Dosing antiretroviral medication when crossing time zones: a review
Identifieur interne : 000055 ( Pmc/Checkpoint ); précédent : 000054; suivant : 000056Dosing antiretroviral medication when crossing time zones: a review
Auteurs : Joseph M. Lewis [Royaume-Uni] ; Alain Volny-Anne [Belgique] ; Catriona Waitt ; Marta Boffito [Royaume-Uni] ; Saye KhooSource :
- AIDS (London, England) [ 0269-9370 ] ; 2016.
Abstract
International tourism continues to increase worldwide, and people living with HIV and their clinicians are increasingly confronted with the problem of how to dose antiretroviral therapy during transmeridian air travel across time zones. No guidance on this topic currently exists. This review is a response to requests from patient groups for clear, practical and evidence-based guidance for travelling on antiretroviral therapy; we present currently available data on the pharmacokinetic forgiveness and toxicity of various antiretroviral regimens, and synthesize this data to provide guidelines on how to safely dose antiretrovirals when travelling across time zones.
Url:
DOI: 10.1097/QAD.0000000000000920
PubMed: 26684823
PubMed Central: 4697953
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dosing antiretroviral medication when crossing time zones: a review</title><author><name sortKey="Lewis, Joseph M" sort="Lewis, Joseph M" uniqKey="Lewis J" first="Joseph M." last="Lewis">Joseph M. Lewis</name><affiliation><nlm:aff id="aff1">Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital</nlm:aff><wicri:noCountry code="subfield">Royal Liverpool University Hospital</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Wellcome Trust Liverpool Glasgow Centre for Global Health Research, University of Liverpool, Liverpool, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Liverpool Glasgow Centre for Global Health Research, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Volny Anne, Alain" sort="Volny Anne, Alain" uniqKey="Volny Anne A" first="Alain" last="Volny-Anne">Alain Volny-Anne</name><affiliation wicri:level="3"><nlm:aff id="aff3">European AIDS Treatment Group, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>European AIDS Treatment Group, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Waitt, Catriona" sort="Waitt, Catriona" uniqKey="Waitt C" first="Catriona" last="Waitt">Catriona Waitt</name><affiliation><nlm:aff id="aff4">Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool</nlm:aff><wicri:noCountry code="subfield">Liverpool</wicri:noCountry></affiliation></author><author><name sortKey="Boffito, Marta" sort="Boffito, Marta" uniqKey="Boffito M" first="Marta" last="Boffito">Marta Boffito</name><affiliation wicri:level="3"><nlm:aff id="aff5">St Stephen's Centre, Chelsea & Westminster Foundation Trust, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>St Stephen's Centre, Chelsea & Westminster Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Khoo, Saye" sort="Khoo, Saye" uniqKey="Khoo S" first="Saye" last="Khoo">Saye Khoo</name><affiliation><nlm:aff id="aff4">Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool</nlm:aff><wicri:noCountry code="subfield">Liverpool</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26684823</idno><idno type="pmc">4697953</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697953</idno><idno type="RBID">PMC:4697953</idno><idno type="doi">10.1097/QAD.0000000000000920</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000024</idno><idno type="wicri:Area/Pmc/Curation">000024</idno><idno type="wicri:Area/Pmc/Checkpoint">000055</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dosing antiretroviral medication when crossing time zones: a review</title><author><name sortKey="Lewis, Joseph M" sort="Lewis, Joseph M" uniqKey="Lewis J" first="Joseph M." last="Lewis">Joseph M. Lewis</name><affiliation><nlm:aff id="aff1">Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital</nlm:aff><wicri:noCountry code="subfield">Royal Liverpool University Hospital</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Wellcome Trust Liverpool Glasgow Centre for Global