T1DBase, a community web-based resource for type 1 diabetes research
Identifieur interne : 001732 ( Main/Exploration ); précédent : 001731; suivant : 001733T1DBase, a community web-based resource for type 1 diabetes research
Auteurs : Luc J. Smink ; Erin M. Helton ; Barry C. Healy ; Christopher C. Cavnor ; Alex C. Lam ; Daisy Flamez ; Oliver S. Burren ; Yang Wang ; Geoffrey E. Dolman ; David B. Burdick ; Vincent H. Everett ; Gustavo Glusman ; Davide Laneri ; Lee Rowen ; Helen Schuilenburg ; Neil M. Walker ; Josyf Mychaleckyj [États-Unis] ; Linda S. Wicker ; Decio L. Eizirik ; John A. Todd ; Nathan GoodmanSource :
- Nucleic Acids Research [ 0305-1048 ] ; 2005-01-01.
Abstract
T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D susceptibility and pathogenesis. It includes the following datasets: annotated genome sequence for human, rat and mouse; information on genetically identified T1D susceptibility regions in human, rat and mouse, and genetic linkage and association studies pertaining to T1D; descriptions of NOD mouse congenic strains; the Beta Cell Gene Expression Bank, which reports expression levels of genes in beta cells under various conditions, and annotations of gene function in beta cells; data on gene expression in a variety of tissues and organs; and biological pathways from KEGG and BioCarta. Tools on the site include the GBrowse genome browser, site-wide context dependent search, Connect-the-Dots for connecting gene and other identifiers from multiple data sources, Cytoscape for visualizing and analyzing biological networks, and the GESTALT workbench for genome annotation. All data are open access and all software is open source.
Url:
DOI: 10.1093/nar/gki095
Affiliations:
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Walker</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Mychaleckyj, Josyf" sort="Mychaleckyj, Josyf" uniqKey="Mychaleckyj J" first="Josyf" last="Mychaleckyj">Josyf Mychaleckyj</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation></affiliation></author><author><name sortKey="Wicker, Linda S" sort="Wicker, Linda S" uniqKey="Wicker L" first="Linda S." last="Wicker">Linda S. Wicker</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Eizirik, Decio L" sort="Eizirik, Decio L" uniqKey="Eizirik D" first="Decio L." last="Eizirik">Decio L. Eizirik</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Todd, John A" sort="Todd, John A" uniqKey="Todd J" first="John A." last="Todd">John A. Todd</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Goodman, Nathan" sort="Goodman, Nathan" uniqKey="Goodman N" first="Nathan" last="Goodman">Nathan Goodman</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Nucleic Acids Research</title><title level="j" type="abbrev">Nucl. Acids Res.</title><idno type="ISSN">0305-1048</idno><idno type="eISSN">1362-4962</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2005-01-01">2005-01-01</date><biblScope unit="volume">33</biblScope><biblScope unit="supplement">suppl_1</biblScope><biblScope unit="page" from="D544">D544</biblScope><biblScope unit="page" to="D549">D549</biblScope></imprint><idno type="ISSN">0305-1048</idno></series><idno type="istex">299F884DFB177EEF6C2892D9CC0662CE80B313F7</idno><idno type="DOI">10.1093/nar/gki095</idno><idno type="local">gki095</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-1048</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D susceptibility and pathogenesis. It includes the following datasets: annotated genome sequence for human, rat and mouse; information on genetically identified T1D susceptibility regions in human, rat and mouse, and genetic linkage and association studies pertaining to T1D; descriptions of NOD mouse congenic strains; the Beta Cell Gene Expression Bank, which reports expression levels of genes in beta cells under various conditions, and annotations of gene function in beta cells; data on gene expression in a variety of tissues and organs; and biological pathways from KEGG and BioCarta. Tools on the site include the GBrowse genome browser, site-wide context dependent search, Connect-the-Dots for connecting gene and other identifiers from multiple data sources, Cytoscape for visualizing and analyzing biological networks, and the GESTALT workbench for genome annotation. All data are open access and all software is open source.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><noCountry><name sortKey="Burdick, David B" sort="Burdick, David B" uniqKey="Burdick D" first="David B." last="Burdick">David B. Burdick</name><name sortKey="Burren, Oliver S" sort="Burren, Oliver S" uniqKey="Burren O" first="Oliver S." last="Burren">Oliver S. Burren</name><name sortKey="Cavnor, Christopher C" sort="Cavnor, Christopher C" uniqKey="Cavnor C" first="Christopher C." last="Cavnor">Christopher C. Cavnor</name><name sortKey="Dolman, Geoffrey E" sort="Dolman, Geoffrey E" uniqKey="Dolman G" first="Geoffrey E." last="Dolman">Geoffrey E. Dolman</name><name sortKey="Eizirik, Decio L" sort="Eizirik, Decio L" uniqKey="Eizirik D" first="Decio L." last="Eizirik">Decio L. Eizirik</name><name sortKey="Everett, Vincent H" sort="Everett, Vincent H" uniqKey="Everett V" first="Vincent H." last="Everett">Vincent H. Everett</name><name sortKey="Flamez, Daisy" sort="Flamez, Daisy" uniqKey="Flamez D" first="Daisy" last="Flamez">Daisy Flamez</name><name sortKey="Glusman, Gustavo" sort="Glusman, Gustavo" uniqKey="Glusman G" first="Gustavo" last="Glusman">Gustavo Glusman</name><name sortKey="Goodman, Nathan" sort="Goodman, Nathan" uniqKey="Goodman N" first="Nathan" last="Goodman">Nathan Goodman</name><name sortKey="Healy, Barry C" sort="Healy, Barry C" uniqKey="Healy B" first="Barry C." last="Healy">Barry C. Healy</name><name sortKey="Helton, Erin M" sort="Helton, Erin M" uniqKey="Helton E" first="Erin M." last="Helton">Erin M. Helton</name><name sortKey="Lam, Alex C" sort="Lam, Alex C" uniqKey="Lam A" first="Alex C." last="Lam">Alex C. Lam</name><name sortKey="Laneri, Davide" sort="Laneri, Davide" uniqKey="Laneri D" first="Davide" last="Laneri">Davide Laneri</name><name sortKey="Rowen, Lee" sort="Rowen, Lee" uniqKey="Rowen L" first="Lee" last="Rowen">Lee Rowen</name><name sortKey="Schuilenburg, Helen" sort="Schuilenburg, Helen" uniqKey="Schuilenburg H" first="Helen" last="Schuilenburg">Helen Schuilenburg</name><name sortKey="Smink, Luc J" sort="Smink, Luc J" uniqKey="Smink L" first="Luc J." last="Smink">Luc J. Smink</name><name sortKey="Todd, John A" sort="Todd, John A" uniqKey="Todd J" first="John A." last="Todd">John A. Todd</name><name sortKey="Walker, Neil M" sort="Walker, Neil M" uniqKey="Walker N" first="Neil M." last="Walker">Neil M. Walker</name><name sortKey="Wang, Yang" sort="Wang, Yang" uniqKey="Wang Y" first="Yang" last="Wang">Yang Wang</name><name sortKey="Wicker, Linda S" sort="Wicker, Linda S" uniqKey="Wicker L" first="Linda S." last="Wicker">Linda S. Wicker</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Mychaleckyj, Josyf" sort="Mychaleckyj, Josyf" uniqKey="Mychaleckyj J" first="Josyf" last="Mychaleckyj">Josyf Mychaleckyj</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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