Common Variant at 16p11.2 Conferring Risk of Psychosis
Identifieur interne : 000135 ( Pmc/Corpus ); précédent : 000134; suivant : 000136Common Variant at 16p11.2 Conferring Risk of Psychosis
Auteurs : Stacy Steinberg ; Simone De Jong ; Manuel Mattheisen ; Javier Costas ; Ditte Demontis ; Stéphane Jamain ; Olli P H. Pietil Inen ; Kuang Lin ; Sergi Papiol ; Johanna Huttenlocher ; Engilbert Sigurdsson ; Evangelos Vassos ; Ina Giegling ; René Breuer ; Gillian Fraser ; Nicholas Walker ; Ingrid Melle ; Srdjan Djurovic ; Ingrid Agartz ; Annamari Tuulio-Henriksson ; Jaana Suvisaari ; Jouko Lönnqvist ; Tiina Paunio ; Line Olsen ; Thomas Hansen ; Andres Ingason ; Matti Pirinen ; Eric Strengman ; David M. Hougaard ; Torben Rntoft ; Michael Didriksen ; Mads V. Hollegaard ; Merete Nordentoft ; Lilia Abramova ; Vasily Kaleda ; Manuel Arrojo ; Julio Sanjuán ; Celso Arango ; Bruno Etain ; Frank Bellivier ; Alexandre Méary ; Franck Schürhoff ; Andrei Szoke ; Michele Ribolsi ; Valentina Magni ; Alberto Siracusano ; Swetlana Sperling ; Moritz Rossner ; Claus Christiansen ; Lambertus A. Kiemeney ; Barbara Franke ; Leonard H. Van Den Berg ; Jan Veldink ; Sarah Curran ; Patrick Bolton ; Martin Poot ; Wouter Staal ; Karola Rehnstrom ; Helena Kilpinen ; Christine M. Freitag ; Jobst Meyer ; Pall Magnusson ; Evald Saemundsen ; Igor Martsenkovsky ; Iana Bikshaieva ; Inna Martsenkovska ; Olesya Vashchenko ; Marija Raleva ; Kamka Paketchieva ; Branislav Stefanovski ; Naser Durmishi ; Milica Pejovic Milovancevic ; Dusica Lecic Tosevski ; Teimuraz Silagadze ; Nino Naneishvili ; Nina Mikeladze ; Simon Surguladze ; John B. Vincent ; Anne Farmer ; Philip B. Mitchell ; Adam Wright ; Peter R. Schofield ; Janice M. Fullerton ; Grant W. Montgomery ; Nicholas G. Martin ; I Alex Rubino ; Ruud Van Winkel ; Gunter Kenis ; Marc De Hert ; János M. Réthelyi ; István Bitter ; Lars Terenius ; Erik G. Jönsson ; Steven Bakker ; Jim Van Os ; Assen Jablensky ; Marion Leboyer ; Elvira Bramon ; John Powell ; Robin Murray ; Aiden Corvin ; Michael Gill ; Derek Morris ; F Anthony O Eill ; Ken Kendler ; Brien Riley ; Nick Craddock ; Michael J. Owen ; Michael C. O Onovan ; Unnur Thorsteinsdottir ; Augustine Kong ; Hannelore Ehrenreich ; Angel Carracedo ; Vera Golimbet ; Ole A. Andreassen ; Anders D. B Rglum ; Ole Mors ; Preben B. Mortensen ; Thomas Werge ; Roel A. Ophoff ; Markus M. Nöthen ; Marcella Rietschel ; Sven Cichon ; Mirella Ruggeri ; Sarah Tosato ; Aarno Palotie ; David St Clair ; Dan Rujescu ; David A. Collier ; Hreinn Stefansson ; Kari StefanssonSource :
- Molecular psychiatry [ 1359-4184 ] ; 2012.
Abstract
Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association (GWA) study, meta-analysis and follow-up (totaling as many as 18,206 cases and 42,536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7,469 bipolar disorder cases, 1,535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46,160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T], OR = 1.08,
Url:
DOI: 10.1038/mp.2012.157
PubMed: 23164818
PubMed Central: 3872086
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PMC:3872086Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common Variant at 16p11.2 Conferring Risk of Psychosis</title><author><name sortKey="Steinberg, Stacy" sort="Steinberg, Stacy" uniqKey="Steinberg S" first="Stacy" last="Steinberg">Stacy Steinberg</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="De Jong, Simone" sort="De Jong, Simone" uniqKey="De Jong S" first="Simone" last="De Jong">Simone De Jong</name><affiliation><nlm:aff id="A2">Center for Neurobehavioral Genetics, UCLA, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name><affiliation><nlm:aff id="A3">Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Institute for Genomic Mathematics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Costas, Javier" sort="Costas, Javier" uniqKey="Costas J" first="Javier" last="Costas">Javier Costas</name><affiliation><nlm:aff id="A6">Galician Foundation of Genomic Medicine-SERGAS, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain</nlm:aff></affiliation></author><author><name sortKey="Demontis, Ditte" sort="Demontis, Ditte" uniqKey="Demontis D" first="Ditte" last="Demontis">Ditte Demontis</name><affiliation><nlm:aff id="A7">Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation></author><author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stéphane" last="Jamain">Stéphane Jamain</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Pietil Inen, Olli P H" sort="Pietil Inen, Olli P H" uniqKey="Pietil Inen O" first="Olli P H" last="Pietil Inen">Olli P H. Pietil Inen</name><affiliation><nlm:aff id="A11">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Institute for Health and Welfare, Public Genomics Unit, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lin, Kuang" sort="Lin, Kuang" uniqKey="Lin K" first="Kuang" last="Lin">Kuang Lin</name><affiliation><nlm:aff id="A14">Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Papiol, Sergi" sort="Papiol, Sergi" uniqKey="Papiol S" first="Sergi" last="Papiol">Sergi Papiol</name><affiliation><nlm:aff id="A15">DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Huttenlocher, Johanna" sort="Huttenlocher, Johanna" uniqKey="Huttenlocher J" first="Johanna" last="Huttenlocher">Johanna Huttenlocher</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Medical Genetics, Institute of Human Genetics, University of Tübingen, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sigurdsson, Engilbert" sort="Sigurdsson, Engilbert" uniqKey="Sigurdsson E" first="Engilbert" last="Sigurdsson">Engilbert Sigurdsson</name><affiliation><nlm:aff id="A18">Department of Psychiatry, National University Hospital, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Vassos, Evangelos" sort="Vassos, Evangelos" uniqKey="Vassos E" first="Evangelos" last="Vassos">Evangelos Vassos</name><affiliation><nlm:aff id="A20">Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Giegling, Ina" sort="Giegling, Ina" uniqKey="Giegling I" first="Ina" last="Giegling">Ina Giegling</name><affiliation><nlm:aff id="A21">Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Breuer, Rene" sort="Breuer, Rene" uniqKey="Breuer R" first="René" last="Breuer">René Breuer</name><affiliation><nlm:aff id="A22">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Fraser, Gillian" sort="Fraser, Gillian" uniqKey="Fraser G" first="Gillian" last="Fraser">Gillian Fraser</name><affiliation><nlm:aff id="A23">Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK</nlm:aff></affiliation></author><author><name sortKey="Walker, Nicholas" sort="Walker, Nicholas" uniqKey="Walker N" first="Nicholas" last="Walker">Nicholas Walker</name><affiliation><nlm:aff id="A24">Ravenscraig Hospital, Greenock, UK</nlm:aff></affiliation></author><author><name sortKey="Melle, Ingrid" sort="Melle, Ingrid" uniqKey="Melle I" first="Ingrid" last="Melle">Ingrid Melle</name><affiliation><nlm:aff id="A25">KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Djurovic, Srdjan" sort="Djurovic, Srdjan" uniqKey="Djurovic S" first="Srdjan" last="Djurovic">Srdjan Djurovic</name><affiliation><nlm:aff id="A25">KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Agartz, Ingrid" sort="Agartz, Ingrid" uniqKey="Agartz I" first="Ingrid" last="Agartz">Ingrid Agartz</name><affiliation><nlm:aff id="A25">KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Tuulio Henriksson, Annamari" sort="Tuulio Henriksson, Annamari" uniqKey="Tuulio Henriksson A" first="Annamari" last="Tuulio-Henriksson">Annamari Tuulio-Henriksson</name><affiliation><nlm:aff id="A26">Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Suvisaari, Jaana" sort="Suvisaari, Jaana" uniqKey="Suvisaari J" first="Jaana" last="Suvisaari">Jaana Suvisaari</name><affiliation><nlm:aff id="A26">Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lonnqvist, Jouko" sort="Lonnqvist, Jouko" uniqKey="Lonnqvist J" first="Jouko" last="Lönnqvist">Jouko Lönnqvist</name><affiliation><nlm:aff id="A26">Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Paunio, Tiina" sort="Paunio, Tiina" uniqKey="Paunio T" first="Tiina" last="Paunio">Tiina Paunio</name><affiliation><nlm:aff id="A27">Public Health Genomics Unit, National Institute for Health and Welfare THL, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Olsen, Line" sort="Olsen, Line" uniqKey="Olsen L" first="Line" last="Olsen">Line Olsen</name><affiliation><nlm:aff id="A28">Institute of Biological Psychiatry, Mental Health Centre Sct Hans & Copenhagen University, Roskilde, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas" sort="Hansen, Thomas" uniqKey="Hansen T" first="Thomas" last="Hansen">Thomas Hansen</name><affiliation><nlm:aff id="A28">Institute of Biological Psychiatry, Mental Health Centre Sct Hans & Copenhagen University, Roskilde, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ingason, Andres" sort="Ingason, Andres" uniqKey="Ingason A" first="Andres" last="Ingason">Andres Ingason</name><affiliation><nlm:aff id="A28">Institute of Biological Psychiatry, Mental Health Centre Sct Hans & Copenhagen University, Roskilde, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pirinen, Matti" sort="Pirinen, Matti" uniqKey="Pirinen M" first="Matti" last="Pirinen">Matti Pirinen</name><affiliation><nlm:aff id="A29">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Strengman, Eric" sort="Strengman, Eric" uniqKey="Strengman E" first="Eric" last="Strengman">Eric Strengman</name><affiliation><nlm:aff id="A30">Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hougaard, David M" sort="Hougaard, David M" uniqKey="Hougaard D" first="David M" last="Hougaard">David M. Hougaard</name><affiliation><nlm:aff id="A31">Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey=" Rntoft, Torben" sort=" Rntoft, Torben" uniqKey=" Rntoft T" first="Torben" last=" Rntoft">Torben Rntoft</name><affiliation><nlm:aff id="A32">Department of Molecular Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Didriksen, Michael" sort="Didriksen, Michael" uniqKey="Didriksen M" first="Michael" last="Didriksen">Michael Didriksen</name><affiliation><nlm:aff id="A33">Synaptic transmission, H. Lundbeck A/S, Valby, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hollegaard, Mads