Getting to the heart of the matter: long non‐coding RNAs in cardiac development and disease
Identifieur interne : 000559 ( Istex/Corpus ); précédent : 000558; suivant : 000560Getting to the heart of the matter: long non‐coding RNAs in cardiac development and disease
Auteurs : Johanna C. Scheuermann ; Laurie A. BoyerSource :
- The EMBO Journal [ 0261-4189 ] ; 2013-07-03.
English descriptors
- Teeft :
- Aberrant expression, Additional lncrnas, Anril, Antisense, Antisense transcript, Antisense transcription, Antisense transcripts, Biol, Biology organization, Boyer, Bruneau, Bvht, Cardiac, Cardiac biology, Cardiac development, Cardiac disease, Cardiac hypertrophy, Cardiac lineage, Cardiogenesis, Cardiomyocyte differentiation, Cardiovascular, Cardiovascular development, Cell biol, Chang, Chromatin, Congenital, Congenital heart disease, Derrien, Drosophila, Drosophila heart, Drosophila heart development, Duplex, Embo, Embo journal, Epigenetic regulation, Eukaryote, Expression patterns, Fendrr, Gene, Gene expression, Genet, Genome, Genomic, Genomic sites, Guttman, Gwas, Heart development, Human genome, Ink4 locus, Intergenic, Klattenhoff, Lateral plate mesoderm, Lincrnas, Lineage, Lncrna, Lncrna function, Lncrna transcripts, Lncrnas, Locus, Long noncoding, Long noncoding rnas, Long rnas, Lower eukaryotes, Mammal, Mammalian heart development, Many cases, Mesoderm, Mesp1, Mrna, Mutation, Myh6, Myh7, Myocardial infarction, Nats, Noncoding, Opposite strand, Pathological conditions, Prc2, Proc natl acad, Progenitor, Promoter, Receptor, Regulator, Rinn, Rna, Scheuermann, Sequence conservation, Small rnas, Srivastava, Steroid receptor, Therapeutic intervention, Transcript, Transcription, Transcription factors, Transcriptional, Transcriptional programs, Ulitsky, Wang.
Abstract
Cardiogenesis in mammals requires exquisite control of gene expression and faulty regulation of transcriptional programs underpins congenital heart disease (CHD), the most common defect among live births. Similarly, many adult cardiac diseases involve transcriptional changes and sometimes have a developmental basis. Long non‐coding RNAs (lncRNAs) are a novel class of transcripts that regulate cellular processes by controlling gene expression; however, detailed insights into their biological and mechanistic functions are only beginning to emerge. Here, we discuss recent findings suggesting that lncRNAs are important factors in regulation of mammalian cardiogenesis and in the pathogenesis of CHD as well as adult cardiac disease. We also outline potential methodological and conceptual considerations for future studies of lncRNAs in the heart and other contexts.
This review highlights newly discovered long non‐coding RNAs generalizing their critical contribution to mammalian cardiogenesis and congenital heart disease.
Url:
DOI: 10.1038/emboj.2013.134
Links to Exploration step
ISTEX:36323683CA9CB1520D5697E22F6C4FE78800D582Le document en format XML
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xml:lang="en">Getting to the heart of the matter: long non‐coding RNAs in cardiac development and disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><availability><p>Copyright © 2013 Wiley Periodicals, IncCopyright © 2013 European Molecular Biology Organization</p></availability><date>2013</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Getting to the heart of the matter: long non‐coding RNAs in cardiac development and disease</title><author xml:id="author-1"><persName><forename type="first">Johanna C</forename><surname>Scheuermann</surname></persName><note type="biography">These authors contributed equally to this work.</note><affiliation>These authors contributed equally to this work.</affiliation><affiliation>Department of Biology, Massachusetts Institute of Technology, MA, Cambridge, USA</affiliation></author><author xml:id="author-2"><persName><forename type="first">Laurie A</forename><surname>Boyer</surname></persName><email>lboyer@mit.edu</email><note type="biography">These authors contributed equally to this work.</note><affiliation>These authors contributed equally to this work.</affiliation><affiliation>Department of Biology, Massachusetts Institute of Technology, MA, Cambridge, USA</affiliation></author></analytic><monogr><title level="j">The EMBO Journal</title><idno type="pISSN">0261-4189</idno><idno type="eISSN">1460-2075</idno><idno type="DOI">10.1002/(ISSN)1460-2075</idno><imprint><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2013-07-03"></date><biblScope unit="volume">32</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1805">1805</biblScope><biblScope unit="page" to="1816">1816</biblScope></imprint></monogr><idno type="istex">36323683CA9CB1520D5697E22F6C4FE78800D582</idno><idno 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Similarly, many adult cardiac diseases involve transcriptional changes and sometimes have a developmental basis. Long non‐coding RNAs (lncRNAs) are a novel class of transcripts that regulate cellular processes by controlling gene expression; however, detailed insights into their biological and mechanistic functions are only beginning to emerge. Here, we discuss recent findings suggesting that lncRNAs are important factors in regulation of mammalian cardiogenesis and in the pathogenesis of CHD as well as adult cardiac disease. We also outline potential methodological and conceptual considerations for future studies of lncRNAs in the heart and other contexts.