Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer
Identifieur interne : 000F08 ( Istex/Corpus ); précédent : 000F07; suivant : 000F09Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer
Auteurs : Marc Buyse ; Sherene Loi ; Laura Van'T Veer ; Giuseppe Viale ; Mauro Delorenzi ; Annuska M. Glas ; Mahasti Saghatchian D'Assignies ; Jonas Bergh ; Rosette Lidereau ; Paul Ellis ; Adrian Harris ; Jan Bogaerts ; Patrick Therasse ; Arno Floore ; Mohamed Amakrane ; Fanny Piette ; Emiel Rutgers ; Christos Sotiriou ; Fatima Cardoso ; Martine J. PiccartSource :
- Journal of the National Cancer Institute [ 0027-8874 ] ; 2006-09-06.
Abstract
Background: A 70-gene signature was previously shown to have prognostic value in patients with node-negative breast cancer. Our goal was to validate the signature in an independent group of patients. Methods: Patients (n = 307, with 137 events after a median follow-up of 13.6 years) from five European centers were divided into high- and low-risk groups based on the gene signature classification and on clinical risk classifications. Patients were assigned to the gene signature low-risk group if their 5-year distant metastasis–free survival probability as estimated by the gene signature was greater than 90%. Patients were assigned to the clinicopathologic low-risk group if their 10-year survival probability, as estimated by Adjuvant! software, was greater than 88% (for estrogen receptor [ER]–positive patients) or 92% (for ER-negative patients). Hazard ratios (HRs) were estimated to compare time to distant metastases, disease-free survival, and overall survival in high- versus low-risk groups. Results: The 70-gene signature outperformed the clinicopathologic risk assessment in predicting all endpoints. For time to distant metastases, the gene signature yielded HR = 2.32 (95% confidence interval [CI] = 1.35 to 4.00) without adjustment for clinical risk and hazard ratios ranging from 2.13 to 2.15 after adjustment for various estimates of clinical risk; clinicopathologic risk using Adjuvant! software yielded an unadjusted HR = 1.68 (95% CI = 0.92 to 3.07). For overall survival, the gene signature yielded an unadjusted HR = 2.79 (95% CI = 1.60 to 4.87) and adjusted hazard ratios ranging from 2.63 to 2.89; clinicopathologic risk yielded an unadjusted HR = 1.67 (95% CI = 0.93 to 2.98). For patients in the gene signature high-risk group, 10-year overall survival was 0.69 for patients in both the low– and high–clinical risk groups; for patients in the gene signature low-risk group, the 10-year survival rates were 0.88 and 0.89, respectively. Conclusions: The 70-gene signature adds independent prognostic information to clinicopathologic risk assessment for patients with early breast cancer.
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DOI: 10.1093/jnci/djj329
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer</title><author><name sortKey="Buyse, Marc" sort="Buyse, Marc" uniqKey="Buyse M" first="Marc" last="Buyse">Marc Buyse</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Van T Veer, Laura" sort="Van T Veer, Laura" uniqKey="Van T Veer L" first="Laura" last="Van'T Veer">Laura Van'T Veer</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Viale, Giuseppe" sort="Viale, Giuseppe" uniqKey="Viale G" first="Giuseppe" last="Viale">Giuseppe Viale</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Delorenzi, Mauro" sort="Delorenzi, Mauro" uniqKey="Delorenzi M" first="Mauro" last="Delorenzi">Mauro Delorenzi</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Glas, Annuska M" sort="Glas, Annuska M" uniqKey="Glas A" first="Annuska M." last="Glas">Annuska M. Glas</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Saghatchian D Assignies, Mahasti" sort="Saghatchian D Assignies, Mahasti" uniqKey="Saghatchian D Assignies M" first="Mahasti" last="Saghatchian D'Assignies">Mahasti Saghatchian D'Assignies</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Bergh, Jonas" sort="Bergh, Jonas" uniqKey="Bergh J" first="Jonas" last="Bergh">Jonas Bergh</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Lidereau, Rosette" sort="Lidereau, Rosette" uniqKey="Lidereau R" first="Rosette" last="Lidereau">Rosette Lidereau</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Ellis, Paul" sort="Ellis, Paul" uniqKey="Ellis P" first="Paul" last="Ellis">Paul Ellis</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Harris, Adrian" sort="Harris, Adrian" uniqKey="Harris A" first="Adrian" last="Harris">Adrian Harris</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Bogaerts, Jan" sort="Bogaerts, Jan" uniqKey="Bogaerts J" first="Jan" last="Bogaerts">Jan Bogaerts</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Therasse, Patrick" sort="Therasse, Patrick" uniqKey="Therasse P" first="Patrick" last="Therasse">Patrick Therasse</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Floore, Arno" sort="Floore, Arno" uniqKey="Floore A" first="Arno" last="Floore">Arno Floore</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Amakrane, Mohamed" sort="Amakrane, Mohamed" uniqKey="Amakrane M" first="Mohamed" last="Amakrane">Mohamed