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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long working hours and alcohol use: systematic review and meta-analysis of published studies and unpublished individual participant data</title><author><name sortKey="Virtanen, Marianna" sort="Virtanen, Marianna" uniqKey="Virtanen M" first="Marianna" last="Virtanen">Marianna Virtanen</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Jokela, Markus" sort="Jokela, Markus" uniqKey="Jokela M" first="Markus" last="Jokela">Markus Jokela</name><affiliation><nlm:aff id="aff2">Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nyberg, Solja T" sort="Nyberg, Solja T" uniqKey="Nyberg S" first="Solja T" last="Nyberg">Solja T. Nyberg</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Madsen, Ida E H" sort="Madsen, Ida E H" uniqKey="Madsen I" first="Ida E H" last="Madsen">Ida E H. Madsen</name><affiliation><nlm:aff id="aff3">National Research Centre for the Working Environment, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Lallukka, Tea" sort="Lallukka, Tea" uniqKey="Lallukka T" first="Tea" last="Lallukka">Tea Lallukka</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Public Health, Faculty of Medicine, University of Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ahola, Kirsi" sort="Ahola, Kirsi" uniqKey="Ahola K" first="Kirsi" last="Ahola">Kirsi Ahola</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Alfredsson, Lars" sort="Alfredsson, Lars" uniqKey="Alfredsson L" first="Lars" last="Alfredsson">Lars Alfredsson</name><affiliation><nlm:aff id="aff5">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Centre for Occupational and Environmental Medicine, Stockholm County Council, Sweden</nlm:aff></affiliation></author><author><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G David" last="Batty">G David Batty</name><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff8">Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff9">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Bjorner, Jakob B" sort="Bjorner, Jakob B" uniqKey="Bjorner J" first="Jakob B" last="Bjorner">Jakob B. Bjorner</name><affiliation><nlm:aff id="aff3">National Research Centre for the Working Environment, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Borritz, Marianne" sort="Borritz, Marianne" uniqKey="Borritz M" first="Marianne" last="Borritz">Marianne Borritz</name><affiliation><nlm:aff id="aff10">Department of Occupational Medicine, Koge Hospital, Koge, Denmark</nlm:aff></affiliation></author><author><name sortKey="Burr, Hermann" sort="Burr, Hermann" uniqKey="Burr H" first="Hermann" last="Burr">Hermann Burr</name><affiliation><nlm:aff id="aff11">Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Casini, Annalisa" sort="Casini, Annalisa" uniqKey="Casini A" first="Annalisa" last="Casini">Annalisa Casini</name><affiliation><nlm:aff id="aff12">School of Public Health, Université Libre de Bruxelles (ULB), Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Clays, Els" sort="Clays, Els" uniqKey="Clays E" first="Els" last="Clays">Els Clays</name><affiliation><nlm:aff id="aff13">Department of Public Health, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="De Bacquer, Dirk" sort="De Bacquer, Dirk" uniqKey="De Bacquer D" first="Dirk" last="De Bacquer">Dirk De Bacquer</name><affiliation><nlm:aff id="aff13">Department of Public Health, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Dragano, Nico" sort="Dragano, Nico" uniqKey="Dragano N" first="Nico" last="Dragano">Nico Dragano</name><affiliation><nlm:aff id="aff14">Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Erbel, Raimund" sort="Erbel, Raimund" uniqKey="Erbel R" first="Raimund" last="Erbel">Raimund Erbel</name><affiliation><nlm:aff id="aff15">Department of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ferrie, Jane E" sort="Ferrie, Jane E" uniqKey="Ferrie J" first="Jane E" last="Ferrie">Jane E. Ferrie</name><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff16">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Fransson, Eleonor I" sort="Fransson, Eleonor I" uniqKey="Fransson E" first="Eleonor I" last="Fransson">Eleonor I. Fransson</name><affiliation><nlm:aff id="aff5">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="aff17">Stress Research Institute, Stockholm University, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="aff18">School of Health Sciences, Jönköping University, Jönköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hamer, Mark" sort="Hamer, Mark" uniqKey="Hamer M" first="Mark" last="Hamer">Mark Hamer</name><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Heikkil, Katriina" sort="Heikkil, Katriina" uniqKey="Heikkil K" first="Katriina" last="Heikkil">Katriina Heikkil</name><affiliation><nlm:aff id="aff19">School of Medicine, University of Tampere, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name><affiliation><nlm:aff id="aff20">Institute for Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Kittel, France" sort="Kittel, France" uniqKey="Kittel F" first="France" last="Kittel">France Kittel</name><affiliation><nlm:aff id="aff12">School of Public Health, Université Libre de Bruxelles (ULB), Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Knutsson, Anders" sort="Knutsson, Anders" uniqKey="Knutsson A" first="Anders" last="Knutsson">Anders Knutsson</name><affiliation><nlm:aff id="aff21">Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden</nlm:aff></affiliation></author><author><name sortKey="Koskenvuo, Markku" sort="Koskenvuo, Markku" uniqKey="Koskenvuo M" first="Markku" last="Koskenvuo">Markku Koskenvuo</name><affiliation><nlm:aff id="aff4">Department of Public Health, Faculty of Medicine, University of Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ladwig, Karl Heinz" sort="Ladwig, Karl Heinz" uniqKey="Ladwig K" first="Karl-Heinz" last="Ladwig">Karl-Heinz Ladwig</name><affiliation><nlm:aff id="aff22">Helmholtz Zentrum München (German Research Center for Environmental Health (GmbH)), 85764 Oberschleißheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Lunau, Thorsten" sort="Lunau, Thorsten" uniqKey="Lunau T" first="Thorsten" last="Lunau">Thorsten Lunau</name><affiliation><nlm:aff id="aff14">Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Martin L" sort="Nielsen, Martin L" uniqKey="Nielsen M" first="Martin L" last="Nielsen">Martin L. Nielsen</name><affiliation><nlm:aff id="aff23">Unit of Social Medicine, Frederiksberg University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordin, Maria" sort="Nordin, Maria" uniqKey="Nordin M" first="Maria" last="Nordin">Maria Nordin</name><affiliation><nlm:aff id="aff17">Stress Research Institute, Stockholm University, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="aff24">Department of Psychology, Umeå University, Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Oksanen, Tuula" sort="Oksanen, Tuula" uniqKey="Oksanen T" first="Tuula" last="Oksanen">Tuula Oksanen</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Pejtersen, Jan H" sort="Pejtersen, Jan H" uniqKey="Pejtersen J" first="Jan H" last="Pejtersen">Jan H. Pejtersen</name><affiliation><nlm:aff id="aff25">Danish National Centre for Social Research, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pentti, Jaana" sort="Pentti, Jaana" uniqKey="Pentti J" first="Jaana" last="Pentti">Jaana Pentti</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Rugulies, Reiner" sort="Rugulies, Reiner" uniqKey="Rugulies R" first="Reiner" last="Rugulies">Reiner Rugulies</name><affiliation><nlm:aff id="aff3">National Research Centre for the Working Environment, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff26">Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Salo, Paula" sort="Salo, Paula" uniqKey="Salo P" first="Paula" last="Salo">Paula Salo</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff27">Department of Psychology, University of Turku, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Schupp, Jurgen" sort="Schupp, Jurgen" uniqKey="Schupp J" first="Jürgen" last="Schupp">Jürgen Schupp</name><affiliation><nlm:aff id="aff28">German Institute for Economic Research, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff29">Free University of Berlin, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Siegrist, Johannes" sort="Siegrist, Johannes" uniqKey="Siegrist J" first="Johannes" last="Siegrist">Johannes Siegrist</name><affiliation><nlm:aff id="aff14">Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Singh Manoux, Archana" sort="Singh Manoux, Archana" uniqKey="Singh Manoux A" first="Archana" last="Singh-Manoux">Archana Singh-Manoux</name><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff30">Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Steptoe, Andrew" sort="Steptoe, Andrew" uniqKey="Steptoe A" first="Andrew" last="Steptoe">Andrew Steptoe</name><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Suominen, Sakari B" sort="Suominen, Sakari B" uniqKey="Suominen S" first="Sakari B" last="Suominen">Sakari B. Suominen</name><affiliation><nlm:aff id="aff31">Department of Public Health, University of Turku, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff32">Nordic School of Public Health, Gothenburg, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="aff33">Folkhälsan Research Center, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Theorell, Tores" sort="Theorell, Tores" uniqKey="Theorell T" first="Töres" last="Theorell">Töres Theorell</name><affiliation><nlm:aff id="aff17">Stress Research Institute, Stockholm University, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Vahtera, Jussi" sort="Vahtera, Jussi" uniqKey="Vahtera J" first="Jussi" last="Vahtera">Jussi Vahtera</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff31">Department of Public Health, University of Turku, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff34">Turku University Hospital, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Wagner, Gert G" sort="Wagner, Gert G" uniqKey="Wagner G" first="Gert G" last="Wagner">Gert G. Wagner</name><affiliation><nlm:aff id="aff28">German Institute for Economic Research, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff35">Max Planck Institute for Human Development, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff36">Berlin University of Technology, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Westerholm, Peter J M" sort="Westerholm, Peter J M" uniqKey="Westerholm P" first="Peter J M" last="Westerholm">Peter J M. Westerholm</name><affiliation><nlm:aff id="aff37">Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Westerlund, Hugo" sort="Westerlund, Hugo" uniqKey="Westerlund H" first="Hugo" last="Westerlund">Hugo Westerlund</name><affiliation><nlm:aff id="aff17">Stress Research Institute, Stockholm University, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kivim Ki, Mika" sort="Kivim Ki, Mika" uniqKey="Kivim Ki M" first="Mika" last="Kivim Ki">Mika Kivim Ki</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Public Health, Faculty of Medicine, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25587065</idno><idno type="pmc">4293546</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293546</idno><idno type="RBID">PMC:4293546</idno><idno type="doi">10.1136/bmj.g7772</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000085</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Long working hours and alcohol use: systematic review and meta-analysis of published studies and unpublished individual participant data</title><author><name sortKey="Virtanen, Marianna" sort="Virtanen, Marianna" uniqKey="Virtanen M" first="Marianna" last="Virtanen">Marianna Virtanen</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Jokela, Markus" sort="Jokela, Markus" uniqKey="Jokela M" first="Markus" last="Jokela">Markus Jokela</name><affiliation><nlm:aff id="aff2">Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nyberg, Solja