Crystal Structure of a Molecular Assembly Line
Identifieur interne : 000A29 ( Istex/Curation ); précédent : 000A28; suivant : 000A30Crystal Structure of a Molecular Assembly Line
Auteurs : Kira Weissman ; Rolf Müller [Allemagne]Source :
- Angewandte Chemie International Edition [ 1433-7851 ] ; 2008-10-20.
English descriptors
- KwdEn :
- Teeft :
- Acceptor, Acore domains, Active sites, Amino, Amino acids, Biol, Building blocks, Chain elongation, Chem, Crystal structure, Diffracting crystals, Domain, Entire module, Essen, Important insights, Marahiel, Module, Multienzymes, Nrps, Nrpss, Peptide, Ppant, Ppant moiety, Stachelhaus, Verlag gmbh, Weinheim angew, Weissman.
Abstract
Domain event: Non‐ribosomal peptide synthetases (NRPSs) are gigantic molecular machines which assemble natural products of high structural complexity in bacteria and fungi. A team of researchers has recently solved the first crystal structure of an entire module of domains from an NRPS system, a breakthrough achievement for the field.
Url:
DOI: 10.1002/anie.200803293
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Kira Weissman<affiliation><mods:affiliation>Department of Pharmaceutical Biotechnology, Saarland University, P.O. Box 151150, 66041 Saarbrücken (Germany), Fax: (+49) 681‐3027‐0201</mods:affiliation>
<wicri:noCountry code="subField">(+49) 681‐3027‐0201</wicri:noCountry>
</affiliation>
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<term>Acore domains</term>
<term>Active sites</term>
<term>Amino</term>
<term>Amino acids</term>
<term>Biol</term>
<term>Building blocks</term>
<term>Chain elongation</term>
<term>Chem</term>
<term>Crystal structure</term>
<term>Diffracting crystals</term>
<term>Domain</term>
<term>Entire module</term>
<term>Essen</term>
<term>Important insights</term>
<term>Marahiel</term>
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<term>Multienzymes</term>
<term>Nrps</term>
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<term>Peptide</term>
<term>Ppant</term>
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<front><div type="abstract">Domain event: Non‐ribosomal peptide synthetases (NRPSs) are gigantic molecular machines which assemble natural products of high structural complexity in bacteria and fungi. A team of researchers has recently solved the first crystal structure of an entire module of domains from an NRPS system, a breakthrough achievement for the field.</div>
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