V" sort="Hollegaard, Mads V" uniqKey="Hollegaard M" first="Mads V" last="Hollegaard">Mads V. Hollegaard</name><affiliation><nlm:aff id="A31">Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordentoft, Merete" sort="Nordentoft, Merete" uniqKey="Nordentoft M" first="Merete" last="Nordentoft">Merete Nordentoft</name><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Psychiatric Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Abramova, Lilia" sort="Abramova, Lilia" uniqKey="Abramova L" first="Lilia" last="Abramova">Lilia Abramova</name><affiliation><nlm:aff id="A35">Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Kaleda, Vasily" sort="Kaleda, Vasily" uniqKey="Kaleda V" first="Vasily" last="Kaleda">Vasily Kaleda</name><affiliation><nlm:aff id="A35">Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Arrojo, Manuel" sort="Arrojo, Manuel" uniqKey="Arrojo M" first="Manuel" last="Arrojo">Manuel Arrojo</name><affiliation><nlm:aff id="A36">Service of Psychiatry, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain</nlm:aff></affiliation></author><author><name sortKey="Sanjuan, Julio" sort="Sanjuan, Julio" uniqKey="Sanjuan J" first="Julio" last="Sanjuán">Julio Sanjuán</name><affiliation><nlm:aff id="A37">Unit of Psychiatry, Faculty of Medicine, University of Valencia, Network Center of Biomedical Research on Mental Health (CIBERSAM), Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Arango, Celso" sort="Arango, Celso" uniqKey="Arango C" first="Celso" last="Arango">Celso Arango</name><affiliation><nlm:aff id="A38">Hospital General Universitario Gregorio Marañón, IiSGM, Universidad Complutense, CIBERSAM, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Etain">Bruno Etain</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Meary, Alexandre" sort="Meary, Alexandre" uniqKey="Meary A" first="Alexandre" last="Méary">Alexandre Méary</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation></author><author><name sortKey="Schurhoff, Franck" sort="Schurhoff, Franck" uniqKey="Schurhoff F" first="Franck" last="Schürhoff">Franck Schürhoff</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Szoke, Andrei" sort="Szoke, Andrei" uniqKey="Szoke A" first="Andrei" last="Szoke">Andrei Szoke</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation></author><author><name sortKey="Ribolsi, Michele" sort="Ribolsi, Michele" uniqKey="Ribolsi M" first="Michele" last="Ribolsi">Michele Ribolsi</name><affiliation><nlm:aff id="A41">Department of Neuroscience, Section of Psychiatry, University of Rome-Tor Vergata, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Magni, Valentina" sort="Magni, Valentina" uniqKey="Magni V" first="Valentina" last="Magni">Valentina Magni</name><affiliation><nlm:aff id="A41">Department of Neuroscience, Section of Psychiatry, University of Rome-Tor Vergata, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Siracusano, Alberto" sort="Siracusano, Alberto" uniqKey="Siracusano A" first="Alberto" last="Siracusano">Alberto Siracusano</name><affiliation><nlm:aff id="A41">Department of Neuroscience, Section of Psychiatry, University of Rome-Tor Vergata, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Sperling, Swetlana" sort="Sperling, Swetlana" uniqKey="Sperling S" first="Swetlana" last="Sperling">Swetlana Sperling</name><affiliation><nlm:aff id="A16">Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Rossner, Moritz" sort="Rossner, Moritz" uniqKey="Rossner M" first="Moritz" last="Rossner">Moritz Rossner</name><affiliation><nlm:aff id="A15">DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Christiansen, Claus" sort="Christiansen, Claus" uniqKey="Christiansen C" first="Claus" last="Christiansen">Claus Christiansen</name><affiliation><nlm:aff id="A43">Nordic Bioscience, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A" last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics and Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><affiliation><nlm:aff id="A45">Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H" last="Van Den Berg">Leonard H. Van Den Berg</name><affiliation><nlm:aff id="A46">Rudolf Magnus Institute of Neuroscience and Department of Neurology, University Medical Center, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Veldink, Jan" sort="Veldink, Jan" uniqKey="Veldink J" first="Jan" last="Veldink">Jan Veldink</name><affiliation><nlm:aff id="A46">Rudolf Magnus Institute of Neuroscience and Department of Neurology, University Medical Center, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Curran, Sarah" sort="Curran, Sarah" uniqKey="Curran S" first="Sarah" last="Curran">Sarah Curran</name><affiliation><nlm:aff id="A20">Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King’s College, London UK</nlm:aff></affiliation></author><author><name sortKey="Bolton, Patrick" sort="Bolton, Patrick" uniqKey="Bolton P" first="Patrick" last="Bolton">Patrick Bolton</name><affiliation><nlm:aff id="A20">Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King’s College, London UK</nlm:aff></affiliation></author><author><name sortKey="Poot, Martin" sort="Poot, Martin" uniqKey="Poot M" first="Martin" last="Poot">Martin Poot</name><affiliation><nlm:aff id="A30">Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Staal, Wouter" sort="Staal, Wouter" uniqKey="Staal W" first="Wouter" last="Staal">Wouter Staal</name><affiliation><nlm:aff id="A48">Department of Cognitive Neuroscience, Radboud University Nijmegen, Nijmegen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rehnstrom, Karola" sort="Rehnstrom, Karola" uniqKey="Rehnstrom K" first="Karola" last="Rehnstrom">Karola Rehnstrom</name><affiliation><nlm:aff id="A11">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kilpinen, Helena" sort="Kilpinen, Helena" uniqKey="Kilpinen H" first="Helena" last="Kilpinen">Helena Kilpinen</name><affiliation><nlm:aff id="A11">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Freitag, Christine M" sort="Freitag, Christine M" uniqKey="Freitag C" first="Christine M" last="Freitag">Christine M. Freitag</name><affiliation><nlm:aff id="A49">Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Frankfurt am Main, Frankfurt am Main, Germany</nlm:aff></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation><nlm:aff id="A50">Department of Neurobehavioural Genetics, University of Trier, Trier, Germany</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Pall" sort="Magnusson, Pall" uniqKey="Magnusson P" first="Pall" last="Magnusson">Pall Magnusson</name><affiliation><nlm:aff id="A51">Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Saemundsen, Evald" sort="Saemundsen, Evald" uniqKey="Saemundsen E" first="Evald" last="Saemundsen">Evald Saemundsen</name><affiliation><nlm:aff id="A52">State Diagnostic and Counseling Centre, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Martsenkovsky, Igor" sort="Martsenkovsky, Igor" uniqKey="Martsenkovsky I" first="Igor" last="Martsenkovsky">Igor Martsenkovsky</name><affiliation><nlm:aff id="A53">Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine</nlm:aff></affiliation></author><author><name sortKey="Bikshaieva, Iana" sort="Bikshaieva, Iana" uniqKey="Bikshaieva I" first="Iana" last="Bikshaieva">Iana Bikshaieva</name><affiliation><nlm:aff id="A53">Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine</nlm:aff></affiliation></author><author><name sortKey="Martsenkovska, Inna" sort="Martsenkovska, Inna" uniqKey="Martsenkovska I" first="Inna" last="Martsenkovska">Inna Martsenkovska</name><affiliation><nlm:aff id="A53">Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine</nlm:aff></affiliation></author><author><name sortKey="Vashchenko, Olesya" sort="Vashchenko, Olesya" uniqKey="Vashchenko O" first="Olesya" last="Vashchenko">Olesya Vashchenko</name><affiliation><nlm:aff id="A53">Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine</nlm:aff></affiliation></author><author><name sortKey="Raleva, Marija" sort="Raleva, Marija" uniqKey="Raleva M" first="Marija" last="Raleva">Marija Raleva</name><affiliation><nlm:aff id="A54">Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia</nlm:aff></affiliation></author><author><name sortKey="Paketchieva, Kamka" sort="Paketchieva, Kamka" uniqKey="Paketchieva K" first="Kamka" last="Paketchieva">Kamka Paketchieva</name><affiliation><nlm:aff id="A54">Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia</nlm:aff></affiliation></author><author><name sortKey="Stefanovski, Branislav" sort="Stefanovski, Branislav" uniqKey="Stefanovski B" first="Branislav" last="Stefanovski">Branislav Stefanovski</name><affiliation><nlm:aff id="A54">Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia</nlm:aff></affiliation></author><author><name sortKey="Durmishi, Naser" sort="Durmishi, Naser" uniqKey="Durmishi N" first="Naser" last="Durmishi">Naser Durmishi</name><affiliation><nlm:aff id="A54">Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia</nlm:aff></affiliation></author><author><name sortKey="Milovancevic, Milica Pejovic" sort="Milovancevic, Milica Pejovic" uniqKey="Milovancevic M" first="Milica Pejovic" last="Milovancevic">Milica Pejovic Milovancevic</name><affiliation><nlm:aff id="A55">Institute of Mental Health, Belgrade, Serbia</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Medical Faculty, University of Belgrade, Belgrade, Serbia</nlm:aff></affiliation></author><author><name sortKey="Tosevski, Dusica Lecic" sort="Tosevski, Dusica Lecic" uniqKey="Tosevski D" first="Dusica Lecic" last="Tosevski">Dusica Lecic Tosevski</name><affiliation><nlm:aff id="A55">Institute of Mental Health, Belgrade, Serbia</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Medical Faculty, University of Belgrade, Belgrade, Serbia</nlm:aff></affiliation></author><author><name sortKey="Silagadze, Teimuraz" sort="Silagadze, Teimuraz" uniqKey="Silagadze T" first="Teimuraz" last="Silagadze">Teimuraz Silagadze</name><affiliation><nlm:aff id="A57">Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Naneishvili, Nino" sort="Naneishvili, Nino" uniqKey="Naneishvili N" first="Nino" last="Naneishvili">Nino Naneishvili</name><affiliation><nlm:aff id="A57">Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Mikeladze, Nina" sort="Mikeladze, Nina" uniqKey="Mikeladze