Genetic and activity‐dependent regulation of Zif268 expression: Association with spatial learning
Identifieur interne : 001901 ( Istex/Corpus ); précédent : 001900; suivant : 001902Genetic and activity‐dependent regulation of Zif268 expression: Association with spatial learning
Auteurs : Diana E. Fordyce ; Ratan V. Bhat ; Jay M. Baraban ; Jay M. WehnerSource :
- Hippocampus [ 1050-9631 ] ; 1994-10.
English descriptors
- KwdEn :
- Teeft :
- Asymptotic performance, Baraban, Basal, Basal expression, Behav brain, Behav neurosci wehner, Behavioral genetics, Cervical dislocation, Chronic cocaine treatment, Cole, Control groups, Control levels, Control mice, Dentate gyrus, Distinct populations, Early genes, Electroconvulsive shock, Exercise bout, Experimental conditions, Fordyce, Gene expression, Genetic, Genetic difference, Genetic differences, Greater number, Hippocampal, Hippocampal protein kinase, Hippocampus, Home cage, Homogenization buffer, Hybridization, Kinase, Latency, Latency data, Main effect, Mouse, Mrna, Mrna levels, Neuron, Nmdarl, Nmdarl riboprobe, Nonstimulated kinase activity, Olfactory bulb, Optical density, Other site locations, Other sites, Overlying, Overlying cortex, Physical activity, Physical activity treatment, Physical enhancement, Platform location, Pool wall, Potentiation, Preference score, Preference scores, Present investigation, Probe trial, Probe trial site crossings, Protein concentrations, Protein kinase, Results section, Room temperature, Same location, Same manner, Same slide, Same time, Sedentary controls, Sifu hybridization, Significance values, Significant difference, Significant effect, Significant interaction, Significant interaction effect, Similar results, Site crossings, Site locations, Somatosensory cortex, Spatial, Spatial cues, Statistical analysis, Synaptic, Synaptic activity, Tissue preparation, Total number, Total volume, Transcription, Transcription factor, Transcription factors, Treadmill, Visible platform, Wehner, Worley.
Abstract
We have reported that C57BL/6 and DBA/2 mice differ in spatial learning performance and associated hippocampal protein kinase C (PKC) activity (Upchurch and Wehner, 1989, Behav Neurosci 103:1251–1258; Wehner et al., 1990, Brain Res 523:181–187) and that physical activity enhances spatial learning with related alterations in protein kinase C (PKC) (Fordyee and Wehner, 1993b, Brain Res 619:111–119). To assess whether physical activity induces alterations in gene expression that may underlie these changes in PKC and learning performance, we examined the effect of physical activity on expression of zif268, a transcription regulatory factor linked to stimulus‐induced neuronal plasticity. C57 and DBA mice, 3 months of age, were subjected to acute (one bout) or chronic (8 weeks) physical activity. The mice were then tested on the Morris water maze task for 6 days with subsequent analysis of PKC activity and zif268 mRNA expression. Control DBA mice, which have poor hippocampal‐specific learning performance compared to C57 mice (Wehner et al., 1990, Brain Res 523:181–187; Fordyce and Wehner, 1993b, Brain Res 619:111–119; Paylor et al., 1993, Psychobiology 27:11–26), displayed lower basal levels of zif268 mRNA (P <.05). As observed previously, chronic physical activity produced an enhancement in spatial learning performance accompanied by alterations in hippocampal PKC activity in both strains of mice (P <.05). In addition, the present investigation demonstrated that acute physical increased mRNA levels of zif268 in hippocampal regions CA1, CA3 and overlying cortex (P <.005) of both C57 and DBA mice. Chronic physical activity suppressed the basal expression of zif268 in C57 mice in CA1 and overlying cortex below control levels. These findings suggest that genetic and activity‐dependent regulation of zif268 may influence learning performance. © 1994 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/hipo.450040505
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ISTEX:EEF4874084F9FB06A01BE9EF82B978DEADDD3A96Le document en format XML
