Somatostatin in eating disorders.
Identifieur interne : 000A12 ( PubMed/Curation ); précédent : 000A11; suivant : 000A13Somatostatin in eating disorders.
Auteurs : K M Pirke [Allemagne] ; E. Friess ; M B Kellner ; J C Krieg ; M M FichterSource :
- The International journal of eating disorders [ 0276-3478 ] ; 1994.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Insulin, Somatostatin.
- blood : Anorexia Nervosa, Obesity.
- diagnosis : Anorexia Nervosa, Obesity.
- Adult, Energy Intake, Female, Humans, Psychiatric Status Rating Scales, Radioimmunoassay.
Abstract
Somatostatin concentrations in plasma were measured before and after a standardized fat and protein-rich fluid test meal in patients with anorexia nervosa, weight-recovered anorectic patients, obese women, and healthy controls. Somatostatin was significantly elevated in all four groups after the test meals. Hormone levels remained elevated for up to 100 min after the test meal. The area under the response curve was significantly higher (p < .01) in the anorectic patients as compared with healthy controls and weight-recovered anorectics. Obese women had blunted somatostatin responses. The findings may explain alterations in insulin secretion and in gastric emptying described earlier in patients with eating disorders.
PubMed: 7907255
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pubmed:7907255Le document en format XML
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<author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K M" last="Pirke">K M Pirke</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychoendocrinology, University of Trier, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychoendocrinology, University of Trier</wicri:regionArea>
</affiliation>
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<author><name sortKey="Friess, E" sort="Friess, E" uniqKey="Friess E" first="E" last="Friess">E. Friess</name>
</author>
<author><name sortKey="Kellner, M B" sort="Kellner, M B" uniqKey="Kellner M" first="M B" last="Kellner">M B Kellner</name>
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<author><name sortKey="Krieg, J C" sort="Krieg, J C" uniqKey="Krieg J" first="J C" last="Krieg">J C Krieg</name>
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<author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K M" last="Pirke">K M Pirke</name>
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<series><title level="j">The International journal of eating disorders</title>
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<term>Anorexia Nervosa (blood)</term>
<term>Anorexia Nervosa (diagnosis)</term>
<term>Energy Intake</term>
<term>Female</term>
<term>Humans</term>
<term>Insulin (blood)</term>
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<term>Energy Intake</term>
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<front><div type="abstract" xml:lang="en">Somatostatin concentrations in plasma were measured before and after a standardized fat and protein-rich fluid test meal in patients with anorexia nervosa, weight-recovered anorectic patients, obese women, and healthy controls. Somatostatin was significantly elevated in all four groups after the test meals. Hormone levels remained elevated for up to 100 min after the test meal. The area under the response curve was significantly higher (p < .01) in the anorectic patients as compared with healthy controls and weight-recovered anorectics. Obese women had blunted somatostatin responses. The findings may explain alterations in insulin secretion and in gastric emptying described earlier in patients with eating disorders.</div>
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<Title>The International journal of eating disorders</Title>
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<Abstract><AbstractText>Somatostatin concentrations in plasma were measured before and after a standardized fat and protein-rich fluid test meal in patients with anorexia nervosa, weight-recovered anorectic patients, obese women, and healthy controls. Somatostatin was significantly elevated in all four groups after the test meals. Hormone levels remained elevated for up to 100 min after the test meal. The area under the response curve was significantly higher (p < .01) in the anorectic patients as compared with healthy controls and weight-recovered anorectics. Obese women had blunted somatostatin responses. The findings may explain alterations in insulin secretion and in gastric emptying described earlier in patients with eating disorders.</AbstractText>
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