N" first="Nina" last="Mikeladze">Nina Mikeladze</name><affiliation><nlm:aff id="A57">Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Surguladze, Simon" sort="Surguladze, Simon" uniqKey="Surguladze S" first="Simon" last="Surguladze">Simon Surguladze</name><affiliation><nlm:aff id="A58">Social & Affective Neuroscience Lab, Ilia State University, Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Vincent, John B" sort="Vincent, John B" uniqKey="Vincent J" first="John B" last="Vincent">John B. Vincent</name><affiliation><nlm:aff id="A59">Molecular Neuropsychiatry and Development Laboratory, Centre for Addiction and Mental Health (CAMH), Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Farmer, Anne" sort="Farmer, Anne" uniqKey="Farmer A" first="Anne" last="Farmer">Anne Farmer</name><affiliation><nlm:aff id="A20">Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B" last="Mitchell">Philip B. Mitchell</name><affiliation><nlm:aff id="A60">Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A61">School of Psychiatry, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation><nlm:aff id="A60">Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A61">School of Psychiatry, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name><affiliation><nlm:aff id="A62">Neuroscience Research Australia, Barker Street, Randwick, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A63">School of Medical Sciences, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M" last="Fullerton">Janice M. Fullerton</name><affiliation><nlm:aff id="A62">Neuroscience Research Australia, Barker Street, Randwick, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A63">School of Medical Sciences, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Rubino, I Alex" sort="Rubino, I Alex" uniqKey="Rubino I" first="I Alex" last="Rubino">I Alex Rubino</name><affiliation><nlm:aff id="A41">Department of Neuroscience, Section of Psychiatry, University of Rome-Tor Vergata, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Van Winkel, Ruud" sort="Van Winkel, Ruud" uniqKey="Van Winkel R" first="Ruud" last="Van Winkel">Ruud Van Winkel</name><affiliation><nlm:aff id="A65">University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kenis, Gunter" sort="Kenis, Gunter" uniqKey="Kenis G" first="Gunter" last="Kenis">Gunter Kenis</name><affiliation><nlm:aff id="A66">Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Hert, Marc" sort="De Hert, Marc" uniqKey="De Hert M" first="Marc" last="De Hert">Marc De Hert</name><affiliation><nlm:aff id="A65">University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium</nlm:aff></affiliation></author><author><name sortKey="Rethelyi, Janos M" sort="Rethelyi, Janos M" uniqKey="Rethelyi J" first="János M" last="Réthelyi">János M. Réthelyi</name><affiliation><nlm:aff id="A67">Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Bitter, Istvan" sort="Bitter, Istvan" uniqKey="Bitter I" first="István" last="Bitter">István Bitter</name><affiliation><nlm:aff id="A67">Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Terenius, Lars" sort="Terenius, Lars" uniqKey="Terenius L" first="Lars" last="Terenius">Lars Terenius</name><affiliation><nlm:aff id="A68">Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Jonsson, Erik G" sort="Jonsson, Erik G" uniqKey="Jonsson E" first="Erik G" last="Jönsson">Erik G. Jönsson</name><affiliation><nlm:aff id="A68">Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bakker, Steven" sort="Bakker, Steven" uniqKey="Bakker S" first="Steven" last="Bakker">Steven Bakker</name><affiliation><nlm:aff id="A69">Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Os, Jim" sort="Van Os, Jim" uniqKey="Van Os J" first="Jim" last="Van Os">Jim Van Os</name><affiliation><nlm:aff id="A70">Department of Psychiatry, Maastricht University Medical Centre, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jablensky, Assen" sort="Jablensky, Assen" uniqKey="Jablensky A" first="Assen" last="Jablensky">Assen Jablensky</name><affiliation><nlm:aff id="A71">Centre for Clinical Research in Neuropsychiatry (CCRN), Graylands Hospital, the University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Bramon, Elvira" sort="Bramon, Elvira" uniqKey="Bramon E" first="Elvira" last="Bramon">Elvira Bramon</name><affiliation><nlm:aff id="A72">Mental Health Sciences Unit and Institute of Cognitive Neuroscience, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Powell, John" sort="Powell, John" uniqKey="Powell J" first="John" last="Powell">John Powell</name><affiliation><nlm:aff id="A14">Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Murray, Robin" sort="Murray, Robin" uniqKey="Murray R" first="Robin" last="Murray">Robin Murray</name><affiliation><nlm:aff id="A73">Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Corvin, Aiden" sort="Corvin, Aiden" uniqKey="Corvin A" first="Aiden" last="Corvin">Aiden Corvin</name><affiliation><nlm:aff id="A74">Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name><affiliation><nlm:aff id="A74">Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Morris, Derek" sort="Morris, Derek" uniqKey="Morris D" first="Derek" last="Morris">Derek Morris</name><affiliation><nlm:aff id="A74">Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="O Eill, F Anthony" sort="O Eill, F Anthony" uniqKey="O Eill F" first="F Anthony" last="O Eill">F Anthony O Eill</name><affiliation><nlm:aff id="A75">Department of Psychiatry, Queens University, Belfast, UK</nlm:aff></affiliation></author><author><name sortKey="Kendler, Ken" sort="Kendler, Ken" uniqKey="Kendler K" first="Ken" last="Kendler">Ken Kendler</name><affiliation><nlm:aff id="A76">Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A78">Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Riley, Brien" sort="Riley, Brien" uniqKey="Riley B" first="Brien" last="Riley">Brien Riley</name><affiliation><nlm:aff id="A76">Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A78">Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Craddock, Nick" sort="Craddock, Nick" uniqKey="Craddock N" first="Nick" last="Craddock">Nick Craddock</name><affiliation><nlm:aff id="A79">MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J" last="Owen">Michael J. Owen</name><affiliation><nlm:aff id="A79">MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="O Onovan, Michael C" sort="O Onovan, Michael C" uniqKey="O Onovan M" first="Michael C" last="O Onovan">Michael C. O Onovan</name><affiliation><nlm:aff id="A79">MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Kong, Augustine" sort="Kong, Augustine" uniqKey="Kong A" first="Augustine" last="Kong">Augustine Kong</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Ehrenreich, Hannelore" sort="Ehrenreich, Hannelore" uniqKey="Ehrenreich H" first="Hannelore" last="Ehrenreich">Hannelore Ehrenreich</name><affiliation><nlm:aff id="A15">DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Carracedo, Angel" sort="Carracedo, Angel" uniqKey="Carracedo A" first="Angel" last="Carracedo">Angel Carracedo</name><affiliation><nlm:aff id="A80">Genomic Medicine Group - Galician Foundation of Genomic Medicine-Biomedical Network Research Centre on Rare Diseases (CIBERER), University of Santiago de Compostela, Spain</nlm:aff></affiliation></author><author><name sortKey="Golimbet, Vera" sort="Golimbet, Vera" uniqKey="Golimbet V" first="Vera" last="Golimbet">Vera Golimbet</name><affiliation><nlm:aff id="A35">Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Andreassen, Ole A" sort="Andreassen, Ole A" uniqKey="Andreassen O" first="Ole A" last="Andreassen">Ole A. Andreassen</name><affiliation><nlm:aff id="A25">KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="B Rglum, Anders D" sort="B Rglum, Anders D" uniqKey="B Rglum A" first="Anders D" last="B Rglum">Anders D. B Rglum</name><affiliation><nlm:aff id="A7">Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark</nlm:aff></affiliation></author><author><name sortKey="Mors, Ole" sort="Mors, Ole" uniqKey="Mors O" first="Ole" last="Mors">Ole Mors</name><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark</nlm:aff></affiliation></author><author><name sortKey="Mortensen, Preben B" sort="Mortensen, Preben B" uniqKey="Mortensen P" first="Preben B" last="Mortensen">Preben B. Mortensen</name><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation><affiliation><nlm:aff id="A82">National Centre for Register-based Research, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Werge, Thomas" sort="Werge, Thomas" uniqKey="Werge T" first="Thomas" last="Werge">Thomas Werge</name><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Institute of Biological Psychiatry, Mental Health Centre Sct Hans & Copenhagen University, Roskilde, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A" last="Ophoff">Roel A. Ophoff</name><affiliation><nlm:aff id="A2">Center for Neurobehavioral Genetics, UCLA, Los Angeles, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:aff id="A83">German Center for Neurodegenerative Disorders (DZNE), Bonn Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation><nlm:aff id="A22">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation><nlm:aff id="A5">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Institute of Neurosciences and Medicine (INM-1), Juelich, Germany</nlm:aff></affiliation></author><author><name sortKey="Ruggeri, Mirella" sort="Ruggeri, Mirella" uniqKey="Ruggeri M" first="Mirella" last="Ruggeri">Mirella Ruggeri</name><affiliation><nlm:aff id="A86">Section of Psychiatry, University of Verona, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Tosato, Sarah" sort="Tosato, Sarah" uniqKey="Tosato S" first="Sarah" last="Tosato">Sarah Tosato</name><affiliation><nlm:aff id="A86">Section of Psychiatry, University of Verona, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff id="A11">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="St Clair, David" sort="St Clair, David" uniqKey="St Clair D" first="David" last="St Clair">David St Clair</name><affiliation><nlm:aff id="A23">Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK</nlm:aff></affiliation></author><author><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name><affiliation><nlm:aff