For whom the bell (curve) tolls: cortisol rapidly affects memory retrieval by an inverted U-shaped dose-response relationship.
Identifieur interne : 000414 ( PubMed/Curation ); précédent : 000413; suivant : 000415For whom the bell (curve) tolls: cortisol rapidly affects memory retrieval by an inverted U-shaped dose-response relationship.
Auteurs : Thomas M. Schilling [Allemagne] ; Monika Kölsch ; Mauro F. Larra ; Carina M. Zech ; Terry D. Blumenthal ; Christian Frings ; Hartmut Sch ChingerSource :
- Psychoneuroendocrinology [ 1873-3360 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Association Learning (drug effects), Association Learning (physiology), Cues, Dose-Response Relationship, Drug, Emotions, Facial Expression, Female, Humans, Hydrocortisone (analysis), Hydrocortisone (pharmacology), Male, Mental Recall (drug effects), Mental Recall (physiology), Saliva (chemistry), Social Behavior, Time Factors, Young Adult.
- MESH :
- chemical , analysis : Hydrocortisone.
- chemistry : Saliva.
- drug effects : Association Learning, Mental Recall.
- chemical , pharmacology : Hydrocortisone.
- physiology : Association Learning, Mental Recall.
- Adult, Cues, Dose-Response Relationship, Drug, Emotions, Facial Expression, Female, Humans, Male, Social Behavior, Time Factors, Young Adult.
Abstract
Stress and cortisol are generally considered to impair declarative memory retrieval, although opposite results have also been reported. Dose-dependent effects and differences between genomic and non-genomic cortisol effects are possible reasons for these discrepancies. The aim of the current experiment was to assess the non-genomic effects of escalating doses of intravenous cortisol on cued recall of socially relevant information in humans. 40 participants (age range 20-30 years; 20 females) learned associations between male faces with a neutral facial expression and descriptions of either positive or negative social behaviors and were tested one week later in a cued recall paradigm. Escalating doses of cortisol (0, 3, 6, 12, 24 mg) were administered 8 min before testing according to a between-subjects design. An inverted U-shaped dose-response relationship between salivary cortisol levels and recall performance was observed, with moderate elevation of salivary cortisol resulting in the best recall performance. This is the first study in humans demonstrating that cortisol rapidly modulates declarative memory retrieval via a dose-dependent, non-genomic mechanism that follows an inverted U-shaped curve. Our result further emphasizes the importance of fast cortisol effects for human cognition.
DOI: 10.1016/j.psyneuen.2013.01.001
PubMed: 23374327
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Electronic address: s1thschi@uni-trier.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier</wicri:regionArea></affiliation></author><author><name sortKey="Kolsch, Monika" sort="Kolsch, Monika" uniqKey="Kolsch M" first="Monika" last="Kölsch">Monika Kölsch</name></author><author><name sortKey="Larra, Mauro F" sort="Larra, Mauro F" uniqKey="Larra M" first="Mauro F" last="Larra">Mauro F. Larra</name></author><author><name sortKey="Zech, Carina M" sort="Zech, Carina M" uniqKey="Zech C" first="Carina M" last="Zech">Carina M. Zech</name></author><author><name sortKey="Blumenthal, Terry D" sort="Blumenthal, Terry D" uniqKey="Blumenthal T" first="Terry D" last="Blumenthal">Terry D. Blumenthal</name></author><author><name sortKey="Frings, Christian" sort="Frings, Christian" uniqKey="Frings C" first="Christian" last="Frings">Christian Frings</name></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23374327</idno><idno type="pmid">23374327</idno><idno type="doi">10.1016/j.psyneuen.2013.01.001</idno><idno type="wicri:Area/PubMed/Corpus">000414</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000414</idno><idno type="wicri:Area/PubMed/Curation">000414</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000414</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">For whom the bell (curve) tolls: cortisol rapidly affects memory retrieval by an inverted U-shaped dose-response relationship.</title><author><name sortKey="Schilling, Thomas M" sort="Schilling, Thomas M" uniqKey="Schilling T" first="Thomas M" last="Schilling">Thomas M. Schilling</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany. Electronic address: s1thschi@uni-trier.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier</wicri:regionArea></affiliation></author><author><name sortKey="Kolsch, Monika" sort="Kolsch, Monika" uniqKey="Kolsch M" first="Monika" last="Kölsch">Monika Kölsch</name></author><author><name sortKey="Larra, Mauro F" sort="Larra, Mauro F" uniqKey="Larra M" first="Mauro F" last="Larra">Mauro F. Larra</name></author><author><name sortKey="Zech, Carina M" sort="Zech, Carina M" uniqKey="Zech C" first="Carina M" last="Zech">Carina M. Zech</name></author><author><name sortKey="Blumenthal, Terry D" sort="Blumenthal, Terry D" uniqKey="Blumenthal T" first="Terry D" last="Blumenthal">Terry D. Blumenthal</name></author><author><name sortKey="Frings, Christian" sort="Frings, Christian" uniqKey="Frings C" first="Christian" last="Frings">Christian Frings</name></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name></author></analytic><series><title level="j">Psychoneuroendocrinology</title><idno type="eISSN">1873-3360</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Association Learning (drug effects)</term><term>Association Learning (physiology)</term><term>Cues</term><term>Dose-Response Relationship, Drug</term><term>Emotions</term><term>Facial Expression</term><term>Female</term><term>Humans</term><term>Hydrocortisone (analysis)</term><term>Hydrocortisone (pharmacology)</term><term>Male</term><term>Mental Recall (drug effects)</term><term>Mental Recall (physiology)</term><term>Saliva (chemistry)</term><term>Social Behavior</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Association Learning</term><term>Mental Recall</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Association Learning</term><term>Mental Recall</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cues</term><term>Dose-Response Relationship, Drug</term><term>Emotions</term><term>Facial Expression</term><term>Female</term><term>Humans</term><term>Male</term><term>Social Behavior</term><term>Time Factors</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Stress and cortisol are generally considered to impair declarative memory retrieval, although opposite results have also been reported. Dose-dependent effects and differences between genomic and non-genomic cortisol effects are possible reasons for these discrepancies. The aim of the current experiment was to assess the non-genomic effects of escalating doses of intravenous cortisol on cued recall of socially relevant information in humans. 