug Discovery (methods)</term><term>Drug Discovery (organization & administration)</term><term>Drug Discovery (statistics & numerical data)</term><term>Software</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Discovery</term></keywords><keywords scheme="MESH" qualifier="organization & administration" xml:lang="en"><term>Drug Discovery</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Drug Discovery</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Databases as Topic</term><term>Software</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Integration of open access, curated, high-quality information from multiple disciplines in the Life and Biomedical Sciences provides a holistic understanding of the domain. Additionally, the effective linking of diverse data sources can unearth hidden relationships and guide potential research strategies. However, given the lack of consistency between descriptors and identifiers used in different resources and the absence of a simple mechanism to link them, gathering and combining relevant, comprehensive information from diverse databases remains a challenge. The Open Pharmacological Concepts Triple Store (Open PHACTS) is an Innovative Medicines Initiative project that uses semantic web technology approaches to enable scientists to easily access and process data from multiple sources to solve real-world drug discovery problems. The project draws together sources of publicly-available pharmacological, physicochemical and biomolecular data, represents it in a stable infrastructure and provides well-defined information exploration and retrieval methods. Here, we highlight the utility of this platform in conjunction with workflow tools to solve pharmacological research questions that require interoperability between target, compound, and pathway data. Use cases presented herein cover 1) the comprehensive identification of chemical matter for a dopamine receptor drug discovery program 2) the identification of compounds active against all targets in the Epidermal growth factor receptor (ErbB) signaling pathway that have a relevance to disease and 3) the evaluation of established targets in the Vitamin D metabolism pathway to aid novel Vitamin D analogue design. The example workflows presented illustrate how the Open PHACTS Discovery Platform can be used to exploit existing knowledge and generate new hypotheses in the process of drug discovery.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25522365</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>19</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>17</Day></DateCompleted><DateRevised><Year>2014</Year><Month>12</Month><Day>27</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>12</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research.</ArticleTitle><Pagination><MedlinePgn>e115460</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0115460</ELocationID><Abstract><AbstractText>Integration of open access, curated, high-quality information from multiple disciplines in the Life and Biomedical Sciences provides a holistic understanding of the domain. Additionally, the effective linking of diverse data sources can unearth hidden relationships and guide potential research strategies. However, given the lack of consistency between descriptors and identifiers used in different resources and the absence of a simple mechanism to link them, gathering and combining relevant, comprehensive information from diverse databases remains a challenge. The Open Pharmacological Concepts Triple Store (Open PHACTS) is an Innovative Medicines Initiative project that uses semantic web technology approaches to enable scientists to easily access and process data from multiple sources to solve real-world drug discovery problems. The project draws together sources of publicly-available pharmacological, physicochemical and biomolecular data, represents it in a stable infrastructure and provides well-defined information exploration and retrieval methods. Here, we highlight the utility of this platform in conjunction with workflow tools to solve pharmacological research questions that require interoperability between target, compound, and pathway data. Use cases presented herein cover 1) the comprehensive identification of chemical matter for a dopamine receptor drug discovery program 2) the identification of compounds active against all targets in the Epidermal growth factor receptor (ErbB) signaling pathway that have a relevance to disease and 3) the evaluation of established targets in the Vitamin D metabolism pathway to aid novel Vitamin D analogue design. The example workflows presented illustrate how the Open PHACTS Discovery Platform can be used to exploit existing knowledge and generate new hypotheses in the process of drug discovery.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ratnam</LastName><ForeName>Joseline</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zdrazil</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Digles</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cuadrado-Rodriguez</LastName><ForeName>Emiliano</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neefs</LastName><ForeName>Jean-Marc</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tipney</LastName><ForeName>Hannah</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siebes</LastName><ForeName>Ronald</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Vrije Universiteit, Faculty of Sciences, division of Math. and Computer Science, De Boelelaan 1081a, 1081 HV Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waagmeester</LastName><ForeName>Andra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bradley</LastName><ForeName>Glyn</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chau</LastName><ForeName>Chau Han</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richter</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brea</LastName><ForeName>Jose</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evelo</LastName><ForeName>Chris T</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacoby</LastName><ForeName>Edgar</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Senger</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loza</LastName><ForeName>Maria Isabel</ForeName><Initials>MI</Initials><AffiliationInfo><Affiliation>Universidade de Santiago de Compostela, Grupo BioFarma-USEF, Departamento de Farmacología, Campus Universitario Sur s/n, 15782 Santiago de Compostela, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ecker</LastName><ForeName>Gerhard F</ForeName><Initials>GF</Initials><AffiliationInfo><Affiliation>University of Vienna, Department of Pharmaceutical Chemistry, Althanstrasse 14, 1090 Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chichester</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Swiss Institute of Bioinformatics, CALIPHO Group, CMU - Rue Michel-Servet 1, 1211 Geneva 4, Switzerland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>Dec</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2008 Jan;36(Database issue):D344-50</RefSource><PMID Version="1">17932057</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Bioinformatics. 2008;9 Suppl 5:S2</RefSource><PMID Version="1">18460184</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biomed Inform. 2008 Oct;41(5):706-16</RefSource><PMID Version="1">18472304</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Aspects Med. 2008 Dec;29(6):433-52</RefSource><PMID Version="1">18554710</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Aspects Med. 2008 Dec;29(6):388-96</RefSource><PMID Version="1">18755215</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioorg Med Chem. 2009 Jul 1;17(13):4296-301</RefSource><PMID Version="1">19482479</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Oncol. 