Clinical and angiographic performance of a new‐generation modular stent design for treatment of de novo coronary lesions
Identifieur interne : 000826 ( Istex/Corpus ); précédent : 000825; suivant : 000827Clinical and angiographic performance of a new‐generation modular stent design for treatment of de novo coronary lesions
Auteurs : Victor M. Legrand ; Eulogio J. Garcia ; Eberhard Grube ; Khalife Khalife ; Hans Bonnier ; Philippe Commeau ; Tadeusz Przewlocki ; Carlos Macaya ; Adam WitkowskiSource :
- Catheterization and Cardiovascular Interventions [ 1522-1946 ] ; 2001-11.
English descriptors
- KwdEn :
- Teeft :
- Acute gain, Angina pectoris, Angiographic, Angiographic evaluation, Angiographic result, Angiographic results, Angiographic success, Angiographic success rate, Angiography, Angioplasty, Balloon angioplasty, Benestent, Binary angiographic restenosis rate, Cardiac event survival, Cardiovasc intervent, Catharina hospital, Cathet cardiovasc diagn, Cathet cardiovasc intervent, Complex lesions, Coronary angiography, Coronary artery disease, Coronary stent system, Hospital discharge, Implantation, Infarction, Invas cardiol, John paul, Krankenhaus siegburg gmbh, Legrand, Lesion, Lesion length, Loss index, Lumen, Medtronic, Minimal lumen diameter, Minimum lumen diameter, Modular design, Modular stent design, Myocardial infarction, National institute, Objective evidence, Other stent models, Percent diameter stenosis, Percutaneous intervention, Present study, Primary endpoint, Private center hospital, Procedural success, Procedural success rate, Quantitative angiographic results, Reference vessel diameter, Residual diameter stenosis, Restenosis, Restenosis rate, Second stent, Secondary endpoints, Serruys, Single lesion, Statistical analysis, Stenosis, Stent, Stent design, Stent implantation, Stent thrombosis, Study stents, Target lesion, Unstable angina pectoris, Vessel size.
Abstract
The objectives of the Race Car study were to assess the safety and efficacy of the Medtronic AVE S670 stent, a new‐generation stent with a modular design consisting of interconnected sinusoidal rings allowing improved flexibility with good conformability and scaffolding. A total of 285 stents were implanted in 267 patients with (un)stable angina pectoris who underwent angioplasty of a single de novo lesion in a native coronary artery with a diameter between 3.0 and 4.0 mm. Available stent lengths were 9, 12, and 15 mm. The primary endpoint was the 6‐month restenosis rate. Secondary endpoints were device and procedural success and major adverse cardiac event (MACE)‐free survival at 1 and 6 months. All patients received the study stents and no other stents were used (angiographic success: 100%). Eight patients experienced a MACE during hospital admission (Q‐wave MI in 2, non–Q‐wave MI in 4, TLR in 2). A procedural success was obtained in 97% of the patients. There were no additional events at 1 month. The clinical endpoints encountered at 6 months were Q‐wave MI in 1, bypass surgery in 3, and repeat angioplasty in 25 (MACE‐free survival: 86.5%). Quantitative angiographic results were the minimum lumen diameter increased from 1.05 ± 0.32 before to 2.73 ± 0.39 mm after stent implantation. At follow‐up, the loss in diameter was 0.74 ± 0.50 mm. The loss index was 0.45 ± 0.31 and restenosis rate was 13.4%. This study has demonstrated that the S670 stent in patients with (un)stable angina pectoris requiring intervention of a single lesion has a low acute and 6‐month major event rate and a low angiographic restenosis rate. Cathet Cardiovasc Intervent 2001;54:276–282. © 2001 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ccd.1284
Links to Exploration step
ISTEX:4E2113C7A267412B46862F48380B04788ED73C1ELe document en format XML