Amakrane</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Piette, Fanny" sort="Piette, Fanny" uniqKey="Piette F" first="Fanny" last="Piette">Fanny Piette</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Rutgers, Emiel" sort="Rutgers, Emiel" uniqKey="Rutgers E" first="Emiel" last="Rutgers">Emiel Rutgers</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Sotiriou, Christos" sort="Sotiriou, Christos" uniqKey="Sotiriou C" first="Christos" last="Sotiriou">Christos Sotiriou</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Cardoso, Fatima" sort="Cardoso, Fatima" uniqKey="Cardoso F" first="Fatima" last="Cardoso">Fatima Cardoso</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Piccart, Martine J" sort="Piccart, Martine J" uniqKey="Piccart M" first="Martine J." last="Piccart">Martine J. Piccart</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8B96C963206FF5419B4949472067D0E883E19343</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1093/jnci/djj329</idno><idno type="url">https://api.istex.fr/document/8B96C963206FF5419B4949472067D0E883E19343/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000F08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer</title><author><name sortKey="Buyse, Marc" sort="Buyse, Marc" uniqKey="Buyse M" first="Marc" last="Buyse">Marc Buyse</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Van T Veer, Laura" sort="Van T Veer, Laura" uniqKey="Van T Veer L" first="Laura" last="Van'T Veer">Laura Van'T Veer</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Viale, Giuseppe" sort="Viale, Giuseppe" uniqKey="Viale G" first="Giuseppe" last="Viale">Giuseppe Viale</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Delorenzi, Mauro" sort="Delorenzi, Mauro" uniqKey="Delorenzi M" first="Mauro" last="Delorenzi">Mauro Delorenzi</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Glas, Annuska M" sort="Glas, Annuska M" uniqKey="Glas A" first="Annuska M." last="Glas">Annuska M. Glas</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Saghatchian D Assignies, Mahasti" sort="Saghatchian D Assignies, Mahasti" uniqKey="Saghatchian D Assignies M" first="Mahasti" last="Saghatchian D'Assignies">Mahasti Saghatchian D'Assignies</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Bergh, Jonas" sort="Bergh, Jonas" uniqKey="Bergh J" first="Jonas" last="Bergh">Jonas Bergh</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Lidereau, Rosette" sort="Lidereau, Rosette" uniqKey="Lidereau R" first="Rosette" last="Lidereau">Rosette Lidereau</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Ellis, Paul" sort="Ellis, Paul" uniqKey="Ellis P" first="Paul" last="Ellis">Paul Ellis</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Harris, Adrian" sort="Harris, Adrian" uniqKey="Harris A" first="Adrian" last="Harris">Adrian Harris</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Bogaerts, Jan" sort="Bogaerts, Jan" uniqKey="Bogaerts J" first="Jan" last="Bogaerts">Jan Bogaerts</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Therasse, Patrick" sort="Therasse, Patrick" uniqKey="Therasse P" first="Patrick" last="Therasse">Patrick Therasse</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Floore, Arno" sort="Floore, Arno" uniqKey="Floore A" first="Arno" last="Floore">Arno Floore</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Amakrane, Mohamed" sort="Amakrane, Mohamed" uniqKey="Amakrane M" first="Mohamed" last="Amakrane">Mohamed Amakrane</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Piette, Fanny" sort="Piette, Fanny" uniqKey="Piette F" first="Fanny" last="Piette">Fanny Piette</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Rutgers, Emiel" sort="Rutgers, Emiel" uniqKey="Rutgers E" first="Emiel" last="Rutgers">Emiel Rutgers</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Sotiriou, Christos" sort="Sotiriou, Christos" uniqKey="Sotiriou C" first="Christos" last="Sotiriou">Christos Sotiriou</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Cardoso, Fatima" sort="Cardoso, Fatima" uniqKey="Cardoso F" first="Fatima" last="Cardoso">Fatima Cardoso</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author><author><name sortKey="Piccart, Martine J" sort="Piccart, Martine J" uniqKey="Piccart M" first="Martine J." last="Piccart">Martine J. Piccart</name><affiliation><mods:affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the National Cancer Institute</title><title level="j" type="abbrev">JNCI J Natl Cancer Inst</title><idno type="ISSN">0027-8874</idno><idno type="eISSN">1460-2105</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2006-09-06">2006-09-06</date><biblScope unit="volume">98</biblScope><biblScope unit="issue">17</biblScope><biblScope unit="page" from="1183">1183</biblScope><biblScope unit="page" to="1192">1192</biblScope></imprint><idno type="ISSN">0027-8874</idno></series><idno type="istex">8B96C963206FF5419B4949472067D0E883E19343</idno><idno type="DOI">10.1093/jnci/djj329</idno><idno type="local">djj329</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0027-8874</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: A 