2009 Aug;35(2):257-63</RefSource><PMID Version="1">19578738</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Carcinogenesis. 2009 Aug;30(8):1459-68</RefSource><PMID Version="1">19502595</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2009 Nov 12;462(7270):175-81</RefSource><PMID Version="1">19881490</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2010 Jan;38(Database issue):D249-54</RefSource><PMID Version="1">19854951</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2010;5(4):e10221</RefSource><PMID Version="1">20421926</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Bioinformatics. 2010;11:255</RefSource><PMID Version="1">20478034</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):106-9</RefSource><PMID Version="1">20138990</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Schizophr Relat Psychoses. 2010 Apr;4(1):56-73</RefSource><PMID Version="1">20643630</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41</RefSource><PMID Version="1">21059682</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pharmacol Rev. 2011 Mar;63(1):182-217</RefSource><PMID Version="1">21303898</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2012 Jan;40(Database issue):D1100-7</RefSource><PMID Version="1">21948594</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2012 Jan;40(Database issue):D1301-7</RefSource><PMID Version="1">22096230</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Biochem Biophys. 2012 Jul 1;523(1):9-18</RefSource><PMID Version="1">22100522</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11178-83</RefSource><PMID Version="1">22711801</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2012 Aug;12(8):553-63</RefSource><PMID Version="1">22785351</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Drug Discov Today. 2012 Nov;17(21-22):1188-98</RefSource><PMID Version="1">22683805</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2013 Jan;41(Database issue):D456-63</RefSource><PMID Version="1">23180789</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEBS Lett. 2013 Apr 2;587(7):957-63</RefSource><PMID Version="1">23462137</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Musculoskelet Neuronal Interact. 2006 Oct-Dec;6(4):336-7</RefSource><PMID Version="1">17185813</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Mol Cell Biol. 2001 Feb;2(2):127-37</RefSource><PMID Version="1">11252954</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FASEB J. 2001 Dec;15(14):2579-85</RefSource><PMID Version="1">11726533</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Mol Med. 2002 Apr;8(4):174-9</RefSource><PMID Version="1">11927275</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Drug Discov. 2002 Jun;1(6):479</RefSource><PMID Version="1">12119750</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Chem Soc. 2002 Nov 20;124(46):13795-805</RefSource><PMID Version="1">12431109</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2004 Jan 1;32(Database issue):D115-9</RefSource><PMID Version="1">14681372</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Biotechnol. 2004 Jul;22(7):340-5</RefSource><PMID Version="1">15245906</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2004 Aug 6;279(32):34048-61</RefSource><PMID Version="1">15175332</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2004 Sep;10(9):917-9</RefSource><PMID Version="1">15322538</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1971 Apr;68(4):803-4</RefSource><PMID Version="1">4323790</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Pharmacol Sci. 1992 Feb;13(2):61-9</RefSource><PMID Version="1">1561715</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Pharmacol Toxicol. 1993;33:281-307</RefSource><PMID Version="1">8494342</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 1994 Apr;134(4):1761-7</RefSource><PMID Version="1">8137741</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 1997 Sep 1;25(17):3389-402</RefSource><PMID Version="1">9254694</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Bone Miner Res. 1998 Mar;13(3):325-49</RefSource><PMID Version="1">9525333</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychopharmacology (Berl). 2007 Apr;191(3):391-431</RefSource><PMID Version="1">17072591</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2007 Oct;148(10):4974-83</RefSource><PMID Version="1">17615144</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Comb Chem High Throughput Screen. 2007 Sep;10(8):719-31</RefSource><PMID Version="1">18045083</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2000 Jan 1;28(1):304-5</RefSource><PMID Version="1">10592255</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2000 May;25(1):25-9</RefSource><PMID Version="1">10802651</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Steroid Biochem Mol Biol. 2013 Jul;136:252-7</RefSource><PMID Version="1">23059474</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Dev Immunol. 2013;2013:939786</RefSource><PMID Version="1">23970926</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Drug Discov Today. 2013 Sep;18(17-18):843-52</RefSource><PMID Version="1">23702085</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2014 Jan;42(Database issue):D1083-90</RefSource><PMID Version="1">24214965</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chem Biol. 1999 May;6(5):265-75</RefSource><PMID Version="1">10322128</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Chem. 1999 Sep 9;42(18):3539-56</RefSource><PMID Version="1">10479287</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Biochem Sci. 2004 Dec;29(12):664-73</RefSource><PMID Version="1">15544953</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2005 May;5(5):341-54</RefSource><PMID Version="1">15864276</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Endocrinol. 2005 Aug;19(8):2060-73</RefSource><PMID Version="1">15860548</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):93-101</RefSource><PMID Version="1">16046118</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Chemother Pharmacol. 2006 Jan;57(2):234-40</RefSource><PMID Version="1">16180015</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2006 Apr;116(4):892-904</RefSource><PMID Version="1">16528410</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2006 Nov 3;127(3):635-48</RefSource><PMID Version="1">17081983</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D019992" MajorTopicYN="Y">Databases as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055808" MajorTopicYN="N">Drug Discovery</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000458" MajorTopicYN="Y">organization & administration</QualifierName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012984" MajorTopicYN="Y">Software</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4270790</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>5</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>10</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25522365</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0115460</ArticleId><ArticleId IdType="pii">PONE-D-14-21970</ArticleId><ArticleId IdType="pmc">PMC4270790</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000036 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000036 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Belgique
|area= OpenAccessBelV2
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:25522365
|texte= The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:25522365" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a OpenAccessBelV2
| This area was generated with Dilib version V0.6.25. |  |