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A total of 285 stents were implanted in 267 patients with (un)stable angina pectoris who underwent angioplasty of a single de novo lesion in a native coronary artery with a diameter between 3.0 and 4.0 mm. Available stent lengths were 9, 12, and 15 mm. The primary endpoint was the 6‐month restenosis rate. Secondary endpoints were device and procedural success and major adverse cardiac event (MACE)‐free survival at 1 and 6 months. All patients received the study stents and no other stents were used (angiographic success: 100%). Eight patients experienced a MACE during hospital admission (Q‐wave MI in 2, non–Q‐wave MI in 4, TLR in 2). A procedural success was obtained in 97% of the patients. There were no additional events at 1 month. The clinical endpoints encountered at 6 months were Q‐wave MI in 1, bypass surgery in 3, and repeat angioplasty in 25 (MACE‐free survival: 86.5%). Quantitative angiographic results were the minimum lumen diameter increased from 1.05 ± 0.32 before to 2.73 ± 0.39 mm after stent implantation. At follow‐up, the loss in diameter was 0.74 ± 0.50 mm. The loss index was 0.45 ± 0.31 and restenosis rate was 13.4%. This study has demonstrated that the S670 stent in patients with (un)stable angina pectoris requiring intervention of a single lesion has a low acute and 6‐month major event rate and a low angiographic restenosis rate. Cathet Cardiovasc Intervent 2001;54:276–282. © 2001 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>stent</json:string><json:string>angiographic</json:string><json:string>restenosis</json:string><json:string>serruys</json:string><json:string>angioplasty</json:string><json:string>stenosis</json:string><json:string>restenosis rate</json:string><json:string>medtronic</json:string><json:string>legrand</json:string><json:string>lesion</json:string><json:string>benestent</json:string><json:string>stent implantation</json:string><json:string>angiography</json:string><json:string>implantation</json:string><json:string>angiographic results</json:string><json:string>minimum lumen diameter</json:string><json:string>stent design</json:string><json:string>procedural success</json:string><json:string>target lesion</json:string><json:string>balloon angioplasty</json:string><json:string>myocardial infarction</json:string><json:string>minimal lumen diameter</json:string><json:string>infarction</json:string><json:string>percent diameter stenosis</json:string><json:string>angiographic success rate</json:string><json:string>lesion length</json:string><json:string>reference vessel diameter</json:string><json:string>modular stent design</json:string><json:string>coronary artery disease</json:string><json:string>invas cardiol</json:string><json:string>lumen</json:string><json:string>john paul</json:string><json:string>national institute</json:string><json:string>study stents</json:string><json:string>angiographic success</json:string><json:string>quantitative angiographic results</json:string><json:string>primary endpoint</json:string><json:string>coronary angiography</json:string><json:string>modular design</json:string><json:string>angina pectoris</json:string><json:string>angiographic evaluation</json:string><json:string>vessel size</json:string><json:string>secondary endpoints</json:string><json:string>loss index</json:string><json:string>single lesion</json:string><json:string>hospital discharge</json:string><json:string>binary angiographic restenosis rate</json:string><json:string>cathet cardiovasc intervent</json:string><json:string>procedural success rate</json:string><json:string>residual diameter stenosis</json:string><json:string>cardiovasc intervent</json:string><json:string>statistical analysis</json:string><json:string>other stent models</json:string><json:string>second stent</json:string><json:string>percutaneous intervention</json:string><json:string>stent thrombosis</json:string><json:string>complex lesions</json:string><json:string>cardiac event survival</json:string><json:string>unstable angina pectoris</json:string><json:string>angiographic result</json:string><json:string>acute gain</json:string><json:string>krankenhaus siegburg gmbh</json:string><json:string>present study</json:string><json:string>catharina hospital</json:string><json:string>private center hospital</json:string><json:string>cathet cardiovasc diagn</json:string><json:string>coronary stent system</json:string><json:string>objective evidence</json:string></teeft></keywords><author><json:item><name>Victor M. Legrand MD</name><affiliations><json:string>Department of Cardiology, C.H.U. de Liège, Liège, Belgium</json:string><json:string>Department of Cardiology, C.H.U. de Liège, Sart‐Tilman, 4000 Liège, Belgium</json:string></affiliations></json:item><json:item><name>Eulogio J. Garcia MD</name><affiliations><json:string>Hospital Gregorio, Marañon, Madrid, Spain</json:string></affiliations></json:item><json:item><name>Eberhard Grube MD</name><affiliations><json:string>Krankenhaus