Veränderung der Acylneuraminsäuregehalte auf T-Lymphozyten und im Plasma bei Erkrankung an Mamma-Karzinom
Identifieur interne : 001A03 ( Istex/Corpus ); précédent : 001A02; suivant : 001A04Veränderung der Acylneuraminsäuregehalte auf T-Lymphozyten und im Plasma bei Erkrankung an Mamma-Karzinom
Auteurs : H. Stickl ; W. Huber ; H. Faillard ; A. Becker ; R. Holzhauser ; H. GraeffSource :
- Klinische Wochenschrift [ 0023-2173 ] ; 1991-01-01.
Abstract
Summary: Increased sialic acid levels reflecting tumor burden are found on the surface of T-lymphocytes and in the plasma of patients with carcinoma of the mammary gland. The data of the determinations of sialic acid content and distribution on T-cells, using microanalytical methods such as HPLC and a colorimetric test, show that the total sialic acid content is increased by about 60% and that nearly 80–90% of the sialic acids consist of Nacetyl-9-O-acetyl-neuraminic acid, in comparison to the healthy controls (not containing O-acetylated neuraminic acid). Investigations on lymphocytes of malignant melanoma patients show similar changes of sialic acid content and distribution on the cell surface. Increased sialic acid levels are also found in the plasma of patients with cancer but no O-acetylated derivative can be found. Furthermore the examinations show that the separation of the T-lymphocytes from the total lymphocyte fraction is not required. Determination of sialic acids in the total lymphocyte fraction can be a simplification in carrying out further diagnostic investigations. A high level of sialic acids as “antirecognition factor” seems to be not only a marker of tumor cells but also an attribute of T-lymphocytes, involved in the defence against the malignoma (malignant melanoma, breast cancer). Considering the possible contribution of sialic acid to the immunoregulatory protective mechanism during the first stage of pregnancy, sialic acid content and distribution on T-cells of pregnant women are investigated. Both an increase and a change in the distribution of sialic acids can be excluded.
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DOI: 10.1007/BF01649046
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ISTEX:F777B79F94F0863ED1FE38768365B136359D9166Le document en format XML
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Stickl</name><affiliation><mods:affiliation>Abteilung für Umwelthygiene und Impfwesen, Fakultät für Medizin der Technischen Universität München, Deutschland</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut für Toxikologie und Umwelthygiene der TU München, Lazarettstr. 62, W-8000, München 19, FRG</mods:affiliation></affiliation></author><author><name sortKey="Huber, W" sort="Huber, W" uniqKey="Huber W" first="W." last="Huber">W. Huber</name><affiliation><mods:affiliation>Abteilung für Umwelthygiene und Impfwesen, Fakultät für Medizin der Technischen Universität München, Deutschland</mods:affiliation></affiliation></author><author><name sortKey="Faillard, H" sort="Faillard, H" uniqKey="Faillard H" first="H." last="Faillard">H. Faillard</name><affiliation><mods:affiliation>Institut für Biochemie, Universität des Saarlandes, Saarbrücken</mods:affiliation></affiliation></author><author><name sortKey="Becker, A" sort="Becker, A" uniqKey="Becker A" first="A." last="Becker">A. Becker</name><affiliation><mods:affiliation>Institut für Biochemie, Universität des Saarlandes, Saarbrücken</mods:affiliation></affiliation></author><author><name sortKey="Holzhauser, R" sort="Holzhauser, R" uniqKey="Holzhauser R" first="R." last="Holzhauser">R. Holzhauser</name><affiliation><mods:affiliation>Institut für Biochemie, Universität des Saarlandes, Saarbrücken</mods:affiliation></affiliation></author><author><name sortKey="Graeff, H" sort="Graeff, H" uniqKey="Graeff H" first="H." last="Graeff">H. Graeff</name><affiliation><mods:affiliation>Universitäts-Frauenklinik der Fakultät für Medizin, Technische Universität München, Deutschland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Klinische Wochenschrift</title><title level="j" type="abbrev">Klin Wochenschr</title><idno type="ISSN">0023-2173</idno><idno type="eISSN">1432-1440</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1991-01-01">1991-01-01</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="5">5</biblScope><biblScope unit="page" to="9">9</biblScope></imprint><idno type="ISSN">0023-2173</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0023-2173</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="de">de</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Increased