</p></abstract><abstract style="short"><p>This review highlights newly discovered long non‐coding RNAs generalizing their critical contribution to mammalian cardiogenesis and congenital heart disease.</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>cardiovascular disease</term></item><item><term>congenital heart disease</term></item><item><term>gene expression</term></item><item><term>heart development</term></item><item><term>long non‐coding RNA</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>index-terms</head><item><term>Chromatin, Epigenetics, Genomics & Functional Genomics</term></item><item><term>RNA Biology</term></item><item><term>Molecular Biology of Disease</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Review</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2013-04-29">Received</change><change when="2013-05-23">Registration</change><change when="2013-07-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/36323683CA9CB1520D5697E22F6C4FE78800D582/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:lang="en" xml:id="embj2013134"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi>10.1002/(ISSN)1460-2075</doi><issn type="print">0261-4189</issn><issn type="electronic">1460-2075</issn><idGroup><id type="product" value="EMBJ"></id></idGroup><titleGroup><title type="main" sort="THE EMBO JOURNAL">The EMBO Journal</title></titleGroup></publicationMeta><publicationMeta level="part" position="130"><doi>10.1002/emboj.v32.13</doi><copyright ownership="publisher">Copyright © 2013 Wiley Periodicals, Inc</copyright><numberingGroup><numbering type="journalVolume" number="32">32</numbering><numbering type="journalIssue">13</numbering></numberingGroup><coverDate startDate="2013-07-03">July 3, 2013</coverDate></publicationMeta><publicationMeta level="unit" position="50" type="article" status="forIssue"><doi>10.1038/emboj.2013.134</doi><idGroup><id type="unit" value="EMBJ2013134"></id></idGroup><countGroup><count type="pageTotal" number="12"></count></countGroup><titleGroup><title type="articleCategory">Review</title><title type="tocHeading1">Review</title></titleGroup><copyright ownership="thirdParty">Copyright © 2013 European Molecular Biology Organization</copyright><eventGroup><event type="manuscriptReceived" date="2013-04-29"></event><event type="manuscriptAccepted" date="2013-05-23"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-06-11"></event><event type="publishedOnlineFinalForm" date="2013-07-03"></event><event type="xmlConverted" agent="SPi Global Converter_TO_WileyML3Gv2.0 version:1.0; WileyML 3G Packaging Tool v1.0" date="2013-10-23"></event><event type="xmlCorrected" agent="Wiley-VCH" date="2013-11-29"></event><event type="firstOnline" date="2013-06-11"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-03"></event></eventGroup><numberingGroup><numbering type="pageFirst">1805</numbering><numbering type="pageLast">1816</numbering></numberingGroup><correspondenceTo>Corresponding author. Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Tel.:+1 617 324 3335; Fax:+1 617 253 8699; E-mail: <email>lboyer@mit.edu</email></correspondenceTo><subjectInfo><subject href="http://psi.embo.org/14602075/EMBO09">Chromatin, Epigenetics, Genomics & Functional Genomics</subject><subject href="http://psi.embo.org/14602075/EMBO36">RNA Biology</subject><subject href="http://psi.embo.org/14602075/EMBO24">Molecular Biology of Disease</subject></subjectInfo><attributeValueGroup><attributeValue element="note" attribute="type" value="equal"></attributeValue></attributeValueGroup><linkGroup><link type="toTypesetVersion" href="file:EMBJ.EMBJ2013134.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Getting to the heart of the matter: long non‐coding RNAs in cardiac development and disease</title><title type="short">Getting to the heart of the matter</title></titleGroup><creators><creator creatorRole="author" xml:id="embj2013134-cr-0001" affiliationRef="#embj2013134-aff-0001" noteRef="#embj2013134-note-0001"><personName><givenNames>Johanna C</givenNames><familyName>Scheuermann</familyName></personName></creator><creator creatorRole="author" xml:id="embj2013134-cr-0002" affiliationRef="#embj2013134-aff-0001" noteRef="#embj2013134-note-0001" corresponding="yes"><personName><givenNames>Laurie A</givenNames><familyName>Boyer</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="US" type="organization" xml:id="embj2013134-aff-0001"><orgName>Department of Biology, Massachusetts Institute of Technology</orgName><address><city>Cambridge</city><countryPart>MA</countryPart><country>USA</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="embj2013134-kwd-0001">cardiovascular disease</keyword><keyword xml:id="embj2013134-kwd-0002">congenital heart disease</keyword><keyword xml:id="embj2013134-kwd-0003">gene expression</keyword><keyword xml:id="embj2013134-kwd-0004">heart