Siegburg GmbH, Siegburg, Germany</json:string></affiliations></json:item><json:item><name>Khalife Khalife MD</name><affiliations><json:string>CHR Hôpital Bon Secours, Metz, France</json:string></affiliations></json:item><json:item><name>Hans Bonnier MD</name><affiliations><json:string>Catharina Hospital, Eindhoven, The Netherlands</json:string></affiliations></json:item><json:item><name>Philippe Commeau MD</name><affiliations><json:string>Private Center Saint‐Martin Hospital, Caen, France</json:string></affiliations></json:item><json:item><name>Tadeusz Przewlocki MD</name><affiliations><json:string>John Paul II University Hospital, Krakow, Poland</json:string></affiliations></json:item><json:item><name>Carlos Macaya MD</name><affiliations><json:string>Hospital Clinico Universidad San Carlos, Madrid, Spain</json:string></affiliations></json:item><json:item><name>Adam Witkowski MD</name><affiliations><json:string>National Institute for Cardiology, Warsaw, Poland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>coronary angioplasty</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>stents</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>coronary disease</value></json:item></subject><articleId><json:string>CCD1284</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The objectives of the Race Car study were to assess the safety and efficacy of the Medtronic AVE S670 stent, a new‐generation stent with a modular design consisting of interconnected sinusoidal rings allowing improved flexibility with good conformability and scaffolding. A total of 285 stents were implanted in 267 patients with (un)stable angina pectoris who underwent angioplasty of a single de novo lesion in a native coronary artery with a diameter between 3.0 and 4.0 mm. Available stent lengths were 9, 12, and 15 mm. The primary endpoint was the 6‐month restenosis rate. Secondary endpoints were device and procedural success and major adverse cardiac event (MACE)‐free survival at 1 and 6 months. All patients received the study stents and no other stents were used (angiographic success: 100%). Eight patients experienced a MACE during hospital admission (Q‐wave MI in 2, non–Q‐wave MI in 4, TLR in 2). A procedural success was obtained in 97% of the patients. There were no additional events at 1 month. The clinical endpoints encountered at 6 months were Q‐wave MI in 1, bypass surgery in 3, and repeat angioplasty in 25 (MACE‐free survival: 86.5%). Quantitative angiographic results were the minimum lumen diameter increased from 1.05 ± 0.32 before to 2.73 ± 0.39 mm after stent implantation. At follow‐up, the loss in diameter was 0.74 ± 0.50 mm. The loss index was 0.45 ± 0.31 and restenosis rate was 13.4%. This study has demonstrated that the S670 stent in patients with (un)stable angina pectoris requiring intervention of a single lesion has a low acute and 6‐month major event rate and a low angiographic restenosis rate. 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J.</forename><surname>Garcia</surname></persName><roleName type="degree">MD</roleName><affiliation>Hospital Gregorio, Marañon, Madrid, Spain</affiliation></author><author xml:id="author-3"><persName><forename type="first">Eberhard</forename><surname>Grube</surname></persName><roleName type="degree">MD</roleName><affiliation>Krankenhaus Siegburg GmbH, Siegburg, Germany</affiliation></author><author xml:id="author-4"><persName><forename type="first">Khalife</forename><surname>Khalife</surname></persName><roleName type="degree">MD</roleName><affiliation>CHR Hôpital Bon Secours, Metz, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Hans</forename><surname>Bonnier</surname></persName><roleName type="degree">MD</roleName><affiliation>Catharina Hospital, Eindhoven, The Netherlands</affiliation></author><author xml:id="author-6"><persName><forename type="first">Philippe</forename><surname>Commeau</surname></persName><roleName type="degree">MD</roleName><affiliation>Private Center Saint‐Martin Hospital, Caen, France</affiliation></author><author xml:id="author-7"><persName><forename type="first">Tadeusz</forename><surname>Przewlocki</surname></persName><roleName type="degree">MD</roleName><affiliation>John Paul II University Hospital, Krakow, Poland</affiliation></author><author xml:id="author-8"><persName><forename type="first">Carlos</forename><surname>Macaya</surname></persName><roleName type="degree">MD</roleName><affiliation>Hospital Clinico Universidad San Carlos, Madrid, Spain</affiliation></author><author xml:id="author-9"><persName><forename type="first">Adam</forename><surname>Witkowski</surname></persName><roleName type="degree">MD</roleName><affiliation>National Institute for Cardiology, Warsaw, Poland</affiliation></author></analytic><monogr><title level="j">Catheterization and Cardiovascular Interventions</title><title level="j" type="abbrev">Cathet. Cardiovasc. Intervent.