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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Visualizing genome and systems biology: technologies, tools, implementation techniques and trends, past, present and future</title><author><name sortKey="Pavlopoulos, Georgios A" sort="Pavlopoulos, Georgios A" uniqKey="Pavlopoulos G" first="Georgios A." last="Pavlopoulos">Georgios A. Pavlopoulos</name><affiliation><nlm:aff id="Aff1">Bioinformatics & Computational Biology Laboratory, Division of Basic Sciences, University of Crete, Medical School, 70013 Heraklion, Crete Greece</nlm:aff></affiliation></author><author><name sortKey="Malliarakis, Dimitris" sort="Malliarakis, Dimitris" uniqKey="Malliarakis D" first="Dimitris" last="Malliarakis">Dimitris Malliarakis</name><affiliation><nlm:aff id="Aff2">Department of Biology, University of Crete, 70013 Heraklion, Crete Greece</nlm:aff></affiliation></author><author><name sortKey="Papanikolaou, Nikolas" sort="Papanikolaou, Nikolas" uniqKey="Papanikolaou N" first="Nikolas" last="Papanikolaou">Nikolas Papanikolaou</name><affiliation><nlm:aff id="Aff1">Bioinformatics & Computational Biology Laboratory, Division of Basic Sciences, University of Crete, Medical School, 70013 Heraklion, Crete Greece</nlm:aff></affiliation></author><author><name sortKey="Theodosiou, Theodosis" sort="Theodosiou, Theodosis" uniqKey="Theodosiou T" first="Theodosis" last="Theodosiou">Theodosis Theodosiou</name><affiliation><nlm:aff id="Aff1">Bioinformatics & Computational Biology Laboratory, Division of Basic Sciences, University of Crete, Medical School, 70013 Heraklion, Crete Greece</nlm:aff></affiliation></author><author><name sortKey="Enright, Anton J" sort="Enright, Anton J" uniqKey="Enright A" first="Anton J." last="Enright">Anton J. Enright</name><affiliation><nlm:aff id="Aff3">EMBL - European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD UK</nlm:aff></affiliation></author><author><name sortKey="Iliopoulos, Ioannis" sort="Iliopoulos, Ioannis" uniqKey="Iliopoulos I" first="Ioannis" last="Iliopoulos">Ioannis Iliopoulos</name><affiliation><nlm:aff id="Aff1">Bioinformatics & Computational Biology Laboratory, Division of Basic Sciences, University of Crete, Medical School, 70013 Heraklion, Crete Greece</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26309733</idno><idno type="pmc">4548842</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548842</idno><idno type="RBID">PMC:4548842</idno><idno type="doi">10.1186/s13742-015-0077-2</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000045</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000045</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Visualizing genome and systems biology: technologies, tools, implementation techniques and trends, past, present and future</title><author><name sortKey="Pavlopoulos, Georgios A" sort="Pavlopoulos, Georgios A" uniqKey="Pavlopoulos G" first="Georgios A." last="Pavlopoulos">Georgios A. Pavlopoulos</name><affiliation><nlm:aff id="Aff1">Bioinformatics & Computational Biology Laboratory, Division of Basic Sciences, University of Crete, Medical School, 70013 Heraklion, Crete Greece</nlm:aff></affiliation></author><author><name sortKey="Malliarakis, Dimitris" sort="Malliarakis, Dimitris" uniqKey="Malliarakis D" first="Dimitris" last="Malliarakis">Dimitris Malliarakis</name><affiliation><nlm:aff id="Aff2">Department of Biology, University of Crete, 70013 Heraklion, Crete Greece</nlm:aff></affiliation></author><author><name sortKey="Papanikolaou, Nikolas" sort="Papanikolaou, Nikolas" uniqKey="Papanikolaou N" first="Nikolas" last="Papanikolaou">Nikolas Papanikolaou</name><affiliation><nlm:aff id="Aff1">Bioinformatics & Computational Biology Laboratory, Division of Basic Sciences, University of Crete, Medical School, 70013 Heraklion, Crete Greece</nlm:aff></affiliation></author><author><name sortKey="Theodosiou, Theodosis" sort="Theodosiou, Theodosis" uniqKey="Theodosiou T" first="Theodosis" last="Theodosiou">Theodosis Theodosiou</name><affiliation><nlm:aff id="Aff1">Bioinformatics & Computational Biology Laboratory, Division of Basic Sciences, University of Crete, Medical School, 70013 Heraklion, Crete Greece</nlm:aff></affiliation></author><author><name sortKey="Enright, Anton J" sort="Enright, Anton J" uniqKey="Enright A" first="Anton J." last="Enright">Anton J. Enright</name><affiliation><nlm:aff id="Aff3">EMBL - European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD UK</nlm:aff></affiliation></author><author><name sortKey="Iliopoulos, Ioannis" sort="Iliopoulos, Ioannis" uniqKey="Iliopoulos I" first="Ioannis" last="Iliopoulos">Ioannis Iliopoulos</name><affiliation><nlm:aff id="Aff1">Bioinformatics & Computational Biology Laboratory, Division of Basic Sciences, University of Crete, Medical School, 70013 Heraklion, Crete Greece</nlm:aff></affiliation></author></analytic><series><title level="j">GigaScience</title><idno type="eISSN">2047-217X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>“Α picture is worth a thousand words.” This widely used adage sums up in a few words the notion that a successful visual representation of a concept should enable easy and rapid absorption of large amounts of information. Although, in general, the notion of capturing complex ideas using images is very appealing, would 1000 words be enough to describe the unknown in a research field such as the life sciences? Life sciences is one of the biggest generators of enormous datasets, mainly as a result of recent and rapid technological advances; their complexity can make these datasets incomprehensible without effective visualization methods. Here we discuss the past, present and future of genomic and systems biology visualization. We briefly comment on many visualization and analysis tools and the purposes that they serve. We focus on the latest libraries and programming languages that enable more effective, efficient and faster approaches for visualizing biological concepts, and also comment on the future human-computer interaction trends that would enable for enhancing visualization further.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Howe, D" uniqKey="Howe D">D Howe</name></author><author><name sortKey="Costanzo, M" uniqKey="Costanzo M">M Costanzo</name></author><author><name sortKey="Fey, P" uniqKey="Fey P">P Fey</name></author><author><name sortKey="Gojobori, T" uniqKey="Gojobori T">T Gojobori</name></author><author><name sortKey="Hannick, L" uniqKey="Hannick L">L Hannick</name></author><author><name sortKey="Hide, W" uniqKey="Hide W">W Hide</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liolios, K" uniqKey="Liolios K">K Liolios</name></author><author><name sortKey="Mavromatis, K" uniqKey="Mavromatis 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Gigascience</journal-id><journal-id journal-id-type="iso-abbrev">Gigascience</journal-id><journal-title-group><journal-title>GigaScience</journal-title></journal-title-group><issn pub-type="epub">2047-217X</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26309733</article-id><article-id pub-id-type="pmc">4548842</article-id><article-id pub-id-type="publisher-id">77</article-id><article-id pub-id-type="doi">10.1186/s13742-015-0077-2</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Visualizing genome and systems biology: technologies, tools, implementation techniques and trends, past, present and future</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Pavlopoulos</surname><given-names>Georgios A.</given-names></name><address><email>g.pavlopoulos@med.uoc.gr</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Malliarakis</surname><given-names>Dimitris</given-names></name><address><email>dim-mal@hotmail.com</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Papanikolaou</surname><given-names>Nikolas</given-names></name><address><email>papnikol@med.uoc.gr</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Theodosiou</surname><given-names>Theodosis</given-names></name><address><email>theodosios.theodosiou@gmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Enright</surname><given-names>Anton J.</given-names></name><address><email>aje@ebi.ac.uk</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Iliopoulos</surname><given-names>Ioannis</given-names></name><address><email>iliopj@med.uoc.gr</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label>Bioinformatics & Computational Biology Laboratory, Division of Basic Sciences, University of Crete, Medical School, 70013 Heraklion, Crete Greece</aff><aff id="Aff2"><label>2</label>Department of Biology, University of Crete, 70013 Heraklion, Crete Greece</aff><aff id="Aff3"><label>3</label>EMBL - European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD UK</aff></contrib-group><pub-date pub-type="epub"><day>25</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>4</volume><elocation-id>38</elocation-id><history><date date-type="received"><day>26</day><month>5</month><year>2015</year></date><date date-type="accepted"><day>3</day><month>8</month><year>2015</year></date></history><permissions><copyright-statement>© Pavlopoulos et al. 2015</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold> This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><p>“Α picture is worth a thousand words.” This widely used adage sums up in a few words the notion that a successful visual representation of a concept should enable easy and rapid absorption of large amounts of information. Although, in general, the notion of capturing complex ideas using images is very appealing, would 1000 words be enough to describe the unknown in a research field such as the life sciences? Life sciences is one of the biggest generators of enormous datasets, mainly as a result of recent and rapid technological advances; their complexity can make these datasets incomprehensible without effective visualization methods. Here we discuss the past, present and future of genomic and systems biology visualization. We briefly comment on many visualization and analysis tools and the purposes that they serve. We focus on the latest libraries and programming languages that enable more effective, efficient and faster approaches for visualizing biological concepts, and also comment on the future human-computer interaction trends that would enable for enhancing visualization further.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Biological data visualization</kwd><kwd>Network biology</kwd><kwd>Genomics</kwd><kwd>Systems biology</kwd><kwd>Multivariate analysis</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2015</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="Sec1"><title>Review</title><sec id="Sec2"><title>Introduction</title><p>In the current ‘big data’ era [<xref ref-type="bibr" rid="CR1">1</xref>], the magnitude of data explosion in life science research is undeniable. The biomedical literature currently includes about 27 million abstracts in PubMed and about 3.5 million full text articles in PubMed Central. Additionally, there are more than 300 established biological databases that store information about various biological entities (bioentities) and their associations. Obvious examples include: diseases, proteins, genes, chemicals, pathways, small molecules, ontologies, sequences, structures and expression data. In the past 250 years, only 1.2 million eukaryotic species (out of the approximately 8.8 million that are estimated to be present on earth) [<xref ref-type="bibr" rid="CR2">2</xref>] have been identified and taxonomically classified in the Catalog of Life and the World Register of Marine Species [<xref ref-type="bibr" rid="CR3">3</xref>]. The sequencing of the first human genome (2002) took 13 years and cost over $3 million to complete. Although the cost for <italic>de novo</italic> assembly of a new genome to acceptable coverage is still high, probably at least $40,000, we can now resequence a human genome for $1000 and can generate more than 320 genomes per week [<xref ref-type="bibr" rid="CR4">4</xref>]. Notably, few species have been fully sequenced, and a large fraction of their gene function is not fully understood or still remains completely unknown [<xref ref-type="bibr" rid="CR5">5</xref>]. The human genome is 3.3 billion base pairs in length and consists of over 20,000 human coding genes organized into 23 pairs of chromosomes [<xref ref-type="bibr" rid="CR6">6</xref>, <xref ref-type="bibr" rid="CR7">7</xref>]. Today over 60,000 solved protein structures are hosted in the Protein Data Bank [<xref ref-type="bibr" rid="CR8">8</xref>]. Nevertheless, many of the protein functions remain unknown or are partially understood.</p><p>Shifting away from basic research to applied sciences, personalized medicine is on the cusp of a revolution allowing the customization of healthcare by tailoring decisions, practices and/or products to the individual patient. To this end, such information should be accompanied by medical history and digital images and should guarantee a high level of privacy. The efficiency and security of distributed cloud computing systems for medical health record organization, storage and handling will be one of the big challenges during the coming years.</p><p>Information overload, data interconnectivity, high dimensionality of data and pattern extraction also pose major hurdles. Visualization is one way of coping with such data complexity. Implementation of efficient visualization technologies is necessary not only to present the known but to also reveal the unknown, allowing inference of conclusions, ideas and concepts [<xref ref-type="bibr" rid="CR9">9</xref>]. Here we focus on visualization advances in the fields of network and systems biology, present the state-of-the-art tools and provide an overview of the technological advances over time, gaining insights into what to expect in the future of visualization in the life sciences.</p><p>In the section on network biology below, we discuss widely used tools related to graph visualization and analysis, we comment on the various network types that often appear in the field of biology and we summarize the strengths of the tools, along with their citation trends over time. In this section we also distinguish between tools for network analysis and tools designed for pathway analysis and visualization. In a section on genomic visualization, we follow the same approach by distinguishing between tools designed for genome browsing and visualization, genome assembly, genome alignments and genome comparisons. Finally, in a section on visualization and analysis of expression data, we distinguish between tree viewers and tools implemented for multivariate analysis.</p></sec><sec id="Sec3"><title>Network biology visualization</title><p>In the field of systems biology, we often meet network representations in which bioentities are interconnected with each other. In such graphs, each node represents a bioentity and edges (connections) represent the associations between them [<xref ref-type="bibr" rid="CR10">10</xref>]. These graphs can be weighted, unweighted, directed or undirected. Among the various networks types within the field, some of the most widely used are protein-protein interaction networks, literature-based co-occurrence networks, metabolic/biochemical, signal transduction, gene regulatory and gene co-expression networks [<xref ref-type="bibr" rid="CR11">11</xref>–<xref ref-type="bibr" rid="CR13">13</xref>]. As new technological advances and high-throughput techniques come to the forefront every few years, such networks can increase dramatically in size and complexity, and therefore more efficient algorithms for analysis and visualization are necessary. Notably, a network consisting of a hundred nodes and connections is incomprehensible and impossible for a human to visually analyze. For example, techniques such as tandem affinity purification (TAP) [<xref ref-type="bibr" rid="CR14">14</xref>], yeast two hybrid (Y2H) [<xref ref-type="bibr" rid="CR15">15</xref>] and mass spectrometry [<xref ref-type="bibr" rid="CR16">16</xref>] can nowadays generate a significant fraction of the physical interactions of a proteome. As network biology evolves over time, we indicate standard procedures that were developed over the past 20 years and highlight key tools and methodologies that had a crucial role in this maturation process (Fig. <xref rid="Fig1" ref-type="fig">1</xref>).