development</keyword><keyword xml:id="embj2013134-kwd-0005">long non‐coding RNA</keyword></keywordGroup><abstractGroup><abstract type="main"><p>Cardiogenesis in mammals requires exquisite control of gene expression and faulty regulation of transcriptional programs underpins congenital heart disease (CHD), the most common defect among live births. Similarly, many adult cardiac diseases involve transcriptional changes and sometimes have a developmental basis. Long non‐coding RNAs (lncRNAs) are a novel class of transcripts that regulate cellular processes by controlling gene expression; however, detailed insights into their biological and mechanistic functions are only beginning to emerge. Here, we discuss recent findings suggesting that lncRNAs are important factors in regulation of mammalian cardiogenesis and in the pathogenesis of CHD as well as adult cardiac disease. We also outline potential methodological and conceptual considerations for future studies of lncRNAs in the heart and other contexts.</p></abstract><abstract type="short"><p>This review highlights newly discovered long non‐coding RNAs generalizing their critical contribution to mammalian cardiogenesis and congenital heart disease.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="embj2013134-note-0001" type="equal">These authors contributed equally to this work.</note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Getting to the heart of the matter: long non‐coding RNAs in cardiac development and disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Getting to the heart of the matter</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Getting to the heart of the matter: long non‐coding RNAs in cardiac development and disease</title></titleInfo><name type="personal"><namePart type="given">Johanna C</namePart><namePart type="family">Scheuermann</namePart><affiliation>Department of Biology, Massachusetts Institute of Technology, MA, Cambridge, USA</affiliation><description>These authors contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laurie A</namePart><namePart type="family">Boyer</namePart><affiliation>Department of Biology, Massachusetts Institute of Technology, MA, Cambridge, USA</affiliation><description>These authors contributed equally to this work.</description><affiliation>E-mail: lboyer@mit.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2013-07-03</dateIssued><dateCaptured encoding="w3cdtf">2013-04-29</dateCaptured><dateValid encoding="w3cdtf">2013-05-23</dateValid><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Cardiogenesis in mammals requires exquisite control of gene expression and faulty regulation of transcriptional programs underpins congenital heart disease (CHD), the most common defect among live births. Similarly, many adult cardiac diseases involve transcriptional changes and sometimes have a developmental basis. Long non‐coding RNAs (lncRNAs) are a novel class of transcripts that regulate cellular processes by controlling gene expression; however, detailed insights into their biological and mechanistic functions are only beginning to emerge. Here, we discuss recent findings suggesting that lncRNAs are important factors in regulation of mammalian cardiogenesis and in the pathogenesis of CHD as well as adult cardiac disease. We also outline potential methodological and conceptual considerations for future studies of lncRNAs in the heart and other contexts.</abstract><abstract type="short">This review highlights newly discovered long non‐coding RNAs generalizing their critical contribution to mammalian cardiogenesis and congenital heart disease.</abstract><subject><genre>keywords</genre><topic>cardiovascular disease</topic><topic>congenital heart disease</topic><topic>gene expression</topic><topic>heart development</topic><topic>long non‐coding RNA</topic></subject><relatedItem type="host"><titleInfo><title>The EMBO Journal</title></titleInfo><genre type="journal">journal</genre><subject><genre>index-terms</genre><topic authorityURI="http://psi.embo.org/14602075/EMBO09">Chromatin, Epigenetics, Genomics & Functional Genomics</topic><topic authorityURI="http://psi.embo.org/14602075/EMBO36">RNA Biology</topic><topic authorityURI="http://psi.embo.org/14602075/EMBO24">Molecular Biology of Disease</topic></subject><subject><genre>article-category</genre><topic>Review</topic></subject><identifier type="ISSN">0261-4189</identifier><identifier type="eISSN">1460-2075</identifier><identifier type="DOI">10.1002/(ISSN)1460-2075</identifier><identifier type="PublisherID">EMBJ</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>13</number></detail><extent unit="pages"><start>1805</start><end>1816</end><total>12</total></extent></part></relatedItem><identifier type="istex">36323683CA9CB1520D5697E22F6C4FE78800D582</identifier><identifier type="DOI">10.1038/emboj.2013.134</identifier><identifier type="ArticleID">EMBJ2013134</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 Wiley Periodicals, IncCopyright © 2013 European Molecular Biology Organization</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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