Drug use and upper gastrointestinal complications in children: a case–control study
Identifieur interne : 000409 ( Main/Curation ); précédent : 000408; suivant : 000410Drug use and upper gastrointestinal complications in children: a case–control study
Auteurs : Manuela Bianciotto [Italie] ; Elena Chiappini [Italie] ; Irene Raffaldi [Italie] ; Clara Gabiano [Italie] ; Pier-Angelo Tovo [Italie] ; Sara Sollai [Italie] ; Maurizio De Martino [Italie] ; Francesco Mannelli [Italie] ; Vincenzo Tipo [Italie] ; Roberto Da Cas [Italie] ; Giuseppe Traversa [Italie] ; Francesca Menniti-Ippolito [Italie] ; Francesca Menniti-Ippolito ; Roberto Da Cas ; Luciano Sagliocca ; Giuseppe Traversa ; Fernanda Ferrazin ; Carmela Santuccio ; Loriana Tartaglia ; Francesco Trotta ; Pasquale Di Pietro ; Salvatore Renna ; Rossella Rossi ; Bianca Domenichini ; Stefania Gamba ; Francesco Trovato ; Pier-Angelo Tovo ; Manuela Bianciotto ; Carmelina Calitri ; Clara Gabiano ; Irene Raffaldi ; Antonio Urbino ; Liviana Da Dalt ; Valentina Favero ; Laura Giordano ; Maura Baraldi ; Federica Bertuola ; Eleonora Lorenzon ; Francesca Parata ; Giorgio Perilongo ; Silvia Vendramin ; Monica Frassineti ; Anna Maria Calvani ; Elena Chiappini ; Maurizio De Martino ; Claudia Fancelli ; Francesco Mannelli ; Rachele Mazzantini ; Sara Sollai ; Elisabetta Venturini ; Nicola Pirozzi ; Umberto Raucci ; Antonino Reale ; Rossella Rossi ; Nadia Mores ; Giulia Bersani ; Alessia De Nisco ; Antonio Chiaretti ; Riccardo Riccardi ; Costantino Romagnoli ; Vincenzo Tipo ; Michele Dinardo ; Teresa Pisapia ; Annalisa Capuano ; Elisabetta Parretta ; Concita Rafaniello ; Fortunata Fucà ; Eleonora Di RosaSource :
- Archives of Disease in Childhood [ 0003-9888 ] ; 2013-03.
Abstract
Objective To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population. Methods This study is part of a large Italian prospective multicentre study. The study population included children hospitalised for acute conditions through the emergency departments of eight clinical centres. Patients admitted for UGIC (defined as endoscopically confirmed gastroduodenal lesions or clinically defined haematemesis or melena) comprised the case series; children hospitalised for neurological disorders formed the control group. Information on drug and vaccine exposure was collected through parental interview during the children's hospitalisation. Logistic regression was used to estimate ORs for the occurrence of UGIC associated with drug use adjusted for age, clinical centre and concomitant use of any drug. Results 486 children hospitalised for UGIC and 1930 for neurological disorders were enrolled between November 1999 and November 2010. Drug use was higher in cases than in controls (73% vs 54%; p<0.001). UGICs were associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs) (adjusted OR 2.9, 95% CI 2.1 to 4.0), oral steroids (adjusted OR 2.9, 95% CI 1.7 to 4.8) and antibiotics (adjusted OR 2.3, 95% CI 1.8 to 3.1). The duration of use of these drug categories was short (range 1–8 days). Paracetamol showed a lower risk (adjusted OR 2.0, 95% CI 1.5 to 2.6) compared to ibuprofen (adjusted OR 3.7, 95% CI 2.3 to 5.9), although with partially overlapping CIs. Conclusions NSAIDs, oral steroids and antibiotics, even when administered for a short period, were associated with an increased risk of UGIC.
