A practical application of text mining to literature on cognitive rehabilitation and enhancement through neurostimulation
Identifieur interne : 000466 ( Pmc/Corpus ); précédent : 000465; suivant : 000467A practical application of text mining to literature on cognitive rehabilitation and enhancement through neurostimulation
Auteurs : Puiu F. Balan ; Annelies Gerits ; Wim VanduffelSource :
- Frontiers in Systems Neuroscience [ 1662-5137 ] ; 2014.
Abstract
The exponential growth in publications represents a major challenge for researchers. Many scientific domains, including neuroscience, are not yet fully engaged in exploiting large bodies of publications. In this paper, we promote the idea to partially automate the processing of scientific documents, specifically using text mining (TM), to efficiently review big corpora of publications. The “cognitive advantage” given by TM is mainly related to the automatic extraction of relevant trends from corpora of literature, otherwise impossible to analyze in short periods of time. Specifically, the benefits of TM are increased speed, quality and reproducibility of text processing, boosted by rapid updates of the results. First, we selected a set of TM-tools that allow user-friendly approaches of the scientific literature, and which could serve as a guide for researchers willing to incorporate TM in their work. Second, we used these TM-tools to obtain basic insights into the relevant literature on cognitive rehabilitation (CR) and cognitive enhancement (CE) using transcranial magnetic stimulation (TMS). TM readily extracted the diversity of TMS applications in CR and CE from vast corpora of publications, automatically retrieving trends already described in published reviews. TMS emerged as one of the important non-invasive tools that can both improve cognitive and motor functions in numerous neurological diseases and induce modulations/enhancements of many fundamental brain functions. TM also revealed trends in big corpora of publications by extracting occurrence frequency and relationships of particular subtopics. Moreover, we showed that CR and CE share research topics, both aiming to increase the brain's capacity to process information, thus supporting their integration in a larger perspective. Methodologically, despite limitations of a simple user-friendly approach, TM served well the reviewing process.
Url:
DOI: 10.3389/fnsys.2014.00182
PubMed: 25309356
PubMed Central: 4176459
Links to Exploration step
PMC:4176459Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A practical application of text mining to literature on cognitive rehabilitation and enhancement through neurostimulation</title><author><name sortKey="Balan, Puiu F" sort="Balan, Puiu F" uniqKey="Balan P" first="Puiu F." last="Balan">Puiu F. Balan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gerits, Annelies" sort="Gerits, Annelies" uniqKey="Gerits A" first="Annelies" last="Gerits">Annelies Gerits</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Vanduffel, Wim" sort="Vanduffel, Wim" uniqKey="Vanduffel W" first="Wim" last="Vanduffel">Wim Vanduffel</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25309356</idno><idno type="pmc">4176459</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176459</idno><idno type="RBID">PMC:4176459</idno><idno type="doi">10.3389/fnsys.2014.00182</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000466</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A practical application of text mining to literature on cognitive rehabilitation and enhancement through neurostimulation</title><author><name sortKey="Balan, Puiu F" sort="Balan, Puiu F" uniqKey="Balan P" first="Puiu F." last="Balan">Puiu F. Balan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gerits, Annelies" sort="Gerits, Annelies" uniqKey="Gerits A" first="Annelies" last="Gerits">Annelies Gerits</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Vanduffel, Wim" sort="Vanduffel, Wim" uniqKey="Vanduffel W" first="Wim" last="Vanduffel">Wim Vanduffel</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers in Systems Neuroscience</title><idno type="eISSN">1662-5137</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The exponential growth in publications represents a major challenge for researchers. Many scientific domains, including neuroscience, are not yet fully engaged in exploiting large bodies of publications. In this paper, we promote the idea to partially automate the processing of scientific documents, specifically using text mining (TM), to efficiently review big corpora of publications. The “cognitive advantage” given by TM is mainly related to the automatic extraction of relevant trends from corpora of literature, otherwise impossible to analyze in short periods of time. Specifically, the benefits of TM are increased speed, quality and reproducibility of text processing, boosted by rapid updates of the results. First, we selected a set of TM-tools that allow user-friendly approaches of the scientific literature, and which could serve as a guide for researchers willing to incorporate TM in their work. Second, we used these TM-tools to obtain basic insights into the relevant literature on cognitive rehabilitation (CR) and cognitive enhancement (CE) using transcranial magnetic stimulation (TMS). TM readily extracted the diversity of TMS applications in CR and CE from vast corpora of publications, automatically retrieving trends already described in published reviews. TMS emerged as one of the important non-invasive tools that can both improve cognitive and motor functions in numerous neurological diseases and induce modulations/enhancements of many fundamental brain functions. TM also revealed trends in big corpora of publications by extracting occurrence frequency and relationships of particular subtopics. Moreover, we showed that CR and CE share research topics, both aiming to increase the brain's capacity to process information, thus supporting their integration in a larger perspective. Methodologically, despite limitations of a simple user-friendly approach, TM served well the reviewing process.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Akil, H" uniqKey="Akil H">H. Akil</name></author><author><name sortKey="Martone, M E" uniqKey="Martone M">M. E. Martone</name></author><author><name sortKey="Van Essen, D C" uniqKey="Van Essen D">D. C. Van Essen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alfred, R" uniqKey="Alfred R">R. Alfred</name></author><author><name sortKey="Razali, M" uniqKey="Razali M">M. Razali</name></author><author><name sortKey="Alias, S" uniqKey="Alias S">S. Alias</name></author><author><name sortKey="On, C" uniqKey="On C">C. On</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baruth, J M" uniqKey="Baruth J">J. M. Baruth</name></author><author><name sortKey="Casanova, M F" uniqKey="Casanova M">M. F. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Syst Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">Front Syst Neurosci</journal-id><journal-id journal-id-type="publisher-id">Front. Syst. Neurosci.</journal-id><journal-title-group><journal-title>Frontiers in Systems Neuroscience</journal-title></journal-title-group><issn pub-type="epub">1662-5137</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25309356</article-id><article-id pub-id-type="pmc">4176459</article-id><article-id pub-id-type="doi">10.3389/fnsys.2014.00182</article-id><article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject><subj-group><subject>Review Article</subject></subj-group></subj-group></article-categories><title-group><article-title>A practical application of text mining to literature on cognitive rehabilitation and enhancement through neurostimulation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Balan</surname><given-names>Puiu F.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/4292"></uri></contrib><contrib contrib-type="author"><name><surname>Gerits</surname><given-names>Annelies</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/66359"></uri></contrib><contrib contrib-type="author"><name><surname>Vanduffel</surname><given-names>Wim</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/55705"></uri></contrib></contrib-group><aff id="aff1"><institution>Laboratory for Neuro-and Psychophysiology, Katholieke Universiteit Leuven Medical School</institution><country>Leuven, Belgium</country></aff><aff id="aff2"><institution>Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital</institution><country>Charlestown, MA, USA</country></aff><aff id="aff3"><institution>Department of Radiology, Harvard Medical School</institution><country>Charlestown, MA, USA</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Ioan Opris, Wake Forest University, USA</p></fn><fn fn-type="edited-by"><p>Reviewed by: Estate M. Sokhadze, University of Louisville, USA; Mikhail Lebedev, Duke University, USA</p></fn><corresp id="fn001">*Correspondence: Puiu F. Balan, Laboratory for Neuro-and Psychophysiology, KU Leuven Medical School, Herestraat 49, Bus 1021, Leuven 3000, Belgium e-mail: <email xlink:type="simple">puiu.balan@med.kuleuven.be</email></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to the journal Frontiers in Systems Neuroscience.</p></fn></author-notes><pub-date pub-type="epub"><day>26</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="collection"><year>2014</year></pub-date><volume>8</volume><elocation-id>182</elocation-id><history><date date-type="received"><day>28</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>08</day><month>9</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 Balan, Gerits and Vanduffel.