Case–control study of male germ cell tumors nested in a cohort of car‐manufacturing workers: Findings from the occupational history
Identifieur interne : 000453 ( Main/Exploration ); précédent : 000452; suivant : 000454Case–control study of male germ cell tumors nested in a cohort of car‐manufacturing workers: Findings from the occupational history
Auteurs : Ingo Langner [Allemagne] ; Nils Schmei Er [Allemagne] ; Birte Mester [Allemagne] ; Thomas Behrens [Allemagne] ; Andrea Gottlieb [Allemagne] ; Wolfgang Ahrens [Allemagne]Source :
- American Journal of Industrial Medicine [ 0271-3586 ] ; 2010-10.
English descriptors
- KwdEn :
- Teeft :
- Accident insurance, Agent exposures, Aircraft ships officers, Appl occup environ, Assembler, Automobile trade repair, Bremen, Broadcasting cinema operators sheet, Building installation automobile trade repair, Business activities, Calendar year, Ceramics stone, Cohort, Complex mixture, Confidence intervals, Construction workers, Control subjects, Correction terms, Corresponding case, Corresponding distribution, Crude odds ratio, Cryptorchidism, Cumulative employment, Cumulative employment time, Cumulative measures, Cumulative person, Cumulative years, Economic activities, Economists accountants, Electrical equipment, Electronic workers, Employment periods, Environ, Epidemiol, European commission, Exposure assessment, Exposure intensity, Exposure levels, Food products, Germ, Germ cell cancer, Hardell, Industry group, Industry groups, International labour, Langner, Leather workers, Machine assemblers, Machinery assemblers precision instrument makers, Male workers, Metal products, Metal workers, Metalworking, Motor vehicle mechanics, Motor vehicles, Ndings, Occup environ, Occupational, Occupational cancer, Occupational exposure, Occupational exposures, Occupational group, Occupational groups, Occupational history, Odds ratio, Odds ratios, Optical instruments, Pearce, Police defense education, Precision instrument makers, Prevention research, Principal task, Real estate, Risk estimate, Risk estimates, Risk factor, Risk increase, School degree, Secondary tasks, Sideline, Sideline jobs, Social medicine, Social security, Statistical analyses, Structural metal preparers, Study plants, Study subject, Study subjects, Subgroup, Subsequent period, Technical college, Testicular, Testicular cancer, Tters, Uids, Vehicle manufacturing, Welder, Wholesale trade, Work health system.
Abstract
To examine whether the previously observed excess risk of male germ cell cancer in a cohort of car‐manufacturing workers can be attributed to occupational activities inside and/or outside the car industry.
A nested case–control study among workers in six plants included 205 cases of germ cell cancer and 1,105 controls, individually matched by year of birth (±2 years). Job periods of the individual occupational histories were coded based on the International Standard Classification of Occupations (ISCO) and the industrial classification of economic activities (NACE). Odds ratios (ORs) and corresponding 95%‐confidence intervals (CI) for ever‐never and cumulative employment were calculated by conditional multivariate logistic regression adjusted for cryptorchidism.
Significantly increased risks were observed for machinery fitters and assemblers (A) (OR = 1.8, 95% CI 1.25–2.53) and “workers not elsewhere classified” (OR = 2.10, 95% CI 1.27–3.54), but no trend was observed for employment duration in either occupational group. Stratification of job group A by metal‐cutting and non‐cutting jobs yielded ORs of 1.87 (95% CI 1.31–2.67) and of 1.24 (95% CI 0.68–2.28), respectively. Among “plumbers, welders, sheet & structural metal workers” (adjusted OR 1.4, 95% CI 0.99–1.95) only “structural metal preparers and erectors” showed a substantially increased risk (OR = 2.30; 95% CI 1.27–4.27).
Our results do not fully explain the increased incidence of germ cell cancer in the cohort, but support previous findings showing increased risks among metal workers. These risks were most strongly pronounced in metal‐cutting activities. Am. J. Ind. Med. 53:1006–1018, 2010. © 2010 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ajim.20865
Affiliations:
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Job periods of the individual occupational histories were coded based on the International Standard Classification of Occupations (ISCO) and the industrial classification of economic activities (NACE). Odds ratios (ORs) and corresponding 95%‐confidence intervals (CI) for ever‐never and cumulative employment were calculated by conditional multivariate logistic regression adjusted for cryptorchidism.</div><div type="abstract">Significantly increased risks were observed for machinery fitters and assemblers (A) (OR = 1.8, 95% CI 1.25–2.53) and “workers not elsewhere classified” (OR = 2.10, 95% CI 1.27–3.54), but no trend was observed for employment duration in either occupational group. Stratification of job group A by metal‐cutting and non‐cutting jobs yielded ORs of 1.87 (95% CI 1.31–2.67) and of 1.24 (95% CI 0.68–2.28), respectively. Among “plumbers, welders, sheet & structural metal workers” (adjusted OR 1.4, 95% CI 0.99–1.95) only “structural metal preparers and erectors” showed a substantially increased risk (OR = 2.30; 95% CI 1.27–4.27).</div><div type="abstract">Our results do not fully explain the increased incidence of germ cell cancer in the cohort, but support previous findings showing increased risks among metal workers. These risks were most strongly pronounced in metal‐cutting activities. Am. J. Ind. Med. 53:1006–1018, 2010. © 2010 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Brême (Land)</li></region><settlement><li>Brême</li></settlement></list><tree><country name="Allemagne"><region name="Brême (Land)"><name sortKey="Langner, Ingo" sort="Langner, Ingo" uniqKey="Langner I" first="Ingo" last="Langner">Ingo Langner</name></region><name sortKey="Ahrens, Wolfgang" sort="Ahrens, Wolfgang" uniqKey="Ahrens W" first="Wolfgang" last="Ahrens">Wolfgang Ahrens</name><name sortKey="Behrens, Thomas" sort="Behrens, Thomas" uniqKey="Behrens T" first="Thomas" last="Behrens">Thomas Behrens</name><name sortKey="Gottlieb, Andrea" sort="Gottlieb, Andrea" uniqKey="Gottlieb A" first="Andrea" last="Gottlieb">Andrea Gottlieb</name><name sortKey="Langner, Ingo" sort="Langner, Ingo" uniqKey="Langner I" first="Ingo" last="Langner">Ingo Langner</name><name sortKey="Mester, Birte" sort="Mester, Birte" uniqKey="Mester B" first="Birte" last="Mester">Birte Mester</name><name sortKey="Schmei Er, Nils" sort="Schmei Er, Nils" uniqKey="Schmei Er N" first="Nils" last="Schmei Er">Nils Schmei Er</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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