T" sort="Nyberg, Solja T" uniqKey="Nyberg S" first="Solja T" last="Nyberg">Solja T. Nyberg</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Madsen, Ida E H" sort="Madsen, Ida E H" uniqKey="Madsen I" first="Ida E H" last="Madsen">Ida E H. Madsen</name><affiliation><nlm:aff id="aff3">National Research Centre for the Working Environment, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Lallukka, Tea" sort="Lallukka, Tea" uniqKey="Lallukka T" first="Tea" last="Lallukka">Tea Lallukka</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Public Health, Faculty of Medicine, University of Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ahola, Kirsi" sort="Ahola, Kirsi" uniqKey="Ahola K" first="Kirsi" last="Ahola">Kirsi Ahola</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Alfredsson, Lars" sort="Alfredsson, Lars" uniqKey="Alfredsson L" first="Lars" last="Alfredsson">Lars Alfredsson</name><affiliation><nlm:aff id="aff5">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Centre for Occupational and Environmental Medicine, Stockholm County Council, Sweden</nlm:aff></affiliation></author><author><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G David" last="Batty">G David Batty</name><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff8">Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff9">Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Bjorner, Jakob B" sort="Bjorner, Jakob B" uniqKey="Bjorner J" first="Jakob B" last="Bjorner">Jakob B. Bjorner</name><affiliation><nlm:aff id="aff3">National Research Centre for the Working Environment, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Borritz, Marianne" sort="Borritz, Marianne" uniqKey="Borritz M" first="Marianne" last="Borritz">Marianne Borritz</name><affiliation><nlm:aff id="aff10">Department of Occupational Medicine, Koge Hospital, Koge, Denmark</nlm:aff></affiliation></author><author><name sortKey="Burr, Hermann" sort="Burr, Hermann" uniqKey="Burr H" first="Hermann" last="Burr">Hermann Burr</name><affiliation><nlm:aff id="aff11">Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Casini, Annalisa" sort="Casini, Annalisa" uniqKey="Casini A" first="Annalisa" last="Casini">Annalisa Casini</name><affiliation><nlm:aff id="aff12">School of Public Health, Université Libre de Bruxelles (ULB), Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Clays, Els" sort="Clays, Els" uniqKey="Clays E" first="Els" last="Clays">Els Clays</name><affiliation><nlm:aff id="aff13">Department of Public Health, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="De Bacquer, Dirk" sort="De Bacquer, Dirk" uniqKey="De Bacquer D" first="Dirk" last="De Bacquer">Dirk De Bacquer</name><affiliation><nlm:aff id="aff13">Department of Public Health, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Dragano, Nico" sort="Dragano, Nico" uniqKey="Dragano N" first="Nico" last="Dragano">Nico Dragano</name><affiliation><nlm:aff id="aff14">Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Erbel, Raimund" sort="Erbel, Raimund" uniqKey="Erbel R" first="Raimund" last="Erbel">Raimund Erbel</name><affiliation><nlm:aff id="aff15">Department of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ferrie, Jane E" sort="Ferrie, Jane E" uniqKey="Ferrie J" first="Jane E" last="Ferrie">Jane E. Ferrie</name><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff16">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Fransson, Eleonor I" sort="Fransson, Eleonor I" uniqKey="Fransson E" first="Eleonor I" last="Fransson">Eleonor I. Fransson</name><affiliation><nlm:aff id="aff5">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="aff17">Stress Research Institute, Stockholm University, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="aff18">School of Health Sciences, Jönköping University, Jönköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hamer, Mark" sort="Hamer, Mark" uniqKey="Hamer M" first="Mark" last="Hamer">Mark Hamer</name><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Heikkil, Katriina" sort="Heikkil, Katriina" uniqKey="Heikkil K" first="Katriina" last="Heikkil">Katriina Heikkil</name><affiliation><nlm:aff id="aff19">School of Medicine, University of Tampere, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name><affiliation><nlm:aff id="aff20">Institute for Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Kittel, France" sort="Kittel, France" uniqKey="Kittel F" first="France" last="Kittel">France Kittel</name><affiliation><nlm:aff id="aff12">School of Public Health, Université Libre de Bruxelles (ULB), Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Knutsson, Anders" sort="Knutsson, Anders" uniqKey="Knutsson A" first="Anders" last="Knutsson">Anders Knutsson</name><affiliation><nlm:aff id="aff21">Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden</nlm:aff></affiliation></author><author><name sortKey="Koskenvuo, Markku" sort="Koskenvuo, Markku" uniqKey="Koskenvuo M" first="Markku" last="Koskenvuo">Markku Koskenvuo</name><affiliation><nlm:aff id="aff4">Department of Public Health, Faculty of Medicine, University of Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Ladwig, Karl Heinz" sort="Ladwig, Karl Heinz" uniqKey="Ladwig K" first="Karl-Heinz" last="Ladwig">Karl-Heinz Ladwig</name><affiliation><nlm:aff id="aff22">Helmholtz Zentrum München (German Research Center for Environmental Health (GmbH)), 85764 Oberschleißheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Lunau, Thorsten" sort="Lunau, Thorsten" uniqKey="Lunau T" first="Thorsten" last="Lunau">Thorsten Lunau</name><affiliation><nlm:aff id="aff14">Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Martin L" sort="Nielsen, Martin L" uniqKey="Nielsen M" first="Martin L" last="Nielsen">Martin L. Nielsen</name><affiliation><nlm:aff id="aff23">Unit of Social Medicine, Frederiksberg University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordin, Maria" sort="Nordin, Maria" uniqKey="Nordin M" first="Maria" last="Nordin">Maria Nordin</name><affiliation><nlm:aff id="aff17">Stress Research Institute, Stockholm University, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="aff24">Department of Psychology, Umeå University, Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Oksanen, Tuula" sort="Oksanen, Tuula" uniqKey="Oksanen T" first="Tuula" last="Oksanen">Tuula Oksanen</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Pejtersen, Jan H" sort="Pejtersen, Jan H" uniqKey="Pejtersen J" first="Jan H" last="Pejtersen">Jan H. Pejtersen</name><affiliation><nlm:aff id="aff25">Danish National Centre for Social Research, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pentti, Jaana" sort="Pentti, Jaana" uniqKey="Pentti J" first="Jaana" last="Pentti">Jaana Pentti</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Rugulies, Reiner" sort="Rugulies, Reiner" uniqKey="Rugulies R" first="Reiner" last="Rugulies">Reiner Rugulies</name><affiliation><nlm:aff id="aff3">National Research Centre for the Working Environment, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="aff26">Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Salo, Paula" sort="Salo, Paula" uniqKey="Salo P" first="Paula" last="Salo">Paula Salo</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff27">Department of Psychology, University of Turku, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Schupp, Jurgen" sort="Schupp, Jurgen" uniqKey="Schupp J" first="Jürgen" last="Schupp">Jürgen Schupp</name><affiliation><nlm:aff id="aff28">German Institute for Economic Research, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff29">Free University of Berlin, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Siegrist, Johannes" sort="Siegrist, Johannes" uniqKey="Siegrist J" first="Johannes" last="Siegrist">Johannes Siegrist</name><affiliation><nlm:aff id="aff14">Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Singh Manoux, Archana" sort="Singh Manoux, Archana" uniqKey="Singh Manoux A" first="Archana" last="Singh-Manoux">Archana Singh-Manoux</name><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff30">Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Steptoe, Andrew" sort="Steptoe, Andrew" uniqKey="Steptoe A" first="Andrew" last="Steptoe">Andrew Steptoe</name><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Suominen, Sakari B" sort="Suominen, Sakari B" uniqKey="Suominen S" first="Sakari B" last="Suominen">Sakari B. Suominen</name><affiliation><nlm:aff id="aff31">Department of Public Health, University of Turku, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff32">Nordic School of Public Health, Gothenburg, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="aff33">Folkhälsan Research Center, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Theorell, Tores" sort="Theorell, Tores" uniqKey="Theorell T" first="Töres" last="Theorell">Töres Theorell</name><affiliation><nlm:aff id="aff17">Stress Research Institute, Stockholm University, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Vahtera, Jussi" sort="Vahtera, Jussi" uniqKey="Vahtera J" first="Jussi" last="Vahtera">Jussi Vahtera</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff31">Department of Public Health, University of Turku, Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff34">Turku University Hospital, Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Wagner, Gert G" sort="Wagner, Gert G" uniqKey="Wagner G" first="Gert G" last="Wagner">Gert G. Wagner</name><affiliation><nlm:aff id="aff28">German Institute for Economic Research, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff35">Max Planck Institute for Human Development, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="aff36">Berlin University of Technology, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Westerholm, Peter J M" sort="Westerholm, Peter J M" uniqKey="Westerholm P" first="Peter J M" last="Westerholm">Peter J M. Westerholm</name><affiliation><nlm:aff id="aff37">Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Westerlund, Hugo" sort="Westerlund, Hugo" uniqKey="Westerlund H" first="Hugo" last="Westerlund">Hugo Westerlund</name><affiliation><nlm:aff id="aff17">Stress Research Institute, Stockholm University, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kivim Ki, Mika" sort="Kivim Ki, Mika" uniqKey="Kivim Ki M" first="Mika" last="Kivim Ki">Mika Kivim Ki</name><affiliation><nlm:aff id="aff1">Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Public Health, Faculty of Medicine, University of Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="aff7">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation></author></analytic><series><title level="j">The BMJ</title><idno type="ISSN">0959-8138</idno><idno type="eISSN">1756-1833</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Objective</bold> To quantify the association between long working hours and alcohol use.</p><p><bold>Design</bold> Systematic review and meta-analysis of published studies and unpublished individual participant data.</p><p><bold>Data sources</bold> A systematic search of PubMed and Embase databases in April 2014 for published studies, supplemented with manual searches. Unpublished individual participant data were obtained from 27 additional studies.</p><p><bold>Review methods</bold> The search strategy was designed to retrieve cross sectional and prospective studies of the association between long working hours and alcohol use. Summary estimates were obtained with random effects meta-analysis. Sources of heterogeneity were examined with meta-regression.