sialic acid levels reflecting tumor burden are found on the surface of T-lymphocytes and in the plasma of patients with carcinoma of the mammary gland. The data of the determinations of sialic acid content and distribution on T-cells, using microanalytical methods such as HPLC and a colorimetric test, show that the total sialic acid content is increased by about 60% and that nearly 80–90% of the sialic acids consist of Nacetyl-9-O-acetyl-neuraminic acid, in comparison to the healthy controls (not containing O-acetylated neuraminic acid). Investigations on lymphocytes of malignant melanoma patients show similar changes of sialic acid content and distribution on the cell surface. Increased sialic acid levels are also found in the plasma of patients with cancer but no O-acetylated derivative can be found. Furthermore the examinations show that the separation of the T-lymphocytes from the total lymphocyte fraction is not required. Determination of sialic acids in the total lymphocyte fraction can be a simplification in carrying out further diagnostic investigations. A high level of sialic acids as “antirecognition factor” seems to be not only a marker of tumor cells but also an attribute of T-lymphocytes, involved in the defence against the malignoma (malignant melanoma, breast cancer). Considering the possible contribution of sialic acid to the immunoregulatory protective mechanism during the first stage of pregnancy, sialic acid content and distribution on T-cells of pregnant women are investigated. Both an increase and a change in the distribution of sialic acids can be excluded.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>Prof. Dr. H. Stickl</name><affiliations><json:string>Abteilung für Umwelthygiene und Impfwesen, Fakultät für Medizin der Technischen Universität München, Deutschland</json:string><json:string>Institut für Toxikologie und Umwelthygiene der TU München, Lazarettstr. 62, W-8000, München 19, FRG</json:string></affiliations></json:item><json:item><name>W. 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The data of the determinations of sialic acid content and distribution on T-cells, using microanalytical methods such as HPLC and a colorimetric test, show that the total sialic acid content is increased by about 60% and that nearly 80–90% of the sialic acids consist of Nacetyl-9-O-acetyl-neuraminic acid, in comparison to the healthy controls (not containing O-acetylated neuraminic acid). Investigations on lymphocytes of malignant melanoma patients show similar changes of sialic acid content and distribution on the cell surface. Increased sialic acid levels are also found in the plasma of patients with cancer but no O-acetylated derivative can be found. Furthermore the examinations show that the separation of the T-lymphocytes from the total lymphocyte fraction is not required. Determination of sialic acids in the total lymphocyte fraction can be a simplification in carrying out further diagnostic investigations. A high level of sialic acids as “antirecognition factor” seems to be not only a marker of tumor cells but also an attribute of T-lymphocytes, involved in the defence against the malignoma (malignant melanoma, breast cancer). Considering the possible contribution of sialic acid to the immunoregulatory protective mechanism during the first stage of pregnancy, sialic acid content and distribution on T-cells of pregnant women are investigated. 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xml:lang="en">Changes of acylneuraminic acids content on T-lymphocytes in patients with mamma carcinoma</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><p>Springer-Verlag, 1991</p></availability><date>1990-07-24</date></publicationStmt><notesStmt><note>Originalien</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="de">Veränderung der Acylneuraminsäuregehalte auf T-Lymphozyten und im Plasma bei Erkrankung an Mamma-Karzinom</title><title level="a" type="alt" xml:lang="en">Changes of acylneuraminic acids content on T-lymphocytes in patients with mamma carcinoma</title><author xml:id="author-0000"><persName><forename type="first">H.</forename><surname>Stickl</surname></persName><roleName type="degree">Prof. Dr.