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Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: a 12-month randomzied, controlled trial

Identifieur interne : 000126 ( Pmc/Curation ); précédent : 000125; suivant : 000127

Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: a 12-month randomzied, controlled trial

Auteurs : Elmar Graessel [Allemagne] ; Renate Stemmer [Allemagne] ; Birgit Eichenseer [Allemagne] ; Sabine Pickel [Allemagne] ; Carolin Donath [Allemagne] ; Johannes Kornhuber [Allemagne] ; Katharina Luttenberger [Allemagne]

Source :

RBID : PMC:3254071

Abstract

Background

Currently available pharmacological and non-pharmacological treatments have shown only modest effects in slowing the progression of dementia. Our objective was to assess the impact of a long-term non-pharmacological group intervention on cognitive function in dementia patients and on their ability to carry out activities of daily living compared to a control group receiving the usual care.

Methods

A randomized, controlled, single-blind longitudinal trial was conducted with 98 patients (follow-up: n = 61) with primary degenerative dementia in five nursing homes in Bavaria, Germany. The highly standardized intervention consisted of motor stimulation, practice in activities of daily living, and cognitive stimulation (acronym MAKS). It was conducted in groups of ten patients led by two therapists for 2 hours, 6 days a week for 12 months. Control patients received treatment as usual. Cognitive function was assessed using the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog), and the ability to carry out activities of daily living using the Erlangen Test of Activities of Daily Living (E-ADL test) at baseline and after 12 months.

Results

Of the 553 individuals screened, 119 (21.5%) were eligible and 98 (17.7%) were ultimately included in the study. At 12 months, the results of the per protocol analysis (n = 61) showed that cognitive function and the ability to carry out activities of daily living had remained stable in the intervention group but had decreased in the control patients (ADAS-Cog: adjusted mean difference: -7.7, 95% CI -14.0 to -1.4, P = 0.018, Cohen's d = 0.45; E-ADL test: adjusted mean difference: 3.6, 95% CI 0.7 to 6.4, P = 0.015, Cohen's d = 0.50). The effect sizes for the intervention were greater in the subgroup of patients (n = 50) with mild to moderate disease (ADAS-Cog: Cohen's d = 0.67; E-ADL test: Cohen's d = 0.69).

Conclusions

A highly standardized, non-pharmacological, multicomponent group intervention conducted in a nursing-home setting was able to postpone a decline in cognitive function in dementia patients and in their ability to carry out activities of daily living for at least 12 months.

