Emotional brain rhythms and their impairment in post‐traumatic patients
Identifieur interne : 000449 ( Istex/Corpus ); précédent : 000448; suivant : 000450Emotional brain rhythms and their impairment in post‐traumatic patients
Auteurs : Jonathan E. Cohen ; Hadar Shalev ; Roee Admon ; Shy Hefetz ; Christopher J. Gasho ; Lavi J. Shachar ; Ilan Shelef ; Talma Hendler ; Alon FriedmanSource :
- Human Brain Mapping [ 1065-9471 ] ; 2013-06.
English descriptors
- KwdEn :
- Teeft :
- Affective, Affective picture processing, Affective stimuli, Amygdala, Aviv university, Behavioral correlates, Behavioral data, Beta, Beta activity, Black screen, Bold response, Brain activity, Brain regions, Caps score, Central region, Choice response task, Cognition, Cognitive control, Coherence, Contract grant sponsor, Control subjects, Cortical regions, Cortical rhythms, Different frequency bands, Emotional attention, Emotional conditions, Emotional distracters, Emotional processing, Emotional response, Emotional stimuli, Emotional valence, Erps, Fmri, Fmri analysis, Frequency bands, Frequency components, Frequency contributions, Frequency response, Frequency responses, Frontal, Frontal regions, Full list, Granger causality analysis, Healthy controls, Healthy individuals, Healthy subjects, Information table, International affective picture system, Late component, Localization, Manikin scale, More posteriorly, Motor response, Movement artifacts, Ndings, Negative emotion, Negative stimuli, Negative valence, Neural mechanisms, Neuronal oscillations, Neurosci, Neurosci methods, Neutral ratio, Neutral stimuli, Occipital activation, Occipital regions, Parietooccipital regions, Physiological substrates, Positive stimuli, Posttraumatic stress disorder, Prefrontal, Prog brain, Ptsd, Ptsd group, Ptsd patients, Ptsd scale, Ptsd subjects, Resonance imaging, Right motor area, Scalp, Scalp maps, Scalp regions, Severe ptsd, Sloreta, Soroka university, Source localization, Statistical analysis, Statistical comparison, Stcc, Stimulus, Stress disorder, Synchronization, Theta, Theta activity, Theta oscillations, Theta synchronization, Time point, Time window, Time windows, Trends cogn, Valence, Voxel size, Wiley periodicals, Xation, Xation block, Xation condition, Zlotowski center.
Abstract
Patients with post‐traumatic stress disorder (PTSD) suffer from a failure of cognitive control over emotional distracters. The physiological substrates of cognitive‐emotional interactions and their breakdown in disease are, however, unknown. Here, we studied brain activity in PTSD patients and healthy controls in response to emotion‐provoking pictures using electroencephalography and functional magnetic resonance imaging (fMRI). We demonstrate that in healthy individuals, emotion‐induced frontal theta rhythm modulates activity in the beta rhythm mainly in sensory‐motor regions. In contrast, in PTSD patients, beta activity is elevated irrespective of emotion, and is not modulated by frontal theta activity in response to negative emotion. EEG source localization and fMRI findings suggest that theta activity is localized to the prefrontal and anterior cingulate cortices while beta activity is localized to sensory‐motor regions. We further found that beta activity in sensory‐motor regions is related to the emotion‐induced slowing of the motor response in healthy controls while the excess frontal theta activity in PTSD is related to the intensity of negative emotional experience. These findings reveal for the first time the importance of brain electrical oscillations and coherence in emotional top‐down modulation and point to specific failure of these mechanisms in PTSD. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/hbm.21516
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ISTEX:2C4D9EFFFB085C75C85F562648B57BE83CF43420Le document en format XML
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The physiological substrates of cognitive‐emotional interactions and their breakdown in disease are, however, unknown. Here, we studied brain activity in PTSD patients and healthy controls in response to emotion‐provoking pictures using electroencephalography and functional magnetic resonance imaging (fMRI). We demonstrate that in healthy individuals, emotion‐induced frontal theta rhythm modulates activity in the beta rhythm mainly in sensory‐motor regions. In contrast, in PTSD patients, beta activity is elevated irrespective of emotion, and is not modulated by frontal theta activity in response to negative emotion. EEG source localization and fMRI findings suggest that theta activity is localized to the prefrontal and anterior cingulate cortices while beta activity is localized to sensory‐motor regions. We further found that beta activity in sensory‐motor regions is related to the emotion‐induced slowing of the motor response in healthy controls while the excess frontal theta activity in PTSD is related to the intensity of negative emotional experience. These findings reveal for the first time the importance of brain electrical oscillations and coherence in emotional top‐down modulation and point to specific failure of these mechanisms in PTSD. 