No change to grey and white matter volumes in bipolar I disorder patients
Identifieur interne : 000022 ( Ncbi/Merge ); précédent : 000021; suivant : 000023No change to grey and white matter volumes in bipolar I disorder patients
Auteurs : Harald Scherk [Allemagne] ; Claudia Kemmer [Allemagne] ; Juliana Usher [Allemagne] ; Wolfgang Reith [Allemagne] ; Peter Falkai [Allemagne] ; Oliver Gruber [Allemagne]Source :
- European Archives of Psychiatry and Clinical Neuroscience [ 0940-1334 ] ; 2008.
Abstract
Structural brain imaging is assumed to be a key method to elucidate the underlying neuropathology of bipolar disorder. However, magnetic resonance imaging studies using region of interest analysis and voxel-based morphometry (VBM) revealed quite inconsistent findings. Hence, there is no clear evidence so far for core regions of cortical or subcortical structural abnormalities in bipolar disorder. The aim of this study was to investigate grey and white matter volumes in a large sample of patients with bipolar I disorder.
Thirty-five patients with bipolar I disorder and 32 healthy controls matched with respect to gender, handedness and education participated in the study. MRI scanning was performed and an optimized VBM analysis was conducted.
We could not observe any significant differences of grey or white matter volumes between patients with bipolar disorder and healthy control subjects. Additional analyses did not reveal significant correlations between grey or white matter volume with number of manic or depressive episodes, duration of illness, existence of psychotic symptoms, and treatment with lithium or antipsychotics.
With this VBM study we were not able to identify core regions of structural abnormalities in bipolar disorder.
Url:
DOI: 10.1007/s00406-007-0801-8
PubMed: 18347837
PubMed Central: 3085759
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type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Reith, Wolfgang" sort="Reith, Wolfgang" uniqKey="Reith W" first="Wolfgang" last="Reith">Wolfgang Reith</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Neuroradiology, Saarland University Hospital, Homburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuroradiology, Saarland University Hospital, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Falkai, Peter" sort="Falkai, Peter" uniqKey="Falkai P" first="Peter" last="Falkai">Peter Falkai</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Psychiatry and Psychotherapy, Georg-August-University of Goettingen, von-Siebold-Str. 5, 37075 Goettingen, Germany</nlm:aff><country 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last="Scherk">Harald Scherk</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Psychiatry and Psychotherapy, Georg-August-University of Goettingen, von-Siebold-Str. 5, 37075 Goettingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Georg-August-University of Goettingen, von-Siebold-Str. 5, 37075 Goettingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Kemmer, Claudia" sort="Kemmer, Claudia" uniqKey="Kemmer C" first="Claudia" last="Kemmer">Claudia Kemmer</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Usher, Juliana" sort="Usher, Juliana" uniqKey="Usher J" first="Juliana" last="Usher">Juliana Usher</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Psychiatry and Psychotherapy, Georg-August-University of Goettingen, von-Siebold-Str. 5, 37075 Goettingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Georg-August-University of Goettingen, von-Siebold-Str. 5, 37075 Goettingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Reith, Wolfgang" sort="Reith, Wolfgang" uniqKey="Reith W" first="Wolfgang" last="Reith">Wolfgang Reith</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Neuroradiology, Saarland University Hospital, Homburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuroradiology, Saarland University Hospital, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Falkai, Peter" sort="Falkai, Peter" uniqKey="Falkai P" first="Peter" last="Falkai">Peter Falkai</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Psychiatry and Psychotherapy, Georg-August-University of Goettingen, von-Siebold-Str. 5, 37075 Goettingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Georg-August-University of Goettingen, von-Siebold-Str. 5, 37075 Goettingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Gruber, Oliver" sort="Gruber, Oliver" uniqKey="Gruber O" first="Oliver" last="Gruber">Oliver Gruber</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author></analytic><series><title level="j">European Archives of Psychiatry and Clinical Neuroscience</title><idno type="ISSN">0940-1334</idno><idno type="eISSN">1433-8491</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Structural brain imaging is assumed to be a key method to elucidate the underlying neuropathology of bipolar disorder. However, magnetic resonance imaging studies using region of interest analysis and voxel-based morphometry (VBM) revealed quite inconsistent findings. Hence, there is no clear evidence so far for core regions of cortical or subcortical structural abnormalities in bipolar disorder. The aim of this study was to investigate grey and white matter volumes in a large sample of patients with bipolar I disorder.</p></sec><sec><title>Methods</title><p>Thirty-five patients with bipolar I disorder and 32 healthy controls matched with respect to gender, handedness and education participated in the study. MRI scanning was performed and an optimized VBM analysis was conducted.</p></sec><sec><title>Results</title><p>We could not observe any significant differences of grey or white matter volumes between patients with bipolar disorder and healthy control subjects. Additional analyses did not reveal significant correlations between grey or white matter volume with number of manic or depressive episodes, duration of illness, existence of psychotic symptoms, and treatment with lithium or antipsychotics.