Patients with intolerance reactions to total knee replacement: combined assessment of allergy diagnostics, periprosthetic histology, and peri-implant cytokine expression pattern.
Identifieur interne : 000287 ( PubMed/Curation ); précédent : 000286; suivant : 000288Patients with intolerance reactions to total knee replacement: combined assessment of allergy diagnostics, periprosthetic histology, and peri-implant cytokine expression pattern.
Auteurs : Peter Thomas [Allemagne] ; Christine Von Der Helm [Allemagne] ; Christoph Schopf [Allemagne] ; Farhad Mazoochian [Allemagne] ; Lars Frommelt [Allemagne] ; Hans Gollwitzer [Allemagne] ; Josef Schneider [Allemagne] ; Michael Flaig [Allemagne] ; Veit Krenn [Allemagne] ; Benjamin Thomas [Allemagne] ; Burkhard Summer [Allemagne]Source :
- BioMed research international [ 2314-6141 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Cytokines.
- diagnosis : Hypersensitivity.
- metabolism : Hypersensitivity, Leukocytes.
- pathology : Hypersensitivity, Leukocytes.
- Adult, Aged, Arthroplasty, Replacement, Knee, Female, Gene Expression Regulation, Humans, Male, Middle Aged.
Abstract
We performed a combined approach to identify suspected allergy to knee arthroplasty (TKR): patch test (PT), lymphocyte transformation test (LTT), histopathology (overall grading; T- and B-lymphocytes, macrophages, and neutrophils), and semiquantitative Real-time-PCR-based periprosthetic inflammatory mediator analysis (IFNγ, TNFα, IL1-β, IL-2, IL-6, IL-8, IL-10, IL17, and TGFβ). We analyzed 25 TKR patients with yet unexplained complications like pain, effusion, and reduced range of motion. They consisted of 20 patients with proven metal sensitization (11 with PT reactions; 9 with only LTT reactivity). Control specimens were from 5 complicated TKR patients without metal sensitization, 12 OA patients before arthroplasty, and 8 PT patients without arthroplasty. Lymphocytic infiltrates were seen and fibrotic (Type IV membrane) tissue response was most frequent in the metal sensitive patients, for example, in 81% of the PT positive patients. The latter also had marked periprosthetic IFNγ expression. 8/9 patients with revision surgery using Ti-coated/oxinium based implants reported symptom relief. Our findings demonstrate that combining allergy diagnostics with histopathology and periprosthetic cytokine assessment could allow us to design better diagnostic strategies.
DOI: 10.1155/2015/910156
PubMed: 25866822
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000287
Links to Exploration step
pubmed:25866822Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Patients with intolerance reactions to total knee replacement: combined assessment of allergy diagnostics, periprosthetic histology, and peri-implant cytokine expression pattern.</title><author><name sortKey="Thomas, Peter" sort="Thomas, Peter" uniqKey="Thomas P" first="Peter" last="Thomas">Peter Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author><author><name sortKey="Von Der Helm, Christine" sort="Von Der Helm, Christine" uniqKey="Von Der Helm C" first="Christine" last="Von Der Helm">Christine Von Der Helm</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author><author><name sortKey="Schopf, Christoph" sort="Schopf, Christoph" uniqKey="Schopf C" first="Christoph" last="Schopf">Christoph Schopf</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Orthopädie der LMU, Marchioninistraße 15, 81377 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Orthopädie der LMU, Marchioninistraße 15, 81377 München</wicri:regionArea></affiliation></author><author><name sortKey="Mazoochian, Farhad" sort="Mazoochian, Farhad" uniqKey="Mazoochian F" first="Farhad" last="Mazoochian">Farhad Mazoochian</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Orthopädie der LMU, Marchioninistraße 15, 81377 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Orthopädie der LMU, Marchioninistraße 15, 81377 München</wicri:regionArea></affiliation></author><author><name sortKey="Frommelt, Lars" sort="Frommelt, Lars" uniqKey="Frommelt L" first="Lars" last="Frommelt">Lars Frommelt</name><affiliation wicri:level="1"><nlm:affiliation>Endoklinik, Abteilung für Mikrobiologie, Holstenstraße 2, 22767 Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Endoklinik, Abteilung für Mikrobiologie, Holstenstraße 2, 22767 Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Gollwitzer, Hans" sort="Gollwitzer, Hans" uniqKey="Gollwitzer H" first="Hans" last="Gollwitzer">Hans Gollwitzer</name><affiliation wicri:level="1"><nlm:affiliation>Klinik für Orthopädie und Sportorthopädie der Technischen Universität München (TU), Ismaninger Straße 22, 81675 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Orthopädie und Sportorthopädie der Technischen Universität München (TU), Ismaninger Straße 22, 81675 München</wicri:regionArea></affiliation></author><author><name sortKey="Schneider, Josef" sort="Schneider, Josef" uniqKey="Schneider J" first="Josef" last="Schneider">Josef Schneider</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author><author><name sortKey="Flaig, Michael" sort="Flaig, Michael" uniqKey="Flaig M" first="Michael" last="Flaig">Michael Flaig</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author><author><name sortKey="Krenn, Veit" sort="Krenn, Veit" uniqKey="Krenn V" first="Veit" last="Krenn">Veit Krenn</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Pathologie, Max-Planck-Straße 5, 54296 Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Pathologie, Max-Planck-Straße 5, 54296 Trier</wicri:regionArea></affiliation></author><author><name sortKey="Thomas, Benjamin" sort="Thomas, Benjamin" uniqKey="Thomas B" first="Benjamin" last="Thomas">Benjamin Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author><author><name sortKey="Summer, Burkhard" sort="Summer, Burkhard" uniqKey="Summer B" first="Burkhard" last="Summer">Burkhard Summer</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25866822</idno><idno type="pmid">25866822</idno><idno type="doi">10.1155/2015/910156</idno><idno type="wicri:Area/PubMed/Corpus">000287</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000287</idno><idno type="wicri:Area/PubMed/Curation">000287</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000287</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Patients with intolerance reactions to total knee replacement: combined assessment of allergy diagnostics, periprosthetic histology, and peri-implant cytokine expression pattern.