Stimulation of keratinocyte differentiation – a new role for the vanilloid receptor subtype 1 (VR1/TRPV1)?
Identifieur interne : 000992 ( Istex/Corpus ); précédent : 000991; suivant : 000993Stimulation of keratinocyte differentiation – a new role for the vanilloid receptor subtype 1 (VR1/TRPV1)?
Auteurs : Sonja St Nder ; Corinna Moormann ; Mark Schumacher ; Dieter Metze ; Thomas A. Luger ; Martin SteinhoffSource :
- Experimental Dermatology [ 0906-6705 ] ; 2005-02.
English descriptors
- Teeft :
- Acth, Androgen, Androgen activity, Antisense oligonucleotides, Atopic dermatitis, Basal serum levels, Biomedical sciences, Calcitriol, Calcitriol synthesis, Campus benjamin franklin, Carl gustav carus, Cell biology, Cell growth, Cholinergic agonists, Clinical monitoring, Collagen synthesis, Complex mechanisms, Connective tissue sheath fibroblasts, Cultured keratinocytes, Cutaneous, Dermal microvascular, Dermal papilla cells, Dermatology, Dresden university, Environmental dermatology, Epidermal, Epidermal differentiation, Epidermal hydration, Epidermal keratinocytes, Epidermis, Epithelial cells, Estrogen, Extracellular matrix, Fibroblast, First time, Follicle, Foreskin keratinocytes, Functional significance, Hair cycle dependence, Hair follicle, Hair follicle biology, Hdmec membranes, Human ache, Human epidermis, Human hair follicles, Human keratinocytes, Human skin, Immunoreactivity, Important role, Inhibitor, Keratinocyte differentiation, Keratinocytes, Local production, Local synthesis, Ludwig boltzmann institute, Malignant melanoma, Mammalian skin, Melanocortin receptors, Melanoma, Melanoma cell lines, Melanoma cells, Melatonin, Munster, Murine hair follicles, Narrowband lamp, Normal skin, Oligonucleotides, Organotypic cultures, Other hand, Oxidative stress, Oxysterols, Pomc, Pomc peptides, Postmenopausal women, Prurigo nodularis, Psoriasis vulgaris, Radical scavenger, Real time, Receptor, Recovery time, Sebaceous, Sebaceous lipogenesis, Sebocyte differentiation, Sexual hormones, Side effects, Skin surface lipids, Splice variants, Such treatment, Terminal differentiation, Tumor necrosis, Vanilloid receptor subtype, Various cell types, Various melanoma cell lines, Various studies, Vitamin growth inhibition, Wahringer gurtel vienna, Western blot analysis, Wolfgang tilgen1, Wound healing.
Abstract
Vanilloids and endogenous cannabinoids mediate their actions via the vanilloid receptor subtype 1 (VR1/TRPV1), a non‐selective cation channel, which is widely distributed in the central and peripheral nervous system. Only recently, VR1 has been shown to be expressed in keratinocytes in vitro and in vivo. However, a precise description of VR1 localization in epithelial cells was missing. To determine this, we investigated VR1‐immunoreactivity as well as mRNA and protein expression in a series of biopsies from normal, diseased, and capsaicin‐treated human skin. VR1 was found in epidermal keratinocytes, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands upon immunohistochemistry, RT‐PCR and Western blot analysis. Interestingly, in diseased skin such as prurigo nodularis, psoriasis vulgaris, and atopic dermatitis, VR1 expression in keratinocytes correlated with the degree of epidermal differentiation. Enhanced VR1 immunoreactivity and protein content was found in prurigo nodularis in which epidermal keratinocytes are highly differentiated. Under effective capsaicin therapy of prurigo nodularis, the epidermis thinned and the distribution pattern of VR1 on epidermal keratinocytes normalized. In psoriasis vulgaris, a disease with disturbed epidermal differentiation, less intense immunostaining for VR1 was observed. This could be confirmed by western blot analysis showing less VR1 protein amount in comparison to prurigo nodularis although histologically both showed a thickened epidermis. In atopic dermatitis, which is characterized by a moderate epidermal hyperplasia only and regular differentiated keratinocytes, VR1 immunoreactivity was unchanged in comparison to normal skin. These findings suggest that VR1 may contribute to regular differentiation of keratinocytes. VR1 activation opens non‐selective cation channels with high permeability to calcium, a ion that is crucially important for the synthesis of cornification proteins such as involucrin, fillagrin and loricrin. The role of VR1 in other epithelial cells of appendage structures remains to be determined. In summary, VR1 is widely distributed in the skin suggesting a central role for this receptor not only in nociception but also maturation and function of epithelial cells.