70-gene signature was previously shown to have prognostic value in patients with node-negative breast cancer. Our goal was to validate the signature in an independent group of patients. Methods: Patients (n = 307, with 137 events after a median follow-up of 13.6 years) from five European centers were divided into high- and low-risk groups based on the gene signature classification and on clinical risk classifications. Patients were assigned to the gene signature low-risk group if their 5-year distant metastasis–free survival probability as estimated by the gene signature was greater than 90%. Patients were assigned to the clinicopathologic low-risk group if their 10-year survival probability, as estimated by Adjuvant! software, was greater than 88% (for estrogen receptor [ER]–positive patients) or 92% (for ER-negative patients). Hazard ratios (HRs) were estimated to compare time to distant metastases, disease-free survival, and overall survival in high- versus low-risk groups. Results: The 70-gene signature outperformed the clinicopathologic risk assessment in predicting all endpoints. For time to distant metastases, the gene signature yielded HR = 2.32 (95% confidence interval [CI] = 1.35 to 4.00) without adjustment for clinical risk and hazard ratios ranging from 2.13 to 2.15 after adjustment for various estimates of clinical risk; clinicopathologic risk using Adjuvant! software yielded an unadjusted HR = 1.68 (95% CI = 0.92 to 3.07). For overall survival, the gene signature yielded an unadjusted HR = 2.79 (95% CI = 1.60 to 4.87) and adjusted hazard ratios ranging from 2.63 to 2.89; clinicopathologic risk yielded an unadjusted HR = 1.67 (95% CI = 0.93 to 2.98). For patients in the gene signature high-risk group, 10-year overall survival was 0.69 for patients in both the low– and high–clinical risk groups; for patients in the gene signature low-risk group, the 10-year survival rates were 0.88 and 0.89, respectively. Conclusions: The 70-gene signature adds independent prognostic information to clinicopathologic risk assessment for patients with early breast cancer.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Marc Buyse</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Sherene Loi</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Laura van't Veer</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Giuseppe Viale</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Mauro Delorenzi</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. 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Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Patrick Therasse</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Arno Floore</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Mohamed Amakrane</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Fanny Piette</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Emiel Rutgers</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Christos Sotiriou</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Fatima Cardoso</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item><json:item><name>Martine J. Piccart</name><affiliations><json:string>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Background: A 70-gene signature was previously shown to have prognostic value in patients with node-negative breast cancer. Our goal was to validate the signature in an independent group of patients. Methods: Patients (n = 307, with 137 events after a median follow-up of 13.6 years) from five European centers were divided into high- and low-risk groups based on the gene signature classification and on clinical risk classifications. Patients were assigned to the gene signature low-risk group if their 5-year distant metastasis–free survival probability as estimated by the gene signature was greater than 90%. Patients were assigned to the clinicopathologic low-risk group if their 10-year survival probability, as estimated by Adjuvant! software, was greater than 88% (for estrogen receptor [ER]–positive patients) or 92% (for ER-negative patients). Hazard ratios (HRs) were estimated to compare time to distant metastases, disease-free survival, and overall survival in high- versus low-risk groups. Results: The 70-gene signature outperformed the clinicopathologic risk assessment in predicting all endpoints. For time to distant metastases, the gene signature yielded HR = 2.32 (95% confidence interval [CI] = 1.35 to 4.00) without adjustment for clinical risk and hazard ratios ranging from 2.13 to 2.15 after adjustment for various estimates of clinical risk; clinicopathologic risk using Adjuvant! software yielded an unadjusted HR = 1.68 (95% CI = 0.92 to 3.07). For overall survival, the gene signature yielded an unadjusted HR = 2.79 (95% CI = 1.60 to 4.87) and adjusted hazard ratios ranging from 2.63 to 2.89; clinicopathologic risk yielded an unadjusted HR = 1.67 (95% CI = 0.93 to 2.98). For patients in the gene signature high-risk group, 10-year overall survival was 0.69 for patients in both the low– and high–clinical risk groups; for patients in the gene signature low-risk group, the 10-year survival rates were 0.88 and 0.89, respectively. Conclusions: The 70-gene signature adds independent prognostic information to clinicopathologic risk assessment for patients with early breast cancer.