Knowledge engineering for health: A new discipline required to bridge the “ICT gap” between research and healthcare
Identifieur interne : 000667 ( Istex/Corpus ); précédent : 000666; suivant : 000668Knowledge engineering for health: A new discipline required to bridge the “ICT gap” between research and healthcare
Auteurs : Tim Beck ; Sirisha Gollapudi ; S Ren Brunak ; Norbert Graf ; Heinz U. Lemke ; Debasis Dash ; Iain Buchan ; Carlos Díaz ; Ferran Sanz ; Anthony J. BrookesSource :
- Human Mutation [ 1059-7794 ] ; 2012-05.
English descriptors
- KwdEn :
- Teeft :
- Biomedical informatics, Biomedical research, Clinical medicine, Computer modeling, Decision support, Ehrs, Free text, Future healthcare, Gen2phen project, Healthcare, Healthcare informatics, Healthcare providers, Human mutation, I4health, I4health concept, Informatics, Interdisciplinary experts, Knowledge engineering, Knowledge transmission, Latest research knowledge, Modeling, More facts, Patient data, Population level, Relevant advances, Research community, Research data, Research world, Treatment response, Wiley periodicals, Workshop delegates.
Abstract
Despite vast amount of money and research being channeled toward biomedical research, relatively little impact has been made on routine clinical practice. At the heart of this failure is the information and communication technology “chasm” that exists between research and healthcare. A new focus on “knowledge engineering for health” is needed to facilitate knowledge transmission across the research–healthcare gap. This discipline is required to engineer the bidirectional flow of data: processing research data and knowledge to identify clinically relevant advances and delivering these into healthcare use; conversely, making outcomes from the practice of medicine suitably available for use by the research community. This system will be able to self‐optimize in that outcomes for patients treated by decisions that were based on the latest research knowledge will be fed back to the research world. A series of meetings, culminating in the “I‐Health 2011” workshop, have brought together interdisciplinary experts to map the challenges and requirements for such a system. Here, we describe the main conclusions from these meetings. An “I4Health” interdisciplinary network of experts now exists to promote the key aims and objectives, namely “integrating and interpreting information for individualized healthcare,” by developing the “knowledge engineering for health” domain. Hum Mutat 33:797–802, 2012. © 2012 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/humu.22066
Links to Exploration step
ISTEX:3FD2846672BF3417AFDCE85F1A73A33521BFE299Le document en format XML
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At the heart of this failure is the information and communication technology “chasm” that exists between research and healthcare. A new focus on “knowledge engineering for health” is needed to facilitate knowledge transmission across the research–healthcare gap. This discipline is required to engineer the bidirectional flow of data: processing research data and knowledge to identify clinically relevant advances and delivering these into healthcare use; conversely, making outcomes from the practice of medicine suitably available for use by the research community. This system will be able to self‐optimize in that outcomes for patients treated by decisions that were based on the latest research knowledge will be fed back to the research world. A series of meetings, culminating in the “I‐Health 2011” workshop, have brought together interdisciplinary experts to map the challenges and requirements for such a system. Here, we describe the main conclusions from these meetings. An “I4Health” interdisciplinary network of experts now exists to promote the key aims and objectives, namely “integrating and interpreting information for individualized healthcare,” by developing the “knowledge engineering for health” domain. 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At the heart of this failure is the information and communication technology “chasm” that exists between research and healthcare. A new focus on “knowledge engineering for health” is needed to facilitate knowledge transmission across the research–healthcare gap. This discipline is required to engineer the bidirectional flow of data: processing research data and knowledge to identify clinically relevant advances and delivering these into healthcare use; conversely, making outcomes from the practice of medicine suitably available for use by the research community. This system will be able to self‐optimize in that outcomes for patients treated by decisions that were based on the latest research knowledge will be fed back to the research world. A series of meetings, culminating in the “I‐Health 2011” workshop, have brought together interdisciplinary experts to map the challenges and requirements for such a system. Here, we describe the main conclusions from these meetings. An “I4Health” interdisciplinary network of experts now exists to promote the key aims and objectives, namely “integrating and interpreting information for individualized healthcare,” by developing the “knowledge engineering for health” domain. 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At the heart of this failure is the information and communication technology “chasm” that exists between research and healthcare. A new focus on “knowledge engineering for health” is needed to facilitate knowledge transmission across the research–healthcare gap. This discipline is required to engineer the bidirectional flow of data: processing research data and knowledge to identify clinically relevant advances and delivering these into healthcare use; conversely, making outcomes from the practice of medicine suitably available for use by the research community. This system will be able to self‐optimize in that outcomes for patients treated by decisions that were based on the latest research knowledge will be fed back to the research world. A series of meetings, culminating in the “I‐Health 2011” workshop, have brought together interdisciplinary experts to map the challenges and requirements for such a system. Here, we describe the main conclusions from these meetings. An “I4Health” interdisciplinary network of experts now exists to promote the key aims and objectives, namely “integrating and interpreting information for individualized healthcare,” by developing the “knowledge engineering for health” domain. Hum Mutat 33:797–802, 2012. © 2012 Wiley Periodicals, Inc.