<fig id="Fig1"><label>Fig. 1</label><caption><p>Visualization for network biology. <bold>a</bold> Timeline of the emergence of relevant technologies and concepts. <bold>b</bold> A simple drawing of an undirected unweighted graph. <bold>c</bold> A 2D representation of a yeast protein-protein interaction network visualized in Cytoscape (<italic>left</italic>) and potential protein complexes identified by the MCL algorithm from that network (<italic>right</italic>). <bold>d</bold> A 3D view of a protein-protein interaction network visualized by BiolayoutExpress<sup>3D</sup>. <bold>e</bold> A multilayered network integrating different types of data visualized by Arena3D. <bold>f</bold> A hive plot view of a network in which nodes are mapped to and positioned on radially distributed linear axes. <bold>g</bold> Visualization of network changes over time. <bold>h</bold> Part of lung cancer pathway visualized by iPath. <bold>i</bold> Remote navigation and control of networks by hand gestures. <bold>j</bold> Integration and control of 3D networks using VR devices</p></caption><graphic xlink:href="13742_2015_77_Fig1_HTML" id="d30e377"></graphic></fig></p><p>In the 1990s, two-dimensional (2D) static graph layouts were developed for visualizing networks. Topological analysis, layout and clustering were pre-calculated and results were captured in a single static image. Clustering analysis was performed to detect cliques or highly connected regions within a graph, layout techniques such as Fruchterman-Reingold [<xref ref-type="bibr" rid="CR17">17</xref>] were implemented to place nodes in positions where the crossovers between the edges are minimized and topological analysis was used for detecting important nodes of the network such as hubs or nodes with high betweenness centrality. The typical visual encoding consisted of using arrows for directed graphs, adjusting the thickness of an edge to show the importance of a connection, using the same color for nodes that belong to the same cluster or modifying the node’s size to show its topological features, such as its neighbor connectivity. As integrative biology and high-throughput techniques advanced over the years, the necessity to move away from static images and add interactivity and navigation for easier data exploration became clearer.</p><p>Bridging between analysis and visualization became necessary, and tools that incorporated both increased the standards in the field. In clustering analysis, for example, new computational methods such as MCL [<xref ref-type="bibr" rid="CR18">18</xref>] and variations [<xref ref-type="bibr" rid="CR19">19</xref>], Cfinder [<xref ref-type="bibr" rid="CR20">20</xref>], MCODE [<xref ref-type="bibr" rid="CR21">21</xref>], Clique [<xref ref-type="bibr" rid="CR22">22</xref>] and others were applied to biological networks to find highly connected regions of importance. DECAFF [<xref ref-type="bibr" rid="CR23">23</xref>], SWEMODE [<xref ref-type="bibr" rid="CR24">24</xref>] or STM [<xref ref-type="bibr" rid="CR25">25</xref>], for example, were developed to predict protein complexes [<xref ref-type="bibr" rid="CR26">26</xref>] incorporating graph annotations, whereas others such as DMSP [<xref ref-type="bibr" rid="CR27">27</xref>], GFA [<xref ref-type="bibr" rid="CR28">28</xref>] and MATISSE [<xref ref-type="bibr" rid="CR29">29</xref>] were focused on gene-expression data. Most of these algorithms were command-line-based and only few tools such as jClust [<xref ref-type="bibr" rid="CR30">30</xref>], GIBA [<xref ref-type="bibr" rid="CR31">31</xref>], ClusterMaker [<xref ref-type="bibr" rid="CR32">32</xref>] or NeAT [<xref ref-type="bibr" rid="CR33">33</xref>] have been developed to integrate data in visual environments. These aforementioned techniques along with others are thoroughly discussed elsewhere [<xref ref-type="bibr" rid="CR26">26</xref>, <xref ref-type="bibr" rid="CR34">34</xref>–<xref ref-type="bibr" rid="CR36">36</xref>].</p><p>Although most network visualization tools are standalone applications, they guarantee efficient data exploration and the manipulation of visualization with mouse-hovering supporting actions. Such tools are for example the Pajek [<xref ref-type="bibr" rid="CR37">37</xref>], Osprey [<xref ref-type="bibr" rid="CR38">38</xref>], VisANT [<xref ref-type="bibr" rid="CR39">39</xref>] and others. Next-generation visualization tools took advantage of standard file formats such as BioPAX [<xref ref-type="bibr" rid="CR40">40</xref>, <xref ref-type="bibr" rid="CR41">41</xref>], SBML [<xref ref-type="bibr" rid="CR42">42</xref>], PSI-MI [<xref ref-type="bibr" rid="CR43">43</xref>] and CellML [<xref ref-type="bibr" rid="CR44">44</xref>]; modern, more sophisticated layouts such as Hive-Plots [<xref ref-type="bibr" rid="CR45">45</xref>]; and the available web services and data integration techniques to directly retrieve and handle information from public repositories on the fly. Functional enrichment of genes using the Gene Ontology (GO) repository [<xref ref-type="bibr" rid="CR46">46</xref>] is a typical example. Among others, current state-of-the-art tools are the Ondex [<xref ref-type="bibr" rid="CR47">47</xref>], Cytoscape [<xref ref-type="bibr" rid="CR48">48</xref>] or Gephi [<xref ref-type="bibr" rid="CR49">49</xref>], while tools such as iPath [<xref ref-type="bibr" rid="CR50">50</xref>], PATIKA [<xref ref-type="bibr" rid="CR51">51</xref>], PathVisio [<xref ref-type="bibr" rid="CR52">52</xref>] and others [<xref ref-type="bibr" rid="CR53">53</xref>] are pathway specific.</p><p>As biological networks became larger over time, consisting of thousands of nodes and connections, the so-called ‘hairball’ effect, where many nodes are densely connected with each other became very difficult to cope with. A partial solution to this was to shift from 2D representations to three-dimensional (3D) representations. Tools such as Arena3D [<xref ref-type="bibr" rid="CR54">54</xref>, <xref ref-type="bibr" rid="CR55">55</xref>] or BioLayout Express 3D [<xref ref-type="bibr" rid="CR56">56</xref>] take advantage of 3D space to show data in a virtual 3D universe. BioLayout Express uses whole 3D space to visualize networks, whereas Arena3D implements a multilayered concept to present 2D networks in a stack. Although a 2D network allows immediate visual feedback, a 3D rendering usually requires the user to interact more with the data in a more explorative mode, but can help reveal interesting features potentially hidden in a 2D representation. Although it is debatable whether 3D rendering is better than 2D visualization, hardware acceleration and performance still need to be taken into account when planning 3D visualizations (Fig. <xref rid="Fig1" ref-type="fig">1</xref>).</p><p>Tables <xref rid="Tab1" ref-type="table">1</xref> and <xref rid="Tab2" ref-type="table">2</xref> present currently freely available network and pathway visualization tools and their main characteristics. However, it is not the purpose of this review to perform a deeper comparative analysis of all available 2D and 3D visualization tools, as this is available elsewhere [<xref ref-type="bibr" rid="CR53">53</xref>, <xref ref-type="bibr" rid="CR57">57</xref>–<xref ref-type="bibr" rid="CR59">59</xref>]. Nevertheless, as network biology is gaining ground over the years, we sought to investigate the impact of the current tools in the field. To accomplish this, we tracked the tools that appeared after year 2000 and whose respective articles are indexed by Scopus (Fig. <xref rid="Fig2" ref-type="fig">2</xref>). We chose to keep track of the citations of only the first original publication for each tool. Although the number of citations is a reasonable indicator of popularity, it can sometimes be misleading as several tool versions appear in different articles that we have not yet tracked. Nevertheless, some immediate conclusions can be reached, such as that Cytoscape seems to be by far the biggest player for network visualization, as it comes with more than 200 plugins [<xref ref-type="bibr" rid="CR60">60</xref>] implemented by an active module community (Fig. <xref rid="Fig1" ref-type="fig">1b</xref>). Similarly, MapMan [<xref ref-type="bibr" rid="CR61">61</xref>] and Reactome SkyPainter [<xref ref-type="bibr" rid="CR62">62</xref>] are the most used tools for pathway visualization (Fig. <xref rid="Fig2" ref-type="fig">2b</xref>).<table-wrap id="Tab1"><label>Table 1</label><caption><p>Visualization tools for network biology</p></caption><table frame="hsides" rules="groups"><thead><tr><th colspan="3">Standalone applications for network analysis</th></tr><tr><th>Tool and references</th><th>Description</th><th>URL</th></tr></thead><tbody><tr><td>Arena 3D [<xref ref-type="bibr" rid="CR54">54</xref>, <xref ref-type="bibr" rid="CR55">55</xref>]</td><td>3D visualization of multi-layer networks</td><td><ext-link ext-link-type="uri" xlink:href="http://www.arena3d.org">http://www.arena3d.org</ext-link></td></tr><tr><td>Biana [<xref ref-type="bibr" rid="CR146">146</xref>]</td><td>Data integration and network management</td><td><ext-link ext-link-type="uri" xlink:href="http://sbi.imim.es/web/BIANA.php">http://sbi.imim.es/web/BIANA.php</ext-link></td></tr><tr><td>BioLayout Express 3D [<xref ref-type="bibr" rid="CR147">147</xref>]</td><td>2D/3D network visualization</td><td><ext-link ext-link-type="uri" xlink:href="http://www.biolayout.org/">http://www.biolayout.org/</ext-link></td></tr><tr><td>BiologicalNetworks [<xref ref-type="bibr" rid="CR148">148</xref>, <xref ref-type="bibr" rid="CR149">149</xref>]</td><td>Efficient integrated multi-level analysis of microarray, sequence, regulatory and other data</td><td><ext-link ext-link-type="uri" xlink:href="http://www.biologicalnetworks.org">http://www.biologicalnetworks.org</ext-link></td></tr><tr><td>BioMiner [<xref ref-type="bibr" rid="CR150">150</xref>]</td><td>Modeling, analyzing and visualizing biochemical pathways and networks</td><td><ext-link ext-link-type="uri" xlink:href="http://www.zbi.uni-saarland.de/chair/projects/BioMiner">http://www.zbi.uni-saarland.de/chair/projects/BioMiner</ext-link></td></tr><tr><td>Cell Illustrator [<xref ref-type="bibr" rid="CR151">151</xref>]</td><td>Petri nets for modeling and simulating biological networks</td><td><ext-link ext-link-type="uri" xlink:href="http://www.cellillustrator.com">http://www.cellillustrator.com</ext-link></td></tr><tr><td>COPASI [<xref ref-type="bibr" rid="CR152">152</xref>]</td><td>Analysis of biochemical networks and their dynamics</td><td><ext-link ext-link-type="uri" xlink:href="http://www.copasi.org/">http://www.copasi.org/</ext-link></td></tr><tr><td>Cytoscape [<xref ref-type="bibr" rid="CR48">48</xref>, <xref ref-type="bibr" rid="CR153">153</xref>]</td><td>Network visualization and analysis. Over 200 plugins [<xref ref-type="bibr" rid="CR60">60</xref>]</td><td><ext-link ext-link-type="uri" xlink:href="http://www.cytoscape.org/">http://www.cytoscape.org/</ext-link></td></tr><tr><td>Dizzy [<xref ref-type="bibr" rid="CR154">154</xref>]</td><td>Chemical kinetics stochastic simulation software</td><td><ext-link ext-link-type="uri" xlink:href="http://magnet.systemsbiology.net/software/Dizzy/">http://magnet.systemsbiology.net/software/Dizzy/</ext-link></td></tr><tr><td>DyCoNet [<xref ref-type="bibr" rid="CR155">155</xref>]</td><td>Gephi plugin that can be used to identify dynamic communities in networks</td><td><ext-link ext-link-type="uri" xlink:href="https://github.com/juliemkauffman/DyCoNet">https://github.com/juliemkauffman/DyCoNet</ext-link></td></tr><tr><td>GENeVis [<xref ref-type="bibr" rid="CR156">156</xref>, <xref ref-type="bibr" rid="CR157">157</xref>]</td><td>Network and pathway visualization</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/genevis/">http://tinyurl.com/genevis/</ext-link></td></tr><tr><td>GEPHI [<xref ref-type="bibr" rid="CR49">49</xref>]</td><td>Interactive visualization and exploration for any network and complex system, dynamic and hierarchical graph.</td><td><ext-link ext-link-type="uri" xlink:href="https://gephi.org">https://gephi.org</ext-link></td></tr><tr><td>Igraph [<xref ref-type="bibr" rid="CR158">158</xref>]</td><td>Collection of network analysis tools with the emphasis on efficiency, portability and ease of use</td><td><ext-link ext-link-type="uri" xlink:href="http://igraph.sourceforge.net">http://igraph.sourceforge.net</ext-link></td></tr><tr><td>Medusa [<xref ref-type="bibr" rid="CR159">159</xref>, <xref ref-type="bibr" rid="CR160">160</xref>]</td><td>Semantic and multi-edged simple networks</td><td><ext-link ext-link-type="uri" xlink:href="https://sites.google.com/site/medusa3visualization/">https://sites.google.com/site/medusa3visualization/</ext-link></td></tr><tr><td>NAViGaTOR [<xref ref-type="bibr" rid="CR161">161</xref>, <xref ref-type="bibr" rid="CR162">162</xref>]</td><td>Visualizing and analyzing protein-protein interaction networks</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/navigator1/">http://tinyurl.com/navigator1/</ext-link></td></tr><tr><td>N-Browse [<xref ref-type="bibr" rid="CR163">163</xref>]</td><td>Interactive graphical browser for biological networks</td><td><ext-link ext-link-type="uri" xlink:href="http://www.gnetbrowse.org/">http://www.gnetbrowse.org/</ext-link></td></tr><tr><td>NeAT [<xref ref-type="bibr" rid="CR33">33</xref>]</td><td>Topological and clustering analysis of networks</td><td><ext-link ext-link-type="uri" xlink:href="http://rsat.ulb.ac.be/neat/">http://rsat.ulb.ac.be/neat/</ext-link></td></tr><tr><td>Ondex [<xref ref-type="bibr" rid="CR47">47</xref>]</td><td>Data integration and visualization of large networks</td><td><ext-link ext-link-type="uri" xlink:href="http://www.ondex.org/">http://www.ondex.org/</ext-link></td></tr><tr><td>Osprey [<xref ref-type="bibr" rid="CR38">38</xref>]</td><td>Visualization and annotation of biological networks</td><td><ext-link ext-link-type="uri" xlink:href="http://biodata.mshri.on.ca/osprey/servlet/Index">http://biodata.mshri.on.ca/osprey/servlet/Index</ext-link></td></tr><tr><td>Pajek [<xref ref-type="bibr" rid="CR37">37</xref>]</td><td>Analysis and visualization of large networks and social network analysis</td><td><ext-link ext-link-type="uri" xlink:href="http://vlado.fmf.uni-lj.si/pub/networks/pajek/">http://vlado.fmf.uni-lj.si/pub/networks/pajek/</ext-link></td></tr><tr><td>PathwayAssist [<xref ref-type="bibr" rid="CR164">164</xref>]</td><td>Navigation and analysis of biological pathways, gene regulation networks and protein interaction maps.