</abstract><qualityIndicators><score>8</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>2115</abstractCharCount><pdfWordCount>7570</pdfWordCount><pdfCharCount>48856</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>316</abstractWordCount></qualityIndicators><title>Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer</title><genre><json:string>research-article</json:string></genre><host><volume>98</volume><publisherId><json:string>jnci</json:string></publisherId><pages><last>1192</last><first>1183</first></pages><issn><json:string>0027-8874</json:string></issn><issue>17</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1460-2105</json:string></eissn><title>Journal of the National Cancer Institute</title></host><categories><wos><json:string>ONCOLOGY</json:string></wos></categories><publicationDate>2006</publicationDate><copyrightDate>2006</copyrightDate><doi><json:string>10.1093/jnci/djj329</json:string></doi><id>8B96C963206FF5419B4949472067D0E883E19343</id><score>0.24773598</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/8B96C963206FF5419B4949472067D0E883E19343/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/8B96C963206FF5419B4949472067D0E883E19343/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/8B96C963206FF5419B4949472067D0E883E19343/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>© 2006 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</p></availability><date>2006</date></publicationStmt><notesStmt><note>Correspondence to: BIG/TRANSBIG Secretariat, Institut Jules Bordet, 121 Boulevard de Waterloo, 1000 Brussels, Belgium (e-mail: TRANSBIG@bordet.be).</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer</title><author xml:id="author-1"><persName><forename type="first">Marc</forename><surname>Buyse</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-2"><persName><forename type="first">Sherene</forename><surname>Loi</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-3"><persName><forename type="first">Laura</forename><surname>van't Veer</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-4"><persName><forename type="first">Giuseppe</forename><surname>Viale</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-5"><persName><forename type="first">Mauro</forename><surname>Delorenzi</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-6"><persName><forename type="first">Annuska M.</forename><surname>Glas</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-7"><persName><forename type="first">Mahasti</forename><surname>Saghatchian d'Assignies</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-8"><persName><forename type="first">Jonas</forename><surname>Bergh</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-9"><persName><forename type="first">Rosette</forename><surname>Lidereau</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-10"><persName><forename type="first">Paul</forename><surname>Ellis</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-11"><persName><forename type="first">Adrian</forename><surname>Harris</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-12"><persName><forename type="first">Jan</forename><surname>Bogaerts</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-13"><persName><forename type="first">Patrick</forename><surname>Therasse</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-14"><persName><forename type="first">Arno</forename><surname>Floore</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-15"><persName><forename type="first">Mohamed</forename><surname>Amakrane</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-16"><persName><forename type="first">Fanny</forename><surname>Piette</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-17"><persName><forename type="first">Emiel</forename><surname>Rutgers</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-18"><persName><forename type="first">Christos</forename><surname>Sotiriou</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-19"><persName><forename type="first">Fatima</forename><surname>Cardoso</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author><author xml:id="author-20"><persName><forename type="first">Martine J.