</p><p><bold>Results</bold> Cross sectional analysis was based on 61 studies representing 333 693 participants from 14 countries. Prospective analysis was based on 20 studies representing 100 602 participants from nine countries. The pooled maximum adjusted odds ratio for the association between long working hours and alcohol use was 1.11 (95% confidence interval 1.05 to 1.18) in the cross sectional analysis of published and unpublished data. Odds ratio of new onset risky alcohol use was 1.12 (1.04 to 1.20) in the analysis of prospective published and unpublished data. In the 18 studies with individual participant data it was possible to assess the European Union Working Time Directive, which recommends an upper limit of 48 hours a week. Odds ratios of new onset risky alcohol use for those working 49-54 hours and ≥55 hours a week were 1.13 (1.02 to 1.26; adjusted difference in incidence 0.8 percentage points) and 1.12 (1.01 to 1.25; adjusted difference in incidence 0.7 percentage points), respectively, compared with working standard 35-40 hours (incidence of new onset risky alcohol use 6.2%). There was no difference in these associations between men and women or by age or socioeconomic groups, geographical regions, sample type (population based <italic>v</italic> occupational cohort), prevalence of risky alcohol use in the cohort, or sample attrition rate.</p><p><bold>Conclusions</bold> Individuals whose working hours exceed standard recommendations are more likely to increase their alcohol use to levels that pose a health risk.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMJ</journal-id><journal-id journal-id-type="iso-abbrev">BMJ</journal-id><journal-id journal-id-type="publisher-id">bmj</journal-id><journal-title-group><journal-title>The BMJ</journal-title></journal-title-group><issn pub-type="ppub">0959-8138</issn><issn pub-type="epub">1756-1833</issn><publisher><publisher-name>BMJ Publishing Group Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25587065</article-id><article-id pub-id-type="pmc">4293546</article-id><article-id pub-id-type="publisher-id">virm021027</article-id><article-id pub-id-type="doi">10.1136/bmj.g7772</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Long working hours and alcohol use: systematic review and meta-analysis of published studies and unpublished individual participant data</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Virtanen</surname><given-names>Marianna</given-names></name><role>professor</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jokela</surname><given-names>Markus</given-names></name><role>associate professor</role><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Nyberg</surname><given-names>Solja T</given-names></name><role>statistician</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Madsen</surname><given-names>Ida E H</given-names></name><role>researcher</role><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lallukka</surname><given-names>Tea</given-names></name><role>specialist researcher</role><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ahola</surname><given-names>Kirsi</given-names></name><role>team leader</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Alfredsson</surname><given-names>Lars</given-names></name><role>professor of epidemiology</role><xref ref-type="aff" rid="aff5">5</xref><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Batty</surname><given-names>G David</given-names></name><role>reader in epidemiology</role><xref ref-type="aff" rid="aff7">7</xref><xref ref-type="aff" rid="aff8">8</xref><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Bjorner</surname><given-names>Jakob B</given-names></name><role>professor</role><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Borritz</surname><given-names>Marianne</given-names></name><role>assistant professor</role><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Burr</surname><given-names>Hermann</given-names></name><role>scientist</role><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Casini</surname><given-names>Annalisa</given-names></name><role>lecturer</role><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Clays</surname><given-names>Els</given-names></name><role>postdoctoral researcher</role><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>De Bacquer</surname><given-names>Dirk</given-names></name><role>professor</role><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Dragano</surname><given-names>Nico</given-names></name><role>professor</role><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Erbel</surname><given-names>Raimund</given-names></name><role>professor of medicine</role><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Ferrie</surname><given-names>Jane E</given-names></name><role>senior research fellow</role><xref ref-type="aff" rid="aff7">7</xref><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib contrib-type="author"><name><surname>Fransson</surname><given-names>Eleonor I</given-names></name><role>associate professor</role><xref ref-type="aff" rid="aff5">5</xref><xref ref-type="aff" rid="aff17">17</xref><xref ref-type="aff" rid="aff18">18</xref></contrib><contrib contrib-type="author"><name><surname>Hamer</surname><given-names>Mark</given-names></name><role>principal research associate</role><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Heikkilä</surname><given-names>Katriina</given-names></name><role>specialist researcher</role><xref ref-type="aff" rid="aff19">19</xref></contrib><contrib contrib-type="author"><name><surname>Jöckel</surname><given-names>Karl-Heinz</given-names></name><role>professor</role><xref ref-type="aff" rid="aff20">20</xref></contrib><contrib contrib-type="author"><name><surname>Kittel</surname><given-names>France</given-names></name><role>professor of health psychology and research methodology</role><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Knutsson</surname><given-names>Anders</given-names></name><role>professor of public health</role><xref ref-type="aff" rid="aff21">21</xref></contrib><contrib contrib-type="author"><name><surname>Koskenvuo</surname><given-names>Markku</given-names></name><role>professor of epidemiology</role><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ladwig</surname><given-names>Karl-Heinz</given-names></name><role>professor of psychosomatic medicine</role><xref ref-type="aff" rid="aff22">22</xref></contrib><contrib contrib-type="author"><name><surname>Lunau</surname><given-names>Thorsten</given-names></name><role>researcher</role><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Nielsen</surname><given-names>Martin L</given-names></name><role>consultant</role><xref ref-type="aff" rid="aff23">23</xref></contrib><contrib contrib-type="author"><name><surname>Nordin</surname><given-names>Maria</given-names></name><role>associate professor of psychology</role><xref ref-type="aff" rid="aff17">17</xref><xref ref-type="aff" rid="aff24">24</xref></contrib><contrib contrib-type="author"><name><surname>Oksanen</surname><given-names>Tuula</given-names></name><role>assistant chief medical officer</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pejtersen</surname><given-names>Jan H</given-names></name><role>senior researcher</role><xref ref-type="aff" rid="aff25">25</xref></contrib><contrib contrib-type="author"><name><surname>Pentti</surname><given-names>Jaana</given-names></name><role>statistician</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rugulies</surname><given-names>Reiner</given-names></name><role>professor of psychosocial work environment and health</role><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff26">26</xref></contrib><contrib contrib-type="author"><name><surname>Salo</surname><given-names>Paula</given-names></name><role>professor of psychology</role><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff27">27</xref></contrib><contrib contrib-type="author"><name><surname>Schupp</surname><given-names>Jürgen</given-names></name><role>professor of sociology</role><xref ref-type="aff" rid="aff28">28</xref><xref ref-type="aff" rid="aff29">29</xref></contrib><contrib contrib-type="author"><name><surname>Siegrist</surname><given-names>Johannes</given-names></name><role>professor</role><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Singh-Manoux</surname><given-names>Archana</given-names></name><role>research director</role><xref ref-type="aff" rid="aff7">7</xref><xref ref-type="aff" rid="aff30">30</xref></contrib><contrib contrib-type="author"><name><surname>Steptoe</surname><given-names>Andrew</given-names></name><role>British Heart Foundation professor of psychology</role><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Suominen</surname><given-names>Sakari B</given-names></name><role>professor</role><xref ref-type="aff" rid="aff31">31</xref><xref ref-type="aff" rid="aff32">32</xref><xref ref-type="aff" rid="aff33">33</xref></contrib><contrib contrib-type="author"><name><surname>Theorell</surname><given-names>Töres</given-names></name><role>professor emeritus</role><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Vahtera</surname><given-names>Jussi</given-names></name><role>professor of public health</role><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff31">31</xref><xref ref-type="aff" rid="aff34">34</xref></contrib><contrib contrib-type="author"><name><surname>Wagner</surname><given-names>Gert G</given-names></name><role>professor</role><xref ref-type="aff" rid="aff28">28</xref><xref ref-type="aff" rid="aff35">35</xref><xref ref-type="aff" rid="aff36">36</xref></contrib><contrib contrib-type="author"><name><surname>Westerholm</surname><given-names>Peter J M</given-names></name><role>professor emeritus</role><xref ref-type="aff" rid="aff37">37</xref></contrib><contrib contrib-type="author"><name><surname>Westerlund</surname><given-names>Hugo</given-names></name><role>professor of epidemiology</role><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Kivimäki</surname><given-names>Mika</given-names></name><role>professor of social epidemiology</role><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="aff" rid="aff7">7</xref></contrib><aff id="aff1"><label>1</label>Finnish Institute of Occupational Health, 00250 Helsinki, Finland</aff><aff id="aff2"><label>2</label>Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland</aff><aff id="aff3"><label>3</label>National Research Centre for the Working Environment, Copenhagen, Denmark</aff><aff id="aff4"><label>4</label>Department of Public Health, Faculty of Medicine, University of Helsinki, Finland</aff><aff id="aff5"><label>5</label>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</aff><aff id="aff6"><label>6</label>Centre for Occupational and Environmental Medicine, Stockholm County Council, Sweden</aff><aff id="aff7"><label>7</label>Department of Epidemiology and Public Health, University College London, London, UK</aff><aff id="aff8"><label>8</label>Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK</aff><aff id="aff9"><label>9</label>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK</aff><aff id="aff10"><label>10</label>Department of Occupational Medicine, Koge Hospital, Koge, Denmark</aff><aff id="aff11"><label>11</label>Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany</aff><aff id="aff12"><label>12</label>School of Public Health, Université Libre de Bruxelles (ULB), Brussels, Belgium</aff><aff id="aff13"><label>13</label>Department of Public Health, Ghent University, Ghent, Belgium</aff><aff id="aff14"><label>14</label>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany</aff><aff id="aff15"><label>15</label>Department of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Essen, Germany</aff><aff id="aff16"><label>16</label>School of Social and Community Medicine, University of Bristol, Bristol, UK</aff><aff id="aff17"><label>17</label>Stress Research Institute, Stockholm University, Stockholm, Sweden</aff><aff id="aff18"><label>18</label>School of Health Sciences, Jönköping University, Jönköping, Sweden</aff><aff id="aff19"><label>19</label>School of Medicine, University of Tampere, Tampere, Finland</aff><aff id="aff20"><label>20</label>Institute for Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany</aff><aff id="aff21"><label>21</label>Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden</aff><aff