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DOI: 10.1136/archdischild-2012-302100
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Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Raffaldi, Irene" sort="Raffaldi, Irene" uniqKey="Raffaldi I" first="Irene" last="Raffaldi">Irene Raffaldi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Regina Margherita Children's Hospital, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Gabiano, Clara" sort="Gabiano, Clara" uniqKey="Gabiano C" first="Clara" last="Gabiano">Clara Gabiano</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Regina Margherita Children's Hospital, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Tovo, Pier Angelo" sort="Tovo, Pier Angelo" 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Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Mannelli, Francesco" sort="Mannelli, Francesco" uniqKey="Mannelli F" first="Francesco" last="Mannelli">Francesco Mannelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Anna Meyer Children's University Hospital, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Tipo, Vincenzo" sort="Tipo, Vincenzo" uniqKey="Tipo V" first="Vincenzo" last="Tipo">Vincenzo Tipo</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Santobono Paediatric Hospital, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Da Cas, Roberto" sort="Da Cas, Roberto" uniqKey="Da Cas R" first="Roberto" last="Da Cas">Roberto Da Cas</name><affiliation wicri:level="3"><country 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Centre for Epidemiology, Italian National Institute of Health, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author wicri:is="80%"><name sortKey="Menniti Ippolito, Francesca" sort="Menniti Ippolito, Francesca" uniqKey="Menniti Ippolito F" first="Francesca" last="Menniti-Ippolito">Francesca Menniti-Ippolito</name></author><author wicri:is="80%"><name sortKey="Da Cas, Roberto" sort="Da Cas, Roberto" uniqKey="Da Cas R" first="Roberto" last="Da Cas">Roberto Da Cas</name></author><author wicri:is="80%"><name sortKey="Sagliocca, Luciano" sort="Sagliocca, Luciano" uniqKey="Sagliocca L" first="Luciano" last="Sagliocca">Luciano Sagliocca</name></author><author wicri:is="80%"><name sortKey="Traversa, Giuseppe" sort="Traversa, Giuseppe" uniqKey="Traversa G" first="Giuseppe" last="Traversa">Giuseppe Traversa</name></author><author wicri:is="80%"><name sortKey="Ferrazin, Fernanda" sort="Ferrazin, Fernanda" uniqKey="Ferrazin F" first="Fernanda" last="Ferrazin">Fernanda Ferrazin</name></author><author wicri:is="80%"><name sortKey="Santuccio, Carmela" sort="Santuccio, Carmela" uniqKey="Santuccio C" first="Carmela" last="Santuccio">Carmela Santuccio</name></author><author wicri:is="80%"><name sortKey="Tartaglia, Loriana" sort="Tartaglia, Loriana" uniqKey="Tartaglia L" first="Loriana" last="Tartaglia">Loriana Tartaglia</name></author><author wicri:is="80%"><name sortKey="Trotta, Francesco" sort="Trotta, Francesco" uniqKey="Trotta F" first="Francesco" last="Trotta">Francesco Trotta</name></author><author wicri:is="80%"><name sortKey="Di Pietro, Pasquale" sort="Di Pietro, Pasquale" uniqKey="Di Pietro P" first="Pasquale" last="Di Pietro">Pasquale Di Pietro</name></author><author wicri:is="80%"><name sortKey="Renna, Salvatore" sort="Renna, Salvatore" uniqKey="Renna S" first="Salvatore" last="Renna">Salvatore Renna</name></author><author wicri:is="80%"><name sortKey="Rossi, Rossella" sort="Rossi, Rossella" uniqKey="Rossi R" first="Rossella" last="Rossi">Rossella Rossi</name></author><author wicri:is="80%"><name sortKey="Domenichini, Bianca" sort="Domenichini, Bianca" uniqKey="Domenichini B" first="Bianca" last="Domenichini">Bianca Domenichini</name></author><author wicri:is="80%"><name sortKey="Gamba, Stefania" sort="Gamba, Stefania" uniqKey="Gamba S" first="Stefania" last="Gamba">Stefania Gamba</name></author><author wicri:is="80%"><name sortKey="Trovato, Francesco" sort="Trovato, Francesco" uniqKey="Trovato F" first="Francesco" last="Trovato">Francesco Trovato</name></author><author wicri:is="80%"><name sortKey="Tovo, Pier Angelo" sort="Tovo, Pier Angelo" uniqKey="Tovo P" first="Pier-Angelo" last="Tovo">Pier-Angelo Tovo</name></author><author wicri:is="80%"><name sortKey="Bianciotto, Manuela" sort="Bianciotto, Manuela" uniqKey="Bianciotto M" first="Manuela" last="Bianciotto">Manuela Bianciotto</name></author><author wicri:is="80%"><name sortKey="Calitri, Carmelina" sort="Calitri, Carmelina" uniqKey="Calitri C" first="Carmelina" last="Calitri">Carmelina