</forename><surname>Piccart</surname></persName><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation></author></analytic><monogr><title level="j">Journal of the National Cancer Institute</title><title level="j" type="abbrev">JNCI J Natl Cancer Inst</title><idno type="pISSN">0027-8874</idno><idno type="eISSN">1460-2105</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2006-09-06"></date><biblScope unit="volume">98</biblScope><biblScope unit="issue">17</biblScope><biblScope unit="page" from="1183">1183</biblScope><biblScope unit="page" to="1192">1192</biblScope></imprint></monogr><idno type="istex">8B96C963206FF5419B4949472067D0E883E19343</idno><idno type="DOI">10.1093/jnci/djj329</idno><idno type="local">djj329</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background: A 70-gene signature was previously shown to have prognostic value in patients with node-negative breast cancer. Our goal was to validate the signature in an independent group of patients. Methods: Patients (n = 307, with 137 events after a median follow-up of 13.6 years) from five European centers were divided into high- and low-risk groups based on the gene signature classification and on clinical risk classifications. Patients were assigned to the gene signature low-risk group if their 5-year distant metastasis–free survival probability as estimated by the gene signature was greater than 90%. Patients were assigned to the clinicopathologic low-risk group if their 10-year survival probability, as estimated by Adjuvant! software, was greater than 88% (for estrogen receptor [ER]–positive patients) or 92% (for ER-negative patients). Hazard ratios (HRs) were estimated to compare time to distant metastases, disease-free survival, and overall survival in high- versus low-risk groups. Results: The 70-gene signature outperformed the clinicopathologic risk assessment in predicting all endpoints. For time to distant metastases, the gene signature yielded HR = 2.32 (95% confidence interval [CI] = 1.35 to 4.00) without adjustment for clinical risk and hazard ratios ranging from 2.13 to 2.15 after adjustment for various estimates of clinical risk; clinicopathologic risk using Adjuvant! software yielded an unadjusted HR = 1.68 (95% CI = 0.92 to 3.07). For overall survival, the gene signature yielded an unadjusted HR = 2.79 (95% CI = 1.60 to 4.87) and adjusted hazard ratios ranging from 2.63 to 2.89; clinicopathologic risk yielded an unadjusted HR = 1.67 (95% CI = 0.93 to 2.98). For patients in the gene signature high-risk group, 10-year overall survival was 0.69 for patients in both the low– and high–clinical risk groups; for patients in the gene signature low-risk group, the 10-year survival rates were 0.88 and 0.89, respectively. Conclusions: The 70-gene signature adds independent prognostic information to clinicopathologic risk assessment for patients with early breast cancer.</p></abstract></profileDesc><revisionDesc><change when="2006-09-06">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-10-14">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8B96C963206FF5419B4949472067D0E883E19343/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="US-ASCII"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">jnci</journal-id><journal-id journal-id-type="nlm-ta">J Natl Cancer Inst</journal-id><journal-id journal-id-type="publisher-id">jnci</journal-id><journal-title>Journal of the National Cancer Institute</journal-title><abbrev-journal-title abbrev-type="publisher">JNCI J Natl Cancer Inst</abbrev-journal-title><issn pub-type="ppub">0027-8874</issn><issn pub-type="epub">1460-2105</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="other">djj329</article-id><article-id pub-id-type="doi">10.1093/jnci/djj329</article-id><article-categories><subj-group subj-group-type="heading"><subject>ARTICLES</subject></subj-group></article-categories><title-group><article-title>Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Buyse</surname><given-names>Marc</given-names></name></contrib><contrib contrib-type="author"><name><surname>Loi</surname><given-names>Sherene</given-names></name></contrib><contrib contrib-type="author"><name><surname>van't Veer</surname><given-names>Laura</given-names></name></contrib><contrib contrib-type="author"><name><surname>Viale</surname><given-names>Giuseppe</given-names></name></contrib><contrib contrib-type="author"><name><surname>Delorenzi</surname><given-names>Mauro</given-names></name></contrib><contrib contrib-type="author"><name><surname>Glas</surname><given-names>Annuska M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Saghatchian d'Assignies</surname><given-names>Mahasti</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bergh</surname><given-names>Jonas</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lidereau</surname><given-names>Rosette</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ellis</surname><given-names>Paul</given-names></name></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Adrian</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bogaerts</surname><given-names>Jan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Therasse</surname><given-names>Patrick</given-names></name></contrib><contrib contrib-type="author"><name><surname>Floore</surname><given-names>Arno</given-names></name></contrib><contrib contrib-type="author"><name><surname>Amakrane</surname><given-names>Mohamed</given-names></name></contrib><contrib contrib-type="author"><name><surname>Piette</surname><given-names>Fanny</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rutgers</surname><given-names>Emiel</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sotiriou</surname><given-names>Christos</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cardoso</surname><given-names>Fatima</given-names></name></contrib><contrib contrib-type="author"><name><surname>Piccart</surname><given-names>Martine J.