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To assess whether physical activity induces alterations in gene expression that may underlie these changes in PKC and learning performance, we examined the effect of physical activity on expression of zif268, a transcription regulatory factor linked to stimulus‐induced neuronal plasticity. C57 and DBA mice, 3 months of age, were subjected to acute (one bout) or chronic (8 weeks) physical activity. The mice were then tested on the Morris water maze task for 6 days with subsequent analysis of PKC activity and zif268 mRNA expression. Control DBA mice, which have poor hippocampal‐specific learning performance compared to C57 mice (Wehner et al., 1990, Brain Res 523:181–187; Fordyce and Wehner, 1993b, Brain Res 619:111–119; Paylor et al., 1993, Psychobiology 27:11–26), displayed lower basal levels of zif268 mRNA (P <.05). As observed previously, chronic physical activity produced an enhancement in spatial learning performance accompanied by alterations in hippocampal PKC activity in both strains of mice (P <.05). In addition, the present investigation demonstrated that acute physical increased mRNA levels of zif268 in hippocampal regions CA1, CA3 and overlying cortex (P <.005) of both C57 and DBA mice. Chronic physical activity suppressed the basal expression of zif268 in C57 mice in CA1 and overlying cortex below control levels. 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To assess whether physical activity induces alterations in gene expression that may underlie these changes in PKC and learning performance, we examined the effect of physical activity on expression of zif268, a transcription regulatory factor linked to stimulus‐induced neuronal plasticity. C57 and DBA mice, 3 months of age, were subjected to acute (one bout) or chronic (8 weeks) physical activity. The mice were then tested on the Morris water maze task for 6 days with subsequent analysis of PKC activity and zif268 mRNA expression. Control DBA mice, which have poor hippocampal‐specific learning performance compared to C57 mice (Wehner et al., 1990, Brain Res 523:181–187; Fordyce and Wehner, 1993b, Brain Res 619:111–119; Paylor et al., 1993, Psychobiology 27:11–26), displayed lower basal levels of zif268 mRNA (P >.05). As observed previously, chronic physical activity produced an enhancement in spatial learning performance accompanied by alterations in hippocampal PKC activity in both strains of mice (P >.05). In addition, the present investigation demonstrated that acute physical increased mRNA levels of zif268 in hippocampal regions CA1, CA3 and overlying cortex (P >.005) of both C57 and DBA mice. Chronic physical activity suppressed the basal expression of zif268 in C57 mice in CA1 and overlying cortex below control levels. 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619:111–119). To assess whether physical activity induces alterations in gene expression that may underlie these changes in PKC and learning performance, we examined the effect of physical activity on expression of zif268, a transcription regulatory factor linked to stimulus‐induced neuronal plasticity. C57 and DBA mice, 3 months of age, were subjected to acute (one bout) or chronic (8 weeks) physical activity. The mice were then tested on the Morris water maze task for 6 days with subsequent analysis of PKC activity and zif268 mRNA expression. Control DBA mice, which have poor hippocampal‐specific learning performance compared to C57 mice (Wehner et al., 1990, Brain Res 523:181–187; Fordyce and Wehner, 1993b, Brain Res 619:111–119; Paylor et al., 1993, Psychobiology 27:11–26), displayed lower basal levels of zif268 mRNA (P <.05). As observed previously, chronic physical activity produced an enhancement in spatial learning performance accompanied by alterations in hippocampal PKC activity in both strains of mice (P <.05). In addition, the present investigation demonstrated that acute physical increased mRNA levels of zif268 in hippocampal regions CA1, CA3 and overlying cortex (P <.005) of both C57 and DBA mice. Chronic physical activity suppressed the basal expression of zif268 in C57 mice in CA1 and overlying cortex below control levels. These findings suggest that genetic and activity‐dependent regulation of zif268 may influence learning performance. © 1994 Wiley‐Liss, Inc.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>hippocampus</term></item><item><term>transcription factor</term></item><item><term>protein kinase C (PKC)</term></item><item><term>mice</term></item><item><term>physical activity or running exercise</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/EEF4874084F9FB06A01BE9EF82B978DEADDD3A96/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1098-1063</doi><issn type="print">1050-9631</issn><issn type="electronic">1098-1063</issn><idGroup><id type="product" value="HIPO"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="HIPPOCAMPUS">Hippocampus</title><title type="short">Hippocampus</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/hipo.v4:5</doi><numberingGroup><numbering type="journalVolume" number="4">4</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="1994-10">October 1994</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley" registered="yes">10.1002/hipo.450040505</doi><idGroup><id type="unit" value="HIPO450040505"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="publisher">Copyright © 1994 Wiley‐Liss, Inc.