</td><td><ext-link ext-link-type="uri" xlink:href="http://www.ariadnegenomics.com/downloads/">http://www.ariadnegenomics.com/downloads/</ext-link></td></tr><tr><td>PIVOT [<xref ref-type="bibr" rid="CR165">165</xref>]</td><td>Layout algorithms for visualizing protein interactions and families</td><td><ext-link ext-link-type="uri" xlink:href="http://acgt.cs.tau.ac.il/pivot/">http://acgt.cs.tau.ac.il/pivot/</ext-link></td></tr><tr><td>ProCope [<xref ref-type="bibr" rid="CR166">166</xref>]</td><td>Prediction and evaluation of protein complexes from purification data experiments</td><td><ext-link ext-link-type="uri" xlink:href="http://www.bio.ifi.lmu.de/Complexes/ProCope/">http://www.bio.ifi.lmu.de/Complexes/ProCope/</ext-link></td></tr><tr><td>ProViz [<xref ref-type="bibr" rid="CR167">167</xref>]</td><td>Visualization and exploration of interaction networks. Gene Ontology and PSI-MI formats supported</td><td><ext-link ext-link-type="uri" xlink:href="http://cbi.labri.fr/eng/proviz.htm">http://cbi.labri.fr/eng/proviz.htm</ext-link></td></tr><tr><td>SpectralNET [<xref ref-type="bibr" rid="CR168">168</xref>]</td><td>Network analysis and visualizations. Scatter plots and dimensionality reduction algorithms</td><td><ext-link ext-link-type="uri" xlink:href="https://www.broadinstitute.org/software/spectralnet">https://www.broadinstitute.org/software/spectralnet</ext-link></td></tr><tr><td>Tulip [<xref ref-type="bibr" rid="CR169">169</xref>]</td><td>Enables the development of algorithms, visual encodings, interaction techniques, data models and domain-specific visualizations</td><td><ext-link ext-link-type="uri" xlink:href="http://tulip.labri.fr/TulipDrupal/">http://tulip.labri.fr/TulipDrupal/</ext-link></td></tr><tr><td>VANESA [<xref ref-type="bibr" rid="CR170">170</xref>]</td><td>Automatic reconstruction and analysis of biological networks and Petri nets based on life-science database information</td><td><ext-link ext-link-type="uri" xlink:href="http://agbi.techfak.uni-bielefeld.de/vanesa/">http://agbi.techfak.uni-bielefeld.de/vanesa/</ext-link></td></tr><tr><td>VANTED [<xref ref-type="bibr" rid="CR171">171</xref>]</td><td>Network reconstruction, data visualization, integration of various data types, network simulation</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/vanted/">http://tinyurl.com/vanted/</ext-link></td></tr><tr><td>yEd</td><td>Creation of diagrams manually and import external data</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/yEdGraph/">http://tinyurl.com/yEdGraph/</ext-link></td></tr><tr><td colspan="3">Web tools for network analysis</td></tr><tr><td>APID [<xref ref-type="bibr" rid="CR172">172</xref>]</td><td>Unified protein-protein interactions from BIND, BioGRID, DIP, HPRD, IntAct and MINT</td><td><ext-link ext-link-type="uri" xlink:href="http://bioinfow.dep.usal.es/apid/">http://bioinfow.dep.usal.es/apid/</ext-link></td></tr><tr><td>Arcadia [<xref ref-type="bibr" rid="CR173">173</xref>]</td><td>Translates text-based descriptions of biological networks (SBML files) into standardized diagrams (Systems Biology Graphical Notation Process Description maps)</td><td><ext-link ext-link-type="uri" xlink:href="http://arcadiapathways.sourceforge.net/">http://arcadiapathways.sourceforge.net/</ext-link></td></tr><tr><td>AVIS [<xref ref-type="bibr" rid="CR174">174</xref>]</td><td>Viewer for signaling networks</td><td><ext-link ext-link-type="uri" xlink:href="http://actin.pharm.mssm.edu/AVIS2">http://actin.pharm.mssm.edu/AVIS2</ext-link></td></tr><tr><td>bioPIXIE [<xref ref-type="bibr" rid="CR175">175</xref>]</td><td>Discovery of biological networks from diverse functional genomic data</td><td><ext-link ext-link-type="uri" xlink:href="http://pixie.princeton.edu/pixie">http://pixie.princeton.edu/pixie</ext-link></td></tr><tr><td>CellPublisher [<xref ref-type="bibr" rid="CR176">176</xref>]</td><td>Interactive representations of biochemical processes</td><td><ext-link ext-link-type="uri" xlink:href="http://cellpublisher.gobics.de/">http://cellpublisher.gobics.de/</ext-link></td></tr><tr><td>Graphle [<xref ref-type="bibr" rid="CR177">177</xref>]</td><td>Distributed network exploration and visualization of interactive large, dense graphs</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/graphle/">http://tinyurl.com/graphle/</ext-link></td></tr><tr><td>GraphWeb [<xref ref-type="bibr" rid="CR178">178</xref>]</td><td>Web server for graph-based analysis of biological networks</td><td><ext-link ext-link-type="uri" xlink:href="http://biit.cs.ut.ee/graphweb/">http://biit.cs.ut.ee/graphweb/</ext-link></td></tr><tr><td>Hubba [<xref ref-type="bibr" rid="CR179">179</xref>]</td><td>Web-based service to explore the essential nodes in a network</td><td><ext-link ext-link-type="uri" xlink:href="http://hub.iis.sinica.edu.tw/Hubba">http://hub.iis.sinica.edu.tw/Hubba</ext-link></td></tr><tr><td>NetworkBLAST [<xref ref-type="bibr" rid="CR180">180</xref>]</td><td>Analysis of protein interaction networks across species to infer protein complexes that are conserved in evolution</td><td><ext-link ext-link-type="uri" xlink:href="http://www.cs.tau.ac.il/~bnet/networkblast.htm">http://www.cs.tau.ac.il/~bnet/networkblast.htm</ext-link></td></tr><tr><td>Pathview [<xref ref-type="bibr" rid="CR181">181</xref>]</td><td>Tool set for pathway-based data integration and visualization</td><td><ext-link ext-link-type="uri" xlink:href="http://pathview.r-forge.r-project.org/">http://Pathview.r-forge.r-project.org/</ext-link></td></tr><tr><td>PINA [<xref ref-type="bibr" rid="CR182">182</xref>]</td><td>Integrated platform for protein interaction network construction, filtering, analysis, visualization and management</td><td><ext-link ext-link-type="uri" xlink:href="http://cbg.garvan.unsw.edu.au/pina/home.do">http://cbg.garvan.unsw.edu.au/pina/home.do</ext-link></td></tr><tr><td>ReMatch [<xref ref-type="bibr" rid="CR183">183</xref>]</td><td>Web-based tool for integration of user-given stoichiometric metabolic models into a database collected from public data sources</td><td><ext-link ext-link-type="uri" xlink:href="http://www.cs.helsinki.fi/group/sysfys/software/rematch/">http://www.cs.helsinki.fi/group/sysfys/software/rematch/</ext-link></td></tr><tr><td>SNOW [<xref ref-type="bibr" rid="CR184">184</xref>]</td><td>Gene mapping on a reference or human protein-protein interaction network that SNOW hosts</td><td><ext-link ext-link-type="uri" xlink:href="http://snow.bioinfo.cipf.es/">http://snow.bioinfo.cipf.es</ext-link></td></tr><tr><td>STITCH [<xref ref-type="bibr" rid="CR185">185</xref>]</td><td>Resource to explore known and predicted interactions of chemicals and proteins</td><td><ext-link ext-link-type="uri" xlink:href="http://stitch.embl.de/">http://stitch.embl.de/</ext-link></td></tr><tr><td>STRING [<xref ref-type="bibr" rid="CR186">186</xref>]</td><td>Protein interaction networks and integration of data such as genomic context, high-throughput experiments, conserved coexpression and previous knowledge derived from the literature</td><td><ext-link ext-link-type="uri" xlink:href="http://string-db.org">http://string-db.org</ext-link></td></tr><tr><td>TVNViewer [<xref ref-type="bibr" rid="CR187">187</xref>]</td><td>An interactive visualization tool for exploring networks that change over time or space</td><td><ext-link ext-link-type="uri" xlink:href="http://www.sailing.cs.cmu.edu/main/?page_id=545">http://www.sailing.cs.cmu.edu/main/?page_id=545</ext-link></td></tr><tr><td>tYNA [<xref ref-type="bibr" rid="CR188">188</xref>]</td><td>System for managing, comparing and mining multiple networks</td><td><ext-link ext-link-type="uri" xlink:href="http://tyna.gersteinlab.org/tyna/">http://tyna.gersteinlab.org/tyna/</ext-link></td></tr><tr><td>VisANT [<xref ref-type="bibr" rid="CR39">39</xref>, <xref ref-type="bibr" rid="CR189">189</xref>]</td><td>Visualization, mining, analysis and modeling of biological networks, metabolic networks and ecosystems</td><td><ext-link ext-link-type="uri" xlink:href="http://visant.bu.edu/">http://visant.bu.edu/</ext-link></td></tr></tbody></table></table-wrap><table-wrap id="Tab2"><label>Table 2</label><caption><p>Visualization tools for pathways</p></caption><table frame="hsides" rules="groups"><thead><tr><th colspan="3">Standalone applications</th></tr><tr><th>Tool and references</th><th>Description</th><th>URL</th></tr></thead><tbody><tr><td>BiNA [<xref ref-type="bibr" rid="CR190">190</xref>]</td><td>Drawings of metabolic networks supporting hiding of cofactors and drawing of chemical structures</td><td><ext-link ext-link-type="uri" xlink:href="http://bina.unipax.info/">http://bina.unipax.info/</ext-link></td></tr><tr><td>BioTapestry [<xref ref-type="bibr" rid="CR191">191</xref>]</td><td>Interactive tool for building, visualizing and sharing gene regulatory network models over the web</td><td><ext-link ext-link-type="uri" xlink:href="http://www.biotapestry.org/">http://www.biotapestry.org/</ext-link></td></tr><tr><td>Caleydo [<xref ref-type="bibr" rid="CR192">192</xref>]</td><td>Visual analysis framework targeted at biomolecular data. Visualization of interdependencies between multiple datasets</td><td><ext-link ext-link-type="uri" xlink:href="http://www.caleydo.org/">http://www.caleydo.org/</ext-link></td></tr><tr><td>CellDesigner [<xref ref-type="bibr" rid="CR193">193</xref>]</td><td>A modeling tool for biochemical networks</td><td><ext-link ext-link-type="uri" xlink:href="http://www.celldesigner.org/">http://www.celldesigner.org/</ext-link></td></tr><tr><td>Edinburgh Pathway Editor [<xref ref-type="bibr" rid="CR194">194</xref>]</td><td>Edit and draw pathway diagrams</td><td><ext-link ext-link-type="uri" xlink:href="http://epe.sourceforge.net/SourceForge/EPE.html">http://epe.sourceforge.net/SourceForge/EPE.html</ext-link></td></tr><tr><td>GenMAPP [<xref ref-type="bibr" rid="CR195">195</xref>]</td><td>Visualization of gene expression and other genomic data on maps representing biological pathways and groupings of genes</td><td><ext-link ext-link-type="uri" xlink:href="http://www.genmapp.org/">http://www.genmapp.org/</ext-link></td></tr><tr><td>Ingenuity IPA</td><td>Data integration platform and manually annotated pathways</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/IngenuityPath">http://tinyurl.com/IngenuityPath</ext-link></td></tr><tr><td>JDesigner [<xref ref-type="bibr" rid="CR196">196</xref>]</td><td>Graphical modeling environment for biochemical reaction networks</td><td><ext-link ext-link-type="uri" xlink:href="http://jdesigner.sourceforge.net/Site/JDesigner.html">http://jdesigner.sourceforge.net/Site/JDesigner.html</ext-link></td></tr><tr><td>KaPPA View [<xref ref-type="bibr" rid="CR197">197</xref>]</td><td>Plant pathways</td><td><ext-link ext-link-type="uri" xlink:href="http://kpv.kazusa.or.jp/">http://kpv.kazusa.or.jp/</ext-link></td></tr><tr><td>KEGG Atlas [<xref ref-type="bibr" rid="CR198">198</xref>]</td><td>Interactive Kyoto Encyclopedia of Genes and Genomes pathways</td><td><ext-link ext-link-type="uri" xlink:href="http://www.genome.jp/kegg/">http://www.genome.jp/kegg/</ext-link></td></tr><tr><td>Omix [<xref ref-type="bibr" rid="CR199">199</xref>]</td><td>Visualizing multi-omics data in metabolic networks</td><td><ext-link ext-link-type="uri" xlink:href="https://www.omix-visualization.com">https://www.omix-visualization.com</ext-link></td></tr><tr><td>PathVisio [<xref ref-type="bibr" rid="CR52">52</xref>]</td><td>Biological pathway analysis software that allows drawing, editing and analysis of biological pathways</td><td><ext-link ext-link-type="uri" xlink:href="http://www.pathvisio.org/">http://www.pathvisio.org/</ext-link></td></tr><tr><td>VitaPad [<xref ref-type="bibr" rid="CR200">200</xref>]</td><td>Application to visualize biological pathways and map experimental data to them</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/vitapad/">http://tinyurl.com/vitapad/</ext-link></td></tr><tr><td colspan="3">Web tools for pathways</td></tr><tr><td>ArrayXPath [<xref ref-type="bibr" rid="CR201">201</xref>]</td><td>Mapping and visualizing microarray gene-expression data and integrated biological pathway resources using SVG</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/ArrayXPath/">http://tinyurl.com/ArrayXPath/</ext-link></td></tr><tr><td>GEPAT [<xref ref-type="bibr" rid="CR202">202</xref>]</td><td>Integrated analysis of transcriptome data in genomic, proteomic and metabolic contexts</td><td><ext-link ext-link-type="uri" xlink:href="http://gepat.sourceforge.net/">http://gepat.sourceforge.net/</ext-link></td></tr><tr><td>iPath [<xref ref-type="bibr" rid="CR50">50</xref>, <xref ref-type="bibr" rid="CR203">203</xref>]</td><td>Web-based tool for the visualization, analysis and customization of pathway maps</td><td><ext-link ext-link-type="uri" xlink:href="http://pathways.embl.de/">http://pathways.embl.de/</ext-link></td></tr><tr><td>Kegg-Based Viewer [<xref ref-type="bibr" rid="CR204">204</xref>]</td><td>KEGG-based pathway visualization tool for complex high-throughput data</td><td><ext-link ext-link-type="uri" xlink:href="http://www.g-language.org/data/marray/">http://www.g-language.org/data/marray/</ext-link></td></tr><tr><td>MapMan [<xref ref-type="bibr" rid="CR61">61</xref>]</td><td>User-driven tool that displays large datasets onto diagrams of metabolic pathways or other processes</td><td><ext-link ext-link-type="uri" xlink:href="http://mapman.gabipd.org/web/guest/mapman">http://mapman.gabipd.org/web/guest/mapman</ext-link></td></tr><tr><td>MetPA [<xref ref-type="bibr" rid="CR205">205</xref>]</td><td>Analysis and visualization of metabolomic data within the biological context of metabolic pathways</td><td><ext-link ext-link-type="uri" xlink:href="http://metpa.metabolomics.ca">http://metpa.metabolomics.ca</ext-link></td></tr><tr><td>Omics Viewer [<xref ref-type="bibr" rid="CR206">206</xref>]</td><td>Data mapping on BioCyc pathways (collection of 5500 pathway/genome databases)</td><td><ext-link ext-link-type="uri" xlink:href="http://www.biocyc.org/">http://www.biocyc.org/</ext-link></td></tr><tr><td>Pathway Explorer [<xref ref-type="bibr" rid="CR207">207</xref>]</td><td>Interactive Java drawing tool for the construction of biological pathway diagrams in a visual way and the annotation of the components and interactions between them</td><td><ext-link ext-link-type="uri" xlink:href="http://genome.tugraz.at/pathwayexplorer/pathwayexplorer_description.shtml">http://genome.tugraz.at/pathwayexplorer/pathwayexplorer_description.shtml</ext-link></td></tr><tr><td>Pathway projector [<xref ref-type="bibr" rid="CR208">208</xref>]</td><td>Zoomable pathway browser using KEGG atlas and Google Maps API</td><td><ext-link ext-link-type="uri" xlink:href="http://www.g-language.org/PathwayProjector/">http://www.g-language.org/PathwayProjector/</ext-link></td></tr><tr><td>PATIKA [<xref ref-type="bibr" rid="CR51">51</xref>]</td><td>Integrated environment composed of a central database and a visual editor, built around an extensive ontology and an integration framework</td><td><ext-link ext-link-type="uri" xlink:href="http://www.cs.bilkent.edu.tr/~patikaweb/">http://www.cs.bilkent.edu.tr/~patikaweb/</ext-link></td></tr><tr><td>Reactome SkyPainter [<xref ref-type="bibr" rid="CR62">62</xref>]</td><td>Visualization of over-represented pathways and reactions from gene lists</td><td><ext-link ext-link-type="uri" xlink:href="http://www.reactome.org/skypainter-2">http://www.reactome.org/skypainter-2</ext-link></td></tr><tr><td>WikiPathways [<xref ref-type="bibr" rid="CR209">209</xref>]</td><td>Wiki-based, open, public platform dedicated to the curation of biological pathways by and for the scientific community</td><td><ext-link ext-link-type="uri" xlink:href="http://www.wikipathways.org/">http://www.wikipathways.org/</ext-link></td></tr></tbody></table></table-wrap><fig id="Fig2"><label>Fig. 2</label><caption><p>Citation trends and key player tools in network biology. <bold>a</bold> Citations of network visualization tools based on Scopus. <bold>b</bold> Citations of pathway visualization tools based on Scopus. The numbers of citations of each tool in 2015 are shown after its name</p></caption><graphic xlink:href="13742_2015_77_Fig2_HTML" id="d30e1950"></graphic></fig></p><p>Over the past 5 years, the data visualization field has become more and more competitive. There is a trend away from standalone applications towards the integration of visualization implementations within web browsers. Therefore, libraries and new programming languages have been dedicated to this task (see the final section below). The greater visibility provided by web implementation means that advanced visualization can more easily become available to non-experts and to the broader community. Finally, one of the biggest visualization challenges today is to capture the dynamics of networks and the way in which topological properties change over time [<xref ref-type="bibr" rid="CR63">63</xref>]. For this, motion or other sophisticated ideas, along with new human-computer interaction (HCI) techniques, should be taken into consideration. Although serious efforts on this are on the way [<xref ref-type="bibr" rid="CR54">54</xref>, <xref ref-type="bibr" rid="CR64">64</xref>, <xref ref-type="bibr" rid="CR65">65</xref>], there are still much to expect in the future as HCI techniques and virtual reality (VR) devices (such as Oculus Rift) become cheaper and more advanced over time (Fig. <xref rid="Fig1" ref-type="fig">1</xref>).</p></sec><sec id="Sec4"><title>Visualization in genomics</title><p>There remain many open challenges for advanced visualization for genome assemblies, alignments, polymorphisms, variations, synteny, single nucleotide polymorphisms (SNPs), rearrangements and annotations [<xref ref-type="bibr" rid="CR66">66</xref>, <xref ref-type="bibr" rid="CR67">67</xref>]. To better follow progress in the visualization field, we first need to follow the way in which new technologies, questions and trends have been shaped over the years (Fig. <xref rid="Fig3" ref-type="fig">3</xref>).