</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>The exponential growth in publications represents a major challenge for researchers. Many scientific domains, including neuroscience, are not yet fully engaged in exploiting large bodies of publications. In this paper, we promote the idea to partially automate the processing of scientific documents, specifically using text mining (TM), to efficiently review big corpora of publications. The “cognitive advantage” given by TM is mainly related to the automatic extraction of relevant trends from corpora of literature, otherwise impossible to analyze in short periods of time. Specifically, the benefits of TM are increased speed, quality and reproducibility of text processing, boosted by rapid updates of the results. First, we selected a set of TM-tools that allow user-friendly approaches of the scientific literature, and which could serve as a guide for researchers willing to incorporate TM in their work. Second, we used these TM-tools to obtain basic insights into the relevant literature on cognitive rehabilitation (CR) and cognitive enhancement (CE) using transcranial magnetic stimulation (TMS). TM readily extracted the diversity of TMS applications in CR and CE from vast corpora of publications, automatically retrieving trends already described in published reviews. TMS emerged as one of the important non-invasive tools that can both improve cognitive and motor functions in numerous neurological diseases and induce modulations/enhancements of many fundamental brain functions. TM also revealed trends in big corpora of publications by extracting occurrence frequency and relationships of particular subtopics. Moreover, we showed that CR and CE share research topics, both aiming to increase the brain's capacity to process information, thus supporting their integration in a larger perspective. Methodologically, despite limitations of a simple user-friendly approach, TM served well the reviewing process.</p></abstract><kwd-group><kwd>text mining</kwd><kwd>transcranial magnetic stimulation</kwd><kwd>cognitive</kwd><kwd>rehabilitation</kwd><kwd>enhancement</kwd></kwd-group><counts><fig-count count="4"></fig-count><table-count count="5"></table-count><equation-count count="0"></equation-count><ref-count count="71"></ref-count><page-count count="14"></page-count><word-count count="9424"></word-count></counts></article-meta></front><body><sec sec-type="intro" id="s1"><title>Introduction</title><p>Gathering accurate and reliable information from web repositories became increasingly complex because of the exponential growth in the number of publications. For example, a PubMed search retrieved 9407 papers including 1172 reviews for TMS in “All Fields,” and the ratio became 8186/988 when the filter “[Title/Abstract]” was applied. Reading without some selection criteria becomes challenging. Even when selectively focusing on specific topics in a review, this increases the chances to miss trends shown only by huge bodies of literature. Thus, when processing vast corpora of publications, we are facing challenges that require automated solutions. One of the most promising approaches to alleviate these problems is to assist the human operator with computers running artificial intelligence applications. Here, we selected one of these applications, text mining (TM), and showed that TM will enable us to efficiently deal with huge amounts of information from the TMS-related literature.</p><p>Our approach was also motivated by the fact that, neuroscience has to make efforts to integrate data mining and TM when dealing with huge and diverse experimental datasets (Akil et al., <xref rid="B1" ref-type="bibr">2011</xref>) and text documents. TM is able to catch the complexity of all relevant studies in an efficient manner. Statistical and natural language processing (NLP) procedures to “mine” the literature have been developed to address big data general problems (Dias et al., <xref rid="B18" ref-type="bibr">2011</xref>). Here, we used a practical approach to promote TM as a tool for the reviewing process. Specifically, we selected a set of TM-tools that allowed user-friendly approaches to reveal relevant outcomes in large corpora of publications. Our intention was to use TM-tools that are not too demanding on programming skills, required knowledge and training period. Therefore, the example set of TM-tools could serve as an attractive guide map for researchers willing to incorporate TM in their work.</p><p>Next, we demonstrate the use of TM-tools in gaining basic insights into the relevant literature on cognitive rehabilitation (CR) and cognitive enhancement (CE) using transcranial magnetic stimulation (TMS). TMS is a valuable non-invasive perturbation method used to address fundamental and clinical neuroscience questions, both in human and animal models. Cognitive rehabilitation (CR-TMS) and cognitive enhancement (CE-TMS) are two important TMS applications. Indeed, TMS is establishing itself as major tool used in rehabilitation improving a wide variety of impaired mental functions (Miniussi and Rossini, <xref rid="B53" ref-type="bibr">2011</xref>; Kammer and Spitzer, <xref rid="B35" ref-type="bibr">2012</xref>; Vicario and Nitsche, <xref rid="B68" ref-type="bibr">2013</xref>). Moreover, recent studies reported TMS-induced enhancements of normal brain functions (Brem et al., <xref rid="B9" ref-type="bibr">2014</xref>; Luber and Lisanby, <xref rid="B48" ref-type="bibr">2014</xref>).</p><p>The TM application to CR- and CE-TMS literature was focused on two main aspects. First, we aimed to show that TM could reveal the diversity of TMS applications in CR and CE, automatically retrieving trends already described in published reviews. Second, we specifically aimed to find trends only noticeable in big corpora of publications. The main feature of our findings is given by the statistical power of such analyses. Detailed analyses of the CR- and CE-TMS literature revealed relevant terms in the form of lists, topics and classes of terms associated with specific subtopics. It also showed relations between the relevant terms in the form of co-occurrences maps, groups of relevant terms with high probability co-occurrences and lists of relevant relational verbs. Moreover, the TM approach revealed conclusive sentences that appeared with a high probability. Finally, a large-scale corpora perspective showed that CR-TMS and CE-TMS share research topics allowing us to make inferences about their similarities. Although they start from specific states of the brain (impaired for CR and normal for CE), both aim to increase the brain's capacity to process information and to optimize adaptation. This unitary perspective is supported by fields that use TMS in diagnostic (TMS-DIAG) or in clinical and fundamental research (TMS-RES), which show that TMS is effective for changing and studying normal and abnormal brain processes. Accordingly, CR-TMS and CE-TMS also share research topics with these fields, showing their appurtenance to a larger context, which integrates diagnostic, fundamental research and fMRI studies.</p></sec><sec><title>Text mining as a method to partially automate the reviewing of big corpora of publications</title><p>Scholarly journals and data sources are increasingly available in electronic and Open Access form. Nonetheless, availability is not enough to extract specific information, mainly due to the abundance of information. TM comes with solutions for this problem offering automated methods to extract condensed information hidden within huge volumes of publications. TM can be achieved using several complementary approaches (Cohen and Hunter, <xref rid="B13" ref-type="bibr">2008</xref>). Co-occurrence-based methods look for concepts that occur in the same unit of text (sentence/abstract) and posit a relationship between them. The statistical or machine learning systems rely on statistic properties of the text and work by building classifiers that operate on any level, from labeling part of speech to classifying full sentences or documents. The rule-based systems use knowledge about how language is structured and about how domain relevant things, facts and their relationships are stated in publications. The main areas/stages of TM are (Lourenco et al., <xref rid="B45" ref-type="bibr">2009</xref>): Information Analysis that includes Information Retrieval and Information Extraction (e.g., Name Entity Recognition, Relationship Extraction, document classification and summarization); Information Synthesis that uses the databases generated by Information Extraction for answering simple questions, discovering new information and generating hypotheses.</p><p>A wide variety of publications and software tools approach TM at different levels of complexity, hampering the selection of relevant TM-tools. We chose a specific set of TM-tools, aiming to evaluate how they can help the TM-non-specialist accelerate the review of big corpora of literature, using the following criteria:</p><list list-type="alpha-lower"><list-item><p>Allow a user-friendly approach by selecting TM-tools requiring medium investments in training, programming and specific knowledge.</p></list-item><list-item><p>Use free open-source software, selected based on features like: easiness of installation; quality of the documentation and support; accessible formats for input and output.</p></list-item><list-item><p>Use TM-tools with general functionalities like: allowance of document corpora; pre-processing the text; built-in biomedical Name Entity Recognition; queries to a document or corpora; support for ontologies and terminologies.</p></list-item></list><p>We used three groups of TM-tools that served different purposes:</p><list list-type="roman-upper"><list-item><p>Basic resources that gave foundation to TM: the MeSH browser; the PubMed repository of publications; repositories of NLP resources (e.g., Neuroscience Information Framework, National Institute of Neurological Disorders and Stroke).</p></list-item><list-item><p>TM-tools II (Table <xref ref-type="table" rid="T1">1</xref>) that are web-based ready-to-use tools requiring no programming efforts and performing simple TM tasks (Lu, <xref rid="B46" ref-type="bibr">2011</xref>).</p></list-item><list-item><p>TM-tools III that were used in the final stage of the study optimized for the reviewed topics:</p><list list-type="order"><list-item><p>Statistical or machine-learning-based approaches: Mallet (McCallum, <xref rid="B50" ref-type="bibr">2002</xref>), Text to Matrix Generator (TMG) (Zeimpekis and Gallopoulos, <xref rid="B70" ref-type="bibr">2006</xref>) and Matlab applications for NLP.</p></list-item><list-item><p>TM-tools with predefined NLP processing stream: KH Coder (Higuchi, <xref rid="B31" ref-type="bibr">2012</xref>).