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Cohen</name><affiliations><json:string>Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</json:string><json:string>Current Address: Sharett Institute of Oncology, Hadassah Medical Organization, Jerusalem, Israel</json:string></affiliations></json:item><json:item><name>Hadar Shalev</name><affiliations><json:string>Department of Psychiatry, Soroka University Medical Center and Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</json:string></affiliations></json:item><json:item><name>Roee Admon</name><affiliations><json:string>Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel</json:string></affiliations></json:item><json:item><name>Shy Hefetz</name><affiliations><json:string>Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</json:string></affiliations></json:item><json:item><name>Christopher J. Gasho</name><affiliations><json:string>Department of Radiology, Soroka University Medical Center and Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</json:string></affiliations></json:item><json:item><name>Lavi J. Shachar</name><affiliations><json:string>Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</json:string></affiliations></json:item><json:item><name>Ilan Shelef</name><affiliations><json:string>Department of Radiology, Soroka University Medical Center and Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</json:string></affiliations></json:item><json:item><name>Talma Hendler</name><affiliations><json:string>Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel</json:string><json:string>Departments of Psychology, Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel</json:string></affiliations></json:item><json:item><name>Alon Friedman</name><affiliations><json:string>Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</json:string><json:string>Department of Physiology and Neurobiology, Faculty of Health Sciences, Ben‐Guion University of the Negev, Beer‐Sheva POB 653, 84105, Israel</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>post‐traumatic stress disorder</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>brain rhythm</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>electroencephalography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>emotion</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>functional magnetic resonance imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>theta</value></json:item></subject><articleId><json:string>HBM21516</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Patients with post‐traumatic stress disorder (PTSD) suffer from a failure of cognitive control over emotional distracters. The physiological substrates of cognitive‐emotional interactions and their breakdown in disease are, however, unknown. Here, we studied brain activity in PTSD patients and healthy controls in response to emotion‐provoking pictures using electroencephalography and functional magnetic resonance imaging (fMRI). We demonstrate that in healthy individuals, emotion‐induced frontal theta rhythm modulates activity in the beta rhythm mainly in sensory‐motor regions. In contrast, in PTSD patients, beta activity is elevated irrespective of emotion, and is not modulated by frontal theta activity in response to negative emotion. EEG source localization and fMRI findings suggest that theta activity is localized to the prefrontal and anterior cingulate cortices while beta activity is localized to sensory‐motor regions. We further found that beta activity in sensory‐motor regions is related to the emotion‐induced slowing of the motor response in healthy controls while the excess frontal theta activity in PTSD is related to the intensity of negative emotional experience. These findings reveal for the first time the importance of brain electrical oscillations and coherence in emotional top‐down modulation and point to specific failure of these mechanisms in PTSD. 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Contract grant sponsor: the Adams Super Center for Brain Studies, Tel Aviv University (fellowship to RA)</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Emotional brain rhythms and their impairment in post‐traumatic patients</title><author xml:id="author-1"><persName><forename type="first">Jonathan E.</forename><surname>Cohen</surname></persName><affiliation>Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</affiliation><affiliation>Current Address: Sharett Institute of Oncology, Hadassah Medical Organization, Jerusalem, Israel</affiliation></author><author xml:id="author-2"><persName><forename type="first">Hadar</forename><surname>Shalev</surname></persName><affiliation>Department of Psychiatry, Soroka University Medical Center and Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</affiliation></author><author xml:id="author-3"><persName><forename type="first">Roee</forename><surname>Admon</surname></persName><affiliation>Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel</affiliation></author><author xml:id="author-4"><persName><forename type="first">Shy</forename><surname>Hefetz</surname></persName><affiliation>Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</affiliation></author><author xml:id="author-5"><persName><forename type="first">Christopher J.