Trial Registration

http://www.isrctn.com Identifier: ISRCTN87391496


Url:
DOI: 10.1186/1741-7015-9-129
PubMed: 22133165
PubMed Central: 3254071

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PMC:3254071

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<title>Background</title>
<p>Currently available pharmacological and non-pharmacological treatments have shown only modest effects in slowing the progression of dementia. Our objective was to assess the impact of a long-term non-pharmacological group intervention on cognitive function in dementia patients and on their ability to carry out activities of daily living compared to a control group receiving the usual care.</p>
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<p>A randomized, controlled, single-blind longitudinal trial was conducted with 98 patients (follow-up: n = 61) with primary degenerative dementia in five nursing homes in Bavaria, Germany. The highly standardized intervention consisted of motor stimulation, practice in activities of daily living, and cognitive stimulation (acronym MAKS). It was conducted in groups of ten patients led by two therapists for 2 hours, 6 days a week for 12 months. Control patients received treatment as usual. Cognitive function was assessed using the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog), and the ability to carry out activities of daily living using the Erlangen Test of Activities of Daily Living (E-ADL test) at baseline and after 12 months.</p>
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<italic>P </italic>
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<p>A highly standardized, non-pharmacological, multicomponent group intervention conducted in a nursing-home setting was able to postpone a decline in cognitive function in dementia patients and in their ability to carry out activities of daily living for at least 12 months.</p>
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Identifier:
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<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">BMC Med</journal-id>
<journal-title-group>
<journal-title>BMC Medicine</journal-title>
</journal-title-group>
<issn pub-type="epub">1741-7015</issn>
<publisher>
<publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">22133165</article-id>
<article-id pub-id-type="pmc">3254071</article-id>
<article-id pub-id-type="publisher-id">1741-7015-9-129</article-id>
<article-id pub-id-type="doi">10.1186/1741-7015-9-129</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: a 12-month randomzied, controlled trial</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" id="A1">
<name>
<surname>Graessel</surname>
<given-names>Elmar</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>elmar.graessel@uk-erlangen.de</email>
</contrib>
<contrib contrib-type="author" id="A2">
<name>
<surname>Stemmer</surname>
<given-names>Renate</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<email>stemmer@kfh-mainz.de</email>
</contrib>
<contrib contrib-type="author" id="A3">
<name>
<surname>Eichenseer</surname>
<given-names>Birgit</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>birgit.eichenseer@uk-erlangen.de</email>
</contrib>
<contrib contrib-type="author" id="A4">
<name>
<surname>Pickel</surname>
<given-names>Sabine</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>sabine.pickel@googlemail.com</email>
</contrib>
<contrib contrib-type="author" id="A5">
<name>
<surname>Donath</surname>
<given-names>Carolin</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>carolin.donath@uk-erlangen.de</email>
</contrib>
<contrib contrib-type="author" id="A6">
<name>
<surname>Kornhuber</surname>
<given-names>Johannes</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>johannes.kornhuber@uk-erlangen.de</email>
</contrib>
<contrib contrib-type="author" corresp="yes" id="A7">
<name>
<surname>Luttenberger</surname>
<given-names>Katharina</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>katharina.luttenberger@uk-erlangen.de</email>
</contrib>
</contrib-group>
<aff id="I1">
<label>1</label>
Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</aff>
<aff id="I2">
<label>2</label>
Catholic University of Applied Sciences Mainz, Department of Health and Nursing, Saarstrasse 3, 55122 Mainz, Germany</aff>
<pub-date pub-type="collection">
<year>2011</year>
</pub-date>
<pub-date pub-type="epub">
<day>1</day>
<month>12</month>
<year>2011</year>
</pub-date>
<volume>9</volume>
<fpage>129</fpage>
<lpage>129</lpage>
<history>
<date date-type="received">
<day>25</day>
<month>8</month>
<year>2011</year>
</date>
<date date-type="accepted">
<day>1</day>
<month>12</month>
<year>2011</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright ©2011 Graessel et al; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2011</copyright-year>
<copyright-holder>Graessel et al; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0">
<license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.biomedcentral.com/1741-7015/9/129"></self-uri>
<abstract>
<sec>
<title>Background</title>
<p>Currently available pharmacological and non-pharmacological treatments have shown only modest effects in slowing the progression of dementia. Our objective was to assess the impact of a long-term non-pharmacological group intervention on cognitive function in dementia patients and on their ability to carry out activities of daily living compared to a control group receiving the usual care.</p>
</sec>
<sec>
<title>Methods</title>
<p>A randomized, controlled, single-blind longitudinal trial was conducted with 98 patients (follow-up: n = 61) with primary degenerative dementia in five nursing homes in Bavaria, Germany. The highly standardized intervention consisted of motor stimulation, practice in activities of daily living, and cognitive stimulation (acronym MAKS). It was conducted in groups of ten patients led by two therapists for 2 hours, 6 days a week for 12 months. Control patients received treatment as usual. Cognitive function was assessed using the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog), and the ability to carry out activities of daily living using the Erlangen Test of Activities of Daily Living (E-ADL test) at baseline and after 12 months.</p>
</sec>
<sec>
<title>Results</title>
<p>Of the 553 individuals screened, 119 (21.5%) were eligible and 98 (17.7%) were ultimately included in the study. At 12 months, the results of the per protocol analysis (n = 61) showed that cognitive function and the ability to carry out activities of daily living had remained stable in the intervention group but had decreased in the control patients (ADAS-Cog: adjusted mean difference: -7.7, 95% CI -14.0 to -1.4,
<italic>P </italic>
= 0.018, Cohen's d = 0.45; E-ADL test: adjusted mean difference: 3.6, 95% CI 0.7 to 6.4,
<italic>P </italic>
= 0.015, Cohen's d = 0.50). The effect sizes for the intervention were greater in the subgroup of patients (n = 50) with mild to moderate disease (ADAS-Cog: Cohen's d = 0.67; E-ADL test: Cohen's d = 0.69).</p>
</sec>
<sec>
<title>Conclusions</title>
<p>A highly standardized, non-pharmacological, multicomponent group intervention conducted in a nursing-home setting was able to postpone a decline in cognitive function in dementia patients and in their ability to carry out activities of daily living for at least 12 months.</p>
</sec>
<sec>
<title>Trial Registration</title>
<p>
<ext-link ext-link-type="uri" xlink:href="http://www.isrctn.com">http://www.isrctn.com</ext-link>
Identifier:
<ext-link ext-link-type="uri" xlink:href="http://www.controlled-trials.com/ISRCTN87391496">ISRCTN87391496</ext-link>
</p>
</sec>
</abstract>
<kwd-group>
<kwd>dementia</kwd>
<kwd>non-pharmacological intervention</kwd>
<kwd>group therapy</kwd>
<kwd>RCT</kwd>
<kwd>nursing home</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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