</title><idno type="pISSN">1522-1946</idno><idno type="eISSN">1522-726X</idno><idno type="DOI">10.1002/(ISSN)1522-726X</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-11"></date><biblScope unit="volume">54</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="276">276</biblScope><biblScope unit="page" to="282">282</biblScope></imprint></monogr><idno type="istex">4E2113C7A267412B46862F48380B04788ED73C1E</idno><idno type="DOI">10.1002/ccd.1284</idno><idno type="ArticleID">CCD1284</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The objectives of the Race Car study were to assess the safety and efficacy of the Medtronic AVE S670 stent, a new‐generation stent with a modular design consisting of interconnected sinusoidal rings allowing improved flexibility with good conformability and scaffolding. A total of 285 stents were implanted in 267 patients with (un)stable angina pectoris who underwent angioplasty of a single de novo lesion in a native coronary artery with a diameter between 3.0 and 4.0 mm. Available stent lengths were 9, 12, and 15 mm. The primary endpoint was the 6‐month restenosis rate. Secondary endpoints were device and procedural success and major adverse cardiac event (MACE)‐free survival at 1 and 6 months. All patients received the study stents and no other stents were used (angiographic success: 100%). Eight patients experienced a MACE during hospital admission (Q‐wave MI in 2, non–Q‐wave MI in 4, TLR in 2). A procedural success was obtained in 97% of the patients. There were no additional events at 1 month. The clinical endpoints encountered at 6 months were Q‐wave MI in 1, bypass surgery in 3, and repeat angioplasty in 25 (MACE‐free survival: 86.5%). Quantitative angiographic results were the minimum lumen diameter increased from 1.05 ± 0.32 before to 2.73 ± 0.39 mm after stent implantation. At follow‐up, the loss in diameter was 0.74 ± 0.50 mm. The loss index was 0.45 ± 0.31 and restenosis rate was 13.4%. This study has demonstrated that the S670 stent in patients with (un)stable angina pectoris requiring intervention of a single lesion has a low acute and 6‐month major event rate and a low angiographic restenosis rate. Cathet Cardiovasc Intervent 2001;54:276–282. © 2001 Wiley‐Liss, Inc.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>coronary angioplasty</term></item><item><term>stents</term></item><item><term>coronary disease</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Original Study</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001-04-05">Received</change><change when="2001-07-20">Registration</change><change when="2001-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/4E2113C7A267412B46862F48380B04788ED73C1E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1522-726X</doi><issn type="print">1522-1946</issn><issn type="electronic">1522-726X</issn><idGroup><id type="product" value="CCD"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS">Catheterization and Cardiovascular Interventions</title><title type="short">Cathet. Cardiovasc. Intervent.</title></titleGroup><selfCitationGroup><citation type="ancestor" xml:id="cit1"><journalTitle>Catheterization and Cardiovascular Diagnosis</journalTitle><accessionId ref="info:x-wiley/issn/00986569">0098-6569</accessionId><accessionId ref="info:x-wiley/issn/10970304">1097-0304</accessionId><pubYear year="1998">1998</pubYear><vol>45</vol><issue>4</issue></citation></selfCitationGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/ccd.v54:3</doi><numberingGroup><numbering type="journalVolume" number="54">54</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2001-11">November 2001</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="1284" status="forIssue"><doi origin="wiley" registered="yes">10.1002/ccd.1284</doi><idGroup><id type="unit" value="CCD1284"></id></idGroup><countGroup><count type="pageTotal" 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M.