Histopathological, immunohistochemical criteria and confocal laser-scanning data of arthrofibrosis.
Identifieur interne : 000406 ( PubMed/Curation ); précédent : 000405; suivant : 000407Histopathological, immunohistochemical criteria and confocal laser-scanning data of arthrofibrosis.
Auteurs : M. Ruppert [Allemagne] ; C. Theiss ; P. Knö ; D. Kendoff ; M G Krukemeyer ; N. Schröder ; B. Brand-Saberi ; T. Gehrke ; V. KrennSource :
- Pathology, research and practice [ 1618-0631 ] ; 2013.
English descriptors
- KwdEn :
- Actins (analysis), Antigens, CD (analysis), Antigens, Differentiation, Myelomonocytic (analysis), Biomarkers (analysis), Biopsy, Case-Control Studies, Fibrosis, Humans, Immunohistochemistry, Joint Diseases (diagnosis), Joint Diseases (metabolism), Joint Diseases (pathology), Microscopy, Confocal, Myofibroblasts (chemistry), Myofibroblasts (pathology), Postoperative Complications (diagnosis), Postoperative Complications (metabolism), Postoperative Complications (pathology), Predictive Value of Tests, Severity of Illness Index, Synovial Membrane (chemistry), Synovial Membrane (pathology), Zonula Occludens-1 Protein (analysis), beta Catenin (analysis).
- MESH :
- chemical , analysis : Actins, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Biomarkers, Zonula Occludens-1 Protein, beta Catenin.
- chemistry : Myofibroblasts, Synovial Membrane.
- diagnosis : Joint Diseases, Postoperative Complications.
- metabolism : Joint Diseases, Postoperative Complications.
- pathology : Joint Diseases, Myofibroblasts, Postoperative Complications, Synovial Membrane.
- Biopsy, Case-Control Studies, Fibrosis, Humans, Immunohistochemistry, Microscopy, Confocal, Predictive Value of Tests, Severity of Illness Index.
Abstract
Arthrofibrosis (af) is defined as a fibrosing disease of the synovial membrane, after joint operations, with painful restricted range of motion. The aim of this paper was to describe the histopathological substrate of af, hitherto only defined by clinical criteria. Based on a group of 222 tissue samples, the characteristic changes to af were analyzed. The control group comprised 29 cases with neosynovialis of the indifferent type. Due to cytoplasmic SM-actin positivity and the absence of specific cytoplasmic reactivity in CD 68 representation, af fibroblasts were characterized as myofibroblasts. In confocal laser-scanning microscopy, β-catenin-positive aggregates were detected in the cytoplasm. Over and above this, unequivocal colocalization of β-catenin and the tight junction protein ZO-1 became manifest, particularly on the cell membrane and, partly, in the cytoplasm. A threshold value of 20 β-catenin-positive cells/HPF was determined. This enables the histopathological diagnosis of an af to be made (sensitivity: 0.733, specificity: 0.867). Af is a fibrosing disease of the synovial membrane with variable grade of fibrotization (fibroblast cellularity). A threshold value of 20 β-catenin-positive fibroblasts per HPF was defined, which enables the histopathological diagnosis of af.
DOI: 10.1016/j.prp.2013.05.009
PubMed: 24075061
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Knö</name></author><author><name sortKey="Kendoff, D" sort="Kendoff, D" uniqKey="Kendoff D" first="D" last="Kendoff">D. Kendoff</name></author><author><name sortKey="Krukemeyer, M G" sort="Krukemeyer, M G" uniqKey="Krukemeyer M" first="M G" last="Krukemeyer">M G Krukemeyer</name></author><author><name sortKey="Schroder, N" sort="Schroder, N" uniqKey="Schroder N" first="N" last="Schröder">N. Schröder</name></author><author><name sortKey="Brand Saberi, B" sort="Brand Saberi, B" uniqKey="Brand Saberi B" first="B" last="Brand-Saberi">B. Brand-Saberi</name></author><author><name sortKey="Gehrke, T" sort="Gehrke, T" uniqKey="Gehrke T" first="T" last="Gehrke">T. Gehrke</name></author><author><name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. 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Electronic address: m.ruppert83@gmx.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max-Planck-Straße 18+20, D-54296 Trier</wicri:regionArea></affiliation></author><author><name sortKey="Theiss, C" sort="Theiss, C" uniqKey="Theiss C" first="C" last="Theiss">C. Theiss</name></author><author><name sortKey="Kno, P" sort="Kno, P" uniqKey="Kno P" first="P" last="Knö">P. Knö</name></author><author><name sortKey="Kendoff, D" sort="Kendoff, D" uniqKey="Kendoff D" first="D" last="Kendoff">D. Kendoff</name></author><author><name sortKey="Krukemeyer, M G" sort="Krukemeyer, M G" uniqKey="Krukemeyer M" first="M G" last="Krukemeyer">M G Krukemeyer</name></author><author><name sortKey="Schroder, N" sort="Schroder, N" uniqKey="Schroder N" first="N" last="Schröder">N. Schröder</name></author><author><name sortKey="Brand Saberi, B" sort="Brand Saberi, B" uniqKey="Brand Saberi B" first="B" last="Brand-Saberi">B. Brand-Saberi</name></author><author><name sortKey="Gehrke, T" sort="Gehrke, T" uniqKey="Gehrke T" first="T" last="Gehrke">T. Gehrke</name></author><author><name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. Krenn</name></author></analytic><series><title level="j">Pathology, research and practice</title><idno type="eISSN">1618-0631</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actins (analysis)</term><term>Antigens, CD (analysis)</term><term>Antigens, Differentiation, Myelomonocytic (analysis)</term><term>Biomarkers (analysis)</term><term>Biopsy</term><term>Case-Control Studies</term><term>Fibrosis</term><term>Humans</term><term>Immunohistochemistry</term><term>Joint Diseases (diagnosis)</term><term>Joint Diseases (metabolism)</term><term>Joint Diseases (pathology)</term><term>Microscopy, Confocal</term><term>Myofibroblasts (chemistry)</term><term>Myofibroblasts (pathology)</term><term>Postoperative Complications (diagnosis)</term><term>Postoperative Complications (metabolism)</term><term>Postoperative Complications (pathology)</term><term>Predictive Value of Tests</term><term>Severity of Illness Index</term><term>Synovial Membrane (chemistry)</term><term>Synovial Membrane (pathology)</term><term>Zonula Occludens-1 Protein (analysis)</term><term>beta Catenin (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Actins</term><term>Antigens, CD</term><term>Antigens, Differentiation, Myelomonocytic</term><term>Biomarkers</term><term>Zonula Occludens-1 Protein</term><term>beta Catenin</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Myofibroblasts</term><term>Synovial Membrane</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Joint Diseases</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Joint Diseases</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Joint Diseases</term><term>Myofibroblasts</term><term>Postoperative Complications</term><term>Synovial Membrane</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biopsy</term><term>Case-Control Studies</term><term>Fibrosis</term><term>Humans</term><term>Immunohistochemistry</term><term>Microscopy, Confocal</term><term>Predictive Value of Tests</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Arthrofibrosis (af) is defined as a fibrosing disease of the synovial membrane, after joint operations, with painful restricted range of motion. The aim of this paper was to describe the histopathological substrate of af, hitherto only defined by clinical criteria. Based on a group of 222 tissue samples, the characteristic changes to af were analyzed. The control group comprised 29 cases with neosynovialis of the indifferent type. Due to cytoplasmic SM-actin positivity and the absence of specific cytoplasmic reactivity in CD 68 representation, af fibroblasts were characterized as myofibroblasts. In confocal laser-scanning microscopy, β-catenin-positive aggregates were detected in the cytoplasm. Over and above this, unequivocal colocalization of β-catenin and the tight junction protein ZO-1 became manifest, particularly on the cell membrane and, partly, in the cytoplasm. A threshold value of 20 β-catenin-positive cells/HPF was determined. This enables the histopathological diagnosis of an af to be made (sensitivity: 0.733, specificity: 0.867). Af is a fibrosing disease of the synovial membrane with variable grade of fibrotization (fibroblast cellularity). A threshold value of 20 β-catenin-positive fibroblasts per HPF was defined, which enables the histopathological diagnosis of af.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24075061</PMID><DateCreated><Year>2013</Year><Month>11</Month><Day>11</Day></DateCreated><DateCompleted><Year>2014</Year><Month>06</Month><Day>24</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1618-0631</ISSN><JournalIssue CitedMedium="Internet"><Volume>209</Volume><Issue>11</Issue><PubDate><Year>2013</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Pathology, research and practice</Title><ISOAbbreviation>Pathol. Res. 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In confocal laser-scanning microscopy, β-catenin-positive aggregates were detected in the cytoplasm. Over and above this, unequivocal colocalization of β-catenin and the tight junction protein ZO-1 became manifest, particularly on the cell membrane and, partly, in the cytoplasm. A threshold value of 20 β-catenin-positive cells/HPF was determined. This enables the histopathological diagnosis of an af to be made (sensitivity: 0.733, specificity: 0.867). Af is a fibrosing disease of the synovial membrane with variable grade of fibrotization (fibroblast cellularity). A threshold value of 20 β-catenin-positive fibroblasts per HPF was defined, which enables the histopathological diagnosis of af.</AbstractText><CopyrightInformation>Copyright © 2013 Elsevier GmbH. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ruppert</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max-Planck-Straße 18+20, D-54296 Trier, Germany. 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Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>07</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Pathol Res Pract</MedlineTA><NlmUniqueID>7806109</NlmUniqueID><ISSNLinking>0344-0338</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C541116">ACTA2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000199">Actins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015703">Antigens, CD</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015214">Antigens, Differentiation, Myelomonocytic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015214" MajorTopicYN="N">Antigens, Differentiation, Myelomonocytic</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005355" MajorTopicYN="N">Fibrosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="Y">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007592" 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MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013583" MajorTopicYN="N">Synovial Membrane</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D062826" MajorTopicYN="N">Zonula Occludens-1 Protein</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051176" MajorTopicYN="N">beta Catenin</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Arthrofibrosis</Keyword><Keyword MajorTopicYN="N">Confocal laser-scanning microscopy</Keyword><Keyword MajorTopicYN="N">Periprosthetic 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