40 participants (age range 20-30 years; 20 females) learned associations between male faces with a neutral facial expression and descriptions of either positive or negative social behaviors and were tested one week later in a cued recall paradigm. Escalating doses of cortisol (0, 3, 6, 12, 24 mg) were administered 8 min before testing according to a between-subjects design. An inverted U-shaped dose-response relationship between salivary cortisol levels and recall performance was observed, with moderate elevation of salivary cortisol resulting in the best recall performance. This is the first study in humans demonstrating that cortisol rapidly modulates declarative memory retrieval via a dose-dependent, non-genomic mechanism that follows an inverted U-shaped curve. Our result further emphasizes the importance of fast cortisol effects for human cognition.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23374327</PMID><DateCreated><Year>2013</Year><Month>09</Month><Day>11</Day></DateCreated><DateCompleted><Year>2014</Year><Month>05</Month><Day>14</Day></DateCompleted><DateRevised><Year>2013</Year><Month>09</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-3360</ISSN><JournalIssue CitedMedium="Internet"><Volume>38</Volume><Issue>9</Issue><PubDate><Year>2013</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Psychoneuroendocrinology</Title><ISOAbbreviation>Psychoneuroendocrinology</ISOAbbreviation></Journal><ArticleTitle>For whom the bell (curve) tolls: cortisol rapidly affects memory retrieval by an inverted U-shaped dose-response relationship.</ArticleTitle><Pagination><MedlinePgn>1565-72</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.psyneuen.2013.01.001</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0306-4530(13)00005-X</ELocationID><Abstract><AbstractText>Stress and cortisol are generally considered to impair declarative memory retrieval, although opposite results have also been reported. Dose-dependent effects and differences between genomic and non-genomic cortisol effects are possible reasons for these discrepancies. The aim of the current experiment was to assess the non-genomic effects of escalating doses of intravenous cortisol on cued recall of socially relevant information in humans. 40 participants (age range 20-30 years; 20 females) learned associations between male faces with a neutral facial expression and descriptions of either positive or negative social behaviors and were tested one week later in a cued recall paradigm. Escalating doses of cortisol (0, 3, 6, 12, 24 mg) were administered 8 min before testing according to a between-subjects design. An inverted U-shaped dose-response relationship between salivary cortisol levels and recall performance was observed, with moderate elevation of salivary cortisol resulting in the best recall performance. This is the first study in humans demonstrating that cortisol rapidly modulates declarative memory retrieval via a dose-dependent, non-genomic mechanism that follows an inverted U-shaped curve. Our result further emphasizes the importance of fast cortisol effects for human cognition.</AbstractText><CopyrightInformation>Copyright © 2013 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schilling</LastName><ForeName>Thomas M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany. Electronic address: s1thschi@uni-trier.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kölsch</LastName><ForeName>Monika</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Larra</LastName><ForeName>Mauro F</ForeName><Initials>MF</Initials></Author><Author ValidYN="Y"><LastName>Zech</LastName><ForeName>Carina M</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Blumenthal</LastName><ForeName>Terry D</ForeName><Initials>TD</Initials></Author><Author ValidYN="Y"><LastName>Frings</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Schächinger</LastName><ForeName>Hartmut</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>01</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Psychoneuroendocrinology</MedlineTA><NlmUniqueID>7612148</NlmUniqueID><ISSNLinking>0306-4530</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001245" MajorTopicYN="N">Association Learning</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003463" MajorTopicYN="N">Cues</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004644" MajorTopicYN="N">Emotions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005149" MajorTopicYN="N">Facial Expression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011939" MajorTopicYN="N">Mental Recall</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012919" MajorTopicYN="N">Social Behavior</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cortisol</Keyword><Keyword MajorTopicYN="N">Declarative memory retrieval</Keyword><Keyword MajorTopicYN="N">Dose–response design</Keyword><Keyword MajorTopicYN="N">Humans</Keyword><Keyword MajorTopicYN="N">Inverted U-shape</Keyword><Keyword MajorTopicYN="N">Non-genomic effects</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>11</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>01</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>01</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>2</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>2</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>5</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23374327</ArticleId><ArticleId IdType="pii">S0306-4530(13)00005-X</ArticleId><ArticleId IdType="doi">10.1016/j.psyneuen.2013.01.001</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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