</given-names></name></contrib><contrib contrib-type="group-author"><on-behalf-of>On behalf of the TRANSBIG Consortium</on-behalf-of></contrib><aff><italic>Affiliations of authors:</italic> International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</aff></contrib-group><author-notes><corresp><italic>Correspondence to:</italic> BIG/TRANSBIG Secretariat, Institut Jules Bordet, 121 Boulevard de Waterloo, 1000 Brussels, Belgium (e-mail: <ext-link xlink:href="TRANSBIG@bordet.be" ext-link-type="email">TRANSBIG@bordet.be</ext-link>).</corresp></author-notes><pub-date pub-type="ppub"><day>6</day><month>September</month><year>2006</year></pub-date><volume>98</volume><issue>17</issue><fpage>1183</fpage><lpage>1192</lpage><history><date date-type="accepted"><day>14</day><month>7</month><year>2006</year></date><date date-type="received"><day>12</day><month>11</month><year>2005</year></date><date date-type="rev-recd"><day>27</day><month>4</month><year>2006</year></date></history><permissions><copyright-statement>© 2006 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</copyright-statement><copyright-year>2006</copyright-year><license license-type="open-access"><p></p></license></permissions><abstract xml:lang="en"><p><italic>Background:</italic> A 70-gene signature was previously shown to have prognostic value in patients with node-negative breast cancer. Our goal was to validate the signature in an independent group of patients. <italic>Methods:</italic> Patients (n = 307, with 137 events after a median follow-up of 13.6 years) from five European centers were divided into high- and low-risk groups based on the gene signature classification and on clinical risk classifications. Patients were assigned to the gene signature low-risk group if their 5-year distant metastasis–free survival probability as estimated by the gene signature was greater than 90%. Patients were assigned to the clinicopathologic low-risk group if their 10-year survival probability, as estimated by Adjuvant! software, was greater than 88% (for estrogen receptor [ER]–positive patients) or 92% (for ER-negative patients). Hazard ratios (HRs) were estimated to compare time to distant metastases, disease-free survival, and overall survival in high- versus low-risk groups. <italic>Results:</italic> The 70-gene signature outperformed the clinicopathologic risk assessment in predicting all endpoints. For time to distant metastases, the gene signature yielded HR = 2.32 (95% confidence interval [CI] = 1.35 to 4.00) without adjustment for clinical risk and hazard ratios ranging from 2.13 to 2.15 after adjustment for various estimates of clinical risk; clinicopathologic risk using Adjuvant! software yielded an unadjusted HR = 1.68 (95% CI = 0.92 to 3.07). For overall survival, the gene signature yielded an unadjusted HR = 2.79 (95% CI = 1.60 to 4.87) and adjusted hazard ratios ranging from 2.63 to 2.89; clinicopathologic risk yielded an unadjusted HR = 1.67 (95% CI = 0.93 to 2.98). For patients in the gene signature high-risk group, 10-year overall survival was 0.69 for patients in both the low– and high–clinical risk groups; for patients in the gene signature low-risk group, the 10-year survival rates were 0.88 and 0.89, respectively. <italic>Conclusions:</italic> The 70-gene signature adds independent prognostic information to clinicopathologic risk assessment for patients with early breast cancer.</p></abstract><custom-meta-wrap><custom-meta><meta-name>hwp-legacy-fpage</meta-name><meta-value>1183</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>6 September 2006</meta-value></custom-meta><custom-meta><meta-name>hwp-legacy-dochead</meta-name><meta-value>ARTICLE</meta-value></custom-meta></custom-meta-wrap></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer</title></titleInfo><name type="personal"><namePart type="given">Marc</namePart><namePart type="family">Buyse</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sherene</namePart><namePart type="family">Loi</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">van't Veer</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giuseppe</namePart><namePart type="family">Viale</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mauro</namePart><namePart type="family">Delorenzi</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Annuska M.