</p></list-item><list-item><p>Integrated environments for visual programming of NLP: VisualText (Meyers, <xref rid="B52" ref-type="bibr">2003</xref>; Alfred et al., <xref rid="B2" ref-type="bibr">2014</xref>).</p></list-item><list-item><p>Biomedical TM rule-based approaches using fully automated stages in text processing: Anote2 (Lourenco et al., <xref rid="B45" ref-type="bibr">2009</xref>) and Biological Research Assistant for TM (BioRAT) (Corney et al., <xref rid="B16" ref-type="bibr">2004</xref>).</p></list-item></list></list-item></list><table-wrap id="T1" position="float"><label>Table 1</label><caption><p><bold>TM-tools II presented in the order (indicated by numbers) of their use</bold>.</p></caption><graphic xlink:href="fnsys-08-00182-i0001"></graphic><table-wrap-foot><p><italic>Gray scale qualitatively codes their weights in TM (the darker, the higher the importance). Each subgroup (1–4) includes kernels of TM-tools (circled red) and “targeted processing” (red text) that have the highest importance for our study. INPUT: query terms (T) = query using combinations of terms; query sentences (S) − query using free text or questions; predefined = fixed user-predefined input consisting of lists of terms or publications; filters = tuning the search using supplementary terms, constrains regarding the type/part of the publication to be processed etc. OUTPUT: Statistic about authors, journals, papers per year, topics; corpus (C) = retrieving sets of relevant papers; terms (T) = extracting lists of frequent and relevant terms and their relationships; sentences (S) = extracting relevant sentences and paper summaries. Targeted processing = processing from the TM-tool repertoire used for this review. The last 7 columns show topics whose corpora of publications were studied with TM (gray scale codes the weight of the approach). References: MEDSUM (Bridges-Webb, <xref rid="B10" ref-type="bibr">1986</xref>), PubReMiner (Koster, <xref rid="B38" ref-type="bibr">2008</xref>), LingerCat (Sarkar et al., <xref rid="B62" ref-type="bibr">2009</xref>), Carrot2 (Carpineto et al., <xref rid="B12" ref-type="bibr">2009</xref>), Anne O'Tate (Smalheiser et al., <xref rid="B63" ref-type="bibr">2008</xref>), BioTextQuest (Iliopoulos et al., <xref rid="B33" ref-type="bibr">2001</xref>), askMEDLINE (Fontelo et al., <xref rid="B23" ref-type="bibr">2005</xref>), Ultimate Research Assistant (Hoskinson, <xref rid="B32" ref-type="bibr">2005</xref>), Quertle (Giglia, <xref rid="B28" ref-type="bibr">2011</xref>), GoPubMed (Doms and Schroeder, <xref rid="B19" ref-type="bibr">2005</xref>), PubMatrix (Becker et al., <xref rid="B4" ref-type="bibr">2003</xref>), Medline Ranker (Fontaine et al., <xref rid="B22" ref-type="bibr">2009</xref>), XplorMed (Perez-Iratxeta et al., <xref rid="B59" ref-type="bibr">2001</xref>), Textpresso for Neuroscience (Muller et al., <xref rid="B55" ref-type="bibr">2008</xref>)</italic>.</p></table-wrap-foot></table-wrap></sec><sec><title>A practical application of the text mining to literature on cognitive rehabilitation and enhancement through neurostimulation</title><p>To show that TM enables us to efficiently deal with big corpora of publications and for publishing practical reasons, the TM application to CR- and CE-TMS literature was limited to few aspects. First, we aimed to show that TM could retrieve the diversity of TMS applications in vast corpora of publications about CR and CE (see Cognitive Rehabilitation and Enhancement Accomplished with TMS), automatically retrieving trends already described in published reviews (see Discussions and Conclusions). Second, we looked for trends noticeable only in big corpora of publications, relying on the statistical power of the analyses and including results like topics' occurrence frequency and relationships, relevant relational verbs, and high probability conclusive sentences (see Cognitive Rehabilitation and Enhancement Accomplished with TMS). Furthermore, we analyzed large context relationships between topics showing how CR- and CE-TMS integrate with diagnostic, fundamental research and fMRI studies (see A General Context).</p><p>Using TM to efficiently review corpora of publications requires roughly three stages: pre-TM-processing, TM-processing, and post-TM-processing. In this paper, we focused on the TM-processing by showing mainly the “raw” TM results. Accordingly, the seemingly redundant diversity of results is determined by our intention to illustrate few similar results given by different TM-tools.</p><p>We used a multi-stage and multi-tool approach ordered by the complexity in TM, which was gradually increased, starting with TM-tools II and continuing with TM-tools III. The same analysis was performed with few TM-tools (Table <xref ref-type="table" rid="T2">2</xref>), which can be regarded as alternative solutions for the same problem. This helped us to cope with the limited perspective offered by different TM-tools, to perform comparisons and cross-validations, and to build synthetic results.</p><table-wrap id="T2" position="float"><label>Table 2</label><caption><p><bold>Number of publications retrieved from PubMed using search queries defined previously</bold>.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1"><bold>Search query</bold></th><th align="center" colspan="3" rowspan="1"><bold>Publications per search filter:</bold></th></tr><tr><th rowspan="1" colspan="1"></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>TIAB</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>PBRK</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>TIABREV</bold></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>CR-TMS</bold></td><td align="center" valign="top" rowspan="1" colspan="1"><bold>4074</bold></td><td align="center" valign="top" rowspan="1" colspan="1"><bold>0.913</bold></td><td align="center" valign="top" rowspan="1" colspan="1"><bold>641</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>CE-TMS</bold></td><td align="center" valign="top" rowspan="1" colspan="1"><bold>181</bold></td><td align="center" valign="top" rowspan="1" colspan="1"><bold>0.956</bold></td><td align="center" valign="top" rowspan="1" colspan="1"><bold>41</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">8386</td><td align="center" valign="top" rowspan="1" colspan="1">0.909</td><td align="center" valign="top" rowspan="1" colspan="1">1018</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">CR</td><td align="center" valign="top" rowspan="1" colspan="1">4220</td><td align="center" valign="top" rowspan="1" colspan="1">0.896</td><td align="center" valign="top" rowspan="1" colspan="1">914</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">CE</td><td align="center" valign="top" rowspan="1" colspan="1">1235</td><td align="center" valign="top" rowspan="1" colspan="1">0.895</td><td align="center" valign="top" rowspan="1" colspan="1">312</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">TMS-DIAG</td><td align="center" valign="top" rowspan="1" colspan="1">212</td><td align="center" valign="top" rowspan="1" colspan="1">0.994</td><td align="center" valign="top" rowspan="1" colspan="1">68</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">TMS-RES</td><td align="center" valign="top" rowspan="1" colspan="1">360</td><td align="center" valign="top" rowspan="1" colspan="1">0.994</td><td align="center" valign="top" rowspan="1" colspan="1">93</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">TMS-fMRI</td><td align="center" valign="top" rowspan="1" colspan="1">875</td><td align="center" valign="top" rowspan="1" colspan="1">0.906</td><td align="center" valign="top" rowspan="1" colspan="1">211</td></tr></tbody></table><table-wrap-foot><p><italic>PBRK, the probability of correct ranking of a random positive-negative pair of publications determined with Medline Ranker</italic>.</p></table-wrap-foot></table-wrap><p>The main classes of TM processing on the selected corpora were:</p><list list-type="simple"><list-item><p>– Statistics about the number of publications, authors, journals; thematic/MeSH headings division of the field; clustering of publications; selection and ranking of relevant corpora of papers necessary for TM-tools III (all performed with TM-tools II).</p></list-item><list-item><p>– Extract relevant terms and their relationships, involving: categorization of key concepts; building correlation matrices for relevant terms and showing the most informative correlations; showing the topological maps of the main terms, using their relationships inferred from co-occurrence in the same text units.</p></list-item><list-item><p>– Retrieve automatically relevant sentences, study their probability of occurrence, and identify parts-of-sentence (e.g., predicates) relevant for deriving conclusions.</p></list-item><list-item><p>– Build a “map of science,” which characterize large-scale relationships between multiple topics. Each topic-topic relationship was evaluated based on common relevant terms retrieved from each corpus, similar thematic clustering of the publications, common authors, journals and publications approaching both topics.</p></list-item></list><p>To create a larger context allowing a better understanding of CR- and CE-TMS, we selected topics like TMS, CR, CE, TMS-RES, TMS-DIAG, and TMS-fMRI. Figure <xref ref-type="fig" rid="F1">1</xref> presents a “qualitative hypothesis” about the topology of this context and we used TM to test it. Corpora of publications for each topic were retrieved using the following PubMed queries:</p><list list-type="simple"><list-item><p>– For CR-TMS: (“transcranial magnetic stimulation”) AND (“cognitive rehabilitation” OR “rehabilitation” OR “cognitive therapy” OR “therapy” OR “cognitive recovery” OR “recovery” OR “cognitive treatment” OR “treatment” OR “cognitive repair” OR “neurorehabilitation” OR “improvement” OR “decrease”).</p></list-item><list-item><p>– For CE-TMS: (“transcranial magnetic stimulation”) AND [(“cognitive enhancement”) OR (“cognitive augmentation”) OR (“cognitive improvement”) OR (“cognitive enrichment”) OR (“cognitive amelioration”) OR (“neuroenhancement”)].</p></list-item><list-item><p>– For TMS: “transcranial magnetic stimulation.”</p></list-item><list-item><p>– Queries for CR/CE include the second operand of the AND operator in the CR-TMS/CE-TMS queries.