</givenNames><familyName>Legrand</familyName><degrees>MD</degrees></personName><contactDetails><email>vlegrand@chu.ulg.ac.be</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Eulogio J.</givenNames><familyName>Garcia</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Eberhard</givenNames><familyName>Grube</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Khalife</givenNames><familyName>Khalife</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Hans</givenNames><familyName>Bonnier</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" 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Universidad San Carlos, Madrid, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="PL" type="organization"><unparsedAffiliation>National Institute for Cardiology, Warsaw, Poland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">coronary angioplasty</keyword><keyword xml:id="kwd2">stents</keyword><keyword xml:id="kwd3">coronary disease</keyword></keywordGroup><fundingInfo><fundingAgency>Medtronic Bakken Research Center</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The objectives of the Race Car study were to assess the safety and efficacy of the Medtronic AVE S670 stent, a new‐generation stent with a modular design consisting of interconnected sinusoidal rings allowing improved flexibility with good conformability and scaffolding. A total of 285 stents were implanted in 267 patients with (un)stable angina pectoris who underwent angioplasty of a single de novo lesion in a native coronary artery with a diameter between 3.0 and 4.0 mm. Available stent lengths were 9, 12, and 15 mm. The primary endpoint was the 6‐month restenosis rate. Secondary endpoints were device and procedural success and major adverse cardiac event (MACE)‐free survival at 1 and 6 months. All patients received the study stents and no other stents were used (angiographic success: 100%). Eight patients experienced a MACE during hospital admission (Q‐wave MI in 2, non–Q‐wave MI in 4, TLR in 2). A procedural success was obtained in 97% of the patients. There were no additional events at 1 month. The clinical endpoints encountered at 6 months were Q‐wave MI in 1, bypass surgery in 3, and repeat angioplasty in 25 (MACE‐free survival: 86.5%). Quantitative angiographic results were the minimum lumen diameter increased from 1.05 ± 0.32 before to 2.73 ± 0.39 mm after stent implantation. At follow‐up, the loss in diameter was 0.74 ± 0.50 mm. The loss index was 0.45 ± 0.31 and restenosis rate was 13.4%. This study has demonstrated that the S670 stent in patients with (un)stable angina pectoris requiring intervention of a single lesion has a low acute and 6‐month major event rate and a low angiographic restenosis rate. Cathet Cardiovasc Intervent 2001;54:276–282. © 2001 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Clinical and angiographic performance of a new‐generation modular stent design for treatment of de novo coronary lesions</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>New‐Generation Modular Stent Design</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Clinical and angiographic performance of a new‐generation modular stent design for treatment of de novo coronary lesions</title></titleInfo><name type="personal"><namePart type="given">Victor M.</namePart><namePart type="family">Legrand</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Cardiology, C.H.U. de Liège, Liège, Belgium</affiliation><affiliation>Department of Cardiology, C.H.U. de Liège, Sart‐Tilman, 4000 Liège, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eulogio J.</namePart><namePart type="family">Garcia</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Hospital Gregorio, Marañon, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eberhard</namePart><namePart type="family">Grube</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Krankenhaus Siegburg GmbH, Siegburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Khalife</namePart><namePart type="family">Khalife</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>CHR Hôpital Bon Secours, Metz, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hans</namePart><namePart type="family">Bonnier</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Catharina Hospital, Eindhoven, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philippe</namePart><namePart