id="A21">Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany</nlm:aff></affiliation></author><author><name sortKey="Collier, David A" sort="Collier, David A" uniqKey="Collier D" first="David A" last="Collier">David A. Collier</name><affiliation><nlm:aff id="A20">Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Eli Lilly and Co. Ltd, Erl Wood Manor, Windlesham, Surrey, UK</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Hreinn" sort="Stefansson, Hreinn" uniqKey="Stefansson H" first="Hreinn" last="Stefansson">Hreinn Stefansson</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23164818</idno><idno type="pmc">3872086</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872086</idno><idno type="RBID">PMC:3872086</idno><idno type="doi">10.1038/mp.2012.157</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000135</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000135</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common Variant at 16p11.2 Conferring Risk of Psychosis</title><author><name sortKey="Steinberg, Stacy" sort="Steinberg, Stacy" uniqKey="Steinberg S" first="Stacy" last="Steinberg">Stacy Steinberg</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="De Jong, Simone" sort="De Jong, Simone" uniqKey="De Jong S" first="Simone" last="De Jong">Simone De Jong</name><affiliation><nlm:aff id="A2">Center for Neurobehavioral Genetics, UCLA, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name><affiliation><nlm:aff id="A3">Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Institute for Genomic Mathematics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Costas, Javier" sort="Costas, Javier" uniqKey="Costas J" first="Javier" last="Costas">Javier Costas</name><affiliation><nlm:aff id="A6">Galician Foundation of Genomic Medicine-SERGAS, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain</nlm:aff></affiliation></author><author><name sortKey="Demontis, Ditte" sort="Demontis, Ditte" uniqKey="Demontis D" first="Ditte" last="Demontis">Ditte Demontis</name><affiliation><nlm:aff id="A7">Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation></author><author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stéphane" last="Jamain">Stéphane Jamain</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Pietil Inen, Olli P H" sort="Pietil Inen, Olli P H" uniqKey="Pietil Inen O" first="Olli P H" last="Pietil Inen">Olli P H. Pietil Inen</name><affiliation><nlm:aff id="A11">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Institute for Health and Welfare, Public Genomics Unit, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lin, Kuang" sort="Lin, Kuang" uniqKey="Lin K" first="Kuang" last="Lin">Kuang Lin</name><affiliation><nlm:aff id="A14">Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Papiol, Sergi" sort="Papiol, Sergi" uniqKey="Papiol S" first="Sergi" last="Papiol">Sergi Papiol</name><affiliation><nlm:aff id="A15">DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Huttenlocher, Johanna" sort="Huttenlocher, Johanna" uniqKey="Huttenlocher J" first="Johanna" last="Huttenlocher">Johanna Huttenlocher</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Medical Genetics, Institute of Human Genetics, University of Tübingen, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sigurdsson, Engilbert" sort="Sigurdsson, Engilbert" uniqKey="Sigurdsson E" first="Engilbert" last="Sigurdsson">Engilbert Sigurdsson</name><affiliation><nlm:aff id="A18">Department of Psychiatry, National University Hospital, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Vassos, Evangelos" sort="Vassos, Evangelos" uniqKey="Vassos E" first="Evangelos" last="Vassos">Evangelos Vassos</name><affiliation><nlm:aff id="A20">Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Giegling, Ina" sort="Giegling, Ina" uniqKey="Giegling I" first="Ina" last="Giegling">Ina Giegling</name><affiliation><nlm:aff id="A21">Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Breuer, Rene" sort="Breuer, Rene" uniqKey="Breuer R" first="René" last="Breuer">René Breuer</name><affiliation><nlm:aff id="A22">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Fraser, Gillian" sort="Fraser, Gillian" uniqKey="Fraser G" first="Gillian" last="Fraser">Gillian Fraser</name><affiliation><nlm:aff id="A23">Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK</nlm:aff></affiliation></author><author><name sortKey="Walker, Nicholas" sort="Walker, Nicholas" uniqKey="Walker N" first="Nicholas" last="Walker">Nicholas Walker</name><affiliation><nlm:aff id="A24">Ravenscraig Hospital, Greenock, UK</nlm:aff></affiliation></author><author><name sortKey="Melle, Ingrid" sort="Melle, Ingrid" uniqKey="Melle I" first="Ingrid" last="Melle">Ingrid Melle</name><affiliation><nlm:aff id="A25">KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Djurovic, Srdjan" sort="Djurovic, Srdjan" uniqKey="Djurovic S" first="Srdjan" last="Djurovic">Srdjan Djurovic</name><affiliation><nlm:aff id="A25">KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Agartz, Ingrid" sort="Agartz, Ingrid" uniqKey="Agartz I" first="Ingrid" last="Agartz">Ingrid Agartz</name><affiliation><nlm:aff id="A25">KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Tuulio Henriksson, Annamari" sort="Tuulio Henriksson, Annamari" uniqKey="Tuulio Henriksson A" first="Annamari" last="Tuulio-Henriksson">Annamari Tuulio-Henriksson</name><affiliation><nlm:aff id="A26">Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Suvisaari, Jaana" sort="Suvisaari, Jaana" uniqKey="Suvisaari J" first="Jaana" last="Suvisaari">Jaana Suvisaari</name><affiliation><nlm:aff id="A26">Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Lonnqvist, Jouko" sort="Lonnqvist, Jouko" uniqKey="Lonnqvist J" first="Jouko" last="Lönnqvist">Jouko Lönnqvist</name><affiliation><nlm:aff id="A26">Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Paunio, Tiina" sort="Paunio, Tiina" uniqKey="Paunio T" first="Tiina" last="Paunio">Tiina Paunio</name><affiliation><nlm:aff id="A27">Public Health Genomics Unit, National Institute for Health and Welfare THL, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Olsen, Line" sort="Olsen, Line" uniqKey="Olsen L" first="Line" last="Olsen">Line Olsen</name><affiliation><nlm:aff id="A28">Institute of Biological Psychiatry, Mental Health Centre Sct Hans & Copenhagen University, Roskilde, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas" sort="Hansen, Thomas" uniqKey="Hansen T" first="Thomas" last="Hansen">Thomas Hansen</name><affiliation><nlm:aff id="A28">Institute of Biological Psychiatry, Mental Health Centre Sct Hans & Copenhagen University, Roskilde, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ingason, Andres" sort="Ingason, Andres" uniqKey="Ingason A" first="Andres" last="Ingason">Andres Ingason</name><affiliation><nlm:aff id="A28">Institute of Biological Psychiatry, Mental Health Centre Sct Hans & Copenhagen University, Roskilde, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pirinen, Matti" sort="Pirinen, Matti" uniqKey="Pirinen M" first="Matti" last="Pirinen">Matti Pirinen</name><affiliation><nlm:aff id="A29">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Strengman, Eric" sort="Strengman, Eric" uniqKey="Strengman E" first="Eric" last="Strengman">Eric Strengman</name><affiliation><nlm:aff id="A30">Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hougaard, David M" sort="Hougaard, David M" uniqKey="Hougaard D" first="David M" last="Hougaard">David M. Hougaard</name><affiliation><nlm:aff id="A31">Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey=" Rntoft, Torben" sort=" Rntoft, Torben" uniqKey=" Rntoft T" first="Torben" last=" Rntoft">Torben Rntoft</name><affiliation><nlm:aff id="A32">Department of Molecular Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Didriksen, Michael" sort="Didriksen, Michael" uniqKey="Didriksen M" first="Michael" last="Didriksen">Michael Didriksen</name><affiliation><nlm:aff id="A33">Synaptic transmission, H. Lundbeck A/S, Valby, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hollegaard, Mads V" sort="Hollegaard, Mads V" uniqKey="Hollegaard M" first="Mads V" last="Hollegaard">Mads V. Hollegaard</name><affiliation><nlm:aff id="A31">Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordentoft, Merete" sort="Nordentoft, Merete" uniqKey="Nordentoft M" first="Merete" last="Nordentoft">Merete Nordentoft</name><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Psychiatric Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Abramova, Lilia" sort="Abramova, Lilia" uniqKey="Abramova L" first="Lilia" last="Abramova">Lilia Abramova</name><affiliation><nlm:aff id="A35">Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Kaleda, Vasily" sort="Kaleda, Vasily" uniqKey="Kaleda V" first="Vasily" last="Kaleda">Vasily Kaleda</name><affiliation><nlm:aff id="A35">Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Arrojo, Manuel" sort="Arrojo, Manuel" uniqKey="Arrojo M" first="Manuel" last="Arrojo">Manuel Arrojo</name><affiliation><nlm:aff id="A36">Service of Psychiatry, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain</nlm:aff></affiliation></author><author><name sortKey="Sanjuan, Julio" sort="Sanjuan, Julio" uniqKey="Sanjuan J" first="Julio" last="Sanjuán">Julio Sanjuán</name><affiliation><nlm:aff id="A37">Unit of Psychiatry, Faculty of Medicine, University of Valencia, Network Center of Biomedical Research on Mental Health (CIBERSAM), Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Arango, Celso" sort="Arango, Celso" uniqKey="Arango C" first="Celso" last="Arango">Celso Arango</name><affiliation><nlm:aff id="A38">Hospital General Universitario Gregorio Marañón, IiSGM, Universidad Complutense, CIBERSAM, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Etain">Bruno Etain</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Meary, Alexandre" sort="Meary, Alexandre" uniqKey="Meary A" first="Alexandre" last="Méary">Alexandre Méary</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation></author><author><name sortKey="Schurhoff, Franck" sort="Schurhoff, Franck" uniqKey="Schurhoff F" first="Franck" last="Schürhoff">Franck Schürhoff</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Szoke, Andrei" sort="Szoke, Andrei" uniqKey="Szoke A" first="Andrei" last="Szoke">Andrei