</p></list-item></list><fig id="F1" position="float"><label>Figure 1</label><caption><p><bold>Qualitative approximation of a larger context for CR- and CE-TMS</bold>. Topics are represented by ellipses with CR-TMS (filled blue) and CE-TMS (red) representing intersections of topics.</p></caption><graphic xlink:href="fnsys-08-00182-g0001"></graphic></fig><p>All queries were used separately with two filters (“[Title/Abstract]” (TIAB-filter) and “[Title/Abstract] AND Review” TIABREV-filter) creating two separate corpora of abstracts: TIAB-corpora (the main target for TM) and TIABREV-corpora (used for comparisons). Empty or less relevant abstracts were removed from the corpora. Corpora were also compared with local databases and missing publications were added manually.</p><p>Finally, the TM results were evaluated in few ways. First of all, we used TM-tools that are already tested and evaluated, building our results on this general basis. Second, we used the <italic>post-hoc</italic> judgment of the system outputs (Cohen and Hunter, <xref rid="B13" ref-type="bibr">2008</xref>) in few stages, and compared: results of similar processing (e.g., term extraction) performed with different TM-tools using TIAB-corpora (see A Practical Application of the Text Mining to Literature on Cognitive Rehabilitation and Enhancement Through Neurostimulation); results of similar processing using TIAB-corpora vs. TIABREV-corpora (see A Practical Application of the Text Mining to Literature on Cognitive Rehabilitation and Enhancement Through Neurostimulation); TM-results vs. manual-curated results (see Discussions and Conclusions).</p><sec><title>A general context</title><p>We used TM-tools II to determine relationships that put CR- and CE-TMS topics in the same neighborhood on a “map of science.” An outline of the main results includes:</p><list list-type="order"><list-item><p>MeSH headings mention TMS as a preferred term, defined by its use in brain mapping, neurophysiology and treatment of depression (replacing electroconvulsive therapy), while paired-pulse TMS, rTMS and single-pulse TMS are narrower concepts. The MeSH tree considers that TMS belongs to the fields of neurological diagnostic and therapeutic techniques. CR is related with MeSH headings like Cognitive Therapy, Rehabilitation and Treatment/Rehabilitation Outcome, and CE is related with Cognitive Therapy, Nootropic Agents and Cognitive Enhancers.</p></list-item><list-item><p>The number of the publications retrieved from PubMed (Table <xref ref-type="table" rid="T2">2</xref>) for each topic.</p></list-item></list><p>It is noteworthy that a large number of reviews were written for each topic.</p><list list-type="simple"><list-item><p>3. The number of publications per year evaluating the interest for each topic (Figure <xref ref-type="fig" rid="F2">2</xref>), which showed the following trends:</p><list list-type="simple"><list-item><p>– The interest for all topics increased in the last decades;</p></list-item><list-item><p>– TMS generated numerous publications per year;</p></list-item><list-item><p>– CR-TMS has a stronger representation than CE-TMS;</p></list-item><list-item><p>– Across-topics perspectives (CR & CE; CR & CE-TMS; TMS-DIAG & RES) are less represented.</p></list-item><list-item><p>– Fundamental research (e.g., TMS-RES, TMS-DIAG) is less represented than practical applications (e.g., CR-TMS).</p></list-item></list></list-item><list-item><p>4. Co-occurrence matrix for terms used to build the search queries, retrieved with PubMatrix (Figures <xref ref-type="fig" rid="F3">3A,B</xref>). We made the following observations:</p><list list-type="simple"><list-item><p>– TMS co-occurred very frequently (publications ~10<sup>3</sup>) with terms like therapy, treatment, brain function, brain physiology, and diagnostic (mainly CR-TMS);</p></list-item><list-item><p>– TMS co-occurred frequently (publications ~10<sup>2</sup>) with rehabilitation, recovery, cognitive treatment, improvement, decrease, brain anatomy, brain performance, brain networks, psychology, brain mapping, MRI, mental disorder, mental disease and psychiatric disorder (mainly CR-TMS and CE-TMS);</p></list-item></list></list-item><list-item><p>5. Frequent terms co-occurring in different corpora (included between brackets):</p><list list-type="alpha-lower"><list-item><p>Among the first 10 MeSH headings, we mention:</p><list list-type="simple"><list-item><p>– [CR-TMS]: Motor Cortex/physiology, TMS/methods, Evoked Potentials, Treatment Outcome, Evoked Potentials, Electromyography, Functional Laterality, Stroke, Brain, Motor, (Major) Depressive Disorder;</p></list-item><list-item><p>– [CE-TMS]: TMS/methods, Brain Mapping, Brain, Functional Laterality, Cognition, Psychomotor Performance, Reaction Time/physiology, Motor Cortex/physiology, Cognition Disorders, Prefrontal Cortex/physiology.</p></list-item></list></list-item><list-item><p>Among the first 100 common MeSH headings (average frequency range [51, 2010]) for groups of topics (included between brackets), we mention:</p><list list-type="simple"><list-item><p>– [CR-TMS; CE-TMS; TMS; TMS-fMRI]: Brain, Cognition, Brain Mapping, Electromyography, Evoked Potentials, Motor Skills, MRI, Motor Cortex/physiology, Neural Inhibition, Neuronal Plasticity, Neuropsychological Tests, Parietal Lobe, Prefrontal Cortex, Psychomotor Performance, Reaction Time, TMS/methods, Treatment Outcome;</p></list-item><list-item><p>– [CR-TMS; CR]: Brain, Chronic Disease, Cognition, (Major) Depressive Disorder, MRI, Motor Cortex, Neuropsychological Tests, Psychomotor Performance, Recovery Of Function, Schizophrenia, Severity Of Illness Index, Treatment Outcome, Neuronal Plasticity/physiology, Recovery of Function/physiology, Stroke;</p></list-item><list-item><p>– [CE-TMS; CE]: Attention, Brain, Cognition, Learning, MRI, Memory, Neurons, Neuropsychological Tests, Psychomotor Performance, Reaction Time, Prefrontal Cortex, Treatment Outcome, Cognition Disorders/diagnosis and etiology.</p></list-item></list></list-item><list-item><p>Other trends noticed using the TM-tools II:</p><list list-type="simple"><list-item><p>– Different groups of topics (e.g., [CR-TMS; CE-TMS]; [TMS; TMS-fMRI; TMS-RES; TMS-DIAG]) are connected as shown by common headings/terms;</p></list-item><list-item><p>– CR-TMS related terms: motor cortex, treatment, excitability, facilitation, antidepressant, plasticity, MEP, stroke, Parkinson, severity of illness index, treatment outcome, (major) depressive disorder, schizophrenia, stroke/complications, neuronal plasticity, rehabilitation, cognition, recovery, parietal lobe, prefrontal cortex, psychomotor performance;</p></list-item><list-item><p>– CE-TMS related terms: prefrontal cortex, DLPFC, cognition, psychomotor performance, attention, learning, memory, performance, placebo, cognition disorders, severity of illness index, treatment outcome, neuroenhancement, Hebbian, neurofeedback, enhancement, improvement;</p></list-item><list-item><p>– [CR-TMS; CE-TMS] and [CR; CE] groups of topics have “mental diseases” and “treatments” as common subtopics, thus supporting the hypothesis that the relative improvement of the mental performance is a common aspect of their definitions.</p></list-item></list></list-item></list></list-item><list-item><p>6. The first 5 authors for different topics (all including Pascual-Leone A on the first place):</p><list list-type="simple"><list-item><p>– [CR-TMS]: Fregni F, Daskalakis ZJ, Fitzgerald PB, Rothwell JC;</p></list-item><list-item><p>– [CE-TMS]: Walsh V, Fregni F, Cowey A, Miniussi C;</p></list-item><list-item><p>– [TMS]: Rothwell JC, Hallett M, Cohen LG, Fitzgerald PB;</p></list-item></list></list-item></list><fig id="F2" position="float"><label>Figure 2</label><caption><p><bold>Number of publication per year (2014<sup>*</sup>, only the first 3 months) for different topics: TMS, CR-TMS, and CE-TMS (A); CE and CR (B); applications of TMS in research (TMS-RES), diagnostic (TMS-DIAG) and concurrent TMS-fMRI (C)</bold>. Results for topics represented by small numbers of publications are multiplied by 10 (×10). We show also results for conjunctions of topics: (CR&CE-TMS) <bold>(A)</bold>; (CR&CE) <bold>(B)</bold>; (TMS-DIAG&RES) <bold>(C)</bold>.</p></caption><graphic xlink:href="fnsys-08-00182-g0002"></graphic></fig><fig id="F3" position="float"><label>Figure 3</label><caption><p><bold>Co-occurrence matrix built with PubMatrix</bold>. The matrix <bold>(B)</bold> represents the decimal logarithm of the number of publications retrieved from PubMed using queries combining all possible conjunctions of pairs of terms (e.g., TMS and neurorehabilitation), which label the lines and the rows of the matrix. Panel <bold>(A)</bold> represents the first line in the matrix, showing co-occurrences involving the term TMS. Different colors (see the left color-coding bar) represent different powers of 10. The color of the text marks terms associated dominantly with: TMS (black); CR-TMS (red); CE-TMS (green); TMS-RES (blue); TMS-DIAG (purple).</p></caption><graphic xlink:href="fnsys-08-00182-g0003"></graphic></fig><p>Some authors covered several of the selected topics (e.g., common authors for [CR-TMS; CE-TMS; TMS; TMS-fMRI]: Pascual-Leone A, Cohen LG, Fregni F, Lisanby SH, Miniussi C, Rothwell JC), and this is an indirect argument for potential connections between topics.</p><list list-type="simple"><list-item><p>7. Finally, comparisons between corpora for different topics showed relevant numbers of common publications (Figure <xref ref-type="fig" rid="F4">4</xref>), thus emphasizing a unitary context. Consistently, clustering the publications for each topic using Carrot2 showed also different clusters sharing publications.</p></list-item></list><fig id="F4" position="float"><label>Figure 4</label><caption><p><bold>Number of common publications (in decimal logarithmic scale) for pairs of corpora representing topics labeling the rows and the columns of the matrix</bold>. Different shades of gray (see the color-coding bar) represent different powers of 10.