type="family">Commeau</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Private Center Saint‐Martin Hospital, Caen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tadeusz</namePart><namePart type="family">Przewlocki</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>John Paul II University Hospital, Krakow, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlos</namePart><namePart type="family">Macaya</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Hospital Clinico Universidad San Carlos, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Adam</namePart><namePart type="family">Witkowski</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>National Institute for Cardiology, Warsaw, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2001-11</dateIssued><dateCaptured encoding="w3cdtf">2001-04-05</dateCaptured><dateValid encoding="w3cdtf">2001-07-20</dateValid><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">5</extent><extent unit="references">16</extent><extent unit="words">4349</extent></physicalDescription><abstract lang="en">The objectives of the Race Car study were to assess the safety and efficacy of the Medtronic AVE S670 stent, a new‐generation stent with a modular design consisting of interconnected sinusoidal rings allowing improved flexibility with good conformability and scaffolding. A total of 285 stents were implanted in 267 patients with (un)stable angina pectoris who underwent angioplasty of a single de novo lesion in a native coronary artery with a diameter between 3.0 and 4.0 mm. Available stent lengths were 9, 12, and 15 mm. The primary endpoint was the 6‐month restenosis rate. Secondary endpoints were device and procedural success and major adverse cardiac event (MACE)‐free survival at 1 and 6 months. All patients received the study stents and no other stents were used (angiographic success: 100%). Eight patients experienced a MACE during hospital admission (Q‐wave MI in 2, non–Q‐wave MI in 4, TLR in 2). A procedural success was obtained in 97% of the patients. There were no additional events at 1 month. The clinical endpoints encountered at 6 months were Q‐wave MI in 1, bypass surgery in 3, and repeat angioplasty in 25 (MACE‐free survival: 86.5%). Quantitative angiographic results were the minimum lumen diameter increased from 1.05 ± 0.32 before to 2.73 ± 0.39 mm after stent implantation. At follow‐up, the loss in diameter was 0.74 ± 0.50 mm. The loss index was 0.45 ± 0.31 and restenosis rate was 13.4%. This study has demonstrated that the S670 stent in patients with (un)stable angina pectoris requiring intervention of a single lesion has a low acute and 6‐month major event rate and a low angiographic restenosis rate. Cathet Cardiovasc Intervent 2001;54:276–282. © 2001 Wiley‐Liss, Inc.</abstract><note type="funding">Medtronic Bakken Research Center</note><subject lang="en"><genre>keywords</genre><topic>coronary angioplasty</topic><topic>stents</topic><topic>coronary disease</topic></subject><relatedItem type="host"><titleInfo><title>Catheterization and Cardiovascular Interventions</title></titleInfo><titleInfo type="abbreviated"><title>Cathet. Cardiovasc. Intervent.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Original Study</topic></subject><identifier type="ISSN">1522-1946</identifier><identifier type="eISSN">1522-726X</identifier><identifier type="DOI">10.1002/(ISSN)1522-726X</identifier><identifier type="PublisherID">CCD</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>54</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>276</start><end>282</end><total>7</total></extent></part></relatedItem><relatedItem type="preceding"><titleInfo><title>Catheterization and Cardiovascular Diagnosis</title></titleInfo><identifier type="ISSN">0098-6569</identifier><identifier type="ISSN">1097-0304</identifier><part><date point="end">1998</date><detail type="volume"><caption>last vol.</caption><number>45</number></detail><detail type="issue"><caption>last no.</caption><number>4</number></detail></part></relatedItem><identifier type="istex">4E2113C7A267412B46862F48380B04788ED73C1E</identifier><identifier type="DOI">10.1002/ccd.1284</identifier><identifier type="ArticleID">CCD1284</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2001 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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