</roleName><affiliation>Abteilung für Umwelthygiene und Impfwesen, Fakultät für Medizin der Technischen Universität München, 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unit="issue">1</biblScope><biblScope unit="page" from="5">5</biblScope><biblScope unit="page" to="9">9</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990-07-24</date></creation><langUsage><language ident="de">de</language></langUsage><abstract xml:lang="en"><p>Summary: Increased sialic acid levels reflecting tumor burden are found on the surface of T-lymphocytes and in the plasma of patients with carcinoma of the mammary gland. The data of the determinations of sialic acid content and distribution on T-cells, using microanalytical methods such as HPLC and a colorimetric test, show that the total sialic acid content is increased by about 60% and that nearly 80–90% of the sialic acids consist of Nacetyl-9-O-acetyl-neuraminic acid, in comparison to the healthy controls (not containing O-acetylated neuraminic acid). Investigations on lymphocytes of malignant melanoma patients show similar changes of sialic acid content and distribution on the cell surface. Increased sialic acid levels are also found in the plasma of patients with cancer but no O-acetylated derivative can be found. Furthermore the examinations show that the separation of the T-lymphocytes from the total lymphocyte fraction is not required. Determination of sialic acids in the total lymphocyte fraction can be a simplification in carrying out further diagnostic investigations. A high level of sialic acids as “antirecognition factor” seems to be not only a marker of tumor cells but also an attribute of T-lymphocytes, involved in the defence against the malignoma (malignant melanoma, breast cancer). Considering the possible contribution of sialic acid to the immunoregulatory protective mechanism during the first stage of pregnancy, sialic acid content and distribution on T-cells of pregnant women are investigated. Both an increase and a change in the distribution of sialic acids can be excluded.</p></abstract><textClass><keywords scheme="keyword"><list><head>Abkürzungen</head><item><term>HPLC</term><term>High performance liquid chromatography</term></item><item><term>Neu 5 Ac</term><term>N-Acetyl-neuraminsäure</term></item><item><term>Neu 5, 9 Ac2</term><term>N-Acetyl-9-O-acetyl-neuraminsäure</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Molecular Medicine</term></item><item><term>Internal Medicine</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1990-07-24">Created</change><change when="1991-01-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/F777B79F94F0863ED1FE38768365B136359D9166/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>109</JournalID><JournalPrintISSN>0023-2173</JournalPrintISSN><JournalElectronicISSN>1432-1440</JournalElectronicISSN><JournalTitle>Klinische Wochenschrift</JournalTitle><JournalAbbreviatedTitle>Klin Wochenschr</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Molecular Medicine</JournalSubject><JournalSubject Type="Secondary">Internal Medicine</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>69</VolumeIDStart><VolumeIDEnd>69</VolumeIDEnd><VolumeIssueCount>24</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd><IssueArticleCount>18</IssueArticleCount><IssueHistory><CoverDate><DateString>4. Januar 1991</DateString><Year>1991</Year><Month>1</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1991</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art3"><ArticleInfo Language="De" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF01649046</ArticleID><ArticleDOI>10.1007/BF01649046</ArticleDOI><ArticleSequenceNumber>3</ArticleSequenceNumber><ArticleTitle Language="De">Veränderung der Acylneuraminsäuregehalte auf T-Lymphozyten und im Plasma bei Erkrankung an Mamma-Karzinom</ArticleTitle><ArticleTitle Language="En">Changes of acylneuraminic acids content on T-lymphocytes in patients with mamma carcinoma</ArticleTitle><ArticleCategory>Originalien</ArticleCategory><ArticleFirstPage>5</ArticleFirstPage><ArticleLastPage>9</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>4</Month><Day>22</Day></RegistrationDate><Received><Year>1990</Year><Month>7</Month><Day>24</Day></Received><Accepted><Year>1990</Year><Month>10</Month><Day>9</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1991</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>109</JournalID><VolumeIDStart>69</VolumeIDStart><VolumeIDEnd>69</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1 Aff2"><AuthorName DisplayOrder="Western"><Prefix>Prof. Dr.</Prefix><GivenName>H.</GivenName><FamilyName>Stickl</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>W.