id="aff22"><label>22</label>Helmholtz Zentrum München (German Research Center for Environmental Health (GmbH)), 85764 Oberschleißheim, Germany</aff><aff id="aff23"><label>23</label>Unit of Social Medicine, Frederiksberg University Hospital, Copenhagen, Denmark</aff><aff id="aff24"><label>24</label>Department of Psychology, Umeå University, Umeå, Sweden</aff><aff id="aff25"><label>25</label>Danish National Centre for Social Research, Copenhagen, Denmark</aff><aff id="aff26"><label>26</label>Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen, Denmark</aff><aff id="aff27"><label>27</label>Department of Psychology, University of Turku, Turku, Finland</aff><aff id="aff28"><label>28</label>German Institute for Economic Research, Berlin, Germany</aff><aff id="aff29"><label>29</label>Free University of Berlin, Berlin, Germany</aff><aff id="aff30"><label>30</label>Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France</aff><aff id="aff31"><label>31</label>Department of Public Health, University of Turku, Turku, Finland</aff><aff id="aff32"><label>32</label>Nordic School of Public Health, Gothenburg, Sweden</aff><aff id="aff33"><label>33</label>Folkhälsan Research Center, Helsinki, Finland</aff><aff id="aff34"><label>34</label>Turku University Hospital, Turku, Finland</aff><aff id="aff35"><label>35</label>Max Planck Institute for Human Development, Berlin, Germany</aff><aff id="aff36"><label>36</label>Berlin University of Technology, Berlin, Germany</aff><aff id="aff37"><label>37</label>Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden</aff></contrib-group><author-notes><corresp>Correspondence to: M Virtanen <email>marianna.virtanen@ttl.fi</email></corresp></author-notes><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>13</day><month>1</month><year>2015</year></pub-date><volume>350</volume><elocation-id>g7772</elocation-id><history><date date-type="accepted"><day>17</day><month>11</month><year>2014</year></date></history><permissions><copyright-statement>© Virtanen et al 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Virtanen et al</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="bmj.g7772.pdf"></self-uri><abstract><p><bold>Objective</bold> To quantify the association between long working hours and alcohol use.</p><p><bold>Design</bold> Systematic review and meta-analysis of published studies and unpublished individual participant data.</p><p><bold>Data sources</bold> A systematic search of PubMed and Embase databases in April 2014 for published studies, supplemented with manual searches. Unpublished individual participant data were obtained from 27 additional studies.</p><p><bold>Review methods</bold> The search strategy was designed to retrieve cross sectional and prospective studies of the association between long working hours and alcohol use. Summary estimates were obtained with random effects meta-analysis. Sources of heterogeneity were examined with meta-regression.</p><p><bold>Results</bold> Cross sectional analysis was based on 61 studies representing 333 693 participants from 14 countries. Prospective analysis was based on 20 studies representing 100 602 participants from nine countries. The pooled maximum adjusted odds ratio for the association between long working hours and alcohol use was 1.11 (95% confidence interval 1.05 to 1.18) in the cross sectional analysis of published and unpublished data. Odds ratio of new onset risky alcohol use was 1.12 (1.04 to 1.20) in the analysis of prospective published and unpublished data. In the 18 studies with individual participant data it was possible to assess the European Union Working Time Directive, which recommends an upper limit of 48 hours a week. Odds ratios of new onset risky alcohol use for those working 49-54 hours and ≥55 hours a week were 1.13 (1.02 to 1.26; adjusted difference in incidence 0.8 percentage points) and 1.12 (1.01 to 1.25; adjusted difference in incidence 0.7 percentage points), respectively, compared with working standard 35-40 hours (incidence of new onset risky alcohol use 6.2%). There was no difference in these associations between men and women or by age or socioeconomic groups, geographical regions, sample type (population based <italic>v</italic> occupational cohort), prevalence of risky alcohol use in the cohort, or sample attrition rate.</p><p><bold>Conclusions</bold> Individuals whose working hours exceed standard recommendations are more likely to increase their alcohol use to levels that pose a health risk.</p></abstract></article-meta><notes notes-type="data-supplement"><label>Web Extra</label><title>Extra material supplied by the author</title><supplementary-material content-type="local-data"><caption><p><bold>Appendix 1</bold>: Data sources and eligibility criteria</p></caption><media xlink:href="virm021027.ww1_default.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data"><caption><p><bold>Appendix 2</bold>: Supplementary tables A and B</p></caption><media xlink:href="virm021027.ww2_default.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></notes></front><body><sec sec-type="intro"><title>Introduction</title><p>Risky alcohol use is common in high income countries, though there is cultural variation in alcohol use between countries; about one in four people are classified as at risk users, and 9% meet the diagnostic criteria for an alcohol use disorder.<xref rid="ref1" ref-type="bibr">1</xref><xref rid="ref2" ref-type="bibr">2</xref><xref rid="ref3" ref-type="bibr">3</xref><xref rid="ref4" ref-type="bibr">4</xref> Risky alcohol use, defined for example, as more than 14 drinks/week among women and more than 21 drinks/week among men,<xref rid="ref5" ref-type="bibr">5</xref><xref rid="ref6" ref-type="bibr">6</xref><xref rid="ref7" ref-type="bibr">7</xref> refers to the level of alcohol consumption at which there might be an increased risk of adverse health consequences, such as liver diseases, cancer, coronary heart disease, stroke, mental disorders, and injuries, as well as considerable social costs because of family disruption, violence, traffic incidents, healthcare costs, reduced work productivity, and permanent exclusion from the labour market.<xref rid="ref1" ref-type="bibr">1</xref><xref rid="ref2" ref-type="bibr">2</xref><xref rid="ref3" ref-type="bibr">3</xref><xref rid="ref8" ref-type="bibr">8</xref></p><p>Although risky alcohol use is common in the workforce,<xref rid="ref3" ref-type="bibr">3</xref> little attention has been paid to any association with work. A recent large scale meta-analysis of data from individual participants provided no clear support for an association between perceived “job strain” (an index of work stress) and risky alcohol use.<xref rid="ref9" ref-type="bibr">9</xref> Another work related factor—long working hours—has been associated with several adverse health outcomes that are linked to alcohol use, including cardiovascular diseases,<xref rid="ref10" ref-type="bibr">10</xref><xref rid="ref11" ref-type="bibr">11</xref><xref rid="ref12" ref-type="bibr">12</xref><xref rid="ref13" ref-type="bibr">13</xref><xref rid="ref14" ref-type="bibr">14</xref> depression and anxiety,<xref rid="ref11" ref-type="bibr">11</xref><xref rid="ref13" ref-type="bibr">13</xref><xref rid="ref14" ref-type="bibr">14</xref><xref rid="ref15" ref-type="bibr">15</xref><xref rid="ref16" ref-type="bibr">16</xref> sleep deprivation,<xref rid="ref11" ref-type="bibr">11</xref><xref rid="ref12" ref-type="bibr">12</xref><xref rid="ref16" ref-type="bibr">16</xref> and occupational injuries.<xref rid="ref15" ref-type="bibr">15</xref><xref rid="ref17" ref-type="bibr">17</xref> Direct evidence on the association between long working hours and alcohol use, however, is based on relatively small studies with insufficient power to detect weak or moderate associations. Three narrative reviews, published in 1999-2006, summarised findings from up to six studies that reported inconclusive results, some studies showing increased alcohol use among people with long working hours, and other studies observing no relation.<xref rid="ref11" ref-type="bibr">11</xref><xref rid="ref13" ref-type="bibr">13</xref><xref rid="ref18" ref-type="bibr">18</xref> To date, there has been no systematic quantification of the link between long working hours and alcohol use.</p><p>Meta-analysis is a powerful tool to examine associations between exposures and health outcomes as it is based on a greater range of participants, a larger sample size, and more events than any individual study. A traditional meta-analysis of published studies is a quantitative synthesis of published aggregate data with a limited ability to control for the effects of publication bias (that is, selective reporting of positive findings) and heterogeneity in the methods used (for example, cut-off levels, method of measurement, analytic strategies, etc).<xref rid="ref19" ref-type="bibr">19</xref> Meta-analysis of individual participant data provides an opportunity to deal with these biases by inclusion of unpublished individual level data to the analysis and by standardisation of definitions of the exposures, outcomes, and statistical methods within these data.<xref rid="ref20" ref-type="bibr">20</xref></p><p>We carried out a meta-analysis of 36 published studies with aggregate data (34 cross sectional and two prospective), identified by a systematic review and supplemented with unpublished individual participant data from 27 studies, of which 18 provided data for prospective analysis. We examined whether long working hours are associated with alcohol use cross sectionally, longitudinally, and in relation to sustained risky alcohol use. We also examined whether any association is apparent across sociodemographic groups, geographical regions, and characteristics of the study cohort. Finally, we compared the findings from published studies and studies with unpublished individual participant data to evaluate publication bias.</p></sec><sec sec-type="methods"><title>Methods</title><sec><title>Search strategy for published studies with aggregate data</title><p>We conducted the meta-analysis according to MOOSE guidelines.<xref rid="ref21" ref-type="bibr">21</xref> We performed a systematic computerised literature search in PubMed and Embase (to April 2014). Exposure search terms, used without restrictions, were: “(work and hours) or (working and hours) or (overtime and work) or overtime”. Outcome search terms were: “alcohol or alcohols or ethanol or wine or beer or liquor or spirit or alcoholism or (alcohol and dependence) or (alcohol and abuse) or (substance) or (drinking and behaviour) or (alcohol and drinking) or (alcoholic and beverages) or (alcohol and consumption) or (alcohol and misuse) or (heavy and drinking) or lifestyle or (life and style) or (health and behaviours) or (health and behaviour)”. We also scrutinised the reference list of all eligible publications and performed a cited reference search of these using the Institute of Scientific Information Web of Science (to May 2014) to identify all studies citing the included studies.</p></sec><sec><title>Study selection criteria</title><p>We included published studies providing aggregate data if they met the following criteria: empirical and peer reviewed study; at least an abstract with estimates and/or full results published in English; individual level exposure and outcome data; examined the association between working hours and alcohol use (reported either by a defined high level of alcohol consumption or as a continuous variable); reported either estimates of relative risk, odds ratios, or hazard ratios with 95% confidence intervals or data to calculate these. Cross sectional, case-control, prospective studies, and trials were eligible for this meta-analysis.