Calitri</name></author><author wicri:is="80%"><name sortKey="Gabiano, Clara" sort="Gabiano, Clara" uniqKey="Gabiano C" first="Clara" last="Gabiano">Clara Gabiano</name></author><author wicri:is="80%"><name sortKey="Raffaldi, Irene" sort="Raffaldi, Irene" uniqKey="Raffaldi I" first="Irene" last="Raffaldi">Irene Raffaldi</name></author><author wicri:is="80%"><name sortKey="Urbino, Antonio" sort="Urbino, Antonio" uniqKey="Urbino A" first="Antonio" last="Urbino">Antonio Urbino</name></author><author wicri:is="80%"><name sortKey="Da Dalt, Liviana" sort="Da Dalt, Liviana" uniqKey="Da Dalt L" first="Liviana" last="Da Dalt">Liviana Da Dalt</name></author><author wicri:is="80%"><name sortKey="Favero, Valentina" sort="Favero, Valentina" uniqKey="Favero V" first="Valentina" last="Favero">Valentina Favero</name></author><author wicri:is="80%"><name sortKey="Giordano, Laura" sort="Giordano, Laura" uniqKey="Giordano L" first="Laura" last="Giordano">Laura Giordano</name></author><author wicri:is="80%"><name sortKey="Baraldi, Maura" sort="Baraldi, Maura" uniqKey="Baraldi M" first="Maura" last="Baraldi">Maura Baraldi</name></author><author wicri:is="80%"><name sortKey="Bertuola, Federica" sort="Bertuola, Federica" uniqKey="Bertuola F" first="Federica" last="Bertuola">Federica Bertuola</name></author><author wicri:is="80%"><name sortKey="Lorenzon, Eleonora" sort="Lorenzon, Eleonora" uniqKey="Lorenzon E" first="Eleonora" last="Lorenzon">Eleonora Lorenzon</name></author><author wicri:is="80%"><name sortKey="Parata, Francesca" sort="Parata, Francesca" uniqKey="Parata F" first="Francesca" last="Parata">Francesca Parata</name></author><author wicri:is="80%"><name sortKey="Perilongo, Giorgio" sort="Perilongo, Giorgio" uniqKey="Perilongo G" first="Giorgio" last="Perilongo">Giorgio Perilongo</name></author><author wicri:is="80%"><name sortKey="Vendramin, Silvia" sort="Vendramin, Silvia" uniqKey="Vendramin S" first="Silvia" last="Vendramin">Silvia Vendramin</name></author><author wicri:is="80%"><name sortKey="Frassineti, Monica" sort="Frassineti, Monica" uniqKey="Frassineti M" first="Monica" last="Frassineti">Monica Frassineti</name></author><author wicri:is="80%"><name sortKey="Calvani, Anna Maria" sort="Calvani, Anna Maria" uniqKey="Calvani A" first="Anna Maria" last="Calvani">Anna Maria Calvani</name></author><author wicri:is="80%"><name sortKey="Chiappini, Elena" sort="Chiappini, Elena" uniqKey="Chiappini E" first="Elena" last="Chiappini">Elena Chiappini</name></author><author wicri:is="80%"><name sortKey="De Martino, Maurizio" sort="De Martino, Maurizio" uniqKey="De Martino M" first="Maurizio" last="De Martino">Maurizio De Martino</name></author><author wicri:is="80%"><name sortKey="Fancelli, Claudia" sort="Fancelli, Claudia" uniqKey="Fancelli C" first="Claudia" last="Fancelli">Claudia Fancelli</name></author><author wicri:is="80%"><name sortKey="Mannelli, Francesco" sort="Mannelli, Francesco" uniqKey="Mannelli F" first="Francesco" last="Mannelli">Francesco Mannelli</name></author><author wicri:is="80%"><name sortKey="Mazzantini, Rachele" sort="Mazzantini, Rachele" uniqKey="Mazzantini R" first="Rachele" last="Mazzantini">Rachele Mazzantini</name></author><author wicri:is="80%"><name sortKey="Sollai, Sara" sort="Sollai, Sara" uniqKey="Sollai S" first="Sara" last="Sollai">Sara Sollai</name></author><author wicri:is="80%"><name sortKey="Venturini, Elisabetta" sort="Venturini, Elisabetta" uniqKey="Venturini E" first="Elisabetta" last="Venturini">Elisabetta Venturini</name></author><author wicri:is="80%"><name sortKey="Pirozzi, Nicola" sort="Pirozzi, Nicola" uniqKey="Pirozzi N" first="Nicola" last="Pirozzi">Nicola Pirozzi</name></author><author wicri:is="80%"><name sortKey="Raucci, Umberto" sort="Raucci, Umberto" uniqKey="Raucci U" first="Umberto" last="Raucci">Umberto Raucci</name></author><author wicri:is="80%"><name sortKey="Reale, Antonino" sort="Reale, Antonino" uniqKey="Reale A" first="Antonino" last="Reale">Antonino Reale</name></author><author wicri:is="80%"><name sortKey="Rossi, Rossella" sort="Rossi, Rossella" uniqKey="Rossi R" first="Rossella" last="Rossi">Rossella Rossi</name></author><author wicri:is="80%"><name sortKey="Mores, Nadia" sort="Mores, Nadia" uniqKey="Mores N" first="Nadia" last="Mores">Nadia Mores</name></author><author wicri:is="80%"><name sortKey="Bersani, Giulia" sort="Bersani, Giulia" uniqKey="Bersani G" first="Giulia" last="Bersani">Giulia Bersani</name></author><author wicri:is="80%"><name sortKey="De