</GivenName><FamilyName>Huber</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Faillard</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>A.</GivenName><FamilyName>Becker</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>R.</GivenName><FamilyName>Holzhauser</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff4"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Graeff</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Abteilung für Umwelthygiene und Impfwesen</OrgDivision><OrgName>Fakultät für Medizin der Technischen Universität München</OrgName><OrgAddress><Country>Deutschland</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Institut für Biochemie</OrgDivision><OrgName>Universität des Saarlandes</OrgName><OrgAddress><City>Saarbrücken</City></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgDivision>Universitäts-Frauenklinik der Fakultät für Medizin</OrgDivision><OrgName>Technische Universität München</OrgName><OrgAddress><Country>Deutschland</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgName>Institut für Toxikologie und Umwelthygiene der TU München</OrgName><OrgAddress><Street>Lazarettstr. 62</Street><Postcode>W-8000</Postcode><City>München 19</City><Country>FRG</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>Increased sialic acid levels reflecting tumor burden are found on the surface of T-lymphocytes and in the plasma of patients with carcinoma of the mammary gland. The data of the determinations of sialic acid content and distribution on T-cells, using microanalytical methods such as HPLC and a colorimetric test, show that the total sialic acid content is increased by about 60% and that nearly 80–90% of the sialic acids consist of Nacetyl-9-O-acetyl-neuraminic acid, in comparison to the healthy controls (not containing O-acetylated neuraminic acid). Investigations on lymphocytes of malignant melanoma patients show similar changes of sialic acid content and distribution on the cell surface.</Para><Para>Increased sialic acid levels are also found in the plasma of patients with cancer but no O-acetylated derivative can be found.</Para><Para>Furthermore the examinations show that the separation of the T-lymphocytes from the total lymphocyte fraction is not required. Determination of sialic acids in the total lymphocyte fraction can be a simplification in carrying out further diagnostic investigations.</Para><Para>A high level of sialic acids as “antirecognition factor” seems to be not only a marker of tumor cells but also an attribute of T-lymphocytes, involved in the defence against the malignoma (malignant melanoma, breast cancer).</Para><Para>Considering the possible contribution of sialic acid to the immunoregulatory protective mechanism during the first stage of pregnancy, sialic acid content and distribution on T-cells of pregnant women are investigated. Both an increase and a change in the distribution of sialic acids can be excluded.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Acyl-neuramic acids</Keyword><Keyword>Plasma</Keyword><Keyword>T-lymphocyte</Keyword><Keyword>Mammary carcinoma</Keyword></KeywordGroup><AbbreviationGroup><Heading>Abkürzungen</Heading><DefinitionList><DefinitionListEntry><Term>HPLC</Term><Description><Para>High performance liquid chromatography</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>Neu 5 Ac</Term><Description><Para>N-Acetyl-neuraminsäure</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>Neu 5, 9 Ac<Subscript>2</Subscript></Term><Description><Para>N-Acetyl-9-O-acetyl-neuraminsäure</Para></Description></DefinitionListEntry></DefinitionList></AbbreviationGroup><ArticleNote Type="Misc"><SimplePara>Diese Arbeit wurde unterstützt von der Deutschen Forschungsgemeinschaft (Fa 45/4).</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="de"><title>Veränderung der Acylneuraminsäuregehalte auf T-Lymphozyten und im Plasma bei Erkrankung an Mamma-Karzinom</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="de"><title>Veränderung der Acylneuraminsäuregehalte auf T-Lymphozyten und im Plasma bei Erkrankung an Mamma-Karzinom</title></titleInfo><titleInfo lang="en"><title>Changes of acylneuraminic acids content on T-lymphocytes in patients with mamma carcinoma</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Changes of acylneuraminic acids content on T-lymphocytes in patients with mamma carcinoma</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Prof. Dr.</namePart><namePart type="given">H.