</p></sec><sec><title>Data extraction from studies with aggregate data</title><p>We extracted the following information from each retrieved article: name of first author, start of follow-up (year) or publication year if start year not reported, study location (country), population, number of participants, mean follow-up time, mean age or age range, proportion of women, method of assessment and definition of long working hours, proportion of employees with long hours, method of assessment of alcohol use, definition of risky alcohol use (when applicable), proportion of employees with risky use at baseline and proportion of new cases at follow-up, and covariates included in the adjusted models.</p></sec><sec><title>Individual participant data</title><p>We also identified 28 datasets with relevant individual participant data. Of these, we excluded the Intervention Project on Absence and Well-being (IPAW) study<xref rid="ref22" ref-type="bibr">22</xref> from the analysis because there were no cases of risky alcohol use among employees with long working hours. Of the remaining 27 datasets, we obtained 15 from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium, which we lead, and 12 from open access data collections. The IPD-Work consortium is a network of investigators established at a meeting in London in 2008 to pool cohort studies with data on work life and health. Individual participant data from 15 cohort studies with measurements of working hours and alcohol consumption were available from IPD-Work. Another source of unpublished data was from open access collections. These were retrieved from collections curated by the Inter-University Consortium for Political and Social Research (ICPSR; <ext-link ext-link-type="uri" xlink:href="http://www.icpsr.umich.edu/icpsrweb/ICPSR/">www.icpsr.umich.edu/icpsrweb/ICPSR/</ext-link>) and the UK Economic and Social Data Service (<ext-link ext-link-type="uri" xlink:href="http://ukdataservice.ac.uk/">http://ukdataservice.ac.uk/</ext-link>). These repositories seek research data and pertinent documents from researchers, research agencies, and government entities and process, preserve, and disseminate the data and documents for researchers. We identified 12 additional studies with data on working hours and alcohol use from these two sources (see appendix 1 for a more detailed description). Each constituent study was approved by the relevant local or national ethics committee, and all participants gave informed consent to participate.</p><p>In line with previous evidence suggesting ≥55 hours of work a week to be harmful for health,<xref rid="ref10" ref-type="bibr">10</xref> and the European Union Directive of a recommended limit of 48 hours a week,<xref rid="ref23" ref-type="bibr">23</xref> we used the following categories of hours worked: <35, 35-40 (reference), 41-48, 49-54, and ≥55 hours. In the Helsinki Health Study,<xref rid="ref24" ref-type="bibr">24</xref> weekly working hours were categorised as <30, 30-40, 41-50, and >50 in the response format. In our analyses, we used the >50 working hours group in the Helsinki Health Study to represent the ≥55 hours group and the 30-40 hours group as the reference group.</p><p>In all individual participant data studies, information on alcohol use was based on survey responses. We defined risky alcohol use by standard categorisations.<xref rid="ref9" ref-type="bibr">9</xref> One drink was considered equivalent to one unit or one glass of alcoholic drink. Participants were classified as follows: non-use or moderate use (up to 14 drinks/week for women and up to 21 drinks/week for men), and risky alcohol use (>14 drinks/week and >21 drinks/week, respectively). According to public health guidelines, these limits define risky alcohol use among men and women in many countries.<xref rid="ref5" ref-type="bibr">5</xref><xref rid="ref6" ref-type="bibr">6</xref><xref rid="ref7" ref-type="bibr">7</xref> In the German Socioeconomic Panel Survey cohort,<xref rid="ref25" ref-type="bibr">25</xref> participants were asked how often they drank beer, wine, spirits, and mixed drinks (0=never, 1=seldom, 2=once in a while, 3=regularly); and risky alcohol use was defined as score of 7 or more on the summed score of these four questions. In the US National Longitudinal Survey of Youth 1979 cohort,<xref rid="ref26" ref-type="bibr">26</xref> risky alcohol use was defined as “binge drinking”—that is, having consumed six or more alcohol units in one evening at least twice during the past month. In the prospective cohort analyses of new onset risky alcohol use, we excluded cases of risky alcohol use at baseline.</p></sec><sec><title>Statistical analysis</title><p>We used a two stage meta-analysis<xref rid="ref20" ref-type="bibr">20</xref> with study specific estimates obtained from published studies with aggregate data and studies with unpublished individual participant data at the first stage. The second stage was an analysis that pooled all the study specific estimates.</p><sec><title>First stage analysis in studies with aggregate data</title><p>We converted means, correlation coefficients, and regression coefficients reported for continuous variables to odds ratios according to published formulas.<xref rid="ref27" ref-type="bibr">27</xref> The studies with aggregate data had used different covariate adjustments. In two published studies, the exposure measure was a continuous variable estimating one hour increase in working hours with a dichotomous alcohol use outcome.<xref rid="ref28" ref-type="bibr">28</xref><xref rid="ref29" ref-type="bibr">29</xref> In these cases, we raised the estimate to the 18th power to get an estimate comparable with that in the individual participant data (≥55 hours <italic>v</italic> 35-40 hours—that is, about an 18 hour difference). </p></sec><sec><title>First stage analysis in studies with individual participant data</title><p>We analysed data from the individual participant data studies to generate study level odds ratios and 95% confidence intervals within each study. These analyses were adjusted for age, sex, race/ethnicity (white/ethnic majority <italic>v</italic> other when available), and socioeconomic status, which was categorised as high, intermediate, and low. In the analyses of individual participant data, this three level socioeconomic status variable was based on register or survey based occupational position or educational qualification.</p></sec><sec><title>Second stage analysis</title><p>In both types of data, we used random effects meta-analysis to combine the results from the individual participant data analyses and the (converted) estimates of the aggregate data. We used odds ratios as an indicator of effect size and their 95% confidence intervals as an indicator of precision. We examined heterogeneity of the estimates by computing an I<sup>2</sup> statistic, presented the summary estimates of the random effects analyses, and assessed the possibility of publication bias in the analysis of published studies by using a funnel plot of the estimates against their standard errors and Egger’s test for small study effects.</p><p>We used cross sectional aggregate and individual participant data for prespecified meta-regression and stratified meta-analyses to examine sex (men only, women only, both), region (Europe, North America, Australia/New Zealand, Asia), number of adjustment variables (none, sociodemographics, multivariable), and population (random sample of the population, occupational cohort with several occupations, occupational cohort with a single occupation (except physicians), physicians, patients) as sources of heterogeneity between studies. In the prospective analysis the corresponding variables were sex, age (<50 <italic>v</italic> ≥50), socioeconomic status, region (North America, United Kingdom, other Europe, Australia), sample type (population based/community sample <italic>v </italic>occupational cohort), the baseline level of alcohol use in the cohort (<9% <italic>v</italic> ≥9%), and participation rate in the prospective cohort (<75% <italic>v</italic> ≥75%). We used SAS 9.4 (Cary, NC) and Stata 13.1 (StataCorp, College Station, TX) to analyse study specific data and Stata 13.1 for meta-analyses.</p></sec></sec></sec><sec sec-type="results"><title>Results</title><sec><title>Aggregate data from published studies</title><p>The literature search identified 3409 citations from PubMed and 2314 from Embase, of which 651 were selected for further review (fig 1<xref ref-type="fig" rid="fig1"></xref>). Of these, 26 fulfilled the eligibility criteria. We identified 10 additional eligible studies from a manual search of the references of the retrieved relevant publications (including reviews and books) and the cited reference search of the articles that were selected for meta-analysis. In total, there were 36 eligible published studies with aggregate data, of which 34 were cross sectional and two were cohort studies.</p><fig id="fig1" position="float"><caption><p><bold>Fig 1</bold> Search strategy and selection of studies for meta-analysis of effect of long working hours on alcohol use</p></caption><graphic xlink:href="virm021027.f1_default"></graphic></fig><p>The total number of participants included in the meta-analysis of published studies with aggregate data was 139 112 in the 34 cross sectional analyses and 6873 in the two prospective analyses (see table A in appendix 2). There were 80 345 men and 61 983 women; in one study (n=3657) sex distribution was not reported. The study entry year/publication year ranged from 1970 to 2013. Only two published studies were prospective.<xref rid="ref28" ref-type="bibr">28</xref><xref rid="ref30" ref-type="bibr">30</xref> Of all published studies, 13 were from Japan,<xref rid="ref31" ref-type="bibr">31</xref><xref rid="ref32" ref-type="bibr">32</xref><xref rid="ref33" ref-type="bibr">33</xref><xref rid="ref34" ref-type="bibr">34</xref><xref rid="ref35" ref-type="bibr">35</xref><xref rid="ref36" ref-type="bibr">36</xref><xref rid="ref37" ref-type="bibr">37</xref><xref rid="ref38" ref-type="bibr">38</xref><xref rid="ref39" ref-type="bibr">39</xref><xref rid="ref40" ref-type="bibr">40</xref><xref rid="ref41" ref-type="bibr">41</xref><xref rid="ref42" ref-type="bibr">42</xref><xref rid="ref43" ref-type="bibr">43</xref> seven from the United States,<xref rid="ref44" ref-type="bibr">44</xref><xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref46" ref-type="bibr">46</xref><xref rid="ref47" ref-type="bibr">47</xref><xref rid="ref48" ref-type="bibr">48</xref><xref rid="ref49" ref-type="bibr">49</xref><xref rid="ref50" ref-type="bibr">50</xref> four from Canada,<xref rid="ref28" ref-type="bibr">28</xref><xref rid="ref29" ref-type="bibr">29</xref><xref rid="ref51" ref-type="bibr">51</xref><xref rid="ref52" ref-type="bibr">52</xref> three from Australia<xref rid="ref53" ref-type="bibr">53</xref><xref rid="ref54" ref-type="bibr">54</xref><xref rid="ref55" ref-type="bibr">55</xref> two from the UK,<xref rid="ref56" ref-type="bibr">56</xref><xref rid="ref57" ref-type="bibr">57</xref> and one each from New Zealand,<xref rid="ref58" ref-type="bibr">58</xref> Denmark,<xref rid="ref59" ref-type="bibr">59</xref> Taiwan,<xref rid="ref60" ref-type="bibr">60</xref> France,<xref rid="ref61" ref-type="bibr">61</xref> Spain,<xref rid="ref62" ref-type="bibr">62</xref> and Sweden.<xref rid="ref30" ref-type="bibr">30</xref> One study included participants from both Australia and New Zealand.