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>personalized medicine</term></item><item><term>biomedical research</term></item><item><term>healthcare</term></item><item><term>ICT</term></item><item><term>I‐Health 2011</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Special Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-01-05">Received</change><change when="2012-02-22">Registration</change><change when="2012-05">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/3FD2846672BF3417AFDCE85F1A73A33521BFE299/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1098-1004</doi><issn type="print">1059-7794</issn><issn type="electronic">1098-1004</issn><idGroup><id type="product" value="HUMU"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="HUMAN MUTATION">Human Mutation</title><title type="short">Hum. Mutat.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/humu.v33.5</doi><titleGroup><title type="specialIssueTitle">Deep Phenotyping for Precision Medicine</title></titleGroup><numberingGroup><numbering type="journalVolume" number="33">33</numbering><numbering type="journalIssue">5</numbering></numberingGroup><creators><creator xml:id="sped1" creatorRole="sponsoringEditor"><personName><givenNames>Peter N.</givenNames><familyName>Robinson</familyName></personName></creator></creators><coverDate startDate="2012-05">May 2012</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="40" status="forIssue"><doi origin="wiley" registered="yes">10.1002/humu.22066</doi><idGroup><id type="unit" value="HUMU22066"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Special Article</title><title type="tocHeading1">Special 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of Genetics, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:HUMU.HUMU22066.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="4"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="8"></count></countGroup><titleGroup><title type="main" xml:lang="en">Knowledge engineering for health: A new discipline required to bridge the “ICT gap” between research and healthcare<link href="#fn1"></link></title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Tim</givenNames><familyName>Beck</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Sirisha</givenNames><familyName>Gollapudi</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Søren</givenNames><familyName>Brunak</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Norbert</givenNames><familyName>Graf</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Heinz U.</givenNames><familyName>Lemke</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Debasis</givenNames><familyName>Dash</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Iain</givenNames><familyName>Buchan</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Carlos</givenNames><familyName>Díaz</familyName></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af9"><personName><givenNames>Ferran</givenNames><familyName>Sanz</familyName></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Anthony J.</givenNames><familyName>Brookes</familyName></personName><contactDetails><email>ajb97@le.ac.uk</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>Department of Genetics, University of Leicester, Leicester, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DK" type="organization"><unparsedAffiliation>Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DK" type="organization"><unparsedAffiliation>Department of Disease Systems Biology, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="DE" type="organization"><unparsedAffiliation>Department of Pediatric Oncology, University of Saarland Medical School, Homburg, Saar, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="DE" type="organization"><unparsedAffiliation>International Foundation for Computer‐Assisted Radiology and Surgery, Kuessaberg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>GNR Knowledge Center for Genome Informatics, Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi, India</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="GB" type="organization"><unparsedAffiliation>North West Institute for BioHealth Informatics, University of Manchester, Manchester, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="ES" type="organization"><unparsedAffiliation>European Projects Management and Coordination Office, Fundació IMIM, Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="ES" type="organization"><unparsedAffiliation>Research Programme on Biomedical Informatics, IMIM‐Hospital del Mar, Pompeu Fabra University, Barcelona, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">personalized medicine</keyword><keyword xml:id="kwd2">biomedical research</keyword><keyword xml:id="kwd3">healthcare</keyword><keyword xml:id="kwd4">ICT</keyword><keyword xml:id="kwd5">I‐Health 2011</keyword></keywordGroup><fundingInfo><fundingAgency>European Community's Seventh Framework Programme projects GEN2PHEN (200754) and INBIOMEDvision (270107)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Despite vast amount of money and research being channeled toward biomedical research, relatively little impact has been made on routine clinical practice. At the heart of this failure is the information and communication technology “chasm” that exists between research and healthcare. A new focus on “knowledge engineering for health” is needed to facilitate knowledge transmission across the research–healthcare gap. This discipline is required to engineer the bidirectional flow of data: processing research data and knowledge to identify clinically relevant advances and delivering these into healthcare use; conversely, making outcomes from the practice of medicine suitably available for use by the research community. This system will be able to self‐optimize in that outcomes for patients treated by decisions that were based on the latest research knowledge will be fed back to the research world. A series of meetings, culminating in the “I‐Health 2011” workshop, have brought together interdisciplinary experts to map the challenges and requirements for such a system. Here, we describe the main conclusions from these meetings. An “I4Health” interdisciplinary network of experts now exists to promote the key aims and objectives, namely “integrating and interpreting information for individualized healthcare,” by developing the “knowledge engineering for health” domain. Hum Mutat 33:797–802, 2012. © 2012 Wiley Periodicals, Inc.