</p></caption><graphic xlink:href="fnsys-08-00182-g0004"></graphic></fig></sec><sec><title>Cognitive rehabilitation and enhancement accomplished with TMS</title><p>First, we need to reiterate that the relevance of all the retrieved terms is based on the idea that words co-occurring frequently in the abstracts are related in ways intrinsically constrained by the topic of the abstracts. Moreover, our specific selection of publications guarantees that term like TMS (all protocols) are present in all abstracts included in corpora. Thus, TMS is strongly related with all frequent terms retrieved with different TM-tools. Specifically, if, for example, the frequent terms are treatment and depression, this means that TMS is used frequently in depression treatment.</p><p>We used TM-tools III to increase our insights in CR-TMS and CE-TMS literature, and selected the following groups of results:</p><list list-type="simple"><list-item><p>1. Statistical or machine-learning-based NLP:</p><list list-type="simple"><list-item><p>a. Topic modeling with Mallet (500 iterations, 7 topics, topics proportion threshold 0.05, and removed the standard Mallet stop-words). Each topic is a set of terms used with high probability by the authors, thus reflecting a specific thinking pattern involving TMS. Without knowing anything about the meaning of the words in a text, topic modeling assumes that any piece of text is written by selecting words from possible topics. Thus, it becomes possible to mathematically decompose a text into probable topics from which the words originated.</p></list-item></list></list-item></list><p>Example topics separated in CR/CE related terms (brackets) and TMS related terms (double brackets):</p><list list-type="simple"><list-item><p>a1. CR-TMS:</p><list list-type="simple"><list-item><p>– [treatment, depression, clinical, therapy, disorder, major, antidepressant, electroconvulsive therapy], [transcranial, magnetic, stimulation, effective];</p></list-item><list-item><p>– [motor, stroke, patients, recovery, function, hemisphere, affected, rehabilitation, limb], [magnetic, transcranial, stimulation].</p></list-item></list></list-item></list><p>The [CR] kernel of 2 topics includes CE-related terms (e.g., [cortex, learn, activity, visual, memory, performance, area]).</p><list list-type="simple"><list-item><p>a2. CE-TMS:</p><list list-type="simple"><list-item><p>– [cortex, DLPFC, prefrontal, dorsolateral, memory, processing], [stimulation, applied, TMS, effect, frequency], significant;</p></list-item><list-item><p>– [cognitive, brain, healthy, functions, enhance, neuroenhancement, parietal, cognition], [stimulation, magnetic, TMS], studies.</p></list-item></list></list-item></list><p>The [CE] kernel of 3 topics includes CR-related terms (e.g., [improvement, depression, treatment, deprivation, sleep, occipital, functional, disease, fluoxetine]).</p><list list-type="simple"><list-item><p>b. Term-related queries with TMG toolbox. Document retrieval relies often on matching terms from documents with those from queries. However, natural languages present some challenges (e.g., polysemy, synonymy) that render term-matching inaccurate. TMG is using latent semantic analysis to overcome these problems (Landauer et al., <xref rid="B40" ref-type="bibr">1998</xref>), based on the application of singular value decomposition of a term-by-document matrix (TDM).</p></list-item></list><p>We performed the indexing for each corpus creating new TDMs using “common-words” stop-list, logarithmic local weights, “GfIdf” global term weighs, normalization of terms, removing of alpha-numerics and numbers. For dimensionality reduction and TDM best rank approximation, we selected the dimensionality via the use of profile likelihood (Zhu and Ghodsi, <xref rid="B71" ref-type="bibr">2006</xref>). Example results:</p><list list-type="simple"><list-item><p>b1. For CR-TMS, the TDM included 607 documents, 6387 terms with average 111 indexing terms/document for the query matrix, and the best rank approximation 360. Among the best retrieved terms (apparition frequency > 86; range [870, 896] terms), we mention: [stimulation, rTMS, treatment, TMS, brain, motor, depression, patients, stroke, cortical, therapy, clinical, effects, disorders, pain, cortex] in the first 20; [recovery, disorder, schizophrenia, tinnitus, excitability, cognitive, plasticity, antidepressant, rehabilitation, mechanisms, psychiatric, symptoms, aphasia, language, noninvasive, sham, EEG, Parkinson, resistant, human, induced, movement, neglect] in the next 80; [cerebral, epilepsy, deep, migraine, neural, bipolar, visual, OCD, seizures, acute, neurological, diagnosis, auditory, neuroimaging, reorganization, prefrontal, inhibition, improvement, mood, neuropsychiatric, neuromodulation] in the next 50 terms.</p></list-item><list-item><p>b2. For CE-TMS, the TDM included 174 documents, 3235 terms with average 117 indexing terms/document for the query matrix, and the best rank approximation 174. Among the best retrieved terms (apparition frequency > 37; range [776, 1010] terms), we mention: [TMS, rTMS, motor, cortex, brain, visual, memory, cognitive, performance, parietal, healthy, patients, learning, improvement, enhancement] in the first 20; [excitability, neural, DLPFC, facilitation, plasticity, attention, control, prefrontal, network, evoked, neuroscience, perception, EEG, mechanisms, modulation, semantic, training, frontal, FEF, treatment, fluoxetine, neuroenhancement, sleep, emotional, skill, inhibition, Parkinson] in the next 80; [fMRI, MEP, Wernicke, search, discrimination, pain, cognition, increased, encoding, oscillatory, language, psychiatric, decrease, experimental, stroke, illness, major, effective, resistant, improve] in the next 50 terms.</p></list-item></list><list list-type="simple"><list-item><p>2. Processing performed with KH Coder:</p><list list-type="simple"><list-item><p>a. Determine the co-occurrence network for CR-TMS and CE-TMS corpora using 7 sets of coding rules. A coding rule is a list of terms connected with OR (|), AND (&) or NOT used to “focus” the TM of the corpora toward specific topics. We used coding rules (marked by brackets) that were common for CR-TMS and CE-TMS: [TMS] (transcranial & magnetic & stimulation | rTMS | TBS etc.); [mental disabilities] (depression | stroke | schizophrenia etc.); [brain functions] (memory | learning | attention etc.); [research methods] (fMRI | EEG etc.); [verbs-] describing negative effects of the stimulation (fail | worsen | damage | debilitate | miss etc.). To these we added a set of rules specific to CR-TMS/CE-TMS: [verbs+] describing positive effects for CR-TMS (rehabilitate | treat | recover | restore etc.) or CE-TMS (enhance | improve | augment | strengthen etc.); [CR-TMS-effects] (rehabilitation | cognitive & rehabilitation | cognitive & therapy | neurorehabilitation etc.); [CE-TMS-effects] (performance | enhancement | neuroenhancement | neuromodulation etc.). The co-occurrence networks revealed that the terms from the coding rules [TMS], [CR-TMS-effects], [mental disabilities] and [Verbs+] have the highest co-occurrence frequency in the CR-TMS corpus. The CE-TMS corpus is characterized by high co-occurrence frequency of the terms from the coding rules [TMS], [CE-TMS-effects] and [Verbs+].</p></list-item><list-item><p>b. Determine the keyword-in-context (KWIC) collection for terms in both CR-TMS (Table <xref ref-type="table" rid="T3">3</xref>) and CE-TMS (Table <xref ref-type="table" rid="T4">4</xref>). The KWIC statistic revealed information about both the relevant terms co-occurring with specific query terms (e.g., TMS) and statistical regularities (e.g., probable word positions) about the way the scientists build their statements.</p></list-item></list></list-item><list-item><p>3. Summary of results obtained with VisualText, ANote2, BioRAT and our Matlab applications (MAPP). All TM-tools used similar resources, including: dictionaries (mental disabilities, brain anatomy, cognitive processes, built using Neuroscience Information Framework (NIF) resources; CR-TMS-effects, CE-TMS-effects and TMS, built using our term statistic, similar with KH Coder coding rules); ontologies (NIF gross-anatomy and NIF dysfunction; human disease and neuro-behavior ontology from The Open Biological and Biomedical Ontologies Foundry); lexical words (Mallet stop-words; verbs+ and verbs- for CR-TMS and CE-TMS, similar with KH Coder rules). Each dictionary/ontology could be considered a class of terms (indicated by brackets; e.g., [mental disabilities]).</p></list-item></list><table-wrap id="T3" position="float"><label>Table 3</label><caption><p><bold>KWIC examples for CR-TMS</bold>.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1"><bold>Word</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>Total</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>LT</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>RT</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>L5</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>L4</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>L3</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>L2</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>L1</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>KW</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>R1</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>R2</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>R3</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>R4</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>R5</bold></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Treatment</td><td align="center" valign="top" rowspan="1" colspan="1">160</td><td align="center" valign="top" rowspan="1" colspan="1">63</td><td align="center" valign="top" rowspan="1" colspan="1">97</td><td align="center" valign="top" rowspan="1" colspan="1">25</td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1">16</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">17</td><td align="center" valign="top" rowspan="1" colspan="1">53</td><td align="center" valign="top" rowspan="1" colspan="1">12</td><td align="center" valign="top" rowspan="1" colspan="1">10</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Depression</td><td align="center" valign="top" rowspan="1" colspan="1">113</td><td align="center" valign="top" rowspan="1" colspan="1">37</td><td