Health Research, University of Liverpool, Liverpool, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Liverpool Glasgow Centre for Global Health Research, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Volny Anne, Alain" sort="Volny Anne, Alain" uniqKey="Volny Anne A" first="Alain" last="Volny-Anne">Alain Volny-Anne</name><affiliation wicri:level="3"><nlm:aff id="aff3">European AIDS Treatment Group, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>European AIDS Treatment Group, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Waitt, Catriona" sort="Waitt, Catriona" uniqKey="Waitt C" first="Catriona" last="Waitt">Catriona Waitt</name><affiliation><nlm:aff id="aff4">Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool</nlm:aff><wicri:noCountry code="subfield">Liverpool</wicri:noCountry></affiliation></author><author><name sortKey="Boffito, Marta" sort="Boffito, Marta" uniqKey="Boffito M" first="Marta" last="Boffito">Marta Boffito</name><affiliation wicri:level="3"><nlm:aff id="aff5">St Stephen's Centre, Chelsea & Westminster Foundation Trust, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>St Stephen's Centre, Chelsea & Westminster Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Khoo, Saye" sort="Khoo, Saye" uniqKey="Khoo S" first="Saye" last="Khoo">Saye Khoo</name><affiliation><nlm:aff id="aff4">Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool</nlm:aff><wicri:noCountry code="subfield">Liverpool</wicri:noCountry></affiliation></author></analytic><series><title level="j">AIDS (London, England)</title><idno type="ISSN">0269-9370</idno><idno type="eISSN">1473-5571</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>International tourism continues to increase worldwide, and people living with HIV and their clinicians are increasingly confronted with the problem of how to dose antiretroviral therapy during transmeridian air travel across time zones. No guidance on this topic currently exists. This review is a response to requests from patient groups for clear, practical and evidence-based guidance for travelling on antiretroviral therapy; we present currently available data on the pharmacokinetic forgiveness and toxicity of various antiretroviral regimens, and synthesize this data to provide guidelines on how to safely dose antiretrovirals when travelling across time zones.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hogg, Rs" uniqKey="Hogg R">RS Hogg</name></author><author><name sortKey="Heath, Kv" uniqKey="Heath K">KV Heath</name></author><author><name sortKey="Yip, B" uniqKey="Yip B">B Yip</name></author><author><name sortKey="Craib, Kj" uniqKey="Craib K">KJ Craib</name></author><author><name sortKey="O Shaughnessy, Mv" uniqKey="O Shaughnessy M">MV O'Shaughnessy</name></author><author><name sortKey="Schechter, Mt" uniqKey="Schechter M">MT 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<front><journal-meta><journal-id journal-id-type="nlm-ta">AIDS</journal-id><journal-id journal-id-type="iso-abbrev">AIDS</journal-id><journal-id journal-id-type="publisher-id">AIDS</journal-id><journal-title-group><journal-title>AIDS (London, England)</journal-title></journal-title-group><issn pub-type="ppub">0269-9370</issn><issn pub-type="epub">1473-5571</issn><publisher><publisher-name>Lippincott Williams & Wilkins</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26684823</article-id><article-id pub-id-type="pmc">4697953</article-id><article-id pub-id-type="doi">10.1097/QAD.0000000000000920</article-id><article-categories><subj-group subj-group-type="heading"><subject>Concise Communications</subject></subj-group></article-categories><title-group><article-title>Dosing antiretroviral medication when crossing time zones: a review</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lewis</surname><given-names>Joseph M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Volny-Anne</surname><given-names>Alain</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Waitt</surname><given-names>Catriona</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Boffito</surname><given-names>Marta</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Khoo</surname><given-names>Saye</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib></contrib-group><aff