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Regional and subcellular distribution of the receptor‐targeting protein PIST in the rat central nervous system

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Regional and subcellular distribution of the receptor‐targeting protein PIST in the rat central nervous system

Auteurs : Annie Chen [Canada, États-Unis] ; Enno K. Gö Ling [Allemagne] ; Leora Witkowski [Canada] ; Amar Bhindi [Canada] ; Carola Bauch [Allemagne] ; Geneviève Roussy [Canada] ; Philippe Sarret [Canada] ; Hans-Jürgen Kreienkamp [Allemagne] ; Thomas Stroh [Canada]

Source :

Journal of Comparative Neurology [ 0021-9967 ] ; 2012-04-01.

RBID : ISTEX:0F7E7E6DCFD81A5F9FCAC5E561B54B8276EA43C6

English descriptors

Abstract

Protein interacting specifically with Tc10, PIST, is a Golgi‐associated sorting protein involved in regulating cell‐surface targeting of plasma membrane receptors. The present study provides the first comprehensive description of PIST distribution in the mammalian central nervous system and of its subcellular localization by immunocytochemistry. PIST is distributed widely throughout the neuraxis, predominantly associated with neuronal cell bodies and dendrites. In hippocampal neurons, in vitro and in situ, PIST displayed a patchy subcellular distribution in an area surrounding the nucleus and extending into one of the major dendrites. By colocalization with the trans‐Golgi marker TGN38, we were able to show that PIST is associated largely but not exclusively with the trans‐Golgi network in central neurons. High or moderate to high levels of PIST‐like immunoreactivity were found in cortical areas, in particular in layer V of the neocortex. The motor cortex was most strongly labeled. Also, the piriform and insular cortices displayed strong PIST labeling. In the hippocampus, CA2 but not CA1 or CA3 pyramidal cells displayed strong PIST‐labeling, extending into their apical dendrites. In the thalamus, ventrolateral and laterodorsal nuclei were most strongly stained, whereas in the hypothalamus the supraoptic nucleus stood out with strong immunoreactivity. Strikingly, in the brainstem all cranial nerve motor nuclei were PIST‐positive at varying levels, which is in keeping with the prominent expression of PIST in forebrain motor areas. This selective distribution of PIST suggests that the protein serves distinctive roles in specific neuronal populations, establishing functionally distinct zones, for instance, in the hippocampus. J. Comp. Neurol. 520:889–913, 2012. © 2011 Wiley Periodicals, Inc.

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https://api.istex.fr/document/0F7E7E6DCFD81A5F9FCAC5E561B54B8276EA43C6/fulltext/pdf

DOI: 10.1002/cne.22774

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<affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Neurosurgery, McGill University, and the Montreal Neurological Institute, Montreal, Quebec, Canada</mods:affiliation>
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<title level="j" type="abbrev">J. Comp. Neurol.</title>
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<term>Basal</term>
<term>Basal forebrain</term>
<term>Brain homogenates</term>
<term>Cell bodies</term>
<term>Cell body</term>
<term>Cell types</term>
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<term>Piriform cortex</term>
<term>Pist</term>
<term>Pist figure</term>
<term>Pist immunoreactivity</term>
<term>Plasma membrane</term>
<term>Pontine</term>
<term>Postsynaptic</term>
<term>Postsynaptic sites</term>
<term>Present study</term>
<term>Primary antibodies</term>
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<term>Purkinje cells</term>
<term>Pyramidal</term>
<term>Pyramidal cells</term>
<term>Raphe</term>
<term>Receptor</term>
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<term>Scale bars</term>
<term>Shrna</term>
<term>Somatostatin receptor subtype</term>
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<term>Subcellular distribution</term>
<term>Subcellular localization</term>
<term>Substantia</term>
<term>Substantia nigra</term>
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<term>Supraoptic nucleus</term>
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<term>Systems neuroscience neuroanatomical distribution</term>
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<term>Thalamus</term>
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<term>Trigeminal</term>
<term>Ventral</term>
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<term>Vesicular organelles</term>
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<front><div type="abstract" xml:lang="en">Protein interacting specifically with Tc10, PIST, is a Golgi‐associated sorting protein involved in regulating cell‐surface targeting of plasma membrane receptors. The present study provides the first comprehensive description of PIST distribution in the mammalian central nervous system and of its subcellular localization by immunocytochemistry. PIST is distributed widely throughout the neuraxis, predominantly associated with neuronal cell bodies and dendrites. In hippocampal neurons, in vitro and in situ, PIST displayed a patchy subcellular distribution in an area surrounding the nucleus and extending into one of the major dendrites. By colocalization with the trans‐Golgi marker TGN38, we were able to show that PIST is associated largely but not exclusively with the trans‐Golgi network in central neurons. High or moderate to high levels of PIST‐like immunoreactivity were found in cortical areas, in particular in layer V of the neocortex. The motor cortex was most strongly labeled. Also, the piriform and insular cortices displayed strong PIST labeling. In the hippocampus, CA2 but not CA1 or CA3 pyramidal cells displayed strong PIST‐labeling, extending into their apical dendrites. In the thalamus, ventrolateral and laterodorsal nuclei were most strongly stained, whereas in the hypothalamus the supraoptic nucleus stood out with strong immunoreactivity. Strikingly, in the brainstem all cranial nerve motor nuclei were PIST‐positive at varying levels, which is in keeping with the prominent expression of PIST in forebrain motor areas. This selective distribution of PIST suggests that the protein serves distinctive roles in specific neuronal populations, establishing functionally distinct zones, for instance, in the hippocampus. J. Comp. Neurol. 520:889–913, 2012. © 2011 Wiley Periodicals, Inc.</div>
</front>
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Regional and subcellular distribution of the receptor‐targeting protein PIST in the rat central nervous system

Regional and subcellular distribution of the receptor‐targeting protein PIST in the rat central nervous system

Source :

English descriptors

Abstract

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Links to Exploration step

Le document en format XML

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