align="center" valign="top" rowspan="1" colspan="1">76</td><td align="center" valign="top" rowspan="1" colspan="1">8</td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1">18</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">22</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="center" valign="top" rowspan="1" colspan="1">14</td><td align="center" valign="top" rowspan="1" colspan="1">27</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Alzheimer</td><td align="center" valign="top" rowspan="1" colspan="1">100</td><td align="center" valign="top" rowspan="1" colspan="1">55</td><td align="center" valign="top" rowspan="1" colspan="1">45</td><td align="center" valign="top" rowspan="1" colspan="1">20</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="center" valign="top" rowspan="1" colspan="1">19</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">12</td><td align="center" valign="top" rowspan="1" colspan="1">10</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">16</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Therapy</td><td align="center" valign="top" rowspan="1" colspan="1">98</td><td align="center" valign="top" rowspan="1" colspan="1">58</td><td align="center" valign="top" rowspan="1" colspan="1">40</td><td align="center" valign="top" rowspan="1" colspan="1">25</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">26</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">22</td><td align="center" valign="top" rowspan="1" colspan="1">4</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">fMRI</td><td align="center" valign="top" rowspan="1" colspan="1">79</td><td align="center" valign="top" rowspan="1" colspan="1">57</td><td align="center" valign="top" rowspan="1" colspan="1">22</td><td align="center" valign="top" rowspan="1" colspan="1">14</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">19</td><td align="center" valign="top" rowspan="1" colspan="1">18</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">8</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">11</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Stroke</td><td align="center" valign="top" rowspan="1" colspan="1">50</td><td align="center" valign="top" rowspan="1" colspan="1">35</td><td align="center" valign="top" rowspan="1" colspan="1">15</td><td align="center" valign="top" rowspan="1" colspan="1">9</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1">10</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">4</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Disorder</td><td align="center" valign="top" rowspan="1" colspan="1">38</td><td align="center" valign="top" rowspan="1" colspan="1">27</td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1">9</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">1</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Recovery</td><td align="center" valign="top" rowspan="1" colspan="1">34</td><td align="center" valign="top" rowspan="1" colspan="1">28</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">15</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">4</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Schizophrenia</td><td align="center" valign="top" rowspan="1" colspan="1">15</td><td align="center" valign="top" rowspan="1" colspan="1">12</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">2</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Parkinson</td><td align="center" valign="top" rowspan="1" colspan="1">14</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">8</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">1</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Improvement</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">8</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">5</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Neurorehabilitation</td><td align="center" valign="top" rowspan="1" colspan="1">20</td><td align="center" valign="top" rowspan="1" colspan="1">14</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">7</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">2</td></tr></tbody></table><table-wrap-foot><p><italic>Columns show the number of co-occurrences of the context word (left) at different positions left/right (L5-L1/R1-R5) in the sentence relative to the query keyword (KW) and their total (LT/RT)</italic>.</p></table-wrap-foot></table-wrap><table-wrap id="T4" position="float"><label>Table 4</label><caption><p><bold>KWIC examples for CE-TMS</bold>.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1"><bold>Word</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>Total</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>LT</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>RT</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>L5</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>L4</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>L3</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>L2</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>L1</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>KW</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>R1</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>R2</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>R3</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>R4</bold></th><th align="center" valign="top" rowspan="1" colspan="1"><bold>R5</bold></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Induce</td><td align="center" valign="top" rowspan="1" colspan="1">29</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">23</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">15</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">2</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Performance</td><td align="center" valign="top" rowspan="1" colspan="1">24</td><td align="center" valign="top" rowspan="1" colspan="1">12</td><td align="center" valign="top" rowspan="1" colspan="1">12</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">7</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">2</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">EEG</td><td align="center" valign="top" rowspan="1" colspan="1">18</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">11</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">0</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Paired-pulse</td><td align="center" valign="top" rowspan="1" colspan="1">17</td><td align="center" valign="top" rowspan="1" colspan="1">16</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">1</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Cognitive</td><td align="center" valign="top" rowspan="1" colspan="1">16</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">12</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">1</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Memory</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="center" valign="top" rowspan="1" colspan="1">9</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Stimulation</td><td align="center" valign="top" rowspan="1" colspan="1">13</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">8</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">1</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">fMRI</td><td align="center" valign="top" rowspan="1" colspan="1">9</td><td align="center" valign="top" rowspan="1" colspan="1">7</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Enhance</td><td align="center" valign="top" rowspan="1" colspan="1">8</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Facilitate</td><td align="center" valign="top" rowspan="1" colspan="1">7</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">1</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Improve</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">1</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Perception</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">2</td></tr></tbody></table></table-wrap><p>The text processing relied on predefined streams of processing or on existing libraries of examples (e.g., TAIParse general text analyzer for VisualText). Our Matlab applications (MAPP) were used to handle the results, to perform relation extraction and to extract sentences with high probability of occurrence (low perplexity coefficients, PP).</p><p>We summarized here few results from the following processing: Evaluate term frequency and co-occurrences and perform Name Entity Recognition using lexical resources (ANote2, MAPP); Relations Extraction (ANote2, MAPP); Extract relevant sentences (VisualText, BioRAT, MAPP). The selected results are:</p><list list-type="simple"><list-item><p>a. Terms statistic from Name Entity Recognition applied to CR-TMS (ANote2; 27506 annotations):</p><list list-type="simple"><list-item><p>– Top terms (number of occurrences): treatment (1177), rTMS (1000), brain (982), TMS (1410), therapy (503), depression (456), stroke (420);</p></list-item><list-item><p>– Classes of terms (class per document, number of occurrences for all terms of the class): [neuro-behavior ontology] (22.8, 14903), [CR-TMS-effects] (4.8, 3163), [TMS] (4.3, 2811), [mental disabilities] (3.2, 2073), [cognitive processes] (1.6, 1028), [CE-TMS-effects] (0.2, 137);</p></list-item><list-item><p>– Examples from the detailed class statistic (ANote2, MAPP; parentheses indicate number of occurrences):</p><list list-type="simple"><list-item><p>° [TMS]: rTMS (1301), TMS (1466), TBS (32);</p></list-item><list-item><p>° [CR-TMS-effects]: treatment (1177), decrease (27), inhibition (96), antidepressant (175), antipsychotic (23), neurorehabilitation (45), recovery (286), rehabilitation (171), therapy (503);</p></list-item><list-item><p>° [mental disabilities]: ADHD (25), Alzheimer's (14), OCD (92), Parkinson (104), Tourette (9), anxiety (49), auditory hallucinations (24), bipolar depression (27), bipolar disorder (25), depression (462), epilepsy (77), major depressive disorder (111), neglect (68), psychiatric disorders (80), schizophrenia (158), seizures (69), stress (25), stroke (422), tinnitus (153);</p></list-item></list></list-item></list></list-item><list-item><p>b. Terms statistic from Name Entity Recognition applied to CE-TMS (ANote2; 7404 