<xref rid="ref63" ref-type="bibr">63</xref> Altogether 11 studies were general population based<xref rid="ref28" ref-type="bibr">28</xref><xref rid="ref29" ref-type="bibr">29</xref><xref rid="ref30" ref-type="bibr">30</xref><xref rid="ref40" ref-type="bibr">40</xref><xref rid="ref43" ref-type="bibr">43</xref><xref rid="ref51" ref-type="bibr">51</xref><xref rid="ref52" ref-type="bibr">52</xref><xref rid="ref55" ref-type="bibr">55</xref><xref rid="ref58" ref-type="bibr">58</xref><xref rid="ref59" ref-type="bibr">59</xref><xref rid="ref60" ref-type="bibr">60</xref>; physicians (six studies),<xref rid="ref47" ref-type="bibr">47</xref><xref rid="ref48" ref-type="bibr">48</xref><xref rid="ref49" ref-type="bibr">49</xref><xref rid="ref54" ref-type="bibr">54</xref><xref rid="ref56" ref-type="bibr">56</xref><xref rid="ref61" ref-type="bibr">61</xref> industrial workers (four),<xref rid="ref31" ref-type="bibr">31</xref><xref rid="ref32" ref-type="bibr">32</xref><xref rid="ref41" ref-type="bibr">41</xref><xref rid="ref45" ref-type="bibr">45</xref> office workers (three),<xref rid="ref34" ref-type="bibr">34</xref><xref rid="ref37" ref-type="bibr">37</xref><xref rid="ref42" ref-type="bibr">42</xref> public sector employees (two),<xref rid="ref38" ref-type="bibr">38</xref><xref rid="ref57" ref-type="bibr">57</xref> nurses (two),<xref rid="ref46" ref-type="bibr">46</xref><xref rid="ref63" ref-type="bibr">63</xref> transport employees (two),<xref rid="ref44" ref-type="bibr">44</xref><xref rid="ref53" ref-type="bibr">53</xref> patients (two),<xref rid="ref35" ref-type="bibr">35</xref><xref rid="ref36" ref-type="bibr">36</xref> information technology engineers (one),<xref rid="ref39" ref-type="bibr">39</xref> police officers (one),<xref rid="ref50" ref-type="bibr">50</xref> managers (one),<xref rid="ref33" ref-type="bibr">33</xref> and university graduates (one).<xref rid="ref62" ref-type="bibr">62</xref> In 15 studies<xref rid="ref32" ref-type="bibr">32</xref><xref rid="ref33" ref-type="bibr">33</xref><xref rid="ref34" ref-type="bibr">34</xref><xref rid="ref35" ref-type="bibr">35</xref><xref rid="ref36" ref-type="bibr">36</xref><xref rid="ref37" ref-type="bibr">37</xref><xref rid="ref39" ref-type="bibr">39</xref><xref rid="ref40" ref-type="bibr">40</xref><xref rid="ref41" ref-type="bibr">41</xref><xref rid="ref42" ref-type="bibr">42</xref><xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref50" ref-type="bibr">50</xref><xref rid="ref55" ref-type="bibr">55</xref><xref rid="ref59" ref-type="bibr">59</xref><xref rid="ref62" ref-type="bibr">62</xref> the association between long working hours and alcohol use was not the main topic of the study—that is, either long working hours or alcohol use were covariates, and unadjusted estimates were usually displayed in a descriptive table.</p><p>There was large variation in the assessment of working hours in published studies with aggregate data: 20 studies used a threshold of 45 hours a week or higher<xref rid="ref33" ref-type="bibr">33</xref><xref rid="ref34" ref-type="bibr">34</xref><xref rid="ref35" ref-type="bibr">35</xref><xref rid="ref36" ref-type="bibr">36</xref><xref rid="ref37" ref-type="bibr">37</xref><xref rid="ref39" ref-type="bibr">39</xref><xref rid="ref40" ref-type="bibr">40</xref><xref rid="ref41" ref-type="bibr">41</xref><xref rid="ref43" ref-type="bibr">43</xref><xref rid="ref46" ref-type="bibr">46</xref><xref rid="ref47" ref-type="bibr">47</xref><xref rid="ref48" ref-type="bibr">48</xref><xref rid="ref49" ref-type="bibr">49</xref><xref rid="ref54" ref-type="bibr">54</xref><xref rid="ref55" ref-type="bibr">55</xref><xref rid="ref58" ref-type="bibr">58</xref><xref rid="ref59" ref-type="bibr">59</xref><xref rid="ref60" ref-type="bibr">60</xref><xref rid="ref62" ref-type="bibr">62</xref><xref rid="ref63" ref-type="bibr">63</xref> (the highest threshold being >80 hours/week<xref rid="ref47" ref-type="bibr">47</xref>) while three studies used >40 hours<xref rid="ref38" ref-type="bibr">38</xref><xref rid="ref45" ref-type="bibr">45</xref><xref rid="ref52" ref-type="bibr">52</xref> and one study used “frequent overtime”<xref rid="ref30" ref-type="bibr">30</xref> (see table A in appendix 2). Of these, 10 studies<xref rid="ref36" ref-type="bibr">36</xref><xref rid="ref41" ref-type="bibr">41</xref><xref rid="ref46" ref-type="bibr">46</xref><xref rid="ref48" ref-type="bibr">48</xref><xref rid="ref54" ref-type="bibr">54</xref><xref rid="ref55" ref-type="bibr">55</xref><xref rid="ref59" ref-type="bibr">59</xref><xref rid="ref60" ref-type="bibr">60</xref><xref rid="ref62" ref-type="bibr">62</xref><xref rid="ref63" ref-type="bibr">63</xref> used standard hours (such as 35-40 hours/week) as a reference group—most often all hours below the exposure group were included in the reference group. In the 12 remaining studies, working hours were treated as a continuous variable.<xref rid="ref28" ref-type="bibr">28</xref><xref rid="ref29" ref-type="bibr">29</xref><xref rid="ref31" ref-type="bibr">31</xref><xref rid="ref32" ref-type="bibr">32</xref><xref rid="ref42" ref-type="bibr">42</xref><xref rid="ref44" ref-type="bibr">44</xref><xref rid="ref50" ref-type="bibr">50</xref><xref rid="ref51" ref-type="bibr">51</xref><xref rid="ref53" ref-type="bibr">53</xref><xref rid="ref56" ref-type="bibr">56</xref><xref rid="ref57" ref-type="bibr">57</xref><xref rid="ref61" ref-type="bibr">61</xref></p><p>With the exception of two studies,<xref rid="ref28" ref-type="bibr">28</xref><xref rid="ref29" ref-type="bibr">29</xref> the studies that treated working hours as a continuous variable also treated alcohol use measure as a continuous variable and reported a correlation or linear regression coefficient between the exposure and outcome (see table A in appendix 2). Two studies calculated the difference in mean alcohol use between groups of working long and shorter hours.<xref rid="ref39" ref-type="bibr">39</xref><xref rid="ref62" ref-type="bibr">62</xref> Probably in part because of large variation in the definition, the prevalence of working long hours also varied substantially, ranging from 4.1% to 69.8%. Alcohol use was based on self reported frequency from questionnaires or amount of alcohol use, except in one study that used the Composite International Diagnostic Interview (CIDI) to determine DSM-IV diagnoses of alcohol use disorders.<xref rid="ref58" ref-type="bibr">58</xref> There was also large variation in the definition of risky alcohol use; and its prevalence between studies ranged from 3.4% to 64.0%.</p></sec><sec><title>Individual participant data</title><p>The 27 studies with individual participant data (fig 1<xref ref-type="fig" rid="fig1"></xref> and table B in appendix 2) drew on populations from the US (eight studies),<xref rid="ref26" ref-type="bibr">26</xref><xref rid="ref64" ref-type="bibr">64</xref><xref rid="ref65" ref-type="bibr">65</xref><xref rid="ref66" ref-type="bibr">66</xref><xref rid="ref67" ref-type="bibr">67</xref><xref rid="ref68" ref-type="bibr">68</xref><xref rid="ref69" ref-type="bibr">69</xref> Germany (five),<xref rid="ref25" ref-type="bibr">25</xref><xref rid="ref70" ref-type="bibr">70</xref><xref rid="ref71" ref-type="bibr">71</xref> Denmark (four),<xref rid="ref72" ref-type="bibr">72</xref><xref rid="ref73" ref-type="bibr">73</xref><xref rid="ref74" ref-type="bibr">74</xref><xref rid="ref75" ref-type="bibr">75</xref> the UK (three),<xref rid="ref76" ref-type="bibr">76</xref><xref rid="ref77" ref-type="bibr">77</xref><xref rid="ref78" ref-type="bibr">78</xref> Finland (three),<xref rid="ref24" ref-type="bibr">24</xref><xref rid="ref79" ref-type="bibr">79</xref><xref rid="ref80" ref-type="bibr">80</xref> Sweden (two)<xref rid="ref81" ref-type="bibr">81</xref><xref rid="ref82" ref-type="bibr">82</xref> Australia (one),<xref rid="ref83" ref-type="bibr">83</xref> and Belgium (one).<xref rid="ref84" ref-type="bibr">84</xref> Eighteen studies were population based or community studies,<xref rid="ref25" ref-type="bibr">25</xref><xref rid="ref26" ref-type="bibr">26</xref><xref rid="ref64" ref-type="bibr">64</xref><xref rid="ref65" ref-type="bibr">65</xref><xref rid="ref66" ref-type="bibr">66</xref><xref rid="ref67" ref-type="bibr">67</xref><xref rid="ref68" ref-type="bibr">68</xref><xref rid="ref70" ref-type="bibr">70</xref><xref rid="ref71" ref-type="bibr">71</xref><xref rid="ref72" ref-type="bibr">72</xref><xref rid="ref73" ref-type="bibr">73</xref><xref rid="ref74" ref-type="bibr">74</xref><xref rid="ref76" ref-type="bibr">76</xref><xref rid="ref77" ref-type="bibr">77</xref><xref rid="ref79" ref-type="bibr">79</xref><xref rid="ref83" ref-type="bibr">83</xref> seven were occupational cohorts,<xref rid="ref24" ref-type="bibr">24</xref><xref rid="ref75" ref-type="bibr">75</xref><xref rid="ref78" ref-type="bibr">78</xref><xref rid="ref80" ref-type="bibr">80</xref><xref rid="ref81" ref-type="bibr">81</xref><xref rid="ref82" ref-type="bibr">82</xref><xref rid="ref84" ref-type="bibr">84</xref> and two were samples of college graduates and their siblings.<xref rid="ref69" ref-type="bibr">69</xref> Of the studies, 26 provided hourly data on daily or weekly working hours, and in one study the number of hours was pre-categorised.<xref rid="ref24" ref-type="bibr">24</xref></p><p>The cross sectional data from the 27 individual participant data studies came from 194 581 participants (89 799 men, 104 782 women). The proportion of employees working long hours (≥55/week) at baseline ranged from 0.8% to 20.2% across the studies (overall 7.5%). The prevalence of risky alcohol use at baseline (n=22 857 cases) varied from 2.3% to 38.8%, and the overall prevalence was 11.7%. Eighteen prospective cohorts provided data from a second wave, which allowed us to calculate new onset risky alcohol use. The prospective data included 93 729 participants (36 342 men, 57 387 women), the follow-up time ranged from 3.4 to 21.9 years (mean 6.0 person years), and the proportion of participants with new onset risky alcohol use (n=5878 new cases) ranged from 1.2% to 17.4%; overall new onset was 6.3%.</p></sec><sec><title>Cross sectional association between working hours and alcohol use</title><p>The overall pooled odds ratio of the association between long working hours and alcohol use in the meta-analysis of 61 cross sectional studies was 1.11 (95% confidence interval 1.05 to 1.18). Similar associations were found in the 27 individual participant data studies (1.10, 1.04 to 1.18; fig 2<xref ref-type="fig" rid="fig2"></xref>) and published studies with aggregate data (1.12, 1.02 to 1.22; fig 3<xref ref-type="fig" rid="fig3"></xref>). The I<sup>2</sup> statistics suggested significant heterogeneity among published studies with aggregate data (I<sup>2</sup>=81%, P<0.001) but not individual participant data (I<sup>2</sup>=18%, P=0.21). The total pooled I<sup>2</sup> was 72%, with P<0.001. In the individual participant data, the overall prevalence of risky alcohol use was 11.8%.</p><fig id="fig2" position="float"><caption><p><bold>Fig 2</bold> Cross sectional associations between long working hours and alcohol use from individual participant data adjusted for sex, age, socioeconomic status, and ethnicity</p></caption><graphic xlink:href="virm021027.f2_default"></graphic></fig><fig id="fig3" position="float"><caption><p><bold>Fig 3</bold> Cross sectional associations between long working hours and alcohol use from published data</p></caption><graphic xlink:href="virm021027.f3_default"></graphic></fig><p>We examined the potential sources for heterogeneity in the aggregate data: sex (men only, women only, both), region (Europe, North America, Australia/New Zealand, Asia), covariate adjustments (none, sociodemographics, multivariate), and population (random sample of the population, occupational cohort with several occupations, occupational cohort with a single occupation (excluding physicians), physicians, patients). Meta-regression models provided no evidence that any of these factors explained the heterogeneity (data not shown; all P>0.11).</p><p>To examine whether a stricter definition of the exposure and outcome would provide different results in the cross sectional studies with aggregate data, we carried out a meta-analysis in a refined subgroup of studies that fulfilled the following criteria: the exposure and outcome were categorical; the cut point defining long hours was high enough (that is, it did not include employees with working hours close to standard hours, such as 41 hours); the reference group did not include employees with long working hours (such as 50 hours); the outcome was based on a specific definition of risky alcohol use. Six studies were eligible for this analysis.