<fig id="Fig3"><label>Fig. 3</label><caption><p>Visualization for genome biology. <bold>a</bold> Timeline of the emergence of relevant technologies and concepts. <bold>b</bold> A typical normal human karyotype. <bold>c</bold> Visualization of BLAST hits and alignment of orthologous genes for the human <italic>TP53</italic> gene. <bold>d</bold> The human <italic>TP53</italic> gene and its annotations visualized by the UCSC genome browser. <bold>e</bold> Visualization of a <italic>de novo</italic> genome assembly from its DNA fragments. <bold>f</bold> Examples of balanced and unbalanced genomic rearrangements. <bold>g</bold> Hypothetical visualization of genomic structural variations across time</p></caption><graphic xlink:href="13742_2015_77_Fig3_HTML" id="d30e2021"></graphic></fig></p><p>Up to the 1990s, local and global pairwise and multiple sequence alignment algorithms such as Smith-Waterman [<xref ref-type="bibr" rid="CR68">68</xref>], Needleman-Wunsch [<xref ref-type="bibr" rid="CR69">69</xref>], FASTA [<xref ref-type="bibr" rid="CR70">70</xref>] and BLAST [<xref ref-type="bibr" rid="CR71">71</xref>] were the focus of bioinformatics methods development. Multiple sequence alignment tools such as the ClustalW/Clustal X [<xref ref-type="bibr" rid="CR72">72</xref>], MUSCLE [<xref ref-type="bibr" rid="CR73">73</xref>], T-Coffee [<xref ref-type="bibr" rid="CR74">74</xref>] and others [<xref ref-type="bibr" rid="CR75">75</xref>] used basic visualization schemes, in which sequences were represented as strings placed vertically in stacks. Colors were used to visually encode base conservation and to indicate matching, non-matching and similar nucleotides [<xref ref-type="bibr" rid="CR76">76</xref>, <xref ref-type="bibr" rid="CR77">77</xref>].</p><p>Although these tools were successful for small numbers of nucleotide or protein sequences, a question was raised regarding their applicability to whole-genome sequencing and comparison. A few years later (2002), the Sanger (dideoxy) first generation sequencing, particularly capillary approaches, allowed the sequencing of the first whole human genome, consisting of about 3 billion base pairs and over 20,000 human genes [<xref ref-type="bibr" rid="CR78">78</xref>, <xref ref-type="bibr" rid="CR79">79</xref>]. Shortly after that, second-generation (Illumina [<xref ref-type="bibr" rid="CR80">80</xref>], Roche/454 [<xref ref-type="bibr" rid="CR81">81</xref>], Biosystems/SOLiD [<xref ref-type="bibr" rid="CR82">82</xref>]) and third-generation techniques (Helicos BioSciences [<xref ref-type="bibr" rid="CR83">83</xref>], Pacific Biosciences [<xref ref-type="bibr" rid="CR84">84</xref>], Oxford Nanopore [<xref ref-type="bibr" rid="CR85">85</xref>] and Complete Genomics [<xref ref-type="bibr" rid="CR86">86</xref>]) high-throughput sequencing techniques [<xref ref-type="bibr" rid="CR87">87</xref>–<xref ref-type="bibr" rid="CR91">91</xref>] allowed the sequencing of a transcriptome, an exome or a whole genome at a much lower cost and within reasonable timeframes.</p><p>Projects such as the 1000 Genomes Project, for comprehensive human genetic variation analysis [<xref ref-type="bibr" rid="CR92">92</xref>–<xref ref-type="bibr" rid="CR94">94</xref>], and the International HapMap Project [<xref ref-type="bibr" rid="CR95">95</xref>–<xref ref-type="bibr" rid="CR99">99</xref>], for the identification of common genetic variations among people from different countries, are just a few examples of the data explosion that has taken place in the era of comparative genomics, after 2005. Such large-scale genomic datasets necessitate powerful tools to link genomic data to its source genome and across genomes. Therefore, among others [<xref ref-type="bibr" rid="CR66">66</xref>], widely used standalone and web-based genome browsers were dedicated to information handling, genome visualization, navigation, exploration and integration with annotations from various repositories. At present, many specialized tools for comparative genomic visualization are available and are widely used.</p><p>To follow trends in the field, we summarize the tools into four categories: genome alignment visualization tools (Table <xref rid="Tab3" ref-type="table">3</xref>); genome assembly visualization tools (Table <xref rid="Tab4" ref-type="table">4</xref>); genome browsers (Table <xref rid="Tab5" ref-type="table">5</xref>); and tools to directly compare different genomes with each other for efficient detection of SNPs and genomic variations (Table <xref rid="Tab6" ref-type="table">6</xref>). Following the same approach used for network biology (above), we examine the citation progress of the first article that was published for each tool using the Scopus repository (Fig. <xref rid="Fig4" ref-type="fig">4</xref>). Consed [<xref ref-type="bibr" rid="CR76">76</xref>] and Gap [<xref ref-type="bibr" rid="CR100">100</xref>, <xref ref-type="bibr" rid="CR101">101</xref>] seem to be the most widely used assembly viewers, while SAMtools tview [<xref ref-type="bibr" rid="CR102">102</xref>] is the favorite tool for genomic assembly visualization. In addition, the University of California, Santa Cruz (UCSC) Genome Browser [<xref ref-type="bibr" rid="CR103">103</xref>], Artemis [<xref ref-type="bibr" rid="CR104">104</xref>] and Ensembl [<xref ref-type="bibr" rid="CR105">105</xref>, <xref ref-type="bibr" rid="CR106">106</xref>] seem to be the go-to genome browsers, while Circos [<xref ref-type="bibr" rid="CR107">107</xref>], VISTA [<xref ref-type="bibr" rid="CR108">108</xref>] and cBio [<xref ref-type="bibr" rid="CR109">109</xref>] are the most widely used tools for comparative genomics.<table-wrap id="Tab3"><label>Table 3</label><caption><p>Visualization tools for genome alignments</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Tool and references</th><th>Description</th><th>URL</th></tr></thead><tbody><tr><td>ABySS Explorer [<xref ref-type="bibr" rid="CR210">210</xref>]</td><td>Interactive Java application that uses a novel graph-based representation to display a sequence assembly and associated metadata</td><td><ext-link ext-link-type="uri" xlink:href="http://www.bcgsc.ca/platform/bioinfo/software/abyss-explorer">http://www.bcgsc.ca/platform/bioinfo/software/abyss-explorer</ext-link></td></tr><tr><td>BamView [<xref ref-type="bibr" rid="CR211">211</xref>]</td><td>Genome browser and annotation tool that allows visualization of sequence features, next-generation sequencing (NGS) data and the results of analyses within the context of the sequence, and also its six-frame translation</td><td><ext-link ext-link-type="uri" xlink:href="http://www.sanger.ac.uk/resources/software/artemis/">http://www.sanger.ac.uk/resources/software/artemis/</ext-link></td></tr><tr><td>DNannotator [<xref ref-type="bibr" rid="CR212">212</xref>]</td><td>Annotation web toolkit for regional genomic sequences</td><td><ext-link ext-link-type="uri" xlink:href="http://bioapp.psych.uic.edu/DNannotator.htm">http://bioapp.psych.uic.edu/DNannotator.htm</ext-link></td></tr><tr><td>JVM [<xref ref-type="bibr" rid="CR213">213</xref>]</td><td>Java Visual Mapping tool for NGS reads</td><td><ext-link ext-link-type="uri" xlink:href="http://www.springer.com/cda/content/document/cda_downloaddocument/9789401792448-c2.pdf?SGWID=0-0-45-1487072-p176815501">http://www.springer.com/cda/content/document/cda_downloaddocument/9789401792448-c2.pdf?SGWID=0-0-45-1487072-p176815501</ext-link></td></tr><tr><td>LookSeq [<xref ref-type="bibr" rid="CR214">214</xref>]</td><td>Web-based visualization of sequences derived from multiple sequencing technologies. Low- or high-depth read pileups and easy visualization of putative single nucleotide and structural variation</td><td><ext-link ext-link-type="uri" xlink:href="http://lookseq.sourceforge.net">http://lookseq.sourceforge.net</ext-link></td></tr><tr><td>MagicViewer [<xref ref-type="bibr" rid="CR215">215</xref>]</td><td>Visualization of short read alignment, identification of genetic variation and association with annotation information of a reference genome</td><td><ext-link ext-link-type="uri" xlink:href="http://bioinformatics.zj.cn/magicviewer/">http://bioinformatics.zj.cn/magicviewer/</ext-link></td></tr><tr><td>MapView [<xref ref-type="bibr" rid="CR216">216</xref>]</td><td>Alignments of huge-scale single-end and pair-end short reads</td><td><ext-link ext-link-type="uri" xlink:href="http://omictools.com/mapview-s1367.html">http://omictools.com/mapview-s1367.html</ext-link></td></tr><tr><td>MultiPipMaker [<xref ref-type="bibr" rid="CR217">217</xref>]</td><td>Computes alignments of similar regions in two DNA sequences. The resulting alignments are summarized with a ‘percent identity plot’ (pip)</td><td><ext-link ext-link-type="uri" xlink:href="http://pipmaker.bx.psu.edu/pipmaker/">http://pipmaker.bx.psu.edu/pipmaker/</ext-link></td></tr><tr><td>PileLineGUI [<xref ref-type="bibr" rid="CR218">218</xref>]</td><td>Handling genome position files in NGS studies</td><td><ext-link ext-link-type="uri" xlink:href="http://sing.ei.uvigo.es/pileline/pilelinegui.html">http://sing.ei.uvigo.es/pileline/pilelinegui.html</ext-link></td></tr><tr><td>SAMtools tview [<xref ref-type="bibr" rid="CR102">102</xref>]</td><td>Simple and fast text alignment viewer; NGS compatible</td><td><ext-link ext-link-type="uri" xlink:href="http://www.htslib.org/">http://www.htslib.org/</ext-link></td></tr><tr><td>SEWAL [<xref ref-type="bibr" rid="CR219">219</xref>]</td><td>Uses a locality-sensitive hashing algorithm to enumerate all unique sequences in an entire Illumina sequencing run</td><td><ext-link ext-link-type="uri" xlink:href="http://www.sourceforge.net/projects/sewal">http://www.sourceforge.net/projects/sewal</ext-link></td></tr><tr><td>STAR [<xref ref-type="bibr" rid="CR220">220</xref>]</td><td>A web-based integrated solution to management and visualization of sequencing data</td><td><ext-link ext-link-type="uri" xlink:href="http://wanglab.ucsd.edu/star/browser">http://wanglab.ucsd.edu/star/browser</ext-link></td></tr><tr><td>SVA [<xref ref-type="bibr" rid="CR221">221</xref>]</td><td>Software for annotating and visualizing sequenced human genomes</td><td><ext-link ext-link-type="uri" xlink:href="http://www.svaproject.org">http://www.svaproject.org</ext-link></td></tr><tr><td>Viewer (IGV) [<xref ref-type="bibr" rid="CR222">222</xref>]</td><td>Visualization of large heterogeneous datasets, providing a smooth and intuitive user experience at all levels of genome resolution</td><td><ext-link ext-link-type="uri" xlink:href="https://www.broadinstitute.org/igv/">https://www.broadinstitute.org/igv/</ext-link></td></tr><tr><td>ZOOM Lite [<xref ref-type="bibr" rid="CR223">223</xref>]</td><td>NGS data mapping and visualization software</td><td><ext-link ext-link-type="uri" xlink:href="http://bioinfor.com/zoom/lite/">http://bioinfor.com/zoom/lite/</ext-link></td></tr></tbody></table></table-wrap><table-wrap id="Tab4"><label>Table 4</label><caption><p>Visualization tools for assemblies</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Tool and references</th><th>Description</th><th>URL</th></tr></thead><tbody><tr><td>Archive Viewer [<xref ref-type="bibr" rid="CR224">224</xref>]</td><td>Web graphical interface to make contigs and trace data changes in the National Center for Biotechnology Information (NCBI)</td><td><ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/Traces/assembly/assmbrowser.cgi?">http://www.ncbi.nlm.nih.gov/Traces/assembly/assmbrowser.cgi?</ext-link></td></tr><tr><td>CBrowse [<xref ref-type="bibr" rid="CR225">225</xref>]</td><td>SAM/BAM-based contig web browser for transcriptome assembly visualization and analysis</td><td><ext-link ext-link-type="uri" xlink:href="http://bioinfolab.muohio.edu/CBrowse/">http://bioinfolab.muohio.edu/CBrowse/</ext-link></td></tr><tr><td>Consed [<xref ref-type="bibr" rid="CR76">76</xref>]</td><td>Assembly finishing package; NGS compatible</td><td><ext-link ext-link-type="uri" xlink:href="http://www.phrap.org/">http://www.phrap.org/</ext-link></td></tr><tr><td>ContigScape [<xref ref-type="bibr" rid="CR226">226</xref>]</td><td>A Cytoscape plugin facilitating microbial genome gap closing</td><td><ext-link ext-link-type="uri" xlink:href="http://sourceforge.net/projects/contigscape/">http://sourceforge.net/projects/contigscape/</ext-link></td></tr><tr><td>DNASTAR Lasergene [<xref ref-type="bibr" rid="CR227">227</xref>]</td><td>Analysis suite with an assembly package</td><td><ext-link ext-link-type="uri" xlink:href="http://www.dnastar.com/">http://www.dnastar.com/</ext-link></td></tr><tr><td>EagleView [<xref ref-type="bibr" rid="CR228">228</xref>]</td><td>An information-rich viewer for genome assemblies with data integration capability</td><td><ext-link ext-link-type="uri" xlink:href="http://www.niehs.nih.gov/research/resources/software/biostatistics/eagleview/">http://www.niehs.nih.gov/research/resources/software/biostatistics/eagleview/</ext-link></td></tr><tr><td>Gap [<xref ref-type="bibr" rid="CR100">100</xref>, <xref ref-type="bibr" rid="CR101">101</xref>]</td><td>A fully developed set of DNA sequence assembly (Gap4 and Gap5), editing and analysis tools</td><td><ext-link ext-link-type="uri" xlink:href="http://staden.sourceforge.net/">http://staden.sourceforge.net/</ext-link></td></tr><tr><td>Hawkeye [<xref ref-type="bibr" rid="CR229">229</xref>]</td><td>An interactive visual analytics tool for genome assemblies. Detection of anomalies in data and visual identification and correction of assembly errors</td><td><ext-link ext-link-type="uri" xlink:href="http://amos.sourceforge.net/wiki/index.php?title=Hawkeye">http://amos.sourceforge.net/wiki/index.php?title=Hawkeye</ext-link></td></tr><tr><td>Tablet [<xref ref-type="bibr" rid="CR230">230</xref>]</td><td>A lightweight, high-performance graphical viewer for NGS assemblies and alignments</td><td><ext-link ext-link-type="uri" xlink:href="http://bioinf.scri.ac.uk/tablet">http://bioinf.scri.ac.uk/tablet</ext-link></td></tr></tbody></table></table-wrap><table-wrap id="Tab5"><label>Table 5</label><caption><p>Genome browsers</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Tool and references</th><th>Description</th><th>URL</th><th>Web-based or standalone</th></tr></thead><tbody><tr><td>ABrowse [<xref ref-type="bibr" rid="CR231">231</xref>]</td><td>A customizable genome browser framework</td><td><ext-link ext-link-type="uri" xlink:href="http://www.abrowse.org/">http://www.abrowse.org/</ext-link></td><td>Web-based</td></tr><tr><td>AnnoJ [<xref ref-type="bibr" rid="CR232">232</xref>]</td><td>A web 2.0 application designed for visualizing deep sequencing data and other genome annotation data</td><td><ext-link ext-link-type="uri" xlink:href="http://www.annoj.org/">http://www.annoj.org/</ext-link></td><td>Web-based</td></tr><tr><td>Argo</td><td>Java tool for visualizing and manually annotating whole genomes</td><td><ext-link ext-link-type="uri" xlink:href="http://www.broadinstitute.org/annotation/argo/">http://www.broadinstitute.org/annotation/argo/</ext-link></td><td>Standalone</td></tr><tr><td>Artemis [<xref ref-type="bibr" rid="CR104">104</xref>]</td><td>Browser and annotation tool that allows visualization of sequence features, data and the results of analyses within the context of the sequence, and also its six-frame translation</td><td><ext-link ext-link-type="uri" xlink:href="https://www.sanger.ac.uk/resources/software/artemis/">https://www.sanger.ac.uk/resources/software/artemis/</ext-link></td><td>Standalone</td></tr><tr><td>CGView [<xref ref-type="bibr" rid="CR233">233</xref>]</td><td>Static and interactive graphical maps of circular genomes using a circular layout</td><td><ext-link ext-link-type="uri" xlink:href="https://www.gview.ca/wiki/GView/">https://www.gview.ca/wiki/GView/</ext-link></td><td>Standalone</td></tr><tr><td>Combo [<xref ref-type="bibr" rid="CR234">234</xref>]</td><td>Dynamic browser to visualize alignments of whole genomes and their associated annotations</td><td><ext-link ext-link-type="uri" xlink:href="http://www.broad.mit.edu/annotation/argo/">http://www.broad.mit.edu/annotation/argo/</ext-link></td><td>Standalone</td></tr><tr><td>Ensembl [<xref ref-type="bibr" rid="CR105">105</xref>, <xref ref-type="bibr" rid="CR106">106</xref>]</td><td>Annotation, analysis and display of vertebrates and other eukaryotic species</td><td><ext-link ext-link-type="uri" xlink:href="http://www.ensembl.org/">http://www.ensembl.org/</ext-link></td><td>Web-based</td></tr><tr><td>Family Genome Browser [<xref ref-type="bibr" rid="CR235">235</xref>]</td><td>Visualizing genomes with pedigree information</td><td><ext-link ext-link-type="uri" xlink:href="http://mlg.hit.edu.cn/FGB/">http://mlg.hit.edu.cn/FGB/</ext-link></td><td>Web-based</td></tr><tr><td>Gaggle [<xref ref-type="bibr" rid="CR236">236</xref>]</td><td>Genome browser within an analysis framework; good microarray support</td><td><ext-link ext-link-type="uri" xlink:href="http://gaggle.systemsbiology.net/">http://gaggle.systemsbiology.net/</ext-link></td><td>Standalone</td></tr><tr><td>GBrowse [<xref ref-type="bibr" rid="CR237">237</xref>, <xref ref-type="bibr" rid="CR238">238</xref>]</td><td>A combination of database and interactive web pages for manipulating and displaying annotations on genomes</td><td><ext-link ext-link-type="uri" xlink:href="http://gmod.org/wiki/Gbrowse">http://gmod.org/wiki/Gbrowse</ext-link></td><td>Web-based</td></tr><tr><td>GenoMap [<xref ref-type="bibr" rid="CR239">239</xref>]</td><td>A circular genome data viewer</td><td><ext-link ext-link-type="uri" xlink:href="http://nsato4.c.u-tokyo.ac.jp/old/GenoMap/GenoMap.html">http://nsato4.c.u-tokyo.ac.jp/old/GenoMap/GenoMap.html</ext-link></td><td>Standalone</td></tr><tr><td>Genome Projector [<xref ref-type="bibr" rid="CR240">240</xref>]</td><td>Circular genome maps, traditional genome maps, plasmid maps, biochemical pathways maps and DNA walks. Google API</td><td><ext-link ext-link-type="uri" xlink:href="http://www.g-language.org/GenomeProjector/">http://www.g-language.org/GenomeProjector/</ext-link></td><td>Web-based</td></tr><tr><td>GenomeView [<xref ref-type="bibr" rid="CR241">241</xref>]</td><td>Designed to visualize and manipulate a multitude of genomics data</td><td><ext-link ext-link-type="uri" xlink:href="http://genomeview.org/content/integration">http://genomeview.org/content/integration</ext-link></td><td>Standalone</td></tr><tr><td>GenPlay [<xref ref-type="bibr" rid="CR242">242</xref>]</td><td>A multipurpose genome analyzer and browser</td><td><ext-link ext-link-type="uri" xlink:href="http://www.genplay.net">http://www.genplay.net</ext-link></td><td>Standalone</td></tr><tr><td>IGB [<xref ref-type="bibr" rid="CR243">243</xref>]</td><td>Optimized to achieve maximum flexibility and high quality genome visualization</td><td><ext-link ext-link-type="uri" xlink:href="http://genoviz.sourceforge.net/">http://genoviz.sourceforge.net/</ext-link></td><td>Standalone</td></tr><tr><td>IGV [<xref ref-type="bibr" rid="CR222">222</xref>]</td><td>A high-performance visualization tool for interactive exploration of large, integrated genomic datasets</td><td><ext-link ext-link-type="uri" xlink:href="http://www.broadinstitute.org/igv/">http://www.broadinstitute.org/igv/</ext-link></td><td>Standalone</td></tr><tr><td>JBrowse [<xref ref-type="bibr" rid="CR244">244</xref>]</td><td>A fast, embeddable genome browser built completely with JavaScript and HTML5</td><td><ext-link ext-link-type="uri" xlink:href="http://jbrowse.org/">http://jbrowse.org/</ext-link></td><td>Web-based</td></tr><tr><td>JGI</td><td>Supports live annotation; primary portal for DOE Joint Genomics Institute genome projects</td><td><ext-link ext-link-type="uri" xlink:href="http://genome.jgi-psf.org/">http://genome.jgi-psf.org/</ext-link></td><td>Web-based</td></tr><tr><td>NCBI Genome Workbench</td><td>An integrated application for viewing and analyzing sequence data</td><td><ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/tools/gbench/">http://www.ncbi.nlm.nih.gov/tools/gbench/</ext-link></td><td>Standalone</td></tr><tr><td>NCBI Map Viewer [<xref ref-type="bibr" rid="CR245">245</xref>]</td><td>Vertically oriented viewer; integrated with NCBI resources and tools</td><td><ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/mapview/">http://www.ncbi.nlm.nih.gov/mapview/</ext-link></td><td>Web-based</td></tr><tr><td>Phytozome [<xref ref-type="bibr" rid="CR246">246</xref>]</td><td>A comparative platform for green plant genomics</td><td><ext-link ext-link-type="uri" xlink:href="http://www.phytozome.net">http://www.phytozome.net</ext-link></td><td>Web-based</td></tr><tr><td>Savant [<xref ref-type="bibr" rid="CR247">247</xref>]</td><td>It was primarily developed for visualizing sequencing data, although it can be used to visualize almost any genome-based sequence, point, interval or continuous dataset</td><td><ext-link ext-link-type="uri" xlink:href="http://compbio.cs.toronto.edu/savant">http://compbio.cs.toronto.edu/savant</ext-link></td><td>Standalone</td></tr><tr><td>Scribl [<xref ref-type="bibr" rid="CR248">248</xref>]</td><td>An HTML5 Canvas-based graphics library for visualizing genomic data over the web</td><td><ext-link ext-link-type="uri" xlink:href="http://chmille4.github.com/Scribl/">http://chmille4.github.com/Scribl/</ext-link></td><td>Web-based</td></tr><tr><td>The HuRef Browser [<xref ref-type="bibr" rid="CR249">249</xref>]</td><td>A web resource for individual human genomics</td><td><ext-link ext-link-type="uri" xlink:href="http://huref.jcvi.org">http://huref.jcvi.org</ext-link></td><td>Web-based</td></tr><tr><td>The personal genome browser [<xref ref-type="bibr" rid="CR250">250</xref>]</td><td>Visualizing functions of genetic variants</td><td><ext-link ext-link-type="uri" xlink:href="http://www.pgbrowser.org/">http://www.pgbrowser.org/</ext-link></td><td>Web-based</td></tr><tr><td>UCSC Cancer Genomics Browser [<xref ref-type="bibr" rid="CR251">251</xref>, <xref ref-type="bibr" rid="CR252">252</xref>]</td><td>Integration of clinical data</td><td><ext-link ext-link-type="uri" xlink:href="http://genome-cancer.ucsc.edu/">http://genome-cancer.ucsc.edu/</ext-link></td><td>Web-based</td></tr><tr><td>UCSC Genome Browser [<xref ref-type="bibr" rid="CR103">103</xref>]</td><td>Rapid linear visualization, examination and querying of the data at many levels</td><td><ext-link ext-link-type="uri" xlink:href="http://genome.ucsc.edu/cgi-bin/hgGateway">http://genome.ucsc.edu/cgi-bin/hgGateway</ext-link></td><td>Web-based</td></tr><tr><td>UTGB [<xref ref-type="bibr" rid="CR253">253</xref>]</td><td>Open-source software for developing personalized genome browsers that work in web browsers</td><td><ext-link ext-link-type="uri" xlink:href="http://utgenome.org/">http://utgenome.org/</ext-link></td><td>Web-based</td></tr><tr><td>X:map [<xref ref-type="bibr" rid="CR254">254</xref>]</td><td>Mappings between genomic features and Affymetrix microarrays</td><td><ext-link ext-link-type="uri" xlink:href="http://xmap.picr.man.ac.uk/">http://xmap.picr.man.ac.uk/</ext-link></td><td>Web-based</td></tr></tbody></table></table-wrap><table-wrap id="Tab6"><label>Table 6</label><caption><p>Visualization tools for comparative genomics</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Tool and references</th><th>Description</th><th>URL</th><th>Web-based or standalone</th></tr></thead><tbody><tr><td>ACT [<xref ref-type="bibr" rid="CR255">255</xref>]</td><td>A tool for displaying pairwise comparisons between two or more DNA sequences</td><td><ext-link ext-link-type="uri" xlink:href="http://www.sanger.ac.uk/Software/ACT/">http://www.sanger.ac.uk/Software/ACT/</ext-link></td><td>Standalone</td></tr><tr><td>cBio [<xref ref-type="bibr" rid="CR109">109</xref>]</td><td>An open-access resource for interactive exploration of multidimensional cancer genomics datasets</td><td><ext-link ext-link-type="uri" xlink:href="http://cbioportal.org">http://cbioportal.org</ext-link></td><td>Web-based</td></tr><tr><td>Cinteny [<xref ref-type="bibr" rid="CR256">256</xref>]</td><td>Detection of syntenic regions across multiple genomes and measuring the extent of genome rearrangement using reversal distance as a measure</td><td><ext-link ext-link-type="uri" xlink:href="http://cinteny.cchmc.org/">http://cinteny.cchmc.org/</ext-link></td><td>Web-based</td></tr><tr><td>Circos [<xref ref-type="bibr" rid="CR107">107</xref>]</td><td>A software package for visualizing data and information. It visualizes data in a circular layout</td><td><ext-link ext-link-type="uri" xlink:href="http://mkweb.bcgsc.ca/circos">http://mkweb.bcgsc.ca/circos</ext-link></td><td>Standalone</td></tr><tr><td>CMap [<xref ref-type="bibr" rid="CR257">257</xref>]</td><td>A browser-based tool for the visual comparison of various maps (sequence, genetic, etc.) from any number of species</td><td><ext-link ext-link-type="uri" xlink:href="http://gmod.org/wiki/CMap">http://gmod.org/wiki/CMap</ext-link></td><td>Standalone</td></tr><tr><td>CoGe SynMap [<xref ref-type="bibr" rid="CR258">258</xref>]</td><td>Generates a syntenic dot-plot between two organisms and identifies syntenic regions</td><td><ext-link ext-link-type="uri" xlink:href="https://genomevolution.org/coge/SynMap.pl">https://genomevolution.org/coge/SynMap.pl</ext-link></td><td>Web-based</td></tr><tr><td>Combo [<xref ref-type="bibr" rid="CR234">234</xref>]</td><td>Dot-plot and linked-track views. Integration of annotation in both views</td><td><ext-link ext-link-type="uri" xlink:href="http://www.broadinstitute.org/annotation/argo/">http://www.broadinstitute.org/annotation/argo/</ext-link></td><td>Standalone</td></tr><tr><td>DHPC [<xref ref-type="bibr" rid="CR259">259</xref>]</td><td>Visualization of large-scale genome sequences by mapping sequences into a 2D using the space-filling function of Hilbert-Peano mapping</td><td><ext-link ext-link-type="uri" xlink:href="http://www.hpcurve.com">http://www.hpcurve.com</ext-link></td><td>Standalone</td></tr><tr><td>DNAPlotter [<xref ref-type="bibr" rid="CR260">260</xref>]</td><td>A Java application for generating circular and linear representations of genomes. Makes use of the Artemis libraries</td><td><ext-link ext-link-type="uri" xlink:href="http://www.sanger.ac.uk/resources/software/dnaplotter/">http://www.sanger.ac.uk/resources/software/dnaplotter/</ext-link></td><td>Standalone</td></tr><tr><td>FilooT [<xref ref-type="bibr" rid="CR261">261</xref>]</td><td>A visualization tool for exploring genomic data</td><td>No URL</td><td>Standalone</td></tr><tr><td>GBrowsesyn [<xref ref-type="bibr" rid="CR262">262</xref>]</td><td>GBrowse-based synteny browser designed to display multiple genomes, with a central reference species compared with two or more additional species</td><td><ext-link ext-link-type="uri" xlink:href="http://gmod.org/wiki/GBrowse_syn">http://gmod.org/wiki/GBrowse_syn</ext-link></td><td>Standalone</td></tr><tr><td>GenomeComp [<xref ref-type="bibr" rid="CR263">263</xref>]</td><td>A tool for summarizing, parsing and visualizing the genome-wide sequence comparison results derived from voluminous BLAST textual output</td><td><ext-link ext-link-type="uri" xlink:href="http://www.mgc.ac.cn/GenomeComp/">http://www.mgc.ac.cn/GenomeComp/</ext-link></td><td>Standalone</td></tr><tr><td>GenomeMatcher [<xref ref-type="bibr" rid="CR264">264</xref>]</td><td>A dot-plot-based viewer for DNA sequence comparison</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/genomematcher/">http://tinyurl.com/genomematcher/</ext-link></td><td>Web-based</td></tr><tr><td>GenPlay Multi-Genome [<xref ref-type="bibr" rid="CR265">265</xref>]</td><td>A tool to compare and analyze multiple human genomes in a graphical interface</td><td><ext-link ext-link-type="uri" xlink:href="http://genplay.einstein.yu.edu">http://genplay.einstein.yu.edu</ext-link></td><td>Standalone</td></tr><tr><td>ggbio [<xref ref-type="bibr" rid="CR266">266</xref>]</td><td>R library to visualize particular genomic regions and genome-wide overviews</td><td><ext-link ext-link-type="uri" xlink:href="http://www.bioconductor.org/packages/2.11/bioc/html/ggbio.html">http://www.bioconductor.org/packages/2.11/bioc/html/ggbio.html</ext-link></td><td>Standalone</td></tr><tr><td>Gramene [<xref ref-type="bibr" rid="CR267">267</xref>, <xref ref-type="bibr" rid="CR268">268</xref>]</td><td>A comparative genome mapping database for grasses and a community resource for <italic>Oryza sativa</italic></td><td><ext-link ext-link-type="uri" xlink:href="http://ensembl.gramene.org/genome_browser/index.html">http://ensembl.gramene.org/genome_browser/index.html</ext-link></td><td>Web-based</td></tr><tr><td>HilbertVis [<xref ref-type="bibr" rid="CR269">269</xref>]</td><td>Functions to visualize long vectors of integer data by means of Hilbert curves</td><td><ext-link ext-link-type="uri" xlink:href="http://www.ebi.ac.uk/huber-srv/hilbert/">http://www.ebi.ac.uk/huber-srv/hilbert/</ext-link></td><td>Standalone</td></tr><tr><td>In-GAVsv [<xref ref-type="bibr" rid="CR270">270</xref>]</td><td>Integrative genome analysis pipeline (inGAP), which uses a Bayesian principle to detect SNPs and small insertion/deletions (indels)</td><td><ext-link ext-link-type="uri" xlink:href="http://ingap.sourceforge.net/">http://ingap.sourceforge.net/</ext-link></td><td>Standalone</td></tr><tr><td>Meander [<xref ref-type="bibr" rid="CR271">271</xref>]</td><td>Hilbert plots to visually discover and explore structural variations in a genome based on read-depth and pair-end information</td><td><ext-link ext-link-type="uri" xlink:href="https://sites.google.com/site/meanderviz/">https://sites.google.com/site/meanderviz/</ext-link></td><td>Standalone</td></tr><tr><td>MEDEA [<xref ref-type="bibr" rid="CR272">272</xref>]</td><td>Genomic feature densities and genome alignments of circular genomes. Comparative genomic visualization with Adobe Flash</td><td><ext-link ext-link-type="uri" xlink:href="http://www.broadinstitute.org/annotation/medea/">http://www.broadinstitute.org/annotation/medea/</ext-link></td><td>Web-based</td></tr><tr><td>MizBee [<xref ref-type="bibr" rid="CR273">273</xref>]</td><td>A multiscale synteny browser for exploring conservation relationships in comparative genomics data. Using side-by-side linked views, it enables efficient data browsing across a range of scales, from the genome to the gene</td><td><ext-link ext-link-type="uri" xlink:href="http://www.cs.utah.edu/~miriah/mizbee">http://www.cs.utah.edu/~miriah/mizbee</ext-link></td><td>Web-based</td></tr><tr><td>MuSiC [<xref ref-type="bibr" rid="CR274">274</xref>]</td><td>Identifying mutational significance in cancer genomes</td><td><ext-link ext-link-type="uri" xlink:href="http://gmt.genome.wustl.edu">http://gmt.genome.wustl.edu</ext-link></td><td>Standalone</td></tr><tr><td>ngs.plot [<xref ref-type="bibr" rid="CR275">275</xref>]</td><td>Quick mining and visualization of NGS data by integrating genomic databases</td><td><ext-link ext-link-type="uri" xlink:href="https://github.com/shenlab-sinai/ngsplot">https://github.com/shenlab-sinai/ngsplot</ext-link></td><td>Standalone</td></tr><tr><td>PhIGs [<xref ref-type="bibr" rid="CR276">276</xref>]</td><td>Ideogram-style interactive display of orthologs across >75 genomes</td><td><ext-link ext-link-type="uri" xlink:href="http://phigs.org">http://phigs.org</ext-link></td><td>Web-based</td></tr><tr><td>PSAT [<xref ref-type="bibr" rid="CR277">277</xref>]</td><td>A web tool to compare genomic neighborhoods of multiple prokaryotic genomes</td><td><ext-link ext-link-type="uri" xlink:href="http://www.nwrce.org/psat">http://www.nwrce.org/psat</ext-link></td><td>Web-based</td></tr><tr><td>Seevolution [<xref ref-type="bibr" rid="CR278">278</xref>]</td><td>Interactive 3D environment that enables visualization of diverse genome evolution processes</td><td><ext-link ext-link-type="uri" xlink:href="http://seevolution.org">http://seevolution.org</ext-link></td><td>Standalone</td></tr><tr><td>Sybil [<xref ref-type="bibr" rid="CR279">279</xref>]</td><td>Comparative genome data, particularly protein and gene clustered data</td><td><ext-link ext-link-type="uri" xlink:href="http://sybil.sourceforge.net/">http://sybil.sourceforge.net/</ext-link></td><td>Web-based</td></tr><tr><td>SynView [<xref ref-type="bibr" rid="CR238">238</xref>]</td><td>A GBrowse-compatible approach to visualizing comparative genome data</td><td><ext-link ext-link-type="uri" xlink:href="http://gmod.org/wiki/SynView">http://gmod.org/wiki/SynView</ext-link></td><td>Standalone</td></tr><tr><td>TREAT [<xref ref-type="bibr" rid="CR280">280</xref>]</td><td>A bioinformatics tool for variant annotations and visualizations in targeted and exome sequencing data</td><td><ext-link ext-link-type="uri" xlink:href="http://ndc.mayo.edu/mayo/research/biostat/stand-alone-packages.cfm">http://ndc.mayo.edu/mayo/research/biostat/stand-alone-packages.cfm</ext-link></td><td>Standalone</td></tr><tr><td>UCSC Genome Browser [<xref ref-type="bibr" rid="CR281">281</xref>]</td><td>Conservation tracks within the popular UCSC genome browser</td><td><ext-link ext-link-type="uri" xlink:href="http://genome.ucsc.edu/cgi-bin/hgGateway/">http://genome.ucsc.edu/cgi-bin/hgGateway/</ext-link></td><td>Web-based</td></tr><tr><td>Vanno [<xref ref-type="bibr" rid="CR282">282</xref>]</td><td>A visualization-aided variant annotation tool</td><td><ext-link ext-link-type="uri" xlink:href="http://cgts.cgu.edu.tw/vanno">http://cgts.cgu.edu.tw/vanno</ext-link></td><td>Web-based</td></tr><tr><td>Variant View [<xref ref-type="bibr" rid="CR283">283</xref>]</td><td>Features an information-dense visual encoding that provides maximal information at the overview level, in contrast to the extensive navigation required by currently prevalent genome browsers</td><td><ext-link ext-link-type="uri" xlink:href="http://www.cs.ubc.ca/labs/imager/tr/2013/VariantView/">http://www.cs.ubc.ca/labs/imager/tr/2013/VariantView/</ext-link></td><td>Web-based</td></tr><tr><td>VISTA [<xref ref-type="bibr" rid="CR108">108</xref>]</td><td>A comprehensive suite of programs and databases for comparative analysis of genomic sequences</td><td><ext-link ext-link-type="uri" xlink:href="http://genome.lbl.gov/vista/index.shtml">http://genome.lbl.gov/vista/index.shtml</ext-link></td><td>Web-based</td></tr><tr><td>VSV, VISTA-Dot [<xref ref-type="bibr" rid="CR284">284</xref>, <xref ref-type="bibr" rid="CR285">285</xref>]</td><td>Three-scale viewer for synteny and dynamic, interactive dot plots for whole-genome DNA alignments</td><td><ext-link ext-link-type="uri" xlink:href="http://genome.jgi-psf.org/synteny/">http://genome.jgi-psf.org/synteny/</ext-link></td><td>Web-based</td></tr></tbody></table></table-wrap><fig id="Fig4"><label>Fig. 4</label><caption><p>Citation trends and key players in genome biology. <bold>a</bold> Citations of genome alignment visualization tools based on Scopus. <bold>b</bold> Citations of genome assembly visualization tools based on Scopus. <bold>c</bold> Citations of genome browsers based on Scopus. <bold>d</bold> Citations of comparative genomics visualization tools based on Scopus. The numbers of citations of each tool in 2015 are shown after its name</p></caption><graphic xlink:href="13742_2015_77_Fig4_HTML" id="d30e4048"></graphic></fig></p><p>Although tremendous progress has been made in genomic visualization and very large amounts of money have been invested in such projects, genome browsers [<xref ref-type="bibr" rid="CR110">110</xref>] still need to address major problems. One of the biggest challenges is the integration of data in different formats (such as genomic and clinical data) as society enters the personalized medicine era. Furthermore, navigation at different resolution or granularity levels and smooth scaling are necessary as long as simultaneous comparisons across millions of elements [<xref ref-type="bibr" rid="CR111">111</xref>] remains a bottleneck. Newer infrastructure and software that allow on-the-fly calculations both in the front end and the back end would definitely be a step forward. Finally, similarly to network biology, time-series data visualization is one of the great challenges. For example, in a hypothetical scenario in which it is required to follow genomic rearrangements over time during tumor development, time-series data visualization would be an invaluable tool. Motion integration and visualization using additional dimensions could be possible solutions. Overall, it would be unrealistic to expect an ideal universal genome browser that serves all the possible purposes in the field.</p></sec><sec id="Sec5"><title>Visualization and analysis of expression data</title><p>Microarrays [<xref ref-type="bibr" rid="CR112">112</xref>] and RNA sequencing [<xref ref-type="bibr" rid="CR87">87</xref>] are the two main high-throughput techniques for measuring expression levels of large numbers of genes simultaneously. Both methods are revolutionary as one can simultaneously monitor the effects of certain treatments, diseases and developmental stages on gene expression across time (Fig. <xref rid="Fig5" ref-type="fig">5a</xref>) and for multiple transcript isoforms. Although microarrays and RNAseq technologies are comparable to each other [<xref ref-type="bibr" rid="CR113">113</xref>], the latter tends to dominate, especially as sequencing technologies have improved, and there now are robust statistics to model the particular noise characteristics of RNAseq, particularly for low expression [<xref ref-type="bibr" rid="CR114">114</xref>]. Microarrays are still cheaper and in some contexts may be more convenient as their analysis is still simpler and requires less computing infrastructure.<fig id="Fig5"><label>Fig. 5</label><caption><p>Multivariate analyses and visualization. <bold>a</bold> Timeline of the emergence of relevant technologies and concepts. <bold>b</bold> Visualization of k-means partitional clustering algorithm. <bold>c</bold> 3D visualization of a principal component analysis. <bold>d</bold> Visualization of gene-expression measures across time using parallel coordinates. <bold>e</bold> Visualization of gene-expression clustering across time. <bold>f</bold> 2D hierarchical clustering to visualize gene expressions against several time points or conditions. <bold>g</bold> Hypothetical integration of analyses and expression heatmaps and the control of objects by VR devices</p></caption><graphic xlink:href="13742_2015_77_Fig5_HTML" id="d30e4108"></graphic></fig></p><p>In both cases, a typical analysis procedure is first to normalize experimental and batch differences between samples and then to identify up- and downregulated genes based on a fold-change level when comparing across samples, such as between a healthy and a non-healthy tissue. Statistical approaches are used to assess how reliable fold-change measurements are for each transcript of interest by modeling variation across transcripts and experiments. Subsequently, functional enrichment is performed to identify pathways and biological processes in which the up- and downregulated genes may be involved. Although there are numerous functional enrichment suites [<xref ref-type="bibr" rid="CR115">115</xref>], David [<xref ref-type="bibr" rid="CR116">116</xref>], Panther [<xref ref-type="bibr" rid="CR117">117</xref>] and WebGestalt [<xref ref-type="bibr" rid="CR118">118</xref>] are among the most widely used.</p><p>When gene expression is measured across many time points or conditions so as to observe, for example, the expression patterns following treatment, various analyses can be taken into consideration. Principal component analysis or partitional clustering algorithms such as k-means [<xref ref-type="bibr" rid="CR119">119</xref>] can be used to group together genes with similar behavior patterns. Scatter-plotting is the typical visualization to represent such groupings. Thus, each point on a plane represents a gene and the closer two genes appear, the more similar they are (Fig. <xref rid="Fig5" ref-type="fig">5b, c</xref>).</p><p>When one wants to categorize genes with similar behavior patterns across time (Fig. <xref rid="Fig5" ref-type="fig">5d</xref>), hierarchical clustering based on expression correlation can be performed. Average linkage, complete linkage, single linkage, neighbor joining [<xref ref-type="bibr" rid="CR120">120</xref>] and UPGMA [<xref ref-type="bibr" rid="CR121">121</xref>] are the most widely used methods. In such approaches, an all-against-all distance or correlation matrix that shows the similarities between each pair of genes is required and genes are placed as leaves in a tree hierarchy. The two most widely used correlation metrics for expression data are the Spearman and Pearson correlation metrics. A list of tree viewers for hierarchical clustering visualization is presented in Table <xref rid="Tab7" ref-type="table">7</xref>. A more advanced visualization method is combining trees with heatmaps (Fig. <xref rid="Fig5" ref-type="fig">5e</xref>): genes are grouped together according to their expression patterns in a tree hierarchy and the heat map is a graphical representation of individual gene-expression values represented as colors. Darker colors indicate a higher expression value and vice versa. An even more complex visualization of a 2D hierarchical clustering is shown in Fig. <xref rid="Fig5" ref-type="fig">5f</xref>, in which genes are clustered based on their expression patterns across several conditions (vertical tree on the left) and conditions are clustered across genes (horizontal tree). The heatmap shows the correlations between gene groups and conditions by allowing the researcher to come to conclusions about whether a group of genes is affected by a set of conditions or not. Heatmaps do, however, have significant drawbacks with regards to color perception. Perception of the color of a cell in a heatmap is shaped by the color of the surrounding cells, so two cells with identical color can look very different depending on their position in the heatmap.<table-wrap id="Tab7"><label>Table 7</label><caption><p>Tree viewers and phylogenies</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Tool and references</th><th>Description</th><th>URL</th></tr></thead><tbody><tr><td>ARB [<xref ref-type="bibr" rid="CR123">123</xref>]</td><td>A graphically oriented package comprising various tools for sequence database handling and data analysis</td><td><ext-link ext-link-type="uri" xlink:href="http://www.arb-home.de/">http://www.arb-home.de/</ext-link></td></tr><tr><td>Bio.Phylo [<xref ref-type="bibr" rid="CR286">286</xref>]</td><td>A unified toolkit for processing, analyzing and visualizing phylogenetic trees in Biopython</td><td><ext-link ext-link-type="uri" xlink:href="http://biopython.org">http://biopython.org</ext-link></td></tr><tr><td>Dendroscope [<xref ref-type="bibr" rid="CR125">125</xref>]</td><td>Software for visualizing phylogenetic trees and rooted networks</td><td><ext-link ext-link-type="uri" xlink:href="http://ab.inf.uni-tuebingen.de/software/dendroscope/">http://ab.inf.uni-tuebingen.de/software/dendroscope/</ext-link></td></tr><tr><td>ETE Toolkit [<xref ref-type="bibr" rid="CR287">287</xref>]</td><td>Python programming toolkit that assists in the automated manipulation, analysis and visualization of phylogenetic and other types of trees</td><td><ext-link ext-link-type="uri" xlink:href="http://etetoolkit.org/">http://etetoolkit.org/</ext-link></td></tr><tr><td>EvolView [<xref ref-type="bibr" rid="CR288">288</xref>]</td><td>Tool for displaying, managing and customizing phylogenetic trees</td><td><ext-link ext-link-type="uri" xlink:href="http://www.evolgenius.info/evolview.html">http://www.evolgenius.info/evolview.html</ext-link></td></tr><tr><td>iTOL [<xref ref-type="bibr" rid="CR126">126</xref>]</td><td>Online tool for the display and manipulation of phylogenetic trees</td><td><ext-link ext-link-type="uri" xlink:href="http://itol.embl.de/">http://itol.embl.de/</ext-link></td></tr><tr><td>MEGA [<xref ref-type="bibr" rid="CR122">122</xref>]</td><td>Integrated tool for phylogenetic analysis and visualization</td><td><ext-link ext-link-type="uri" xlink:href="http://www.megasoftware.net/">http://www.megasoftware.net/</ext-link></td></tr><tr><td>NJplot [<xref ref-type="bibr" rid="CR124">124</xref>]</td><td>A tree drawing program able to draw any phylogenetic tree expressed in the Newick phylogenetic tree format</td><td><ext-link ext-link-type="uri" xlink:href="http://doua.prabi.fr/software/njplot">http://doua.prabi.fr/software/njplot</ext-link></td></tr><tr><td>OneZoom [<xref ref-type="bibr" rid="CR289">289</xref>]</td><td>Committed to heightening awareness about the diversity of life on earth and its evolutionary history</td><td><ext-link ext-link-type="uri" xlink:href="http://www.onezoom.org/">http://www.onezoom.org/</ext-link></td></tr><tr><td>Paloverde [<xref ref-type="bibr" rid="CR290">290</xref>]</td><td>3D visualization of phylogenetic structure of moderately large trees on the scale of 100–2500 leaf nodes</td><td><ext-link ext-link-type="uri" xlink:href="http://loco.biosci.arizona.edu/paloverde/paloverde.html">http://loco.biosci.arizona.edu/paloverde/paloverde.html</ext-link></td></tr><tr><td>PhyloDraw [<xref ref-type="bibr" rid="CR291">291</xref>]</td><td>Drawing tool for creating phylogenetic trees</td><td><ext-link ext-link-type="uri" xlink:href="http://jade.cs.pusan.ac.kr/phylodraw/">http://jade.cs.pusan.ac.kr/phylodraw/</ext-link></td></tr><tr><td>PhyloExplorer [<xref ref-type="bibr" rid="CR292">292</xref>]</td><td>Tool to facilitate assessment and management of phylogenetic tree collections</td><td><ext-link ext-link-type="uri" xlink:href="http://www.ncbi.orthomam.univ-montp2.fr/phyloexplorer/">http://www.ncbi.orthomam.univ-montp2.fr/phyloexplorer/</ext-link></td></tr><tr><td>PhyloWidget [<xref ref-type="bibr" rid="CR293">293</xref>]</td><td>Program for viewing, editing and publishing phylogenetic trees online</td><td><ext-link ext-link-type="uri" xlink:href="http://www.phylowidget.org/">http://www.phylowidget.org/</ext-link></td></tr><tr><td>TreeDyn [<xref ref-type="bibr" rid="CR294">294</xref>]</td><td>TreeDyn links unique leaf labels to lists of variables/values pairs of annotations, independently of the tree topologies</td><td><ext-link ext-link-type="uri" xlink:href="http://www.treedyn.org/">http://www.treedyn.org/</ext-link></td></tr><tr><td>TreeGraph [<xref ref-type="bibr" rid="CR295">295</xref>]</td><td>A graphical editor for phylogenetic trees that allows many graphical formats for the elements of the tree</td><td><ext-link ext-link-type="uri" xlink:href="http://treegraph.bioinfweb.info/">http://treegraph.bioinfweb.info/</ext-link></td></tr><tr><td>TreeQ-Vista [<xref ref-type="bibr" rid="CR296">296</xref>]</td><td>Designed for presenting functional annotations in a phylogenetic context</td><td><ext-link ext-link-type="uri" xlink:href="http://genome.lbl.gov/vista/TreeQVista/">http://genome.lbl.gov/vista/TreeQVista/</ext-link></td></tr><tr><td>TreeVector [<xref ref-type="bibr" rid="CR297">297</xref>]</td><td>Web utility to create and integrate phylogenetic trees as Scalable Vector Graphics (SVG) files</td><td><ext-link ext-link-type="uri" xlink:href="http://supfam.cs.bris.ac.uk/TreeVector/">http://supfam.cs.bris.ac.uk/TreeVector/</ext-link></td></tr><tr><td>TreeVolution [<xref ref-type="bibr" rid="CR298">298</xref>]</td><td>Java tool to support visual analysis of phylogenetic trees</td><td><ext-link ext-link-type="uri" xlink:href="http://vis.usal.es/treevolution">http://vis.usal.es/treevolution</ext-link></td></tr><tr><td>T-REX [<xref ref-type="bibr" rid="CR299">299</xref>]</td><td>Web server dedicated to the reconstruction of phylogenetic trees and reticulation networks and to the inference of horizontal gene transfer events</td><td><ext-link ext-link-type="uri" xlink:href="http://www.trex.uqam.ca/">http://www.trex.uqam.ca/</ext-link></td></tr><tr><td>ViPhy [<xref ref-type="bibr" rid="CR300">300</xref>]</td><td>Comparison of multiple phylogenetic trees</td><td><ext-link ext-link-type="uri" xlink:href="http://www.gris.tu-darmstadt.de/research/vissearch/projects/ViPhy/">http://www.gris.tu-darmstadt.de/research/vissearch/projects/ViPhy/</ext-link></td></tr></tbody></table></table-wrap></p><p>Although RNAseq analysis is still an active field, microarray analysis has matured a lot over the past 15 years and many suites for analyzing such data are currently available (Table <xref rid="Tab8" ref-type="table">8</xref>). To identify the key players in the field of microarray/RNAseq visualization we followed the citation patterns of the available tools from Scopus (Fig. <xref rid="Fig6" ref-type="fig">6</xref>). MEGA [<xref ref-type="bibr" rid="CR122">122</xref>], ARB [<xref ref-type="bibr" rid="CR123">123</xref>], NJplot [<xref ref-type="bibr" rid="CR124">124</xref>], Dendroscope [<xref ref-type="bibr" rid="CR125">125</xref>] and iTOL [<xref ref-type="bibr" rid="CR126">126</xref>] are the most widely used tree viewers to visualize phylogenies and hierarchical clustering results. MultiExperiment Viewer [<xref ref-type="bibr" rid="CR127">127</xref>], Genesis [<xref ref-type="bibr" rid="CR128">128</xref>], GenePattern [<xref ref-type="bibr" rid="CR129">129</xref>] and EXPANDER [<xref ref-type="bibr" rid="CR130">130</xref>] are advanced suites that can perform various multivariate analyses such as the ones discussed in this section. Nevertheless, the commercial GeneSpring platform and the entire R/BioConductor framework [<xref ref-type="bibr" rid="CR131">131</xref>, <xref ref-type="bibr" rid="CR132">132</xref>] are mostly used in such analyses.