Nisco, Alessia" sort="De Nisco, Alessia" uniqKey="De Nisco A" first="Alessia" last="De Nisco">Alessia De Nisco</name></author><author wicri:is="80%"><name sortKey="Chiaretti, Antonio" sort="Chiaretti, Antonio" uniqKey="Chiaretti A" first="Antonio" last="Chiaretti">Antonio Chiaretti</name></author><author wicri:is="80%"><name sortKey="Riccardi, Riccardo" sort="Riccardi, Riccardo" uniqKey="Riccardi R" first="Riccardo" last="Riccardi">Riccardo Riccardi</name></author><author wicri:is="80%"><name sortKey="Romagnoli, Costantino" sort="Romagnoli, Costantino" uniqKey="Romagnoli C" first="Costantino" last="Romagnoli">Costantino Romagnoli</name></author><author wicri:is="80%"><name sortKey="Tipo, Vincenzo" sort="Tipo, Vincenzo" uniqKey="Tipo V" first="Vincenzo" last="Tipo">Vincenzo Tipo</name></author><author wicri:is="80%"><name sortKey="Dinardo, Michele" sort="Dinardo, Michele" uniqKey="Dinardo M" first="Michele" last="Dinardo">Michele Dinardo</name></author><author wicri:is="80%"><name sortKey="Pisapia, Teresa" sort="Pisapia, Teresa" uniqKey="Pisapia T" first="Teresa" last="Pisapia">Teresa Pisapia</name></author><author wicri:is="80%"><name sortKey="Capuano, Annalisa" sort="Capuano, Annalisa" uniqKey="Capuano A" first="Annalisa" last="Capuano">Annalisa Capuano</name></author><author wicri:is="80%"><name sortKey="Parretta, Elisabetta" sort="Parretta, Elisabetta" uniqKey="Parretta E" first="Elisabetta" last="Parretta">Elisabetta Parretta</name></author><author wicri:is="80%"><name sortKey="Rafaniello, Concita" sort="Rafaniello, Concita" uniqKey="Rafaniello C" first="Concita" last="Rafaniello">Concita Rafaniello</name></author><author wicri:is="80%"><name sortKey="Fuca, Fortunata" sort="Fuca, Fortunata" uniqKey="Fuca F" first="Fortunata" last="Fucà">Fortunata Fucà</name></author><author wicri:is="80%"><name sortKey="Di Rosa, Eleonora" sort="Di Rosa, Eleonora" uniqKey="Di Rosa E" first="Eleonora" last="Di Rosa">Eleonora Di Rosa</name></author></analytic><monogr></monogr><series><title level="j">Archives of Disease in Childhood</title><title level="j" type="abbrev">Arch Dis Child</title><idno type="ISSN">0003-9888</idno><idno type="eISSN">1468-2044</idno><imprint><publisher>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><date type="published" when="2013-03">2013-03</date><biblScope unit="volume">98</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="218">218</biblScope></imprint><idno type="ISSN">0003-9888</idno></series><idno type="istex">72B3DB96F35726A7D6EA32A4DBC643D22666C33B</idno><idno type="DOI">10.1136/archdischild-2012-302100</idno><idno type="href">archdischild-98-218.pdf</idno><idno type="ArticleID">archdischild-2012-302100</idno><idno type="PMID">23264432</idno><idno type="local">archdischild;98/3/218</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-9888</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population. Methods This study is part of a large Italian prospective multicentre study. The study population included children hospitalised for acute conditions through the emergency departments of eight clinical centres. Patients admitted for UGIC (defined as endoscopically confirmed gastroduodenal lesions or clinically defined haematemesis or melena) comprised the case series; children hospitalised for neurological disorders formed the control group. Information on drug and vaccine exposure was collected through parental interview during the children's hospitalisation. Logistic regression was used to estimate ORs for the occurrence of UGIC associated with drug use adjusted for age, clinical centre and concomitant use of any drug. Results 486 children hospitalised for UGIC and 1930 for neurological disorders were enrolled between November 1999 and November 2010. Drug use was higher in cases than in controls (73% vs 54%; p<0.001). UGICs were associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs) (adjusted OR 2.9, 95% CI 2.1 to 4.0), oral steroids (adjusted OR 2.9, 95% CI 1.7 to 4.8) and antibiotics (adjusted OR 2.3, 95% CI 1.8 to 3.1). The duration of use of these drug categories was short (range 1–8 days). Paracetamol showed a lower risk (adjusted OR 2.0, 95% CI 1.5 to 2.6) compared to ibuprofen (adjusted OR 3.7, 95% CI 2.3 to 5.9), although with partially overlapping CIs. Conclusions NSAIDs, oral steroids and antibiotics, even when administered for a short period, were associated with an increased risk of UGIC.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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