Url:
DOI: 10.1111/j.0906-6705.2005.0266h.x
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Vanilloids and endogenous cannabinoids mediate their actions via the vanilloid receptor subtype 1 (VR1/TRPV1), a non‐selective cation channel, which is widely distributed in the central and peripheral nervous system. Only recently, VR1 has been shown to be expressed in keratinocytes in vitro and in vivo. However, a precise description of VR1 localization in epithelial cells was missing. To determine this, we investigated VR1‐immunoreactivity as well as mRNA and protein expression in a series of biopsies from normal, diseased, and capsaicin‐treated human skin. VR1 was found in epidermal keratinocytes, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands upon immunohistochemistry, RT‐PCR and Western blot analysis. Interestingly, in diseased skin such as prurigo nodularis, psoriasis vulgaris, and atopic dermatitis, VR1 expression in keratinocytes correlated with the degree of epidermal differentiation. Enhanced VR1 immunoreactivity and protein content was found in prurigo nodularis in which epidermal keratinocytes are highly differentiated. Under effective capsaicin therapy of prurigo nodularis, the epidermis thinned and the distribution pattern of VR1 on epidermal keratinocytes normalized. In psoriasis vulgaris, a disease with disturbed epidermal differentiation, less intense immunostaining for VR1 was observed. This could be confirmed by western blot analysis showing less VR1 protein amount in comparison to prurigo nodularis although histologically both showed a thickened epidermis. In atopic dermatitis, which is characterized by a moderate epidermal hyperplasia only and regular differentiated keratinocytes, VR1 immunoreactivity was unchanged in comparison to normal skin. These findings suggest that VR1 may contribute to regular differentiation of keratinocytes. VR1 activation opens non‐selective cation channels with high permeability to calcium, a ion that is crucially important for the synthesis of cornification proteins such as involucrin, fillagrin and loricrin. The role of VR1 in other epithelial cells of appendage structures remains to be determined. In summary, VR1 is widely distributed in the skin suggesting a central role for this receptor not only in nociception but also maturation and function of epithelial cells.</div>
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<abstract>Vanilloids and endogenous cannabinoids mediate their actions via the vanilloid receptor subtype 1 (VR1/TRPV1), a non‐selective cation channel, which is widely distributed in the central and peripheral nervous system. Only recently, VR1 has been shown to be expressed in keratinocytes in vitro and in vivo. However, a precise description of VR1 localization in epithelial cells was missing. To determine this, we investigated VR1‐immunoreactivity as well as mRNA and protein expression in a series of biopsies from normal, diseased, and capsaicin‐treated human skin. VR1 was found in epidermal keratinocytes, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands upon immunohistochemistry, RT‐PCR and Western blot analysis. Interestingly, in diseased skin such as prurigo nodularis, psoriasis vulgaris, and atopic dermatitis, VR1 expression in keratinocytes correlated with the degree of epidermal differentiation. Enhanced VR1 immunoreactivity and protein content was found in prurigo nodularis in which epidermal keratinocytes are highly differentiated. Under effective capsaicin therapy of prurigo nodularis, the epidermis thinned and the distribution pattern of VR1 on epidermal keratinocytes normalized. In psoriasis vulgaris, a disease with disturbed epidermal differentiation, less intense immunostaining for VR1 was observed. This could be confirmed by western blot analysis showing less VR1 protein amount in comparison to prurigo nodularis although histologically both showed a thickened epidermis. In atopic dermatitis, which is characterized by a moderate epidermal hyperplasia only and regular differentiated keratinocytes, VR1 immunoreactivity was unchanged in comparison to normal skin. These findings suggest that VR1 may contribute to regular differentiation of keratinocytes. VR1 activation opens non‐selective cation channels with high permeability to calcium, a ion that is crucially important for the synthesis of cornification proteins such as involucrin, fillagrin and loricrin. The role of VR1 in other epithelial cells of appendage structures remains to be determined. In summary, VR1 is widely distributed in the skin suggesting a central role for this receptor not only in nociception but also maturation and function of epithelial cells.</abstract>
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<abstract lang="en">Vanilloids and endogenous cannabinoids mediate their actions via the vanilloid receptor subtype 1 (VR1/TRPV1), a non‐selective cation channel, which is widely distributed in the central and peripheral nervous system. Only recently, VR1 has been shown to be expressed in keratinocytes in vitro and in vivo. However, a precise description of VR1 localization in epithelial cells was missing. To determine this, we investigated VR1‐immunoreactivity as well as mRNA and protein expression in a series of biopsies from normal, diseased, and capsaicin‐treated human skin. VR1 was found in epidermal keratinocytes, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands upon immunohistochemistry, RT‐PCR and Western blot analysis. Interestingly, in diseased skin such as prurigo nodularis, psoriasis vulgaris, and atopic dermatitis, VR1 expression in keratinocytes correlated with the degree of epidermal differentiation. Enhanced VR1 immunoreactivity and protein content was found in prurigo nodularis in which epidermal keratinocytes are highly differentiated. Under effective capsaicin therapy of prurigo nodularis, the epidermis thinned and the distribution pattern of VR1 on epidermal keratinocytes normalized. In psoriasis vulgaris, a disease with disturbed epidermal differentiation, less intense immunostaining for VR1 was observed. This could be confirmed by western blot analysis showing less VR1 protein amount in comparison to prurigo nodularis although histologically both showed a thickened epidermis. In atopic dermatitis, which is characterized by a moderate epidermal hyperplasia only and regular differentiated keratinocytes, VR1 immunoreactivity was unchanged in comparison to normal skin. These findings suggest that VR1 may contribute to regular differentiation of keratinocytes. VR1 activation opens non‐selective cation channels with high permeability to calcium, a ion that is crucially important for the synthesis of cornification proteins such as involucrin, fillagrin and loricrin. The role of VR1 in other epithelial cells of appendage structures remains to be determined. In summary, VR1 is widely distributed in the skin suggesting a central role for this receptor not only in nociception but also maturation and function of epithelial cells.</abstract>
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