<table-wrap id="Tab8"><label>Table 8</label><caption><p>Microarray and RNAseq analysis viewers</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Tool and references</th><th>Description</th><th>URL</th></tr></thead><tbody><tr><td>ArrayXPath [<xref ref-type="bibr" rid="CR201">201</xref>]</td><td>Mapping and visualizing microarray gene-expression data with integrated biological pathway resources using scalable vector graphics</td><td><ext-link ext-link-type="uri" xlink:href="http://www.snubi.org/software/ArrayXPath/">http://www.snubi.org/software/ArrayXPath/</ext-link></td></tr><tr><td>BicOverlapper [<xref ref-type="bibr" rid="CR301">301</xref>, <xref ref-type="bibr" rid="CR302">302</xref>]</td><td>Supports visual analysis of gene expression by means of biclustering</td><td><ext-link ext-link-type="uri" xlink:href="http://vis.usal.es/bicoverlapper/">http://vis.usal.es/bicoverlapper/</ext-link></td></tr><tr><td>BiGGEsTS [<xref ref-type="bibr" rid="CR303">303</xref>]</td><td>Tool providing an integrated environment for the biclustering analysis of time-series gene-expression data</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/BiGGEsTS/">http://tinyurl.com/BiGGEsTS/</ext-link></td></tr><tr><td>eRNA [<xref ref-type="bibr" rid="CR304">304</xref>]</td><td>RNA data analysis tool for high-throughput RNA sequencing experiments</td><td><ext-link ext-link-type="uri" xlink:href="https://sourceforge.net/projects/erna/?source=directory">https://sourceforge.net/projects/erna/?source=directory</ext-link></td></tr><tr><td>EXPANDER [<xref ref-type="bibr" rid="CR130">130</xref>]</td><td>A Java-based tool for analysis of gene-expression and NGS data</td><td><ext-link ext-link-type="uri" xlink:href="http://acgt.cs.tau.ac.il/expander/">http://acgt.cs.tau.ac.il/expander/</ext-link></td></tr><tr><td>ExpressionProfiler [<xref ref-type="bibr" rid="CR305">305</xref>]</td><td>Web-based platform for microarray gene-expression and other functional-genomics-related data analysis</td><td><ext-link ext-link-type="uri" xlink:href="http://www.ebi.ac.uk/expressionprofiler">http://www.ebi.ac.uk/expressionprofiler</ext-link></td></tr><tr><td>GenePattern [<xref ref-type="bibr" rid="CR129">129</xref>]</td><td>Modular analysis web platform; several visualization modules available</td><td><ext-link ext-link-type="uri" xlink:href="http://genepattern.broadinstitute.org/gp/pages/login.jsf">http://genepattern.broadinstitute.org/gp/pages/login.jsf</ext-link></td></tr><tr><td>Genesis [<xref ref-type="bibr" rid="CR128">128</xref>]</td><td>Java package of tools to simultaneously visualize and analyze a whole set of gene-expression experiments</td><td><ext-link ext-link-type="uri" xlink:href="http://genome.tugraz.at/genesisclient/genesisclient_description.shtml">http://genome.tugraz.at/genesisclient/genesisclient_description.shtml</ext-link></td></tr><tr><td>GeneVAnD [<xref ref-type="bibr" rid="CR306">306</xref>]</td><td>Linked heatmaps, dendrograms and 2D/3D scatter plots</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/GeneVAnD/">http://tinyurl.com/GeneVAnD/</ext-link></td></tr><tr><td>geWorkbench [<xref ref-type="bibr" rid="CR307">307</xref>]</td><td>A Java-based open-source platform for integrated genomics. It allows individually developed plugins to be configured into complex bioinformatic applications. Currently more than 70 available plugins supporting the visualization and analysis</td><td><ext-link ext-link-type="uri" xlink:href="http://wiki.c2b2.columbia.edu/workbench/index.php/Home">http://wiki.c2b2.columbia.edu/workbench/index.php/Home</ext-link></td></tr><tr><td>Gitools [<xref ref-type="bibr" rid="CR308">308</xref>]</td><td>Analysis and visualization of genomic data using interactive heatmaps</td><td><ext-link ext-link-type="uri" xlink:href="http://www.gitools.org/">http://www.gitools.org</ext-link></td></tr><tr><td>HCE [<xref ref-type="bibr" rid="CR309">309</xref>]</td><td>Linked heat map, profile and scatter plots; systematic exploration</td><td><ext-link ext-link-type="uri" xlink:href="http://www.cs.umd.edu/hcil/hce/">http://www.cs.umd.edu/hcil/hce/</ext-link></td></tr><tr><td>HeatmapGenerator [<xref ref-type="bibr" rid="CR310">310</xref>]</td><td>Create customized gene-expression heatmaps from RNAseq and microarray data</td><td><ext-link ext-link-type="uri" xlink:href="http://sourceforge.net/projects/heatmapgenerator/">http://sourceforge.net/projects/heatmapgenerator/</ext-link></td></tr><tr><td>HeatMapViewer [<xref ref-type="bibr" rid="CR311">311</xref>]</td><td>Interactive display of microarray experiments or the outcome of mutational studies and the study of SNP-like sequence variants</td><td><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.5281/zenodo.7706">http://dx.doi.org/10.5281/zenodo.7706</ext-link></td></tr><tr><td>Mayday [<xref ref-type="bibr" rid="CR312">312</xref>]</td><td>A graphical user interface that supports the development and integration of existing and new analysis methods. Many linked visualizations</td><td><ext-link ext-link-type="uri" xlink:href="http://it.informatik.uni-tuebingen.de/?page_id=248/wp/">http://it.informatik.uni-tuebingen.de/?page_id=248/wp/</ext-link></td></tr><tr><td>MultiExperiment Viewer [<xref ref-type="bibr" rid="CR127">127</xref>]</td><td>Analysis suite. Heatmaps, dendrograms, profile and scatter plots</td><td><ext-link ext-link-type="uri" xlink:href="http://www.tm4.org/">http://www.tm4.org/</ext-link></td></tr><tr><td>PointCloudXplore [<xref ref-type="bibr" rid="CR313">313</xref>]</td><td>Visualization of transcription data in <italic>Drosophila</italic> embryos. Multiple views to ease analysis of complex gene-expression data. This type of interaction blends high-dimensional information exploration with interactive, 3D visualization</td><td><ext-link ext-link-type="uri" xlink:href="http://tinyurl.com/PointCloudXplore/">http://tinyurl.com/PointCloudXplore/</ext-link></td></tr><tr><td>RNASeqBrowser [<xref ref-type="bibr" rid="CR314">314</xref>]</td><td>A genome browser for simultaneous visualization of raw strand specific RNAseq reads and UCSC genome browser custom tracks</td><td><ext-link ext-link-type="uri" xlink:href="http://www.australianprostatecentre.org/research/software/rnaseqbrowser">http://www.australianprostatecentre.org/research/software/rnaseqbrowser</ext-link></td></tr><tr><td>RNAseqViewer [<xref ref-type="bibr" rid="CR315">315</xref>]</td><td>Visualization of the various data from the RNAseq analyzing process, for single or multiple samples</td><td><ext-link ext-link-type="uri" xlink:href="http://bioinfo.au.tsinghua.edu.cn/software/RNAseqViewer/">http://bioinfo.au.tsinghua.edu.cn/software/RNAseqViewer/</ext-link></td></tr><tr><td>TimeSearcher [<xref ref-type="bibr" rid="CR316">316</xref>]</td><td>Interactive querying and exploration of time-series data</td><td><ext-link ext-link-type="uri" xlink:href="http://www.cs.umd.edu/hcil/timesearcher/">http://www.cs.umd.edu/hcil/timesearcher/</ext-link></td></tr><tr><td>TraV [<xref ref-type="bibr" rid="CR317">317</xref>]</td><td>Visualization and analysis of multiple transcriptome sequencing experiments</td><td><ext-link ext-link-type="uri" xlink:href="http://appmibio.uni-goettingen.de/index.php?sec=serv">http://appmibio.uni-goettingen.de/index.php?sec=serv</ext-link></td></tr></tbody></table></table-wrap><fig id="Fig6"><label>Fig. 6</label><caption><p>Citation trends and tools for gene-expression analysis. <bold>a</bold> Citations of microarray/RNAseq visualization tools based on Scopus. <bold>b</bold> Citations of tree viewers based on Scopus. The numbers of citations of each tool in 2015 are shown after its name</p></caption><graphic xlink:href="13742_2015_77_Fig6_HTML" id="d30e5001"></graphic></fig></p><p>Concerning the future of multivariate data visualization, new HCI techniques and VR devices could allow parallel visualizations, analyses and data integration simultaneously (Fig. <xref rid="Fig5" ref-type="fig">5g</xref>).</p></sec><sec id="Sec6"><title>Programming languages and complementary libraries for building visual prototypes</title><p>Although the field of biological data visualization has been active for 25 years, it is still evolving rapidly today, as the complexity and the size of results produced by high-throughput approaches increase. Although most of the current software is offered in the form of standalone distributions, a shift towards web visualization is growing. Important features of modern visualization tools include: interactivity; interoperability; efficient data exploration; quick visual data querying; smart visual adjustment for different devices with different dimensions and resolutions; fast panning; fast zooming in or out; multilayered visualization; visual comparison of data; and smart visual data filtering. As functions and libraries implementing these features for standalone applications become available, similar libraries for web visualizations immediately follow. Therefore, in this section we discuss the latest programming languages, libraries and application program interfaces (APIs) that automate and simplify many of the aforementioned features, enabling higher-quality visualization implementations. It is not in the scope of this review to extensively describe all programming language possibilities for data visualization; therefore, we focus on the five languages that are mostly used for high-throughput biological data. Nevertheless, Table <xref rid="Tab9" ref-type="table">9</xref> summarizes other languages, along with generic and language-specific libraries (for R, Perl and Python), that target specific problems and make the implementation of biological data visualization more practical.<table-wrap id="Tab9"><label>Table 9</label><caption><p>Programming languages and libraries to build visual prototype</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Language/Library</th><th>Description</th><th>URL</th></tr></thead><tbody><tr><td>Adobe Edge</td><td>Animated, interactive web content for projects that previously required Flash</td><td><ext-link ext-link-type="uri" xlink:href="https://creative.adobe.com/products/animate">https://creative.adobe.com/products/animate</ext-link></td></tr><tr><td>Arbor.js</td><td>Efficient, force-directed layout algorithm plus abstractions for graph organization and screen refresh handling</td><td><ext-link ext-link-type="uri" xlink:href="http://arborjs.org/">http://arborjs.org/</ext-link></td></tr><tr><td>Biojs</td><td>BioJS enables a full-featured biological workbench directly in your browser</td><td><ext-link ext-link-type="uri" xlink:href="http://biojs.net/">http://biojs.net/</ext-link></td></tr><tr><td>Bonsai.js</td><td>Lightweight graphics library with an intuitive graphics API and an SVG renderer</td><td><ext-link ext-link-type="uri" xlink:href="https://bonsaijs.org/">https://bonsaijs.org/</ext-link></td></tr><tr><td>Chart.js</td><td>Object oriented client side graphs. Data visualization in six animated, fully customizable chart types</td><td><ext-link ext-link-type="uri" xlink:href="http://www.chartjs.org/">http://www.chartjs.org/</ext-link></td></tr><tr><td>Cube</td><td>Time-series data, built on MongoDB, Node and D3. Real-time visualizations of aggregate metrics</td><td><ext-link ext-link-type="uri" xlink:href="https://square.github.io/cube/">https://square.github.io/cube/</ext-link></td></tr><tr><td>Cubism</td><td>D3 plugin for visualizing time series</td><td><ext-link ext-link-type="uri" xlink:href="https://square.github.io/cubism/">https://square.github.io/cubism/</ext-link></td></tr><tr><td>Cytoscape Web</td><td>Easily embed interactive networks in your website</td><td><ext-link ext-link-type="uri" xlink:href="http://cytoscapeweb.cytoscape.org/">http://cytoscapeweb.cytoscape.org/</ext-link></td></tr><tr><td>D4</td><td>Friendly charting domain-specific language for D3</td><td><ext-link ext-link-type="uri" xlink:href="https://github.com/heavysixer/d4">https://github.com/heavysixer/d4</ext-link></td></tr><tr><td>Easeljs</td><td>API to work with rich graphics and interactivity with HTML5 Canvas</td><td><ext-link ext-link-type="uri" xlink:href="http://www.createjs.com/EaselJS">http://www.createjs.com/EaselJS</ext-link></td></tr><tr><td>Ember Charts</td><td>Ember.js and d3.js based time series, bar, pie and scatter charts that are easy to extend and modify</td><td><ext-link ext-link-type="uri" xlink:href="http://addepar.github.io/">http://addepar.github.io/</ext-link></td></tr><tr><td>Envision</td><td>Fast, dynamic and interactive HTML5 visualizations</td><td><ext-link ext-link-type="uri" xlink:href="http://www.humblesoftware.com/envision">http://www.humblesoftware.com/envision</ext-link></td></tr><tr><td>Flare</td><td>Interactive data visualizations in Flash (ActionScript)</td><td><ext-link ext-link-type="uri" xlink:href="http://flare.prefuse.org/">http://flare.prefuse.org/</ext-link></td></tr><tr><td>Foamtree</td><td>Tree map visualization with innovative layout algorithms and animations such as Voronoi Treemaps</td><td><ext-link ext-link-type="uri" xlink:href="http://carrotsearch.com/foamtree-overview">http://carrotsearch.com/foamtree-overview</ext-link></td></tr><tr><td>Highcharts.js</td><td>HTML5/JavaScript-based line, spline, area, area-spline, column, bar, pie, scatter, angular gauges, area-range, area-spline-range, column-range, bubble, box plot, error bars, funnel, waterfall and polar charts</td><td><ext-link ext-link-type="uri" xlink:href="http://www.highcharts.com/">http://www.highcharts.com/</ext-link></td></tr><tr><td>Infovis Toolkit</td><td>A comprehensive range of tools for creating Interactive Data Visualizations for the Web</td><td><ext-link ext-link-type="uri" xlink:href="http://philogb.github.io/jit/">http://philogb.github.io/jit/</ext-link></td></tr><tr><td>Jgrapht</td><td>A free Java graph library that provides mathematical graph-theory objects and algorithms</td><td><ext-link ext-link-type="uri" xlink:href="http://jgrapht.org/">http://jgrapht.org/</ext-link></td></tr><tr><td>Kartograph</td><td>Kartograph is a simple and lightweight framework for creating beautiful, interactive vector maps</td><td><ext-link ext-link-type="uri" xlink:href="http://kartograph.org/">http://kartograph.org/</ext-link></td></tr><tr><td>Matplotlib</td><td>A Python 2D plotting library that produces publication quality figures</td><td><ext-link ext-link-type="uri" xlink:href="http://matplotlib.org/">http://matplotlib.org/</ext-link></td></tr><tr><td>Miso</td><td>Interactive storytelling and data visualization content</td><td><ext-link ext-link-type="uri" xlink:href="http://misoproject.com/">http://misoproject.com/</ext-link></td></tr><tr><td>Netadvantage</td><td>Charts with a range of frameworks including asp.net and Silverlight. Visualization options include bar, bubble, Gantt, line, radial, scatter, spline and doughnut charts</td><td><ext-link ext-link-type="uri" xlink:href="http://www.infragistics.com/products">http://www.infragistics.com/products</ext-link></td></tr><tr><td>Orange</td><td>Data mining through visual programming or Python scripting. Components for machine learning. Add-ons for bioinformatics and text mining. Packed with features for data analytics</td><td><ext-link ext-link-type="uri" xlink:href="http://orange.biolab.si/">http://orange.biolab.si/</ext-link></td></tr><tr><td>Paper.js</td><td>A vector graphics scripting framework that runs on top of the HTML5 Canvas</td><td><ext-link ext-link-type="uri" xlink:href="http://paperjs.org/">http://paperjs.org/</ext-link></td></tr><tr><td>Pivotviewer</td><td>A Silverlight control that makes it easier to interact with massive amounts of data on the web</td><td><ext-link ext-link-type="uri" xlink:href="http://www.microsoft.com/silverlight/pivotviewer/">http://www.microsoft.com/silverlight/pivotviewer/</ext-link></td></tr><tr><td>Polychart.js</td><td>A JavaScript graphing library capable of producing a wide array of graphics fairly easily</td><td><ext-link ext-link-type="uri" xlink:href="http://www.polychartjs.com/">http://www.polychartjs.com/</ext-link></td></tr><tr><td>Prefuse</td><td>Java-based interactive data. Data structures for tables, graphs and trees, a host of layout and visual encoding techniques, animation, dynamic queries, integrated search and database connectivity</td><td><ext-link ext-link-type="uri" xlink:href="http://prefuse.org/">http://prefuse.org/</ext-link></td></tr><tr><td>Prefuse Flare</td><td>Visualization and animation for ActionScript. From