id="aff1"><label>a</label>Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital</aff><aff id="aff2"><label>b</label>Wellcome Trust Liverpool Glasgow Centre for Global Health Research, University of Liverpool, Liverpool, UK</aff><aff id="aff3"><label>c</label>European AIDS Treatment Group, Brussels, Belgium</aff><aff id="aff4"><label>d</label>Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool</aff><aff id="aff5"><label>e</label>St Stephen's Centre, Chelsea & Westminster Foundation Trust, London, UK.</aff><author-notes><corresp>Correspondence to Joseph M. Lewis, BA, MA, MSc, MBBS, Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, Prescot St, Liverpool, L7 8XP, UK. Tel: +0151 7063835; fax: +0151 706 5944; e-mail: <email>joseph.lewis@liverpool.ac.uk</email></corresp></author-notes><pub-date pub-type="ppub"><day>14</day><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>06</day><month>1</month><year>2016</year></pub-date><volume>30</volume><issue>2</issue><fpage>267</fpage><lpage>271</lpage><history><date date-type="received"><day>11</day><month>8</month><year>2015</year></date><date date-type="rev-recd"><day>28</day><month>9</month><year>2015</year></date><date date-type="accepted"><day>28</day><month>9</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0"><license-p>This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0">http://creativecommons.org/licenses/by-nc-nd/4.0</ext-link></license-p></license></permissions><self-uri xlink:type="simple" xlink:href="aids-30-267.pdf"></self-uri><abstract><p>International tourism continues to increase worldwide, and people living with HIV and their clinicians are increasingly confronted with the problem of how to dose antiretroviral therapy during transmeridian air travel across time zones. No guidance on this topic currently exists. This review is a response to requests from patient groups for clear, practical and evidence-based guidance for travelling on antiretroviral therapy; we present currently available data on the pharmacokinetic forgiveness and toxicity of various antiretroviral regimens, and synthesize this data to provide guidelines on how to safely dose antiretrovirals when travelling across time zones.</p></abstract><kwd-group><title>Keywords</title><kwd>antiretroviral</kwd><kwd>HAART</kwd><kwd>HIV</kwd><kwd>pharmacokinetics</kwd><kwd>travel</kwd><kwd>travel medicine</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta></custom-meta-group></article-meta></front><floats-group><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Data from tail studies showing proportion of trial participants with plasma drug concentrations below estimated MEC at time in hours post drug cessation.</p></caption><table frame="hsides" rules="groups"><thead><tr><td rowspan="1" colspan="1">Drug</td><td rowspan="1" colspan="1">ATV/r OD</td><td rowspan="1" colspan="1">ATV/r OD</td><td rowspan="1" colspan="1">LPV/r BD</td><td rowspan="1" colspan="1">LPV/r OD</td><td rowspan="1" colspan="1">DRV/r OD</td><td rowspan="1" colspan="1">EFV OD</td><td rowspan="1" colspan="1">EVG/COBI OD</td><td rowspan="1" colspan="1">DTG OD</td><td rowspan="1" colspan="1">RPV OD</td></tr></thead><tbody><tr><td rowspan="1" colspan="1">Dose</td><td rowspan="1" colspan="1">300 mg/100 mg</td><td rowspan="1" colspan="1">300 mg/100 mg</td><td rowspan="1" colspan="1">400 mg/100 mg</td><td rowspan="1" colspan="1">800 mg/200 mg</td><td rowspan="1" colspan="1">800 mg/100 mg</td><td rowspan="1" colspan="1">600 mg</td><td rowspan="1" colspan="1">150 mg/150 mg</td><td rowspan="1" colspan="1">50 mg</td><td rowspan="1" colspan="1">25 mg</td></tr><tr><td rowspan="1" colspan="1">MEC</td><td rowspan="1" colspan="1">150 ng/ml</td><td rowspan="1" colspan="1">150 ng/ml</td><td rowspan="1" colspan="1">1000 ng/ml</td><td rowspan="1" colspan="1">1000 ng/ml</td><td rowspan="1" colspan="1">550 ng/ml</td><td rowspan="1" colspan="1">1000 ng/ml</td><td