</p></sec><sec><title>Conclusions</title><p>With this VBM study we were not able to identify core regions of structural abnormalities in bipolar disorder.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adler, Cm" uniqKey="Adler C">CM Adler</name></author><author><name sortKey="Levine, Ad" uniqKey="Levine A">AD Levine</name></author><author><name sortKey="Delbello, Mp" uniqKey="Delbello M">MP DelBello</name></author><author><name sortKey="Strakowski, Sm" uniqKey="Strakowski S">SM Strakowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashburner, J" uniqKey="Ashburner J">J Ashburner</name></author><author><name sortKey="Friston, Kj" uniqKey="Friston 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Eur Arch Psychiatry Clin Neurosci</journal-id><journal-title-group><journal-title>European Archives of Psychiatry and Clinical Neuroscience</journal-title></journal-title-group><issn pub-type="ppub">0940-1334</issn><issn pub-type="epub">1433-8491</issn><publisher><publisher-name>D. Steinkopff-Verlag</publisher-name><publisher-loc>Dordrecht</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18347837</article-id><article-id pub-id-type="pmc">3085759</article-id><article-id pub-id-type="publisher-id">801</article-id><article-id pub-id-type="doi">10.1007/s00406-007-0801-8</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject></subj-group></article-categories><title-group><article-title>No change to grey and white matter volumes in bipolar I disorder patients</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Scherk</surname><given-names>Harald</given-names></name><address><phone>+49-551/39-3838</phone><fax>+49-551/39-8952</fax><email>hscherk@uni-goettingen.de</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kemmer</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Usher</surname><given-names>Juliana</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Reith</surname><given-names>Wolfgang</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Falkai</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gruber</surname><given-names>Oliver</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label>Department of Psychiatry and Psychotherapy, Georg-August-University of Goettingen, von-Siebold-Str. 5, 37075 Goettingen, Germany</aff><aff id="Aff2"><label>2</label>Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany</aff><aff id="Aff3"><label>3</label>Department of Neuroradiology, Saarland University Hospital, Homburg, Germany</aff></contrib-group><pub-date pub-type="epub"><day>17</day><month>3</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>3</month><year>2008</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2008</year></pub-date><volume>258</volume><issue>6</issue><fpage>345</fpage><lpage>349</lpage><history><date date-type="received"><day>18</day><month>12</month><year>2006</year></date><date date-type="accepted"><day>4</day><month>12</month><year>2007</year></date></history><permissions><copyright-statement>© Springer 2008</copyright-statement></permissions><abstract id="Abs1"><sec><title>Background</title><p>Structural brain imaging is assumed to be a key method to elucidate the underlying neuropathology of bipolar disorder. However, magnetic resonance imaging studies using region of interest analysis and voxel-based morphometry (VBM) revealed quite inconsistent findings. Hence, there is no clear evidence so far for core regions of cortical or subcortical structural abnormalities in bipolar disorder. The aim of this study was to investigate grey and white matter volumes in a large sample of patients with bipolar I disorder.</p></sec><sec><title>Methods</title><p>Thirty-five patients with bipolar I disorder and 32 healthy controls matched with respect to gender, handedness and education participated in the study. MRI scanning was performed and an optimized VBM analysis was conducted.</p></sec><sec><title>Results</title><p>We could not observe any significant differences of grey or white matter volumes between patients with bipolar disorder and healthy control subjects. Additional analyses did not reveal significant correlations between grey or white matter volume with number of manic or depressive episodes, duration of illness, existence of psychotic symptoms, and treatment with lithium or antipsychotics.</p></sec><sec><title>Conclusions</title><p>With this VBM study we were not able to identify core regions of structural abnormalities in bipolar disorder.</p></sec></abstract><kwd-group><title>Key words</title><kwd>grey matter volume</kwd><kwd>white matter volume</kwd><kwd>bipolar disorder</kwd><kwd>VBM</kwd><kwd>MRI</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer 2008</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li></region><settlement><li>Göttingen</li></settlement></list><tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Scherk, Harald" sort="Scherk, Harald" uniqKey="Scherk H" first="Harald" last="Scherk">Harald Scherk</name></region><name sortKey="Falkai, Peter" sort="Falkai, Peter" uniqKey="Falkai P" first="Peter" last="Falkai">Peter Falkai</name><name sortKey="Gruber, Oliver" sort="Gruber, Oliver" uniqKey="Gruber O" first="Oliver" last="Gruber">Oliver Gruber</name><name sortKey="Kemmer, Claudia" sort="Kemmer, Claudia" uniqKey="Kemmer C" first="Claudia" last="Kemmer">Claudia Kemmer</name><name sortKey="Reith, Wolfgang" sort="Reith, Wolfgang" uniqKey="Reith W" first="Wolfgang" last="Reith">Wolfgang Reith</name><name sortKey="Usher, Juliana" sort="Usher, Juliana" uniqKey="Usher J" first="Juliana" last="Usher">Juliana Usher</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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