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>For the Deep Phenotyping Special Issue</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Knowledge engineering for health: A new discipline required to bridge the “ICT gap” between research and healthcare</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Knowledge engineering for health: A new discipline required to bridge the “ICT gap” between research and healthcare</title></titleInfo><name type="personal"><namePart type="given">Tim</namePart><namePart type="family">Beck</namePart><affiliation>Department of Genetics, University of Leicester, Leicester, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sirisha</namePart><namePart type="family">Gollapudi</namePart><affiliation>Department of Genetics, University of Leicester, Leicester, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Søren</namePart><namePart type="family">Brunak</namePart><affiliation>Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark</affiliation><affiliation>Department of Disease Systems Biology, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Norbert</namePart><namePart type="family">Graf</namePart><affiliation>Department of Pediatric Oncology, University of Saarland Medical School, Homburg, Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Heinz U.</namePart><namePart type="family">Lemke</namePart><affiliation>International Foundation for Computer‐Assisted Radiology and Surgery, Kuessaberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Debasis</namePart><namePart type="family">Dash</namePart><affiliation>GNR Knowledge Center for Genome Informatics, Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Iain</namePart><namePart type="family">Buchan</namePart><affiliation>North West Institute for BioHealth Informatics, University of Manchester, Manchester, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlos</namePart><namePart type="family">Díaz</namePart><affiliation>European Projects Management and Coordination Office, Fundació IMIM, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ferran</namePart><namePart type="family">Sanz</namePart><affiliation>Research Programme on Biomedical Informatics, IMIM‐Hospital del Mar, Pompeu Fabra University, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anthony J.</namePart><namePart type="family">Brookes</namePart><affiliation>Department of Genetics, University of Leicester, Leicester, United Kingdom</affiliation><affiliation>Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2012-05</dateIssued><dateCaptured encoding="w3cdtf">2012-01-05</dateCaptured><dateValid encoding="w3cdtf">2012-02-22</dateValid><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="references">8</extent></physicalDescription><abstract lang="en">Despite vast amount of money and research being channeled toward biomedical research, relatively little impact has been made on routine clinical practice. At the heart of this failure is the information and communication technology “chasm” that exists between research and healthcare. A new focus on “knowledge engineering for health” is needed to facilitate knowledge transmission across the research–healthcare gap. This discipline is required to engineer the bidirectional flow of data: processing research data and knowledge to identify clinically relevant advances and delivering these into healthcare use; conversely, making outcomes from the practice of medicine suitably available for use by the research community. This system will be able to self‐optimize in that outcomes for patients treated by decisions that were based on the latest research knowledge will be fed back to the research world. A series of meetings, culminating in the “I‐Health 2011” workshop, have brought together interdisciplinary experts to map the challenges and requirements for such a system. Here, we describe the main conclusions from these meetings. An “I4Health” interdisciplinary network of experts now exists to promote the key aims and objectives, namely “integrating and interpreting information for individualized healthcare,” by developing the “knowledge engineering for health” domain. Hum Mutat 33:797–802, 2012. © 2012 Wiley Periodicals, Inc.</abstract><note type="content">*For the Deep Phenotyping Special Issue</note><note type="funding">European Community's Seventh Framework Programme projects GEN2PHEN (200754) and INBIOMEDvision (270107)</note><subject lang="en"><genre>keywords</genre><topic>personalized medicine</topic><topic>biomedical research</topic><topic>healthcare</topic><topic>ICT</topic><topic>I‐Health 2011</topic></subject><relatedItem type="host"><titleInfo><title>Human Mutation</title></titleInfo><titleInfo type="abbreviated"><title>Hum. Mutat.</title></titleInfo><name type="personal"><namePart type="given">Peter N.</namePart><namePart type="family">Robinson</namePart></name><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Special Article</topic></subject><identifier type="ISSN">1059-7794</identifier><identifier type="eISSN">1098-1004</identifier><identifier type="DOI">10.1002/(ISSN)1098-1004</identifier><identifier type="PublisherID">HUMU</identifier><part><date>2012</date><detail type="title"><title>Deep Phenotyping for Precision Medicine</title></detail><detail type="volume"><caption>vol.</caption><number>33</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>797</start><end>802</end><total>6</total></extent></part></relatedItem><identifier type="istex">3FD2846672BF3417AFDCE85F1A73A33521BFE299</identifier><identifier type="DOI">10.1002/humu.22066</identifier><identifier type="ArticleID">HUMU22066</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2012 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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