rowspan="1" colspan="1">45 ng/ml</td><td rowspan="1" colspan="1">64 ng/ml</td><td rowspan="1" colspan="1">50 ng/ml<xref ref-type="table-fn" rid="TF1-1"><sup>a</sup></xref></td></tr><tr><td rowspan="1" colspan="1">Reference</td><td rowspan="1" colspan="1">Boffito 2008 [<xref rid="R20" ref-type="bibr">20</xref>]</td><td rowspan="1" colspan="1">Boffito 2011 [<xref rid="R19" ref-type="bibr">19</xref>]</td><td rowspan="1" colspan="1">Boffito 2008 [<xref rid="R20" ref-type="bibr">20</xref>]</td><td rowspan="1" colspan="1">Boffito 2008 [<xref rid="R20" ref-type="bibr">20</xref>]</td><td rowspan="1" colspan="1">Boffito 2011 [<xref rid="R19" ref-type="bibr">19</xref>]</td><td rowspan="1" colspan="1">Jackson 2013 [<xref rid="R21" ref-type="bibr">21</xref>]</td><td rowspan="1" colspan="1">Elliot 2015 [<xref rid="R22" ref-type="bibr">22</xref>]</td><td rowspan="1" colspan="1">Elliot 2015 [<xref rid="R22" ref-type="bibr">22</xref>]</td><td rowspan="1" colspan="1">Dicknson 2015 [<xref rid="R23" ref-type="bibr">23</xref>]</td></tr><tr><td colspan="10" rowspan="1">Participants, <italic>n</italic>/<italic>N</italic> with plasma drug concentration below MEC post drug cessation</td></tr><tr><td rowspan="1" colspan="1">Time (hours)</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1">12</td><td rowspan="1" colspan="1">0/16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">0/16</td><td rowspan="1" colspan="1">0/16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1">16</td><td rowspan="1" colspan="1">0/16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">2/16</td><td rowspan="1" colspan="1">0/16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1">20</td><td rowspan="1" colspan="1">0/16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">10/16</td><td rowspan="1" colspan="1">0/16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1">24</td><td rowspan="1" colspan="1">0/16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">13/16</td><td rowspan="1" colspan="1">7/16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">0/17</td><td rowspan="1" colspan="1">0/17</td><td rowspan="1" colspan="1">2/18</td></tr><tr><td rowspan="1" colspan="1">30</td><td rowspan="1" colspan="1">2/16</td><td rowspan="1" colspan="1">0/17</td><td rowspan="1" colspan="1">15/16</td><td rowspan="1" colspan="1">15/16</td><td rowspan="1" colspan="1">3/17</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1">36</td><td rowspan="1" colspan="1">5 /16</td><td rowspan="1" colspan="1">8/17</td><td rowspan="1" colspan="1">16/16</td><td rowspan="1" colspan="1">16/16</td><td rowspan="1" colspan="1">8/17</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">11/17</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">6/18</td></tr><tr><td rowspan="1" colspan="1">48</td><td rowspan="1" colspan="1">11/16</td><td rowspan="1" colspan="1">12/17</td><td rowspan="1" colspan="1">16/16</td><td rowspan="1" colspan="1">16/16</td><td rowspan="1" colspan="1">15/17</td><td rowspan="1" colspan="1">5/16</td><td rowspan="1" colspan="1">16/17</td><td rowspan="1" colspan="1">0/17</td><td rowspan="1" colspan="1">7/18</td></tr><tr><td rowspan="1" colspan="1">60</td><td rowspan="1" colspan="1">16 /16</td><td rowspan="1" colspan="1">15/17</td><td rowspan="1" colspan="1">16/16</td><td rowspan="1" colspan="1">16/16</td><td rowspan="1" colspan="1">16/16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">1/17</td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1">72</td><td rowspan="1" colspan="1">16 /16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">16/16</td><td rowspan="1" colspan="1">16/16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">1/17</td><td rowspan="1" colspan="1">11/18</td></tr><tr><td rowspan="1" colspan="1">84</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">8/16</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn fn-type="abbr"><p>ATV/r, atazanavir/ritonavir; BD, twice daily; DRV/r, darunavir/r; DTG, once-daily dolutegravir; EFV, efavirenz; EVG/COBI, elvitegravir/cobicistat; LPV/r, lopinavir/ritonavir; MEC, minimum effective concentration; OD, once-daily; RPV, rilpivirine.