</copyright><eventGroup><event type="firstOnline" date="2004-10-13"></event><event type="publishedOnlineFinalForm" date="2004-10-13"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-27"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-24"></event></eventGroup><numberingGroup><numbering type="pageFirst">559</numbering><numbering type="pageLast">568</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:HIPO.HIPO450040505.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="49"></count></countGroup><titleGroup><title type="main" xml:lang="en">Genetic and activity‐dependent regulation of <i>Zif268</i> expression: Association with spatial learning</title><title type="short" xml:lang="en">GENETIC AND ACTIVITY‐DEPENDENT <fi>Zif268</fi></title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Diana E.</givenNames><familyName>Fordyce</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Ratan V.</givenNames><familyName>Bhat</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Jay M.</givenNames><familyName>Baraban</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2" currentRef="#curr1"><personName><honorifics>Dr.</honorifics><givenNames>Jeanne M.</givenNames><familyName>Wehner</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>School of Pharmacy, University of Colorado, Boulder, Colorado</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Departments of Neuroscience and Psychiatry and Behavioral Sciences, Johns Hipkins University School of Medicine, Baltimore, Maryland</unparsedAffiliation></affiliation><affiliation xml:id="curr1" countryCode="US"><unparsedAffiliation>IBG, University of Colorado, Boulder, CO 803090477</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">hippocampus</keyword><keyword xml:id="kwd2">transcription factor</keyword><keyword xml:id="kwd3">protein kinase C (PKC)</keyword><keyword xml:id="kwd4">mice</keyword><keyword xml:id="kwd5">physical activity or running exercise</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="fr"><title type="main">Abstract</title><p>We have reported that C57BL/6 and DBA/2 mice differ in spatial learning performance and associated hippocampal protein kinase C (PKC) activity (Upchurch and Wehner, 1989, Behav Neurosci 103:1251–1258; Wehner et al., 1990, Brain Res 523:181–187) and that physical activity enhances spatial learning with related alterations in protein kinase C (PKC) (Fordyee and Wehner, 1993b, Brain Res 619:111–119). To assess whether physical activity induces alterations in gene expression that may underlie these changes in PKC and learning performance, we examined the effect of physical activity on expression of <i>zif268</i>, a transcription regulatory factor linked to stimulus‐induced neuronal plasticity. C57 and DBA mice, 3 months of age, were subjected to acute (one bout) or chronic (8 weeks) physical activity. The mice were then tested on the Morris water maze task for 6 days with subsequent analysis of PKC activity and <i>zif268</i> mRNA expression. Control DBA mice, which have poor hippocampal‐specific learning performance compared to C57 mice (Wehner et al., 1990, Brain Res 523:181–187; Fordyce and Wehner, 1993b, Brain Res 619:111–119; Paylor et al., 1993, Psychobiology 27:11–26), displayed lower basal levels of <i>zif268</i> mRNA (P <.05). As observed previously, chronic physical activity produced an enhancement in spatial learning performance accompanied by alterations in hippocampal PKC activity in both strains of mice (P <.05). In addition, the present investigation demonstrated that acute physical increased mRNA levels of <i>zif268</i> in hippocampal regions CA1, CA3 and overlying cortex (P <.005) of both C57 and DBA mice. Chronic physical activity suppressed the basal expression of <i>zif268</i> in C57 mice in CA1 and overlying cortex below control levels. These findings suggest that genetic and activity‐dependent regulation of <i>zif268</i> may influence learning performance. © 1994 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Genetic and activity‐dependent regulation of Zif268 expression: Association with spatial learning</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>GENETIC AND ACTIVITY‐DEPENDENT Zif268</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Genetic and activity‐dependent regulation of Zif268 expression: Association with spatial learning</title></titleInfo><name type="personal"><namePart type="given">Diana E.