Szoke</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation></author><author><name sortKey="Ribolsi, Michele" sort="Ribolsi, Michele" uniqKey="Ribolsi M" first="Michele" last="Ribolsi">Michele Ribolsi</name><affiliation><nlm:aff id="A41">Department of Neuroscience, Section of Psychiatry, University of Rome-Tor Vergata, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Magni, Valentina" sort="Magni, Valentina" uniqKey="Magni V" first="Valentina" last="Magni">Valentina Magni</name><affiliation><nlm:aff id="A41">Department of Neuroscience, Section of Psychiatry, University of Rome-Tor Vergata, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Siracusano, Alberto" sort="Siracusano, Alberto" uniqKey="Siracusano A" first="Alberto" last="Siracusano">Alberto Siracusano</name><affiliation><nlm:aff id="A41">Department of Neuroscience, Section of Psychiatry, University of Rome-Tor Vergata, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Sperling, Swetlana" sort="Sperling, Swetlana" uniqKey="Sperling S" first="Swetlana" last="Sperling">Swetlana Sperling</name><affiliation><nlm:aff id="A16">Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Rossner, Moritz" sort="Rossner, Moritz" uniqKey="Rossner M" first="Moritz" last="Rossner">Moritz Rossner</name><affiliation><nlm:aff id="A15">DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Christiansen, Claus" sort="Christiansen, Claus" uniqKey="Christiansen C" first="Claus" last="Christiansen">Claus Christiansen</name><affiliation><nlm:aff id="A43">Nordic Bioscience, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A" last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A44">Department of Epidemiology and Biostatistics and Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><affiliation><nlm:aff id="A45">Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H" last="Van Den Berg">Leonard H. Van Den Berg</name><affiliation><nlm:aff id="A46">Rudolf Magnus Institute of Neuroscience and Department of Neurology, University Medical Center, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Veldink, Jan" sort="Veldink, Jan" uniqKey="Veldink J" first="Jan" last="Veldink">Jan Veldink</name><affiliation><nlm:aff id="A46">Rudolf Magnus Institute of Neuroscience and Department of Neurology, University Medical Center, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Curran, Sarah" sort="Curran, Sarah" uniqKey="Curran S" first="Sarah" last="Curran">Sarah Curran</name><affiliation><nlm:aff id="A20">Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King’s College, London UK</nlm:aff></affiliation></author><author><name sortKey="Bolton, Patrick" sort="Bolton, Patrick" uniqKey="Bolton P" first="Patrick" last="Bolton">Patrick Bolton</name><affiliation><nlm:aff id="A20">Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King’s College, London UK</nlm:aff></affiliation></author><author><name sortKey="Poot, Martin" sort="Poot, Martin" uniqKey="Poot M" first="Martin" last="Poot">Martin Poot</name><affiliation><nlm:aff id="A30">Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Staal, Wouter" sort="Staal, Wouter" uniqKey="Staal W" first="Wouter" last="Staal">Wouter Staal</name><affiliation><nlm:aff id="A48">Department of Cognitive Neuroscience, Radboud University Nijmegen, Nijmegen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rehnstrom, Karola" sort="Rehnstrom, Karola" uniqKey="Rehnstrom K" first="Karola" last="Rehnstrom">Karola Rehnstrom</name><affiliation><nlm:aff id="A11">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Kilpinen, Helena" sort="Kilpinen, Helena" uniqKey="Kilpinen H" first="Helena" last="Kilpinen">Helena Kilpinen</name><affiliation><nlm:aff id="A11">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Freitag, Christine M" sort="Freitag, Christine M" uniqKey="Freitag C" first="Christine M" last="Freitag">Christine M. Freitag</name><affiliation><nlm:aff id="A49">Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Frankfurt am Main, Frankfurt am Main, Germany</nlm:aff></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation><nlm:aff id="A50">Department of Neurobehavioural Genetics, University of Trier, Trier, Germany</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Pall" sort="Magnusson, Pall" uniqKey="Magnusson P" first="Pall" last="Magnusson">Pall Magnusson</name><affiliation><nlm:aff id="A51">Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Saemundsen, Evald" sort="Saemundsen, Evald" uniqKey="Saemundsen E" first="Evald" last="Saemundsen">Evald Saemundsen</name><affiliation><nlm:aff id="A52">State Diagnostic and Counseling Centre, Kopavogur, Iceland</nlm:aff></affiliation></author><author><name sortKey="Martsenkovsky, Igor" sort="Martsenkovsky, Igor" uniqKey="Martsenkovsky I" first="Igor" last="Martsenkovsky">Igor Martsenkovsky</name><affiliation><nlm:aff id="A53">Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine</nlm:aff></affiliation></author><author><name sortKey="Bikshaieva, Iana" sort="Bikshaieva, Iana" uniqKey="Bikshaieva I" first="Iana" last="Bikshaieva">Iana Bikshaieva</name><affiliation><nlm:aff id="A53">Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine</nlm:aff></affiliation></author><author><name sortKey="Martsenkovska, Inna" sort="Martsenkovska, Inna" uniqKey="Martsenkovska I" first="Inna" last="Martsenkovska">Inna Martsenkovska</name><affiliation><nlm:aff id="A53">Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine</nlm:aff></affiliation></author><author><name sortKey="Vashchenko, Olesya" sort="Vashchenko, Olesya" uniqKey="Vashchenko O" first="Olesya" last="Vashchenko">Olesya Vashchenko</name><affiliation><nlm:aff id="A53">Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine</nlm:aff></affiliation></author><author><name sortKey="Raleva, Marija" sort="Raleva, Marija" uniqKey="Raleva M" first="Marija" last="Raleva">Marija Raleva</name><affiliation><nlm:aff id="A54">Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia</nlm:aff></affiliation></author><author><name sortKey="Paketchieva, Kamka" sort="Paketchieva, Kamka" uniqKey="Paketchieva K" first="Kamka" last="Paketchieva">Kamka Paketchieva</name><affiliation><nlm:aff id="A54">Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia</nlm:aff></affiliation></author><author><name sortKey="Stefanovski, Branislav" sort="Stefanovski, Branislav" uniqKey="Stefanovski B" first="Branislav" last="Stefanovski">Branislav Stefanovski</name><affiliation><nlm:aff id="A54">Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia</nlm:aff></affiliation></author><author><name sortKey="Durmishi, Naser" sort="Durmishi, Naser" uniqKey="Durmishi N" first="Naser" last="Durmishi">Naser Durmishi</name><affiliation><nlm:aff id="A54">Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia</nlm:aff></affiliation></author><author><name sortKey="Milovancevic, Milica Pejovic" sort="Milovancevic, Milica Pejovic" uniqKey="Milovancevic M" first="Milica Pejovic" last="Milovancevic">Milica Pejovic Milovancevic</name><affiliation><nlm:aff id="A55">Institute of Mental Health, Belgrade, Serbia</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Medical Faculty, University of Belgrade, Belgrade, Serbia</nlm:aff></affiliation></author><author><name sortKey="Tosevski, Dusica Lecic" sort="Tosevski, Dusica Lecic" uniqKey="Tosevski D" first="Dusica Lecic" last="Tosevski">Dusica Lecic Tosevski</name><affiliation><nlm:aff id="A55">Institute of Mental Health, Belgrade, Serbia</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Medical Faculty, University of Belgrade, Belgrade, Serbia</nlm:aff></affiliation></author><author><name sortKey="Silagadze, Teimuraz" sort="Silagadze, Teimuraz" uniqKey="Silagadze T" first="Teimuraz" last="Silagadze">Teimuraz Silagadze</name><affiliation><nlm:aff id="A57">Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Naneishvili, Nino" sort="Naneishvili, Nino" uniqKey="Naneishvili N" first="Nino" last="Naneishvili">Nino Naneishvili</name><affiliation><nlm:aff id="A57">Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Mikeladze, Nina" sort="Mikeladze, Nina" uniqKey="Mikeladze N" first="Nina" last="Mikeladze">Nina Mikeladze</name><affiliation><nlm:aff id="A57">Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Surguladze, Simon" sort="Surguladze, Simon" uniqKey="Surguladze S" first="Simon" last="Surguladze">Simon Surguladze</name><affiliation><nlm:aff id="A58">Social & Affective Neuroscience Lab, Ilia State University, Tbilisi, Georgia</nlm:aff></affiliation></author><author><name sortKey="Vincent, John B" sort="Vincent, John B" uniqKey="Vincent J" first="John B" last="Vincent">John B. Vincent</name><affiliation><nlm:aff id="A59">Molecular Neuropsychiatry and Development Laboratory, Centre for Addiction and Mental Health (CAMH), Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Farmer, Anne" sort="Farmer, Anne" uniqKey="Farmer A" first="Anne" last="Farmer">Anne Farmer</name><affiliation><nlm:aff id="A20">Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B" last="Mitchell">Philip B. Mitchell</name><affiliation><nlm:aff id="A60">Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A61">School of Psychiatry, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation><nlm:aff id="A60">Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A61">School of Psychiatry, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name><affiliation><nlm:aff id="A62">Neuroscience Research Australia, Barker Street, Randwick, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A63">School of Medical Sciences, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M" last="Fullerton">Janice M. Fullerton</name><affiliation><nlm:aff id="A62">Neuroscience Research Australia, Barker Street, Randwick, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A63">School of Medical Sciences, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Rubino, I Alex" sort="Rubino, I Alex" uniqKey="Rubino I" first="I Alex" last="Rubino">I Alex Rubino</name><affiliation><nlm:aff id="A41">Department of Neuroscience, Section of Psychiatry, University of Rome-Tor Vergata, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Van Winkel, Ruud" sort="Van Winkel, Ruud" uniqKey="Van Winkel R" first="Ruud" last="Van Winkel">Ruud Van Winkel</name><affiliation><nlm:aff