</p></fn><fn id="TF1-1"><p><sup>a</sup>MEC for rilpivirine is not well defined but 50 ng/ml has been suggested; interpret results with caution.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>Recommendations for antiretroviral intake for transmeridian travel more than 8 h.</p></caption><table frame="hsides" rules="groups"><thead><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Drug</td><td rowspan="1" colspan="1">Dosing recommendation for travel</td></tr></thead><tbody><tr><td rowspan="1" colspan="1">Likely to be tolerant of late dosing</td><td rowspan="1" colspan="1">Tenofovir, emtricitabine, lamivudine, abacavir, didanosine</td><td rowspan="1" colspan="1">OD dosing – adjust intake to dose before travel, and after arrival. For efavirenz, dosing immediately prior to departure should be avoided – instead dosing can be safely stretched from previous evening (from FOTO data)</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Efavirenz OD</td><td rowspan="1" colspan="1">BD dosing – adjust intake to dose before departure (for flights of 12 h or less), or take an extra dose in-flight at a convenient time for longer duration flights. Take next dose after arrival</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Nevirapine OD or BD</td><td rowspan="1" colspan="1">All subsequent dosing according to new time zone</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Rilpivirine OD</td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Boosted atazanavir<xref ref-type="table-fn" rid="TF2-1"><sup>a</sup></xref> OD</td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Boosted darunavir<xref ref-type="table-fn" rid="TF2-1"><sup>a</sup></xref> OD or BD</td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Boosted elvitegravir<xref ref-type="table-fn" rid="TF2-1"><sup>a</sup></xref> OD</td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Dolutegravir OD or BD</td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Maraviroc OD<xref ref-type="table-fn" rid="TF2-1"><sup>a</sup></xref> or BD</td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1">Likely to be moderately tolerant of late dosing</td><td rowspan="1" colspan="1">Stavudine, zidovudine lopinavir/ritonavir BID</td><td rowspan="1" colspan="1">As above for BD dosing. All subsequent dosing according to new time zone</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Raltegravir BD</td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Darunavir/ritonavir monotherapy</td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1">Likely to be poorly tolerant of late dosing</td><td rowspan="1" colspan="1">Lopinavir/ritonavir OD</td><td rowspan="1" colspan="1">Take an extra dose in-flight. All subsequent dosing according to new time zone</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Unboosted atazanavir</td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">Monotherapy with boosted atazanavir or lopinavir</td><td rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn fn-type="other"><p>BD, twice daily; FOTO, five-days-on, two-days-off; OD, once-daily.</p></fn><fn id="TF2-1" fn-type="other"><p><sup>a</sup>Boosted with ritonavir or cobicistat.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Belgique</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Khoo, Saye" sort="Khoo, Saye" uniqKey="Khoo S" first="Saye" last="Khoo">Saye Khoo</name><name sortKey="Waitt, Catriona" sort="Waitt, Catriona" uniqKey="Waitt C" first="Catriona" last="Waitt">Catriona Waitt</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Lewis, Joseph M" sort="Lewis, Joseph M" uniqKey="Lewis J" first="Joseph M." last="Lewis">Joseph M. Lewis</name></noRegion><name sortKey="Boffito, Marta" sort="Boffito, Marta" uniqKey="Boffito M" first="Marta" last="Boffito">Marta Boffito</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Volny Anne, Alain" sort="Volny Anne, Alain" uniqKey="Volny Anne A" first="Alain" last="Volny-Anne">Alain Volny-Anne</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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