annotations):</p><list list-type="simple"><list-item><p>– Top terms (number of occurrences): TMS (727), rTMS (360), brain (207), cognitive (131), performance (130), facilitation (67);</p></list-item><list-item><p>– Classes of terms (class per document, number of occurrences for all terms of the class): [neuro-behavior ontology] (22.97, 4111), [TMS] (6.23, 1116), [CE-TMS-effects] (3.70, 663), [cognitive processes] (3.49, 624), [mental disabilities] (0.35, 63), [CR-TMS-effects] (0.32, 57);</p></list-item><list-item><p>– Examples from the detailed class statistic (ANote2, MAPP):</p><list list-type="simple"><list-item><p>° [TMS]: TMS (739), rTMS (365);</p></list-item><list-item><p>° [CE-TMS-effects]: activation (28), cognitive (131), cognitive enhancement (19), enhancement (34), facilitation (67), improvement (29), neuroenhancement (27), performance (130), performance enhancement (8), rehabilitation (27), therapy (37);</p></list-item><list-item><p>° [cognitive processes]: attention (53), cognition (25), learning (70), memory (85), working memory (46), perception (37), visual search (19), skill acquisition (12), consolidation (9), decision (14), emotion (8), encoding (23), language (21), movement (17), recognition (13), semantic processing (2), speech (7);</p></list-item></list></list-item></list></list-item><list-item><p>c. Relationship Extraction for CR-TMS (ANote2; 27506 annotations). From 6754 relations, 2163 were verb associated relations, and we found among the top 30 the following verbs: induced, related, controlled, based, treating, underlying, compared, modulate, affected, applied, provide, discuss, to study, has been used, combined, to treat, improving. The statistics showed positive (89.1%), negative (1.7%), conditional (9.2%) for the polarity of the relations, and one-one (11.8%), one-many (16.7%), many-one (13.4%), many-many (12.1%) for their cardinality.</p></list-item><list-item><p>d. Examples of terms from classes [TMS] (omitted, next) & [CR-TMS-effects] & [mental disabilities] co-occurring in the same sentence (MAPP; 1290 sentences; | = OR):</p><list list-type="simple"><list-item><p>– [treat] & [depression (24%)| disorder (12%)| tinnitus (4.3%)| schizophrenia (3%)| stress (1%)| pain (1%)| stroke (1%)| epilepsy (1%)| anxiety (1%)| seizures (0.2%)| neglect (0.1%)];</p></list-item><list-item><p>– [therapy] & [depression (5%)| stroke (3%)| pain (1%)| epilepsy (0.4%)| seizures (0.5%)| schizophrenia (0.2%)| mood (0.2%)];</p></list-item><list-item><p>– [improve] & [stroke (3%)| depression (0.6%)| tinnitus (0.3%)| reading (0.1%)| attention (0.1%)| schizophrenia (0.1%)];</p></list-item></list></list-item><list-item><p>e. Relationship Extraction for CE-TMS (ANote2; 7404 annotations). From 2025 relations, 903 were verbs associated relations, and we found among the top 30 the following verbs: is, induced, applied, guided, learning, improved, increasing, enhancing, was applied, paired, stimulated, delivered, reduced, impaired, performed, encoding. The statistics showed positive (92.0%), negative (1.2%), conditional (6.8%) for the polarity of the relations, and one-one (14.0%), one-many (17.6%), many-one (14.5%), many-many (12.4%) for their cardinality.</p></list-item><list-item><p>f. Example of terms from classes [TMS] (omitted, next) & [CE-TMS-effects] & [cognitive processes] occurring in the same sentence (MAPP; 1591 sentences):</p><list list-type="simple"><list-item><p>– [performance] & [memory (3.7%)| attention (1%)| language (1%)| motor (1%)| visual (1%)];</p></list-item><list-item><p>– [facilitation] & [motor (6%)| memory (2%)| linguistic (2%)| concept (1%)| control (1%)| knowledge (1%)| logical (1%)| awareness (1%)| visual (1%)];</p></list-item><list-item><p>– [improve] & [memory (1%)| visual (1%)| language (1%)];</p></list-item></list></list-item><list-item><p>g. Example of high probability sentences (PP, range [4, 99]) from the CR-TMS corpus including terms from classes [TMS] & [CR-TMS-effects] & [mental disabilities] (see d):</p><list list-type="simple"><list-item><p>– “Daily rTMS improves mood in depression” (PP 13.0).</p></list-item><list-item><p>– “Excitatory rTMS induces improvements in chronic post-stroke aphasia” (PP 13.5).</p></list-item><list-item><p>– “Slow TMS can rapidly reduce resistant auditory hallucinations in schizophrenia” (PP 16.8).</p></list-item></list></list-item></list><p>Using VisualText we showed also that from 4085 sentences, 1417 include terms from [TMS] hierarchy, and 847 include terms from [TMS] & [CR-TMS-effects OR mental disabilities]. Examples from the last group:</p><list list-type="simple"><list-item><p>– “TMS has been shown to be an effective treatment for mental illnesses including major depressive disorder.”</p></list-item><list-item><p>– “…rTMS has been developed for the treatment of major depression and schizophrenia.”</p></list-item></list><list list-type="simple"><list-item><p>h. Example of high probability sentences (PP; range [3, 50]) from the CE-TMS corpus including terms from classes [TMS] & [CE-TMS-effects] & [cognitive processes] (see f):</p><list list-type="simple"><list-item><p>– “…rTMS to left dorsal premotor cortex enhances motor consolidation of new skills” (PP 9).</p></list-item><list-item><p>– “rTMS over Wernicke's area leads to a brief facilitation of picture naming by shortening linguistic processing time” (PP 11).</p></list-item><list-item><p>– “…rTMS at alpha frequency can modulate short-term memory capacity by influencing the ability to suppress distracting information” (PP 15).</p></list-item></list></list-item></list><p>Using VisualText we showed that from 1008 sentences, 445 included terms from [TMS], and 238 include terms from [TMS] & [CE-TMS-effects OR cognitive processes]. Examples from the last group:</p><list list-type="simple"><list-item><p>– “…rTMS of the DLPFC can affect the performance in an affective go-no-go task.”</p></list-item><list-item><p>– “…here we report the ipsilateral enhancement of visual attention after rTMS of parietal cortex at parameters known to reduce cortical excitability.”</p></list-item></list><list list-type="simple"><list-item><p>k. Example of sentences extracted with BioRAT from the CR-TMS corpus using a specific rule, which indicate classes of terms that have to be found at specific locations (block) in the sentence (Table <xref ref-type="table" rid="T5">5</xref>).</p></list-item></list><table-wrap id="T5" position="float"><label>Table 5</label><caption><p><bold>Example sentences retrieved with BioRAT using a specific rule</bold>.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" colspan="6" rowspan="1"><bold>Blocks of the rule</bold></th><th align="left" valign="top" rowspan="1" colspan="1"><bold>Context</bold></th></tr><tr><th align="left" valign="top" rowspan="1" colspan="1"><bold></bold> </th><th align="left" valign="top" rowspan="1" colspan="1"><bold></bold> </th><th align="left" valign="top" rowspan="1" colspan="1"><bold></bold> </th><th align="left" valign="top" rowspan="1" colspan="1"><bold></bold> </th><th align="left" valign="top" rowspan="1" colspan="1"><bold></bold> </th><th align="left" valign="top" rowspan="1" colspan="1"><bold></bold> </th><th rowspan="1" colspan="1"></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">rTMS</td><td align="left" valign="top" rowspan="1" colspan="1">for</td><td align="left" valign="top" rowspan="1" colspan="1">–</td><td align="left" valign="top" rowspan="1" colspan="1">treatment</td><td align="left" valign="top" rowspan="1" colspan="1">of</td><td align="left" valign="top" rowspan="1" colspan="1">depression</td><td align="left" valign="top" rowspan="1" colspan="1">“… the first cases report of using rTMS for the treatment of depression … ”</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">TMS</td><td align="left" valign="top" rowspan="1" colspan="1">for</td><td align="left" valign="top" rowspan="1" colspan="1">–</td><td align="left" valign="top" rowspan="1" colspan="1">treatment</td><td align="left" valign="top" rowspan="1" colspan="1">of</td><td align="left" valign="top" rowspan="1" colspan="1">obsessive compulsive disorder</td><td align="left" valign="top" rowspan="1" colspan="1">“… TMS for the treatment of obsessive compulsive disorder … ”</td></tr></tbody></table><table-wrap-foot><p><italic>“< >” delimitate a block of the rule; LOOKUP, looking for a term included in a class ([TMS], [CR-TMS-effects] or [mental disabilities]); MACRO WORD, any word; “?”, the block is optional</italic>.</p></table-wrap-foot></table-wrap></sec></sec><sec><title>Discussions and conclusions</title><p>We here used a set of selected TM-tools to obtain basic insights into the relevant literature on the CR- and CE-TMS. For obvious reasons, we limited this application to few simple aspects. First, we showed that TM could retrieve from vast corpora of publications the diversity of TMS applications in CR and CE, automatically extracting trends already described in published reviews. Second, we searched for trends noticeable only in big corpora of publications.</p><p>Along this exercise, we attempted to validate our results in different ways. For example, we compared similar results obtained using different TM-tools applied to different corpora (TIAB-corpora or TIABREV-corpora). Relevant and common aspects, synthesized in unique results per type of analysis and topics were shown in the paper. Finally, we compared TM to human curation efforts. Accordingly, we selected for human curation 30 of the top ranked (with Medline Ranker) publications from the TIABREV-corpora, separately for CR-TMS and CR-TMS. We performed a selective manual curation aimed to retrieve relevant terms co-occurring with TMS (all types of protocol) in the abstracts, which belong to the following classes: mental functions, healthy or impaired, modulated by TMS; mental disabilities treated with TMS; rehabilitation or enhancement effects of TMS. We also searched for relationships between classes of relevant terms and conclusive sentences summarizing research results.