</namePart><namePart type="family">Stickl</namePart><affiliation>Abteilung für Umwelthygiene und Impfwesen, Fakultät für Medizin der Technischen Universität München, Deutschland</affiliation><affiliation>Institut für Toxikologie und Umwelthygiene der TU München, Lazarettstr. 62, W-8000, München 19, FRG</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Huber</namePart><affiliation>Abteilung für Umwelthygiene und Impfwesen, Fakultät für Medizin der Technischen Universität München, Deutschland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Faillard</namePart><affiliation>Institut für Biochemie, Universität des Saarlandes, Saarbrücken</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Becker</namePart><affiliation>Institut für Biochemie, Universität des Saarlandes, Saarbrücken</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Holzhauser</namePart><affiliation>Institut für Biochemie, Universität des Saarlandes, Saarbrücken</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Graeff</namePart><affiliation>Universitäts-Frauenklinik der Fakultät für Medizin, Technische Universität München, Deutschland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1990-07-24</dateCreated><dateIssued encoding="w3cdtf">1991-01-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">de</languageTerm><languageTerm type="code" authority="iso639-2b">ger</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: Increased sialic acid levels reflecting tumor burden are found on the surface of T-lymphocytes and in the plasma of patients with carcinoma of the mammary gland. The data of the determinations of sialic acid content and distribution on T-cells, using microanalytical methods such as HPLC and a colorimetric test, show that the total sialic acid content is increased by about 60% and that nearly 80–90% of the sialic acids consist of Nacetyl-9-O-acetyl-neuraminic acid, in comparison to the healthy controls (not containing O-acetylated neuraminic acid). Investigations on lymphocytes of malignant melanoma patients show similar changes of sialic acid content and distribution on the cell surface. Increased sialic acid levels are also found in the plasma of patients with cancer but no O-acetylated derivative can be found. Furthermore the examinations show that the separation of the T-lymphocytes from the total lymphocyte fraction is not required. Determination of sialic acids in the total lymphocyte fraction can be a simplification in carrying out further diagnostic investigations. A high level of sialic acids as “antirecognition factor” seems to be not only a marker of tumor cells but also an attribute of T-lymphocytes, involved in the defence against the malignoma (malignant melanoma, breast cancer). Considering the possible contribution of sialic acid to the immunoregulatory protective mechanism during the first stage of pregnancy, sialic acid content and distribution on T-cells of pregnant women are investigated. Both an increase and a change in the distribution of sialic acids can be excluded.</abstract><note>Originalien</note><subject><genre>Abkürzungen</genre><topic>HPLC : High performance liquid chromatography</topic><topic>Neu 5 Ac : N-Acetyl-neuraminsäure</topic><topic>Neu 5, 9 Ac2 : N-Acetyl-9-O-acetyl-neuraminsäure</topic></subject><relatedItem type="host"><titleInfo><title>Klinische Wochenschrift</title></titleInfo><titleInfo type="abbreviated"><title>Klin Wochenschr</title></titleInfo><genre type="journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1991-01-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Molecular Medicine</topic><topic>Internal Medicine</topic></subject><identifier type="ISSN">0023-2173</identifier><identifier type="eISSN">1432-1440</identifier><identifier type="JournalID">109</identifier><identifier type="IssueArticleCount">18</identifier><identifier type="VolumeIssueCount">24</identifier><part><date>1991</date><detail type="volume"><number>69</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>5</start><end>9</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1991</recordOrigin></recordInfo></relatedItem><identifier type="istex">F777B79F94F0863ED1FE38768365B136359D9166</identifier><identifier type="DOI">10.1007/BF01649046</identifier><identifier type="ArticleID">BF01649046</identifier><identifier type="ArticleID">Art3</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1991</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1991</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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