</namePart><namePart type="family">Fordyce</namePart><affiliation>Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ratan V.</namePart><namePart type="family">Bhat</namePart><affiliation>Departments of Neuroscience and Psychiatry and Behavioral Sciences, Johns Hipkins University School of Medicine, Baltimore, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jay M.</namePart><namePart type="family">Baraban</namePart><affiliation>Departments of Neuroscience and Psychiatry and Behavioral Sciences, Johns Hipkins University School of Medicine, Baltimore, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="family">Wehner</namePart><affiliation>Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado</affiliation><affiliation>School of Pharmacy, University of Colorado, Boulder, Colorado</affiliation><affiliation>Current Address: IBG, University of Colorado, Boulder, CO 803090477</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1994-10</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="references">49</extent></physicalDescription><abstract lang="fr">We have reported that C57BL/6 and DBA/2 mice differ in spatial learning performance and associated hippocampal protein kinase C (PKC) activity (Upchurch and Wehner, 1989, Behav Neurosci 103:1251–1258; Wehner et al., 1990, Brain Res 523:181–187) and that physical activity enhances spatial learning with related alterations in protein kinase C (PKC) (Fordyee and Wehner, 1993b, Brain Res 619:111–119). To assess whether physical activity induces alterations in gene expression that may underlie these changes in PKC and learning performance, we examined the effect of physical activity on expression of zif268, a transcription regulatory factor linked to stimulus‐induced neuronal plasticity. C57 and DBA mice, 3 months of age, were subjected to acute (one bout) or chronic (8 weeks) physical activity. The mice were then tested on the Morris water maze task for 6 days with subsequent analysis of PKC activity and zif268 mRNA expression. Control DBA mice, which have poor hippocampal‐specific learning performance compared to C57 mice (Wehner et al., 1990, Brain Res 523:181–187; Fordyce and Wehner, 1993b, Brain Res 619:111–119; Paylor et al., 1993, Psychobiology 27:11–26), displayed lower basal levels of zif268 mRNA (P <.05). As observed previously, chronic physical activity produced an enhancement in spatial learning performance accompanied by alterations in hippocampal PKC activity in both strains of mice (P <.05). In addition, the present investigation demonstrated that acute physical increased mRNA levels of zif268 in hippocampal regions CA1, CA3 and overlying cortex (P <.005) of both C57 and DBA mice. Chronic physical activity suppressed the basal expression of zif268 in C57 mice in CA1 and overlying cortex below control levels. These findings suggest that genetic and activity‐dependent regulation of zif268 may influence learning performance. © 1994 Wiley‐Liss, Inc.</abstract><subject lang="en"><genre>keywords</genre><topic>hippocampus</topic><topic>transcription factor</topic><topic>protein kinase C (PKC)</topic><topic>mice</topic><topic>physical activity or running exercise</topic></subject><relatedItem type="host"><titleInfo><title>Hippocampus</title></titleInfo><titleInfo type="abbreviated"><title>Hippocampus</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Article</topic></subject><identifier type="ISSN">1050-9631</identifier><identifier type="eISSN">1098-1063</identifier><identifier type="DOI">10.1002/(ISSN)1098-1063</identifier><identifier type="PublisherID">HIPO</identifier><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>559</start><end>568</end><total>10</total></extent></part></relatedItem><identifier type="istex">EEF4874084F9FB06A01BE9EF82B978DEADDD3A96</identifier><identifier type="DOI">10.1002/hipo.450040505</identifier><identifier type="ArticleID">HIPO450040505</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1994 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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