</forename><surname>Gasho</surname></persName><affiliation>Department of Radiology, Soroka University Medical Center and Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</affiliation></author><author xml:id="author-6"><persName><forename type="first">Lavi J.</forename><surname>Shachar</surname></persName><affiliation>Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</affiliation></author><author xml:id="author-7"><persName><forename type="first">Ilan</forename><surname>Shelef</surname></persName><affiliation>Department of Radiology, Soroka University Medical Center and Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</affiliation></author><author xml:id="author-8"><persName><forename type="first">Talma</forename><surname>Hendler</surname></persName><affiliation>Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel</affiliation><affiliation>Departments of Psychology, Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel</affiliation></author><author xml:id="author-9"><persName><forename type="first">Alon</forename><surname>Friedman</surname></persName><affiliation>Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben‐Gurion University of the Negev, POB 653, Beer‐Sheva 84105, Israel</affiliation><affiliation>Department of Physiology and Neurobiology, Faculty of Health Sciences, Ben‐Guion University of the Negev, Beer‐Sheva POB 653, 84105, Israel</affiliation></author></analytic><monogr><title level="j">Human Brain Mapping</title><title level="j" type="abbrev">Hum. 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We further found that beta activity in sensory‐motor regions is related to the emotion‐induced slowing of the motor response in healthy controls while the excess frontal theta activity in PTSD is related to the intensity of negative emotional experience. These findings reveal for the first time the importance of brain electrical oscillations and coherence in emotional top‐down modulation and point to specific failure of these mechanisms in PTSD. 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The physiological substrates of cognitive‐emotional interactions and their breakdown in disease are, however, unknown. Here, we studied brain activity in PTSD patients and healthy controls in response to emotion‐provoking pictures using electroencephalography and functional magnetic resonance imaging (fMRI). We demonstrate that in healthy individuals, emotion‐induced frontal theta rhythm modulates activity in the beta rhythm mainly in sensory‐motor regions. In contrast, in PTSD patients, beta activity is elevated irrespective of emotion, and is not modulated by frontal theta activity in response to negative emotion. EEG source localization and fMRI findings suggest that theta activity is localized to the prefrontal and anterior cingulate cortices while beta activity is localized to sensory‐motor regions. 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The physiological substrates of cognitive‐emotional interactions and their breakdown in disease are, however, unknown. Here, we studied brain activity in PTSD patients and healthy controls in response to emotion‐provoking pictures using electroencephalography and functional magnetic resonance imaging (fMRI). We demonstrate that in healthy individuals, emotion‐induced frontal theta rhythm modulates activity in the beta rhythm mainly in sensory‐motor regions. In contrast, in PTSD patients, beta activity is elevated irrespective of emotion, and is not modulated by frontal theta activity in response to negative emotion. EEG source localization and fMRI findings suggest that theta activity is localized to the prefrontal and anterior cingulate cortices while beta activity is localized to sensory‐motor regions. We further found that beta activity in sensory‐motor regions is related to the emotion‐induced slowing of the motor response in healthy controls while the excess frontal theta activity in PTSD is related to the intensity of negative emotional experience. These findings reveal for the first time the importance of brain electrical oscillations and coherence in emotional top‐down modulation and point to specific failure of these mechanisms in PTSD. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.</abstract><note type="funding">The Israel Science Foundation (BIKURA Program)</note><note type="funding">Israel Ministry of Science (the “Merkava” program)</note><note type="funding">The Chief Scientist's Office, Israeli Ministry of Health</note><note type="funding">The German Research Foundation (DFG) Trilateral Program; Contract grant sponsor: the Adams Super Center for Brain Studies, Tel Aviv University (fellowship to RA)</note><subject lang="en"><genre>keywords</genre><topic>post‐traumatic stress disorder</topic><topic>brain rhythm</topic><topic>electroencephalography</topic><topic>emotion</topic><topic>functional magnetic resonance imaging</topic><topic>theta</topic></subject><relatedItem type="host"><titleInfo><title>Human Brain Mapping</title></titleInfo><titleInfo type="abbreviated"><title>Hum. 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