</p><p>Very briefly, the manual curation gave the following perspective over the main topics:</p><list list-type="alpha-lower"><list-item><p>CR-TMS. TMS is continuously establishing itself as one of the “tools of the trade” in psychiatric therapeutic practice (Kammer and Spitzer, <xref rid="B35" ref-type="bibr">2012</xref>) improving mental functions in: Parkinson's disease (Pascual-Leone et al., <xref rid="B58" ref-type="bibr">1994</xref>), aphasia (Medina et al., <xref rid="B51" ref-type="bibr">2012</xref>), motor control after stroke (Takeuchi et al., <xref rid="B65" ref-type="bibr">2005</xref>), epilepsy (Nitsche and Paulus, <xref rid="B56" ref-type="bibr">2009</xref>), depression (Lisanby et al., <xref rid="B44" ref-type="bibr">2009</xref>; Conforto et al., <xref rid="B14" ref-type="bibr">2014</xref>), schizophrenia (Levkovitz et al., <xref rid="B43" ref-type="bibr">2011</xref>; Kammer and Spitzer, <xref rid="B35" ref-type="bibr">2012</xref>), autism (Krause et al., <xref rid="B39" ref-type="bibr">2012</xref>), chronic migraine (Conforto et al., <xref rid="B14" ref-type="bibr">2014</xref>), dyslexia (Costanzo et al., <xref rid="B17" ref-type="bibr">2013</xref>), neglect (Fasotti and Van Kessel, <xref rid="B20" ref-type="bibr">2013</xref>), obsessive-compulsive disorder (OCD) (Mantovani et al., <xref rid="B49" ref-type="bibr">2013</xref>), chronic pain (Moreno-Duarte et al., <xref rid="B54" ref-type="bibr">2014</xref>), and social anxiety disorder (Paes et al., <xref rid="B57" ref-type="bibr">2013</xref>). The TMS therapy applied to younger patients (children and adolescents) improves cognitive functions (Vicario and Nitsche, <xref rid="B68" ref-type="bibr">2013</xref>) in: stroke affecting the motor cortex (Kirton et al., <xref rid="B37" ref-type="bibr">2008</xref>), epilepsy (Fregni et al., <xref rid="B24" ref-type="bibr">2005</xref>), ADHD (Weaver et al., <xref rid="B69" ref-type="bibr">2012</xref>), Tourette syndrome (Le et al., <xref rid="B41" ref-type="bibr">2013</xref>), autism (Baruth et al., <xref rid="B3" ref-type="bibr">2010</xref>), treatment-resistant depression (Bloch et al., <xref rid="B5" ref-type="bibr">2008</xref>), and medication-resistant schizophrenia (Jardri et al., <xref rid="B34" ref-type="bibr">2012</xref>).</p></list-item><list-item><p>CE-TMS. CE is defined as any augmentation of core information processing systems in the brain underlying perception, attention, conceptualization, memory, reasoning and motor performance (Sandberg and Bostrom, <xref rid="B61" ref-type="bibr">2006</xref>; Luber and Lisanby, <xref rid="B48" ref-type="bibr">2014</xref>). Studies reported TMS-induced modulations and enhancements of brain functioning and neural processing involved in: language comprehension (Floel et al., <xref rid="B21" ref-type="bibr">2008</xref>), learning and memory (Vicario et al., <xref rid="B67" ref-type="bibr">2013</xref>), cortical plasticity improving learning (Vallence and Ridding, <xref rid="B66" ref-type="bibr">2014</xref>), motor memory (Butefisch et al., <xref rid="B11" ref-type="bibr">2004</xref>), working memory (Gaudeau-Bosma et al., <xref rid="B26" ref-type="bibr">2013</xref>), memory (Gagnon et al., <xref rid="B25" ref-type="bibr">2011</xref>; Blumenfeld et al., <xref rid="B6" ref-type="bibr">2014</xref>), phonological memory (Kirschen et al., <xref rid="B36" ref-type="bibr">2006</xref>), perception (Hamilton et al., <xref rid="B30" ref-type="bibr">2013</xref>), perceptual discrimination (Luber and Lisanby, <xref rid="B48" ref-type="bibr">2014</xref>), eye movements and visual search, (Gerits et al., <xref rid="B27" ref-type="bibr">2011</xref>; Luber and Lisanby, <xref rid="B48" ref-type="bibr">2014</xref>), attention (Cooper et al., <xref rid="B15" ref-type="bibr">2004</xref>; Lee et al., <xref rid="B42" ref-type="bibr">2013</xref>), reward behavior (Stanford et al., <xref rid="B64" ref-type="bibr">2013</xref>), analogic reasoning (Boroojerdi et al., <xref rid="B7" ref-type="bibr">2001</xref>), motor learning (Luber and Lisanby, <xref rid="B48" ref-type="bibr">2014</xref>), consolidation of new skills (Boyd and Linsdell, <xref rid="B8" ref-type="bibr">2009</xref>), visual awareness (Grosbras and Paus, <xref rid="B29" ref-type="bibr">2003</xref>), activity of specific frequencies supporting functions of the brain (Rahnev, <xref rid="B60" ref-type="bibr">2013</xref>), and Pavlovian conditioning (Luber et al., <xref rid="B47" ref-type="bibr">2007</xref>).</p></list-item></list><p>CR-TMS and CE-TMS used various TMS paradigms, including single-pulse, theta-burst, paired-pulse, and trains of rTMS at both low and high frequencies (Luber and Lisanby, <xref rid="B48" ref-type="bibr">2014</xref>).</p><p>Comparisons with the manual curation showed that the TM-tools were also able to extract:</p><list list-type="simple"><list-item><p>– All the relevant terms for CR-TMS and CE-TMS in the form of: lists; topics; classes of terms associated with specific subtopics (e.g., mental disabilities, cognitive processes).</p></list-item><list-item><p>– Relations between relevant terms in the form of: co-occurrences maps (Figure <xref ref-type="fig" rid="F3">3</xref>); groups of relevant terms with high probabilities co-occurrences; KWIC (Tables <xref ref-type="table" rid="T3">3</xref>, <xref ref-type="table" rid="T4">4</xref>); lists of relevant relational verbs.</p></list-item><list-item><p>– High probability and relevance conclusive sentences (see examples and Table <xref ref-type="table" rid="T5">5</xref>). We studied also structural statistical regularities in both conclusive sentences and abstracts shown by: the relative position in the sentence for groups of relevant terms (Tables <xref ref-type="table" rid="T3">3</xref>–<xref ref-type="table" rid="T5">5</xref>); combinations of relevant terms with high probability occurrence; the occurrence frequency for conclusive sentences.</p></list-item></list><p>In addition, the TM approach has clear advantages emerging from the statistical properties of big corpora. Accordingly, the tirade (terms, terms-relationships, sentences) gained statistical strength, enabling us to quantify the frequency of a term or occurrence probabilities for specific relationships between terms or for conclusive sentences. For example, the hierarchy of the top terms for the CR-TMS-corpus includes TMS, treatment, rTMS, brain, therapy, depression, and stroke. We also found hierarchies for classes of terms like [CR-TMS-effects] (e.g., treatment, therapy, recovery, antidepressant, rehabilitation, neurorehabilitation) and [mental disabilities] (e.g., depression, stroke, schizophrenia, tinnitus, major depressive disorder, Parkinson, OCD, epilepsy, seizures, neglect, anxiety, ADHD, stress, Alzheimer's). For the CE-TMS-corpus the top terms are TMS, rTMS, brain, cognitive, performance, and facilitation. We also added hierarchies for classes of terms like [CE-TMS-effects] (e.g., performance enhancement, improvement, facilitation, neuromodulation, neurostimulation, therapy, neuroenhancement, rehabilitation, CE) and [cognitive processes] (e.g., memory, learning, attention, working memory, perception, language skill acquisition, decision, emotion, speech, semantic processing).</p><p>The relevance of all the retrieved terms and of their relationships is based on the idea that words co-occurring frequently in the abstracts are related in specific ways intrinsically constrained by the (TMS-related) topic of the abstracts. Thus, TMS is strongly related with all frequent terms retrieved with different TM-tools. Although in a relatively crude form, determined by our intention to show “raw” TM results, our study is showing that TMS emerged as one of the important non-invasive tools that can both improve cognitive and motor functions in numerous neurological diseases and induce enhancements of many fundamental brain functions.</p><p>We were able to characterize topics considering their dynamic relationships, trends in research and the interest shown by the scientific community. For example, CR-TMS and CE-TMS share studies (Figure <xref ref-type="fig" rid="F4">4</xref>), being an argument for their similarity. The reviewed topics share also publications with other fields suggesting their appurtenance to a larger context, which integrates diagnostic, fundamental research and fMRI studies. TMS can be used both to investigate and to modify brain physiology and performance in healthy and diseased subjects (Vicario and Nitsche, <xref rid="B68" ref-type="bibr">2013</xref>).</p><p>Methodologically speaking, we conclude that TM was helpful in getting an overall perspective on a huge corpus of literature with some level of detail, intentionally limited to handle complexity. Richer information can be extracted using more complex TM methods focused on narrower topics, but this requires extensive training and knowledge.</p><p>A decision factor to use TM relates to how profitable and how difficult the tools may be. The study aimed to address these simple issues in a pragmatic way. First and foremost, we argue that TM-tools may become a basic component in the methodological library. Unfortunately, it is equally clear that TM is a difficult task. With this in mind, we aimed to evaluate relatively immediate advantages of a user-friendly TM approach, based on easy-to-use TM-tools applied to CR- and CE-TMS corpora of abstracts. The hierarchical structure of our example set of TM-tools could serve as a guide for researchers aiming to use TM. Accordingly, for a rapid enrichment of the PubMed search, TM-tools II could be used, with special considerations for Carrot2, PubReMiner, Quertle, Medline Ranker, and Textpresso for Neuroscience. All TM-tools III could help a more elaborate TM without a considerable increase in demands to the user. For complex studies combining multiple aspects of the “mining,” we recommend systems like Knime, RapidMiner, and Taverna.</p><sec><title>Conflict of interest statement</title><p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p></sec></sec></body><back><ack><p>This work was supported by IUAP 7-11, PF10/008, FWO- K714811, and G.083111.</p></ack><ref-list><title>References</title><ref id="B1"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Akil</surname><given-names>H.</given-names></name><name><surname>Martone</surname><given-names>M. E.</given-names></name><name><surname>Van Essen</surname><given-names>D. 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