id="A65">University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kenis, Gunter" sort="Kenis, Gunter" uniqKey="Kenis G" first="Gunter" last="Kenis">Gunter Kenis</name><affiliation><nlm:aff id="A66">Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Hert, Marc" sort="De Hert, Marc" uniqKey="De Hert M" first="Marc" last="De Hert">Marc De Hert</name><affiliation><nlm:aff id="A65">University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium</nlm:aff></affiliation></author><author><name sortKey="Rethelyi, Janos M" sort="Rethelyi, Janos M" uniqKey="Rethelyi J" first="János M" last="Réthelyi">János M. Réthelyi</name><affiliation><nlm:aff id="A67">Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Bitter, Istvan" sort="Bitter, Istvan" uniqKey="Bitter I" first="István" last="Bitter">István Bitter</name><affiliation><nlm:aff id="A67">Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Terenius, Lars" sort="Terenius, Lars" uniqKey="Terenius L" first="Lars" last="Terenius">Lars Terenius</name><affiliation><nlm:aff id="A68">Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Jonsson, Erik G" sort="Jonsson, Erik G" uniqKey="Jonsson E" first="Erik G" last="Jönsson">Erik G. Jönsson</name><affiliation><nlm:aff id="A68">Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bakker, Steven" sort="Bakker, Steven" uniqKey="Bakker S" first="Steven" last="Bakker">Steven Bakker</name><affiliation><nlm:aff id="A69">Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Os, Jim" sort="Van Os, Jim" uniqKey="Van Os J" first="Jim" last="Van Os">Jim Van Os</name><affiliation><nlm:aff id="A70">Department of Psychiatry, Maastricht University Medical Centre, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jablensky, Assen" sort="Jablensky, Assen" uniqKey="Jablensky A" first="Assen" last="Jablensky">Assen Jablensky</name><affiliation><nlm:aff id="A71">Centre for Clinical Research in Neuropsychiatry (CCRN), Graylands Hospital, the University of Western Australia, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation><nlm:aff id="A9">Fondation FondaMental, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">INSERM U 955, Psychiatrie Génétique, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Bramon, Elvira" sort="Bramon, Elvira" uniqKey="Bramon E" first="Elvira" last="Bramon">Elvira Bramon</name><affiliation><nlm:aff id="A72">Mental Health Sciences Unit and Institute of Cognitive Neuroscience, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Powell, John" sort="Powell, John" uniqKey="Powell J" first="John" last="Powell">John Powell</name><affiliation><nlm:aff id="A14">Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Murray, Robin" sort="Murray, Robin" uniqKey="Murray R" first="Robin" last="Murray">Robin Murray</name><affiliation><nlm:aff id="A73">Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Corvin, Aiden" sort="Corvin, Aiden" uniqKey="Corvin A" first="Aiden" last="Corvin">Aiden Corvin</name><affiliation><nlm:aff id="A74">Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name><affiliation><nlm:aff id="A74">Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Morris, Derek" sort="Morris, Derek" uniqKey="Morris D" first="Derek" last="Morris">Derek Morris</name><affiliation><nlm:aff id="A74">Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="O Eill, F Anthony" sort="O Eill, F Anthony" uniqKey="O Eill F" first="F Anthony" last="O Eill">F Anthony O Eill</name><affiliation><nlm:aff id="A75">Department of Psychiatry, Queens University, Belfast, UK</nlm:aff></affiliation></author><author><name sortKey="Kendler, Ken" sort="Kendler, Ken" uniqKey="Kendler K" first="Ken" last="Kendler">Ken Kendler</name><affiliation><nlm:aff id="A76">Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A78">Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Riley, Brien" sort="Riley, Brien" uniqKey="Riley B" first="Brien" last="Riley">Brien Riley</name><affiliation><nlm:aff id="A76">Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A78">Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA</nlm:aff></affiliation></author><author><name sortKey="Craddock, Nick" sort="Craddock, Nick" uniqKey="Craddock N" first="Nick" last="Craddock">Nick Craddock</name><affiliation><nlm:aff id="A79">MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J" last="Owen">Michael J. Owen</name><affiliation><nlm:aff id="A79">MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="O Onovan, Michael C" sort="O Onovan, Michael C" uniqKey="O Onovan M" first="Michael C" last="O Onovan">Michael C. O Onovan</name><affiliation><nlm:aff id="A79">MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Kong, Augustine" sort="Kong, Augustine" uniqKey="Kong A" first="Augustine" last="Kong">Augustine Kong</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Ehrenreich, Hannelore" sort="Ehrenreich, Hannelore" uniqKey="Ehrenreich H" first="Hannelore" last="Ehrenreich">Hannelore Ehrenreich</name><affiliation><nlm:aff id="A15">DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Carracedo, Angel" sort="Carracedo, Angel" uniqKey="Carracedo A" first="Angel" last="Carracedo">Angel Carracedo</name><affiliation><nlm:aff id="A80">Genomic Medicine Group - Galician Foundation of Genomic Medicine-Biomedical Network Research Centre on Rare Diseases (CIBERER), University of Santiago de Compostela, Spain</nlm:aff></affiliation></author><author><name sortKey="Golimbet, Vera" sort="Golimbet, Vera" uniqKey="Golimbet V" first="Vera" last="Golimbet">Vera Golimbet</name><affiliation><nlm:aff id="A35">Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia</nlm:aff></affiliation></author><author><name sortKey="Andreassen, Ole A" sort="Andreassen, Ole A" uniqKey="Andreassen O" first="Ole A" last="Andreassen">Ole A. Andreassen</name><affiliation><nlm:aff id="A25">KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="B Rglum, Anders D" sort="B Rglum, Anders D" uniqKey="B Rglum A" first="Anders D" last="B Rglum">Anders D. B Rglum</name><affiliation><nlm:aff id="A7">Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark</nlm:aff></affiliation></author><author><name sortKey="Mors, Ole" sort="Mors, Ole" uniqKey="Mors O" first="Ole" last="Mors">Ole Mors</name><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark</nlm:aff></affiliation></author><author><name sortKey="Mortensen, Preben B" sort="Mortensen, Preben B" uniqKey="Mortensen P" first="Preben B" last="Mortensen">Preben B. Mortensen</name><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation><affiliation><nlm:aff id="A82">National Centre for Register-based Research, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Werge, Thomas" sort="Werge, Thomas" uniqKey="Werge T" first="Thomas" last="Werge">Thomas Werge</name><affiliation><nlm:aff id="A8">The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Institute of Biological Psychiatry, Mental Health Centre Sct Hans & Copenhagen University, Roskilde, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A" last="Ophoff">Roel A. Ophoff</name><affiliation><nlm:aff id="A2">Center for Neurobehavioral Genetics, UCLA, Los Angeles, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:aff id="A83">German Center for Neurodegenerative Disorders (DZNE), Bonn Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation><nlm:aff id="A22">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation><nlm:aff id="A5">Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Institute of Neurosciences and Medicine (INM-1), Juelich, Germany</nlm:aff></affiliation></author><author><name sortKey="Ruggeri, Mirella" sort="Ruggeri, Mirella" uniqKey="Ruggeri M" first="Mirella" last="Ruggeri">Mirella Ruggeri</name><affiliation><nlm:aff id="A86">Section of Psychiatry, University of Verona, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Tosato, Sarah" sort="Tosato, Sarah" uniqKey="Tosato S" first="Sarah" last="Tosato">Sarah Tosato</name><affiliation><nlm:aff id="A86">Section of Psychiatry, University of Verona, Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:aff id="A11">Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="St Clair, David" sort="St Clair, David" uniqKey="St Clair D" first="David" last="St Clair">David St Clair</name><affiliation><nlm:aff id="A23">Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK</nlm:aff></affiliation></author><author><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name><affiliation><nlm:aff id="A21">Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany</nlm:aff></affiliation></author><author><name sortKey="Collier, David A" sort="Collier, David A" uniqKey="Collier D" first="David A" last="Collier">David A. Collier</name><affiliation><nlm:aff id="A20">Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Eli Lilly and Co. Ltd, Erl Wood Manor, Windlesham, Surrey, UK</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Hreinn" sort="Stefansson, Hreinn" uniqKey="Stefansson H" first="Hreinn" last="Stefansson">Hreinn Stefansson</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A1">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author></analytic><series><title level="j">Molecular psychiatry</title><idno type="ISSN">1359-4184</idno><idno type="eISSN">1476-5578</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association (GWA) study, meta-analysis and follow-up (totaling as many as 18,206 cases and 42,536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7,469 bipolar disorder cases, 1,535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46,160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T], OR = 1.08, <italic>P</italic> = 6.6 × 10<sup>−11</sup>). The new variant is located within a 593 kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (<italic>P</italic> = 0.0039 in the public GIANT consortium dataset; <italic>P</italic> = 0.00047 in 22,651 additional Icelanders).