<xref rid="ref36" ref-type="bibr">36</xref><xref rid="ref54" ref-type="bibr">54</xref><xref rid="ref55" ref-type="bibr">55</xref><xref rid="ref58" ref-type="bibr">58</xref><xref rid="ref59" ref-type="bibr">59</xref><xref rid="ref60" ref-type="bibr">60</xref> The odds ratio for risky alcohol use was 1.14 (95% confidence interval 0.89 to 1.47) and the I<sup>2</sup> was 68.6% (P=0.007; data not shown), again suggesting a similar estimate but with considerably high heterogeneity among published studies.</p><p>The funnel plot for published cross sectional studies appears symmetrical (fig 4<xref ref-type="fig" rid="fig4"></xref>) and is not dependent on whether long working hours and alcohol consumption was the main research question in the study or not. No evidence of an association between study size and the estimates was found in Egger’s test: 0.12 (95% confidence interval −0.38 to 0.63), P=0.62 for the total data; 0.10 (−0.71 to 0.90), P=0.81 for studies with long hours and alcohol use as the main research question; 0.22 (−0.58 to 1.02), P=0.57 for studies with another main research question.</p><fig id="fig4" position="float"><caption><p><bold>Fig 4</bold> Funnel plot with pseudo 95% confidence limits stratified by whether long working hours and alcohol use was main or secondary research question</p></caption><graphic xlink:href="virm021027.f4_default"></graphic></fig></sec><sec><title>Prospective association between long working hours and new onset risky alcohol use</title><p>In the meta-analysis of the 18 prospective individual participant data studies and two studies with published aggregate data, participants who used alcohol above the recommended limits at baseline were excluded. The adjusted pooled odds ratio for new onset risky alcohol use was 1.12 (95% confidence interval 1.04 to 1.20) for those working long hours (≥55 in the individual participant data studies), compared with those working standard hours (35-40) (fig 5<xref ref-type="fig" rid="fig5"></xref>). The associations were similar in the individual participant data (1.12, 1.01 to 1.25) and two studies with published aggregate data (1.10, 0.66 to 1.84). The I<sup>2</sup> statistic for heterogeneity was 0% (P=0.96) overall; 0% (P=0.99) in the individual participant data studies and 56% (P=0.10) in the aggregate data.</p><fig id="fig5" position="float"><caption><p><bold>Fig 5</bold> Associations between long working hours and new onset risky alcohol use (individual participant data adjusted for sex, age, socioeconomic status, and ethnicity at baseline)</p></caption><graphic xlink:href="virm021027.f5_default"></graphic></fig><p>We further examined whether the prospective associations were similar in men and women, in older (≥50) and younger (<50) employees, among socioeconomic groups, in different geographical areas, in different study samples, and different levels of risky drinking (<9.0% <italic>v</italic> ≥9.0%) in the cohort (fig 6<xref ref-type="fig" rid="fig6"></xref>). The analyses of sex, age, and socioeconomic group were carried out in the individual participant data studies; for geographical region and type of study sample, all prospective studies were included and for the level of drinking, one study with aggregate data<xref rid="ref28" ref-type="bibr">28</xref> provided data. Although the odds ratio among women seemed greater (1.36, 95% confidence interval 1.10 to 1.68) than among men (1.11, 0.98 to 1.25), the difference was not significant (P=0.09). The associations were not dependent on age or socioeconomic group, region, sample type, or the level of risky drinking in the cohort (all P>0.09 for heterogeneity). To examine whether the association was dependent on sample attrition, we performed the analyses in subgroups with follow-up participation rate of <75% <italic>v</italic> ≥75%. The corresponding odds ratio in the former group was 1.18 (1.02 to 1.36) and 1.10 (1.01 to 1.20) in the latter, with P=0.44 for heterogeneity (data not shown).</p><fig id="fig6" position="float"><caption><p><bold>Fig 6</bold> Pooled associations between long working hours and new onset risky alcohol use by sex, age group, socioeconomic status, geographic region, sample type, and prevalence of risky alcohol use in cohort</p></caption><graphic xlink:href="virm021027.f6_default"></graphic></fig><p>In the individual participant data studies, we examined the association between each working hours category (<35, 41-48, 49-54, and ≥55) in comparison with 35-40 hours a week associated with risky alcohol use. In the prospective analysis that excluded those who were risky users at baseline (fig 7<xref ref-type="fig" rid="fig7"></xref>), the overall incidence of risky alcohol use was 6.3% and the incidence among those working 35-40 hours was 6.2%. A part time job (<35 hours) and working 41-48 hours were not associated with new onset risky alcohol use whereas working 49-54 hours was associated with an odds ratio of 1.13 (95% confidence interval 1.02 to 1.26; adjusted difference in incidence 0.8 percentage points) and working 55 hours or more was associated with an odds ratio of 1.12 (1.01 to 1.25; adjusted difference in incidence 0.7 percentage points).</p><fig id="fig7" position="float"><caption><p><bold>Fig 7</bold> Pooled association between weekly working hours and new onset risky alcohol use, adjusted for sex, age, socioeconomic status, and ethnicity at baseline</p></caption><graphic xlink:href="virm021027.f7_default"></graphic></fig><p>In the corresponding cross sectional analysis the adjusted odds ratio of risky alcohol use was 0.94 (95% confidence interval 0.88 to 1.02) for <35 hours, 1.03 (0.97 to 1.09) for 41-48 hours, 1.13 (1.05 to 1.22) for 49-54 hours, and 1.10 (1.04 to 1.18) for ≥55 hours when compared with standard 35-40 weekly working hours (data not shown). The adjusted difference in prevalence was 1.5 percentage points among those with 49-54 weekly working hours and 1.1 percentage points among those with 55 hours or more, when compared with the prevalence among employees working 35-40 hours (11.3%).</p><p>Finally, we used the individual participant data studies to examine whether long working hours were associated with sustained risky alcohol use among those who were risky users at baseline (data not shown). The odds ratio for sustained risky alcohol use among risky users who worked ≥55 hours at baseline was 1.16 (95% confidence interval 0.83 to 1.61) compared with those working standard 35-40 hours a week, suggesting a similar though non-significant association to that found for new onset risky use among non-risky users at baseline.</p></sec></sec><sec sec-type="discussion"><title>Discussion</title><p>This systematic review and meta-analysis of 63 studies provides comprehensive evidence of an association between long working hours and alcohol use. Long working hours were associated with 1.11-fold likelihood of higher levels of alcohol use in the cross sectional analysis of 333 693 participants from 14 countries. A similar association (odds ratio 1.12) for new onset risky alcohol use was observed in a prospective analysis of 20 studies including 100 602 participants from nine countries. The associations were not dependent on participants’ sex, age, socioeconomic status, geographical region, type of study sample, prevalence of risky alcohol use in the cohort, or participation rate at follow-up. Eighteen prospective studies with individual participant data allowed us to perform a more refined comparison between work hour categories. Compared with the standard (35-40) weekly working hours, working 49-54 hours was associated with an odds ratio of 1.13 and working ≥55 hours a week was associated with an odds ratio of 1.12 for new onset risky alcohol use.</p><sec><title>Strengths and limitations</title><p>Our systematic review and meta-analysis provides the first quantitative summary estimate of the association between long working hours and alcohol use. This has not been provided in previous narrative reviews.<xref rid="ref11" ref-type="bibr">11</xref><xref rid="ref13" ref-type="bibr">13</xref><xref rid="ref18" ref-type="bibr">18</xref> We found only two published studies with a prospective design. Our meta-analysis, however, included 18 prospective cohort studies with unpublished individual participant data, which allowed us to examine the prospective association between long working hours and the onset of risky alcohol use in a large dataset with a harmonised exposure and outcome measurements.</p><p>Comparison of published studies with aggregate data and studies with unpublished individual participant data allowed us to account for publication bias, which can bias results from meta-analyses that use only published studies.<xref rid="ref19" ref-type="bibr">19</xref> We observed no evidence for publication bias. Firstly, we found similar associations among both types of study. Secondly, statistical assessment of publication bias among published studies, stratified by whether long working hours and alcohol use was the main or secondary research question, and use of a funnel plot and Egger’s test of a small study effect suggested no indication of publication bias.</p><p>The present meta-analysis has limitations. With the exception of three published studies that used roster or payroll data,<xref rid="ref39" ref-type="bibr">39</xref><xref rid="ref50" ref-type="bibr">50</xref><xref rid="ref53" ref-type="bibr">53</xref> exposure to long working hours was based on self reports and measured only once. Prolonged exposure to long working hours, as identified in repeat data, might carry a greater risk of risky alcohol use than long working hours measured only once. Self reported working hours might involve recall bias arising from the inability of the employees to accurately recall hours worked. Some investigators, however, have shown that self reported work hours is a reliable measure (for example, two week test-retest intraclass correlation coefficient <italic>r</italic>=0.91),<xref rid="ref85" ref-type="bibr">85</xref><xref rid="ref86" ref-type="bibr">86</xref> and a major bias in longitudinal analysis is likely only if the error in estimating the number of hours worked varies according to alcohol use.</p><p>Alcohol use was based on self reported frequency or amount of alcohol used, except in one cross sectional study that used the Composite International Diagnostic Interview (CIDI) to assess DSM-IV diagnoses of alcohol use disorders.<xref rid="ref58" ref-type="bibr">58</xref> Under-reporting of alcohol use has been shown to occur in survey questionnaires<xref rid="ref87" ref-type="bibr">87</xref> and might be particularly common in heavy drinkers. A major bias would occur if under-reporting was also associated with reporting of working hours. Misclassification of alcohol use could have introduced heterogeneity into the meta-analyses.</p><p>Furthermore, this meta-analysis was based on observational studies, which are generalisable only within the study context. Despite cultural variations in drinking habits, even between developed countries,<xref rid="ref1" ref-type="bibr">1</xref> our findings regarding long working hours and alcohol use were similar across the different geographical regions examined. Our results are also in accordance with global reports of alcohol use, which have shown large differences in alcohol consumption between countries.<xref rid="ref1" ref-type="bibr">1</xref> We found, for example, that the prevalence of risky alcohol use was lower in the US than in Europe. Although the prevalence of risky alcohol use varied substantially among the cohorts, we found no evidence to suggest that the association between long working hours and alcohol use would be dependent on the prevalence of risky alcohol use in the cohort.