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CO and NO in medicine

Identifieur interne : 000634 ( Istex/Checkpoint ); précédent : 000633; suivant : 000635

CO and NO in medicine

Auteurs : Brian E. Mann [Royaume-Uni] ; Roberto Motterlini [Royaume-Uni]

Source :

RBID : ISTEX:FEF654C14ACAEF0CF440FCDC9E3A3F547A88002A

English descriptors

Abstract

The occurrence, role and consequences of CO and NO in biological systems are reviewed. This includes their syntheses by heme oxygenases and NO synthases, their biological targets and the physiological effects of their signals. The use of CO and NO gases in medicine are discussed and methods of delivery are illustrated with particular emphasis on the therapeutic properties of compounds that generate controlled amounts of NO and CO in vivo.

Url:
DOI: 10.1039/b704873d


Affiliations:


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ISTEX:FEF654C14ACAEF0CF440FCDC9E3A3F547A88002A

Le document en format XML

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<term>Biochem</term>
<term>Biol</term>
<term>Biological activity</term>
<term>Biological function</term>
<term>Biological systems</term>
<term>Boca raton</term>
<term>Carbon monoxide</term>
<term>Cardiovascular</term>
<term>Cardiovascular functions</term>
<term>Cardiovascular system</term>
<term>Chem</term>
<term>Choi</term>
<term>Chronic inflammation</term>
<term>Circumstantial evidence</term>
<term>Commun</term>
<term>Consequential chemistry</term>
<term>Corm</term>
<term>Cyclase</term>
<term>Cyclic guanylyl monophosphate</term>
<term>Cytochrome</term>
<term>Dalton trans</term>
<term>Energy source</term>
<term>Essential part</term>
<term>Feii</term>
<term>Foresti</term>
<term>Guanosine triphosphate</term>
<term>Guanylyl</term>
<term>Guanylyl cyclase</term>
<term>Heme</term>
<term>Heme oxygenase</term>
<term>Inflammation</term>
<term>Ligand</term>
<term>Mammal</term>
<term>Many years</term>
<term>Medical research</term>
<term>Metal carbonyls</term>
<term>Molecular level</term>
<term>Molecular mechanisms</term>
<term>Monoxide</term>
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<term>Nitric oxide</term>
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<div type="abstract">The occurrence, role and consequences of CO and NO in biological systems are reviewed. This includes their syntheses by heme oxygenases and NO synthases, their biological targets and the physiological effects of their signals. The use of CO and NO gases in medicine are discussed and methods of delivery are illustrated with particular emphasis on the therapeutic properties of compounds that generate controlled amounts of NO and CO in vivo.</div>
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