</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9607835</journal-id><journal-id journal-id-type="pubmed-jr-id">20545</journal-id><journal-id journal-id-type="nlm-ta">Mol Psychiatry</journal-id><journal-id journal-id-type="iso-abbrev">Mol. Psychiatry</journal-id><journal-title-group><journal-title>Molecular psychiatry</journal-title></journal-title-group><issn pub-type="ppub">1359-4184</issn><issn pub-type="epub">1476-5578</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23164818</article-id><article-id pub-id-type="pmc">3872086</article-id><article-id pub-id-type="doi">10.1038/mp.2012.157</article-id><article-id pub-id-type="manuscript">EMS54529</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Common Variant at 16p11.2 Conferring Risk of Psychosis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Steinberg</surname><given-names>Stacy</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>de Jong</surname><given-names>Simone</given-names></name><degrees>PhD</degrees><xref 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PhD</degrees><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Vashchenko</surname><given-names>Olesya</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Raleva</surname><given-names>Marija</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Paketchieva</surname><given-names>Kamka</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Stefanovski</surname><given-names>Branislav</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Durmishi</surname><given-names>Naser</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Milovancevic</surname><given-names>Milica Pejovic</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A55">55</xref><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Tosevski</surname><given-names>Dusica Lecic</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A55">55</xref><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Silagadze</surname><given-names>Teimuraz</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Naneishvili</surname><given-names>Nino</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Mikeladze</surname><given-names>Nina</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Surguladze</surname><given-names>Simon</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Vincent</surname><given-names>John B</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Farmer</surname><given-names>Anne</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Philip B</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A60">60</xref><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Adam</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A60">60</xref><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Schofield</surname><given-names>Peter R</given-names></name><degrees>PhD DSc</degrees><xref ref-type="aff" rid="A62">62</xref><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Fullerton</surname><given-names>Janice M</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A62">62</xref><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Montgomery</surname><given-names>Grant W</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Nicholas G</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Rubino</surname><given-names>I Alex</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>van Winkel</surname><given-names>Ruud</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A65">65</xref><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Kenis</surname><given-names>Gunter</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>De Hert</surname><given-names>Marc</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Réthelyi</surname><given-names>János M</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Bitter</surname><given-names>István</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Terenius</surname><given-names>Lars</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A68">68</xref></contrib><contrib contrib-type="author"><name><surname>Jönsson</surname><given-names>Erik G</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A68">68</xref></contrib><contrib contrib-type="author"><name><surname>Bakker</surname><given-names>Steven</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>van Os</surname><given-names>Jim</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A70">70</xref></contrib><contrib contrib-type="author"><name><surname>Jablensky</surname><given-names>Assen</given-names></name><degrees>MD DMSc</degrees><xref ref-type="aff" rid="A71">71</xref></contrib><contrib contrib-type="author"><name><surname>Leboyer</surname><given-names>Marion</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A39">39</xref><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Bramon</surname><given-names>Elvira</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A72">72</xref></contrib><contrib contrib-type="author"><name><surname>Powell</surname><given-names>John</given-names></name><degrees>DPhil</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Murray</surname><given-names>Robin</given-names></name><degrees>MD DSc FRS</degrees><xref ref-type="aff" rid="A73">73</xref></contrib><contrib contrib-type="author"><name><surname>Corvin</surname><given-names>Aiden</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Gill</surname><given-names>Michael</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Morris</surname><given-names>Derek</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>O’Neill</surname><given-names>F Anthony</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A75">75</xref></contrib><contrib contrib-type="author"><name><surname>Kendler</surname><given-names>Ken</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A76">76</xref><xref ref-type="aff" rid="A77">77</xref><xref ref-type="aff" rid="A78">78</xref></contrib><contrib contrib-type="author"><name><surname>Riley</surname><given-names>Brien</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A76">76</xref><xref ref-type="aff" rid="A77">77</xref><xref ref-type="aff" rid="A78">78</xref></contrib><contrib contrib-type="author"><collab>Wellcome Trust Case Control Consortium 2</collab><xref ref-type="author-notes" rid="FN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Craddock</surname><given-names>Nick</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A79">79</xref></contrib><contrib contrib-type="author"><name><surname>Owen</surname><given-names>Michael J</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A79">79</xref></contrib><contrib contrib-type="author"><name><surname>O’Donovan</surname><given-names>Michael C</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A79">79</xref></contrib><contrib contrib-type="author"><name><surname>Thorsteinsdottir</surname><given-names>Unnur</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Kong</surname><given-names>Augustine</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ehrenreich</surname><given-names>Hannelore</given-names></name><degrees>MD DVM</degrees><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Carracedo</surname><given-names>Angel</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A80">80</xref></contrib><contrib contrib-type="author"><name><surname>Golimbet</surname><given-names>Vera</given-names></name><degrees>PhD DrSci</degrees><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Andreassen</surname><given-names>Ole A</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Børglum</surname><given-names>Anders D</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A81">81</xref></contrib><contrib contrib-type="author"><name><surname>Mors</surname><given-names>Ole</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A81">81</xref></contrib><contrib contrib-type="author"><name><surname>Mortensen</surname><given-names>Preben B</given-names></name><degrees>MD DMedSci</degrees><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A82">82</xref></contrib><contrib contrib-type="author"><name><surname>Werge</surname><given-names>Thomas</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Ophoff</surname><given-names>Roel A</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>Nöthen</surname><given-names>Markus M</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A83">83</xref><xref ref-type="aff" rid="A84">84</xref></contrib><contrib contrib-type="author"><name><surname>Rietschel</surname><given-names>Marcella</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Cichon</surname><given-names>Sven</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A84">84</xref><xref ref-type="aff" rid="A85">85</xref></contrib><contrib contrib-type="author"><name><surname>Ruggeri</surname><given-names>Mirella</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A86">86</xref></contrib><contrib contrib-type="author"><name><surname>Tosato</surname><given-names>Sarah</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A86">86</xref></contrib><contrib contrib-type="author"><name><surname>Palotie</surname><given-names>Aarno</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A87">87</xref><xref ref-type="aff" rid="A88">88</xref></contrib><contrib contrib-type="author"><name><surname>St Clair</surname><given-names>David</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Rujescu</surname><given-names>Dan</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A89">89</xref></contrib><contrib contrib-type="author"><name><surname>Collier</surname><given-names>David A</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A90">90</xref></contrib><contrib contrib-type="author"><name><surname>Stefansson</surname><given-names>Hreinn</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Stefansson</surname><given-names>Kari</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A19">19</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>deCODE genetics, Reykjavik, Iceland</aff><aff id="A2"><label>2</label>Center for Neurobehavioral Genetics, UCLA, Los Angeles, California, USA</aff><aff id="A3"><label>3</label>Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</aff><aff id="A4"><label>4</label>Institute for Genomic Mathematics, University of Bonn, Bonn, Germany</aff><aff id="A5"><label>5</label>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</aff><aff id="A6"><label>6</label>Galician Foundation of Genomic Medicine-SERGAS, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain</aff><aff id="A7"><label>7</label>Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark</aff><aff id="A8"><label>8</label>The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH</aff><aff id="A9"><label>9</label>Fondation