</namePart><namePart type="family">Glas</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mahasti</namePart><namePart type="family">Saghatchian d'Assignies</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jonas</namePart><namePart type="family">Bergh</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rosette</namePart><namePart type="family">Lidereau</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul</namePart><namePart type="family">Ellis</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Adrian</namePart><namePart type="family">Harris</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Bogaerts</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Patrick</namePart><namePart type="family">Therasse</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arno</namePart><namePart type="family">Floore</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mohamed</namePart><namePart type="family">Amakrane</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fanny</namePart><namePart type="family">Piette</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Emiel</namePart><namePart type="family">Rutgers</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christos</namePart><namePart type="family">Sotiriou</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fatima</namePart><namePart type="family">Cardoso</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martine J.</namePart><namePart type="family">Piccart</namePart><affiliation>International Drug Development Institute, Brussels, Belgium (MB, MA, FP); Institut Jules Bordet, Brussels, Belgium (SL, CS, FC, MJP); Netherlands Cancer Institute, Amsterdam, The Netherlands (LvV, ER); European Institute of Oncology and University of Milan School of Medicine, Milan, Italy (GV); National Center of Competence in Research Molecular Oncology, Swiss Institute of Experimental Cancer Research, Epalinges & the Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Agendia B.V. Amsterdam, The Netherlands (LvV, AMG, AF); Institut Gustave Roussy, Villejuif, France (MSd'A); Karolinska Institute, Stockholm, Sweden (JB); Centre René Huguenin and Institut National de la Santé et de la Recherche Médicale, St Cloud, France (RL); Guy's Hospital, London, U.K. (PE); John Radcliffe Hospital, Oxford, U.K. (AH); European Organisation for the Research and Treatment of Cancer Data Center, Brussels, Belgium (JB, PT)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2006-09-06</dateIssued><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Background: A 70-gene signature was previously shown to have prognostic value in patients with node-negative breast cancer. Our goal was to validate the signature in an independent group of patients. Methods: Patients (n = 307, with 137 events after a median follow-up of 13.6 years) from five European centers were divided into high- and low-risk groups based on the gene signature classification and on clinical risk classifications. Patients were assigned to the gene signature low-risk group if their 5-year distant metastasis–free survival probability as estimated by the gene signature was greater than 90%. Patients were assigned to the clinicopathologic low-risk group if their 10-year survival probability, as estimated by Adjuvant! software, was greater than 88% (for estrogen receptor [ER]–positive patients) or 92% (for ER-negative patients). Hazard ratios (HRs) were estimated to compare time to distant metastases, disease-free survival, and overall survival in high- versus low-risk groups. Results: The 70-gene signature outperformed the clinicopathologic risk assessment in predicting all endpoints. For time to distant metastases, the gene signature yielded HR = 2.32 (95% confidence interval [CI] = 1.35 to 4.00) without adjustment for clinical risk and hazard ratios ranging from 2.13 to 2.15 after adjustment for various estimates of clinical risk; clinicopathologic risk using Adjuvant! software yielded an unadjusted HR = 1.68 (95% CI = 0.92 to 3.07). For overall survival, the gene signature yielded an unadjusted HR = 2.79 (95% CI = 1.60 to 4.87) and adjusted hazard ratios ranging from 2.63 to 2.89; clinicopathologic risk yielded an unadjusted HR = 1.67 (95% CI = 0.93 to 2.98). For patients in the gene signature high-risk group, 10-year overall survival was 0.69 for patients in both the low– and high–clinical risk groups; for patients in the gene signature low-risk group, the 10-year survival rates were 0.88 and 0.89, respectively. Conclusions: The 70-gene signature adds independent prognostic information to clinicopathologic risk assessment for patients with early breast cancer.</abstract><note type="author-notes">Correspondence to: BIG/TRANSBIG Secretariat, Institut Jules Bordet, 121 Boulevard de Waterloo, 1000 Brussels, Belgium (e-mail: TRANSBIG@bordet.be).</note><relatedItem type="host"><titleInfo><title>Journal of the National Cancer Institute</title></titleInfo><titleInfo type="abbreviated"><title>JNCI J Natl Cancer Inst</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0027-8874</identifier><identifier type="eISSN">1460-2105</identifier><identifier type="PublisherID">jnci</identifier><identifier type="PublisherID-hwp">jnci</identifier><identifier type="PublisherID-nlm-ta">J Natl Cancer Inst</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>98</number></detail><detail type="issue"><caption>no.</caption><number>17</number></detail><extent unit="pages"><start>1183</start><end>1192</end></extent></part></relatedItem><identifier type="istex">8B96C963206FF5419B4949472067D0E883E19343</identifier><identifier type="DOI">10.1093/jnci/djj329</identifier><identifier type="local">djj329</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2006 The Author(s). 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