</p><p>Even though our IPD-Work collaboration includes several major cohort studies in Europe and the two open access databases are large, including cohorts from the US, UK, and Australia, the meta-analysis of individual participant data is based on a convenience sample and does not include all potential data. Thus, availability bias might have affected the findings.<xref rid="ref19" ref-type="bibr">19</xref> Finally, it is not possible to draw causal inference based on observational studies, which means that our data cannot provide direct evidence for policy recommendations.<xref rid="ref88" ref-type="bibr">88</xref> Prospective analyses, however, allowed us to get some indication of temporal order of associations, which is consistent with a causal effect, and partially overcomes the problem of reverse causality (risky alcohol use leading to longer working hours), which can bias cross sectional analyses.</p></sec><sec><title>Comparison with previous research and sources of heterogeneity</title><p>Previous narrative reviews of long working hours and alcohol use including up to six studies have reported mixed findings.<xref rid="ref11" ref-type="bibr">11</xref><xref rid="ref13" ref-type="bibr">13</xref><xref rid="ref18" ref-type="bibr">18</xref> Similarly, we observed substantial heterogeneity among published studies with aggregate data (I<sup>2</sup>=81%, P<0.001). Importantly, this heterogeneity was not present in the meta-analysis of individual participant data studies with harmonised exposure and outcome measures (I<sup>2</sup>=18%, P=0.21 in the cross-sectional analysis; 0%, P=0.99 in the prospective analysis). None of the potential sources of heterogeneity examined in this study explained the heterogeneity found among the cross sectional studies with aggregate data. We explored whether use of a definition of the exposure and outcome close to that used in the individual participant data studies would remove the heterogeneity observed in the six published studies but found no such reduction (I<sup>2</sup>=68.6%, P=0.007). It seems that the sources of heterogeneity must relate to other differences between published studies with aggregate data.</p></sec><sec><title>Interpretation of findings</title><p>In this meta-analysis, working very long hours (≥55 a week) was associated with a 1.12-fold increase in the odds ratio of new onset risky alcohol use among employees whose alcohol use was within the recommended limits at baseline. A similar (1.13-fold) association was found among those who worked 49-54 hours a week. To protect employee health and safety, the European Union Working Time Directive requires EU countries to guarantee all workers the right to work a maximum of 48 hours a week, on average, including overtime.<xref rid="ref23" ref-type="bibr">23</xref> This threshold is supported by our analyses. At risk alcohol use has previously been associated with increased risk of liver cirrhosis, cancers, seizure disorders, and stroke.<xref rid="ref2" ref-type="bibr">2</xref> A recent meta-analysis of 56 epidemiological studies using Mendelian randomisation analysis suggested that reduction of alcohol consumption, even for light to moderate drinkers, might be beneficial for cardiovascular health.<xref rid="ref89" ref-type="bibr">89</xref></p><p>Possible explanations for the association between long working hours and risky alcohol use might involve the work environment as well as individual characteristics.<xref rid="ref90" ref-type="bibr">90</xref> One view is that alcohol use alleviates stress that is caused by work pressure and working conditions. Working overtime and characteristics such as high demands and lack of control might contribute to stress at work.<xref rid="ref91" ref-type="bibr">91</xref><xref rid="ref92" ref-type="bibr">92</xref> Although our recent individual participant data meta-analysis found little evidence to support a combination of high demands and low job control as a predictor of risky alcohol use,<xref rid="ref9" ref-type="bibr">9</xref> it remains to be investigated whether a combination of long working hours and low control over work increases the risk. It has also been hypothesised that employees who are not well integrated and supervised by the work organisation are at a higher risk of developing alcohol use problems.<xref rid="ref90" ref-type="bibr">90</xref></p><p>Depression and sleep problems might contribute to the link between long working hours and alcohol use.<xref rid="ref16" ref-type="bibr">16</xref> Other factors, such as personality traits, could confound the association because they might make people work long hours and also be related to a tendency to risky alcohol use. For example, individuals with “type A” behaviour pattern,<xref rid="ref93" ref-type="bibr">93</xref> which is characterised by aggressiveness and irritability and a chronic struggle to achieve more and more in less and less time,<xref rid="ref94" ref-type="bibr">94</xref> can end up in highly competitive jobs and work communities characterised by a “work hard play hard” culture with positive attitudes towards heavy alcohol use.<xref rid="ref95" ref-type="bibr">95</xref><xref rid="ref96" ref-type="bibr">96</xref> Personality traits of impulsivity and novelty seeking have also been found to be associated with risky alcohol use.<xref rid="ref97" ref-type="bibr">97</xref></p><p>Although the legislation in European countries provides employees with the right to restrict maximum working hours to 48 hours a week, many people still work long hours either as their own choice or because of external pressure to do so.<xref rid="ref98" ref-type="bibr">98</xref> Choosing to work long hours is common among the higher socioeconomic groups, with highly educated managers and professionals expecting dedication to work from themselves and others. This strategy can be highly rewarding in terms of rapid promotions, salary increases, and control over work. On the other hand, involuntary long hours could reflect, for example, financial difficulties and striving for a living wage or coercion. We did not find differences in the association between long working hours and risky alcohol use between socioeconomic groups. It is possible that voluntary and involuntary overtime is more evenly distributed across socioeconomic groups than previously thought.</p></sec><sec><title>Conclusions and unanswered questions</title><p>The workplace is an important setting for the prevention of alcohol misuse because more than half of the adult population are employed.<xref rid="ref4" ref-type="bibr">4</xref> Risky alcohol use is an issue in the workplace because it can have adverse and serious effects on employees, such as absenteeism,<xref rid="ref80" ref-type="bibr">80</xref> inefficiency, poor performance, impaired decision making, damaged customer relations, and injuries at work.<xref rid="ref2" ref-type="bibr">2</xref><xref rid="ref3" ref-type="bibr">3</xref><xref rid="ref4" ref-type="bibr">4</xref><xref rid="ref8" ref-type="bibr">8</xref> Brief interventions by healthcare personnel that involve assessment of the individual’s drinking habits in combination with feedback about health risks might be useful in efforts to reduce problems with alcohol use in the working population.<xref rid="ref4" ref-type="bibr">4</xref> Our findings suggest that alcohol consumption is more likely to rise to risky levels among employees who work more than 48 hours a week compared with those with standard working hours. In absolute terms, however, the difference between these groups was relatively small because the adjusted incidence in new onset risky alcohol use was only 0.8 and 0.7 percentage points higher among individuals who worked 49-54 and 55 hours or more compared with those who worked standard hours. Further research is needed to assess whether preventive interventions against risky alcohol use could benefit from information on working hours.</p><boxed-text position="float" content-type="style3"><sec><title>What is already known on this topic</title><list list-type="simple"><list-item><p>The European Union Working Time Directive threshold for long working hours is 48 hours a week</p></list-item><list-item><p>Long working hours are thought to increase the risk of cardiovascular diseases, sleep deprivation, occupational injuries, and mental health problems</p></list-item><list-item><p>The association between long working hours and risky alcohol use has not been systematically evaluated</p></list-item></list></sec><sec><title>What this study adds</title><list list-type="simple"><list-item><p>This meta-analysis of 36 published studies, identified by systematic literature searches, and 27 studies with unpublished individual participant data synthesised evidence on the association between long working hours and alcohol use</p></list-item><list-item><p>Long working hours were linked to increased alcohol use in cross sectional and prospective analyses. People working more than 48 hours a week at baseline had 1.13 times higher likelihood of new onset risky alcohol use compared with those working standard hours</p></list-item><list-item><p>No heterogeneity was observed between men and women or by age group, socioeconomic status, geographical region, or characteristics of the study cohort</p></list-item></list></sec></boxed-text></sec></sec></body><back><notes><fn-group><fn fn-type="participating-researchers"><p>Contributors: MV and MK developed the hypothesis and study design and supervised this study. MJ, MV, SN, IM, and TL performed statistical analyses. All authors contributed to study concept and design, analysis and interpretation of data, and drafting or critical revision of the manuscript for important intellectual content, or in addition, data acquisition. MV and KA performed the literature searches and/or screened papers. MK, TT, RR, and ND obtained funding for the IPD-Work Consortium. MJ, SN, and MK had full access to individual participant data in the study and take responsibility for the integrity of the unpublished data and the accuracy of the data analysis. MV is guarantor. </p></fn><fn fn-type="financial-disclosure"><p>Funding: The IPD-Work Consortium is supported by the EU New OSH ERA Research Program (funded by the Finnish Work Environment Fund and the Academy of Finland, Finland; the Swedish Research Council for Health, Working Life and Welfare, Sweden; the German Social Accident Insurance, Germany; and the Danish Work Environment Research Fund, Denmark); the BUPA Foundation (grant 22094477), and the Dutch Ministry of Social Affairs and Employment, Netherlands. MV is supported by the Academy of Finland (grants 258598, 265174), MK is supported by the Medical Research Council (grant K013351), the Economic and Social Research Council, and the US National Institutes of Health (grants R01HL036310 and R01AG034454), and SN is supported by the Finnish Work Environment Fund. AS is a BHF professor. Funding bodies for each participating cohort study are listed on their websites. The sponsors had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of this manuscript.</p></fn><fn fn-type="conflict"><p>Competing interests: All authors have completed the ICMJE uniform disclosure form at <ext-link ext-link-type="uri" xlink:href="http://www.icmje.org/coi_disclosure.pdf">www.icmje.org/coi_disclosure.pdf</ext-link> and declare: no support from any organisation for the submitted work other than those mentioned above; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work.</p></fn><fn><p>Ethical approval: Each constituent study with individual participant data was approved by the relevant local or national ethics committee, and all participants gave informed consent to participate.</p></fn><fn><p>Data sharing: No additional data from our meta-analysis are available. 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