FondaMental, Créteil, France</aff><aff id="A10"><label>10</label>INSERM U 955, Psychiatrie Génétique, Créteil, France</aff><aff id="A11"><label>11</label>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</aff><aff id="A12"><label>12</label>Institute for Health and Welfare, Public Genomics Unit, Helsinki, Finland</aff><aff id="A13"><label>13</label>Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK</aff><aff id="A14"><label>14</label>Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King’s College, London, UK</aff><aff id="A15"><label>15</label>DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany</aff><aff id="A16"><label>16</label>Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany</aff><aff id="A17"><label>17</label>Department of Medical Genetics, Institute of Human Genetics, University of Tübingen, Tübingen, Germany</aff><aff id="A18"><label>18</label>Department of Psychiatry, National University Hospital, Reykjavik, Iceland</aff><aff id="A19"><label>19</label>School of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A20"><label>20</label>Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King’s College, London, UK</aff><aff id="A21"><label>21</label>Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany</aff><aff id="A22"><label>22</label>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany</aff><aff id="A23"><label>23</label>Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK</aff><aff id="A24"><label>24</label>Ravenscraig Hospital, Greenock, UK</aff><aff id="A25"><label>25</label>KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway</aff><aff id="A26"><label>26</label>Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A27"><label>27</label>Public Health Genomics Unit, National Institute for Health and Welfare THL, Helsinki, Finland</aff><aff id="A28"><label>28</label>Institute of Biological Psychiatry, Mental Health Centre Sct Hans & Copenhagen University, Roskilde, Denmark</aff><aff id="A29"><label>29</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A30"><label>30</label>Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands</aff><aff id="A31"><label>31</label>Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark</aff><aff id="A32"><label>32</label>Department of Molecular Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark</aff><aff id="A33"><label>33</label>Synaptic transmission, H. Lundbeck A/S, Valby, Denmark</aff><aff id="A34"><label>34</label>Psychiatric Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A35"><label>35</label>Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia</aff><aff id="A36"><label>36</label>Service of Psychiatry, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain</aff><aff id="A37"><label>37</label>Unit of Psychiatry, Faculty of Medicine, University of Valencia, Network Center of Biomedical Research on Mental Health (CIBERSAM), Valencia, Spain</aff><aff id="A38"><label>38</label>Hospital General Universitario Gregorio Marañón, IiSGM, Universidad Complutense, CIBERSAM, Madrid, Spain</aff><aff id="A39"><label>39</label>AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Créteil France</aff><aff id="A40"><label>40</label>Université Paris Est, Faculté de Médecine, Créteil, France</aff><aff id="A41"><label>41</label>Department of Neuroscience, Section of Psychiatry, University of Rome-Tor Vergata, Rome, Italy</aff><aff id="A42"><label>42</label>Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany</aff><aff id="A43"><label>43</label>Nordic Bioscience, Herlev, Denmark</aff><aff id="A44"><label>44</label>Department of Epidemiology and Biostatistics and Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</aff><aff id="A45"><label>45</label>Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</aff><aff id="A46"><label>46</label>Rudolf Magnus Institute of Neuroscience and Department of Neurology, University Medical Center, Utrecht, the Netherlands</aff><aff id="A47"><label>47</label>Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King’s College, London UK</aff><aff id="A48"><label>48</label>Department of Cognitive Neuroscience, Radboud University Nijmegen, Nijmegen, the Netherlands</aff><aff id="A49"><label>49</label>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Frankfurt am Main, Frankfurt am Main, Germany</aff><aff id="A50"><label>50</label>Department of Neurobehavioural Genetics, University of Trier, Trier, Germany</aff><aff id="A51"><label>51</label>Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, Iceland</aff><aff id="A52"><label>52</label>State Diagnostic and Counseling Centre, Kopavogur, Iceland</aff><aff id="A53"><label>53</label>Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine</aff><aff id="A54"><label>54</label>Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia</aff><aff id="A55"><label>55</label>Institute of Mental Health, Belgrade, Serbia</aff><aff id="A56"><label>56</label>Medical Faculty, University of Belgrade, Belgrade, Serbia</aff><aff id="A57"><label>57</label>Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia</aff><aff id="A58"><label>58</label>Social & Affective Neuroscience Lab, Ilia State University, Tbilisi, Georgia</aff><aff id="A59"><label>59</label>Molecular Neuropsychiatry and Development Laboratory, Centre for Addiction and Mental Health (CAMH), Toronto, Canada</aff><aff id="A60"><label>60</label>Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</aff><aff id="A61"><label>61</label>School of Psychiatry, University of New South Wales, Sydney, Australia</aff><aff id="A62"><label>62</label>Neuroscience Research Australia, Barker Street, Randwick, Sydney, Australia</aff><aff id="A63"><label>63</label>School of Medical Sciences, University of New South Wales, Sydney, Australia</aff><aff id="A64"><label>64</label>Queensland Institute of Medical Research, Brisbane, Australia</aff><aff id="A65"><label>65</label>University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium</aff><aff id="A66"><label>66</label>Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, the Netherlands</aff><aff id="A67"><label>67</label>Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary</aff><aff id="A68"><label>68</label>Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden</aff><aff id="A69"><label>69</label>Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, the Netherlands</aff><aff id="A70"><label>70</label>Department of Psychiatry, Maastricht University Medical Centre, the Netherlands</aff><aff id="A71"><label>71</label>Centre for Clinical Research in Neuropsychiatry (CCRN), Graylands Hospital, the University of Western Australia, Perth, Australia</aff><aff id="A72"><label>72</label>Mental Health Sciences Unit and Institute of Cognitive Neuroscience, University College London, London, UK</aff><aff id="A73"><label>73</label>Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King’s College, London, UK</aff><aff id="A74"><label>74</label>Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland</aff><aff id="A75"><label>75</label>Department of Psychiatry, Queens University, Belfast, UK</aff><aff id="A76"><label>76</label>Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA</aff><aff id="A77"><label>77</label>Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA</aff><aff id="A78"><label>78</label>Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA</aff><aff id="A79"><label>79</label>MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK</aff><aff id="A80"><label>80</label>Genomic Medicine Group - Galician Foundation of Genomic Medicine-Biomedical Network Research Centre on Rare Diseases (CIBERER), University of Santiago de Compostela, Spain</aff><aff id="A81"><label>81</label>Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark</aff><aff id="A82"><label>82</label>National Centre for Register-based Research, Aarhus University, Aarhus, Denmark</aff><aff id="A83"><label>83</label>German Center for Neurodegenerative Disorders (DZNE), Bonn Germany</aff><aff id="A84"><label>84</label>Institute of Human Genetics, University of Bonn, Bonn, Germany</aff><aff id="A85"><label>85</label>Institute of Neurosciences and Medicine (INM-1), Juelich, Germany</aff><aff id="A86"><label>86</label>Section of Psychiatry, University of Verona, Verona, Italy</aff><aff id="A87"><label>87</label>Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA</aff><aff id="A88"><label>88</label>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</aff><aff id="A89"><label>89</label>Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany</aff><aff id="A90"><label>90</label>Eli Lilly and Co. Ltd, Erl Wood Manor, Windlesham, Surrey, UK</aff><author-notes><corresp id="CR1"><label>*</label>Correspondence: Kari Stefansson, deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland <email>kstefans@decode.is</email> phone: +354-570-1900 fax: +354-570-1903</corresp><fn id="FN1"><label>†</label><p id="P1">see <xref ref-type="app" rid="APP1">Appendix</xref></p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>9</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>20</day><month>11</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2014</year></pub-date><volume>19</volume><issue>1</issue><elocation-id>10.1038/mp.2012.157</elocation-id><abstract><p id="P2">Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association (GWA) study, meta-analysis and follow-up (totaling as many as 18,206 cases and 42,536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7,469 bipolar disorder cases, 1,535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46,160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T], OR = 1.08, <italic>P</italic> = 6.6 × 10<sup>−11</sup>). The new variant is located within a 593 kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (<italic>P</italic> = 0.0039 in the public GIANT consortium dataset; <italic>P</italic> = 0.00047 in 22,651 additional Icelanders).</p></abstract><kwd-group><kwd>schizophrenia</kwd><kwd>bipolar disorder</kwd><kwd>association</kwd><kwd>16p11.2</kwd><kwd>cross-disorder</kwd></kwd-group><funding-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>098051 || WT</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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