basic charts and graphs to complex interactive graphics. Data management, visual encoding, animation and interaction techniques</td><td><ext-link ext-link-type="uri" xlink:href="http://flare.prefuse.org/">http://flare.prefuse.org/</ext-link></td></tr><tr><td>Ractive.js</td><td>It transforms templates into blueprints for apps that are interactive by default. Two-way binding, animations, SVG support and more</td><td><ext-link ext-link-type="uri" xlink:href="http://www.ractivejs.org/">http://www.ractivejs.org/</ext-link></td></tr><tr><td>Raphael.js</td><td>JavaScript library for vector graphics on the web. To create a specific chart or image. Crop and rotate widget</td><td><ext-link ext-link-type="uri" xlink:href="http://raphaeljs.com/">http://raphaeljs.com/</ext-link></td></tr><tr><td>Rcharts</td><td>R package to create, customize and publish interactive JavaScript visualizations from R using a familiar lattice style plotting interface</td><td><ext-link ext-link-type="uri" xlink:href="http://rcharts.io/">http://rcharts.io/</ext-link></td></tr><tr><td>Seaborn</td><td>A Python visualization library based on matplotlib. It provides a high-level interface for drawing attractive statistical graphics</td><td><ext-link ext-link-type="uri" xlink:href="http://stanford.edu/~mwaskom/software/seaborn/">http://stanford.edu/~mwaskom/software/seaborn/</ext-link></td></tr><tr><td>Shiny</td><td>A web application framework for R to turn an analysis into interactive web applications. No HTML, CSS or JavaScript knowledge required</td><td><ext-link ext-link-type="uri" xlink:href="http://shiny.rstudio.com/">http://shiny.rstudio.com/</ext-link></td></tr><tr><td>Sigma.js</td><td>A JavaScript library dedicated to graph drawing. It makes easy to publish networks on Web pages and allows developers to integrate network exploration in rich web applications</td><td><ext-link ext-link-type="uri" xlink:href="http://sigmajs.org/">http://sigmajs.org/</ext-link></td></tr><tr><td>Three.js</td><td>A lightweight cross-browser JavaScript library/API used to create and display animated 3D computer graphics on a web browser that supports WebGL</td><td><ext-link ext-link-type="uri" xlink:href="http://threejs.org/">http://threejs.org/</ext-link></td></tr><tr><td>Timeline.js</td><td>Visually rich interactive timelines, available in 40 languages</td><td><ext-link ext-link-type="uri" xlink:href="http://timeline.knightlab.com/">http://timeline.knightlab.com/</ext-link></td></tr><tr><td>Variance</td><td>Build powerful data visualizations for the web without writing JavaScript. Wide range of visualizations</td><td><ext-link ext-link-type="uri" xlink:href="https://variancecharts.com/">https://variancecharts.com/</ext-link></td></tr><tr><td>Vega</td><td>A visualization grammar, a declarative format for creating, saving and sharing visualization designs. Data visualizations in JSON format and interactive views using either HTML5 Canvas or SVG</td><td><ext-link ext-link-type="uri" xlink:href="http://trifacta.github.io/vega/">http://trifacta.github.io/vega/</ext-link></td></tr><tr><td>Vida.io</td><td>A way to build reusable cloud visualizations: clone visualization templates, customize without coding skills and embed or share in the cloud</td><td><ext-link ext-link-type="uri" xlink:href="https://vida.io/">https://vida.io/</ext-link></td></tr><tr><td>Vis</td><td>A data visualization platform designed to assist investigative journalists, activists and others in mapping complex business or crime networks</td><td><ext-link ext-link-type="uri" xlink:href="http://vis.occrp.org/">http://vis.occrp.org/</ext-link></td></tr><tr><td>Visual Sedimentation</td><td>A JavaScript library for visualizing streaming data, inspired by the process of physical sedimentation. jQuery (to facilitate HTML and JavaScript development) and Box2DWeb (for physical world simulation)</td><td><ext-link ext-link-type="uri" xlink:href="http://www.visualsedimentation.org/">http://www.visualsedimentation.org/</ext-link></td></tr><tr><td>WebGL</td><td>A JavaScript API for rendering interactive 3D computer graphics and 2D graphics within any compatible web browser without the use of plugins</td><td><ext-link ext-link-type="uri" xlink:href="https://www.khronos.org/webgl/">https://www.khronos.org/webgl/</ext-link></td></tr></tbody></table></table-wrap></p><sec id="Sec7"><title>Processing</title><p>‘Processing’ is a programming language and a development platform for writing generative, interactive and animated standalone applications. Basic shapes such as lines, triangles, rectangles and ellipses, inner/outer coloring and basic operations such as transformations, translations, scaling and rotations can be implemented in a single line of code and each shape can be drawn within a canvas of a given dimension and a given refresh rate. It is designed for easier implementations of 2D dynamic visualizations but it also supports 3D rendering, although not optimized. Its core library is now extended by more than 100 other libraries and it is one of the best documented languages in the field. The integrated development environment allows exporting of executable files for all Windows, MacOS and Linux operating systems as well as Java applet .jar files. Finally, it can be used as an excellent educational tool for computer programming fundamentals in a visual context. It is free for download, can easily be plugged in a Java standalone application, and is fully cooperative with the NetBeans and Eclipse environments. Code examples and tutorials can be found at [<xref ref-type="bibr" rid="CR133">133</xref>].</p></sec><sec id="Sec8"><title>Processing.js</title><p>Java applets were an easy way to run standalone applications within web browsers. This technology has now mainly been abandoned because of security considerations. To avoid JavaScript’s complexity and compensate for applet limitations, Processing.js was implemented, as the sister project of the popular Processing programming language, to allow interactive web visualization. It is a mediator between HTML5 and Processing and is designed to allow visual prototypes, digital arts, interactive animations, educational graphs and so on to run immediately within any HTML5-compatible browser, such as Firefox, Safari, Chrome, Opera or Internet Explorer. No plugins are required and one can code any visualization directly in the Processing language, include it in a web page, and let Processing.js bridge the two technologies. Processing.js brings the best of visual programming to the web, both for Processing and web developers. Code examples and tutorials can be found at [<xref ref-type="bibr" rid="CR134">134</xref>].</p></sec><sec id="Sec9"><title>D3</title><p>D3 is the main competitor of Processing/Processing.js and has gained ground over recent years. It was initially used to generate scalable vector graphics (SVG). Like Processing.js, it is designed for powerful interactive web visualizations and it comes with its own JavaScript-like syntax. It is a JavaScript library for manipulating document object model objects and a programming interface for HTML, XML and SVG. The idea behind this approach is to load data into a browser and then generate document object model elements based on that data. Subsequently, one can apply data-driven transformations on the document. This avoids proprietary representation and affords extraordinary flexibility. With minimal overhead, D3 is extremely fast and supports large datasets and dynamic behaviors for interaction and animation. D3’s functional style allows code reuse through a diverse collection of components and plugins. It is extensively documented and code examples can be found at [<xref ref-type="bibr" rid="CR135">135</xref>].</p></sec><sec id="Sec10"><title>Flash</title><p>Adobe Flash was once the industry standard for authoring innovative, interactive content. In conjunction with the platform’s programming language, ActionScript, Flash allows designers to implement dynamic visualization, opening up many possibilities for creativity. Some of the most pioneering, best practice visualizations built in Flash can be found with online news and media sites, introducing interactivity to supplement and enhance the presentation of information. Because of the lack of support for Flash across Apple’s suite of devices and the emergence of competing developments, demanding less computational power, including D3 and HTML5, this technology is now fading.</p></sec><sec id="Sec11"><title>Java3D</title><p>Java 3D is an API, acting as a mediator between OpenGL and Java and enables the creation of standalone 3D graphics applications and internet-based 3D applets. It is easy to use and provides high-level functions for creating and manipulating 3D objects in space and their geometry. Programmers initially create a virtual world and then place any 3D object anywhere in this world. Rotation in three axes, zooming in or out and translation of the whole canvas are functions are offered by default, and the hierarchy of the transformation groups define the 3D transformations that can be applied individually to an object or a set of objects. Java3D code can be compiled under any of the Windows, MacOS and Unix Systems.</p></sec></sec></sec><sec id="Sec12"><title>Conclusion</title><sec id="Sec13"><title>The future of biological data visualization</title><p>Biological data visualization is a rapidly evolving field. Nevertheless, it is still in its infancy. Hardware acceleration, standardized exchangeable file formats, dimensionality reduction, visual feature selection, multivariate data analyses, interoperability, 3D rendering and visualization of complex data at different resolutions are areas in which great progress has been achieved. Additionally, image processing combined with artificial-intelligence-based pattern recognition, new libraries and programming languages for web visualization, interactivity, visual analytics and visual data retrieval, storing and filtering are still ongoing efforts with remarkable advances over the past years [<xref ref-type="bibr" rid="CR58">58</xref>, <xref ref-type="bibr" rid="CR136">136</xref>, <xref ref-type="bibr" rid="CR137">137</xref>]. Today, many of the current visualization tools serve as front ends for very advanced infrastructures dedicated to data manipulation and have driven significant advances in user interfaces. Although the implementation of sophisticated graphical user interfaces is necessary, the effort to minimize back-end calculations is of great importance. Unfortunately, only a limited number of visualization tools today take advantage of libraries designed for parallelization. Multi-threading, for example, allows the distribution of computational tasks in terminals over the network, and CUDA (available on Nvidia graphic cards) allows parallel calculations at multiple graphical processing units.</p><p>Despite the fact that multiple screens, light and laser projectors and other technologies partially solve the space limitation problem, HCI techniques are changing the rules of the game and biological data visualization is expected to adjust to these trends in the longer term. 3D control can be achieved without intermediate devices such as mouse, keyboards or touch screens [<xref ref-type="bibr" rid="CR138">138</xref>] in modern perceptual input systems. Sony’s EyeToy, Playstation Eye and Artag, for example, use non-spatial computer vision to determine hand gestures. Similarly, the Nintendo Wii and Sony Move devices support object manipulation in 3D space. These actions are mediated through the detection of the position in space of physical devices held by the user or, even more impressively, through immediate tracking of the human body or parts of the human body. Equally impressive is the prospect of ocular tracking, one implementation of which has recently been introduced by the VR startup Fove. The Fove headset tracks eye movement and translates into spatial movement or even other types of action within the simulated 3D space. The recently implemented Molecular Control Toolkit [<xref ref-type="bibr" rid="CR139">139</xref>] is a characteristic example of a new API based on the Kinect and Leap Motion devices (which track the human body and human fingers, respectively) to control molecular graphics such as 3D protein structures. Moreover, large screens, tiled arrays or VR environments should be taken into consideration by programmers and designers as they become more and more affordable over time. A great benefit of such technologies is that they allow the representation of complete datasets without the need for algorithms dedicated to dimensionality reduction, which might lead to information loss.</p><p>VR environments are expected to bring a revolution in biological data visualization as one could integrate metabolomics networks and gene expression in virtual worlds, as in MetNet3D [<xref ref-type="bibr" rid="CR140">140</xref>], or create virtual universes of living systems such as a whole cell [<xref ref-type="bibr" rid="CR59">59</xref>, <xref ref-type="bibr" rid="CR141">141</xref>–<xref ref-type="bibr" rid="CR144">144</xref>]. A visual representation of the whole cell with its components in an immense environment in which users can visually explore the location of molecules and their interaction in space and time could lead to a better understanding of the biological systems. Oculus Rift (which promoted the reemergence of VR devices), Project Morpheus, Google Cardboard, Sony Smart Eyeglass, HTC Vive, Samsung Gear VR, Avegant Glyph, Razer OSVR, Archos VR Headset and Carl Zeiss VR One are state-of-the-art commercial devices that offer VR experiences. All of them overlay the user’s eyesight with some kind of screen and aim to replace the field of view with a digital 3D alternative. Between them, those devices use many technologies and new ideas such as the monitoring of the position of the head (allowing for more axes of movement), the substitution of the VR screen with smartphones (thus harnessing efficient modern smartphone processors), eye tracking and projection of images straight onto the retina.</p><p>Approaching the problem from a different angle, Google Glass, HoloLens and Magic Leap offer an augmented reality experience (the latter is rumored to achieve that by projecting a digital light field into the user’s eye). Augmented reality can facilitate the learning process of the biological systems because it builds on exploratory learning. This allows scientists to visualize existing knowledge, whereas the unstructured nature of augmented reality could allow them to construct knowledge themselves by making connections between information and their own experiences or intuition and thus offer novel insights to the studied biological system [<xref ref-type="bibr" rid="CR145">145</xref>]. Efforts such as the Visible Cell [<xref ref-type="bibr" rid="CR141">141</xref>] and CELLmicrocosmos have already begun. The Visible Cell project aims to inform advanced <italic>in silico</italic> studies of cell and molecular organization in 3D using the mammalian cell as a unitary example of an ordered complex system; the CELLmicrocosmos integrative cell modeling and stereoscopic 3D visualization project is a typical example of the use of 3D vision.</p><p>Finally, starting from a living entity, the process of digitizing it, visualizing it, placing it in virtual worlds or even recreating it as a physical object using 3D printing is no longer the realm of science fiction. Data visualization and biological data visualization are rapidly developing in parallel with advances in the gaming industry and HCI. These efforts are complementary and there are already strong interactions developing between these fields, something that is expected to become more obvious in the future.</p></sec></sec></body><back><fn-group><fn><p><bold>Competing interests</bold></p><p>The authors declare that they have no competing interests.</p></fn><fn><p><bold>Authors’ contributions</bold></p><p>GAP was the main writer of the article and the one who was inspired about the topic. DM collected all the necessary information about the tools and their citation trends. NP and TT provided fruitful feedback about the recent HCI technologies. AE provided information about the latest technological trends in the areas of genomics. II was the main supervisor of the project. 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