</title><author><name sortKey="Thomas, Peter" sort="Thomas, Peter" uniqKey="Thomas P" first="Peter" last="Thomas">Peter Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author><author><name sortKey="Von Der Helm, Christine" sort="Von Der Helm, Christine" uniqKey="Von Der Helm C" first="Christine" last="Von Der Helm">Christine Von Der Helm</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author><author><name sortKey="Schopf, Christoph" sort="Schopf, Christoph" uniqKey="Schopf C" first="Christoph" last="Schopf">Christoph Schopf</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Orthopädie der LMU, Marchioninistraße 15, 81377 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Orthopädie der LMU, Marchioninistraße 15, 81377 München</wicri:regionArea></affiliation></author><author><name sortKey="Mazoochian, Farhad" sort="Mazoochian, Farhad" uniqKey="Mazoochian F" first="Farhad" last="Mazoochian">Farhad Mazoochian</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Orthopädie der LMU, Marchioninistraße 15, 81377 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Orthopädie der LMU, Marchioninistraße 15, 81377 München</wicri:regionArea></affiliation></author><author><name sortKey="Frommelt, Lars" sort="Frommelt, Lars" uniqKey="Frommelt L" first="Lars" last="Frommelt">Lars Frommelt</name><affiliation wicri:level="1"><nlm:affiliation>Endoklinik, Abteilung für Mikrobiologie, Holstenstraße 2, 22767 Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Endoklinik, Abteilung für Mikrobiologie, Holstenstraße 2, 22767 Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Gollwitzer, Hans" sort="Gollwitzer, Hans" uniqKey="Gollwitzer H" first="Hans" last="Gollwitzer">Hans Gollwitzer</name><affiliation wicri:level="1"><nlm:affiliation>Klinik für Orthopädie und Sportorthopädie der Technischen Universität München (TU), Ismaninger Straße 22, 81675 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Orthopädie und Sportorthopädie der Technischen Universität München (TU), Ismaninger Straße 22, 81675 München</wicri:regionArea></affiliation></author><author><name sortKey="Schneider, Josef" sort="Schneider, Josef" uniqKey="Schneider J" first="Josef" last="Schneider">Josef Schneider</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author><author><name sortKey="Flaig, Michael" sort="Flaig, Michael" uniqKey="Flaig M" first="Michael" last="Flaig">Michael Flaig</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author><author><name sortKey="Krenn, Veit" sort="Krenn, Veit" uniqKey="Krenn V" first="Veit" last="Krenn">Veit Krenn</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Pathologie, Max-Planck-Straße 5, 54296 Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Pathologie, Max-Planck-Straße 5, 54296 Trier</wicri:regionArea></affiliation></author><author><name sortKey="Thomas, Benjamin" sort="Thomas, Benjamin" uniqKey="Thomas B" first="Benjamin" last="Thomas">Benjamin Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author><author><name sortKey="Summer, Burkhard" sort="Summer, Burkhard" uniqKey="Summer B" first="Burkhard" last="Summer">Burkhard Summer</name><affiliation wicri:level="1"><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München</wicri:regionArea></affiliation></author></analytic><series><title level="j">BioMed research international</title><idno type="eISSN">2314-6141</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Arthroplasty, Replacement, Knee</term><term>Cytokines (biosynthesis)</term><term>Female</term><term>Gene Expression Regulation</term><term>Humans</term><term>Hypersensitivity (diagnosis)</term><term>Hypersensitivity (metabolism)</term><term>Hypersensitivity (pathology)</term><term>Leukocytes (metabolism)</term><term>Leukocytes (pathology)</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypersensitivity</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hypersensitivity</term><term>Leukocytes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hypersensitivity</term><term>Leukocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Arthroplasty, Replacement, Knee</term><term>Female</term><term>Gene Expression Regulation</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed a combined approach to identify suspected allergy to knee arthroplasty (TKR): patch test (PT), lymphocyte transformation test (LTT), histopathology (overall grading; T- and B-lymphocytes, macrophages, and neutrophils), and semiquantitative Real-time-PCR-based periprosthetic inflammatory mediator analysis (IFNγ, TNFα, IL1-β, IL-2, IL-6, IL-8, IL-10, IL17, and TGFβ). We analyzed 25 TKR patients with yet unexplained complications like pain, effusion, and reduced range of motion. They consisted of 20 patients with proven metal sensitization (11 with PT reactions; 9 with only LTT reactivity). Control specimens were from 5 complicated TKR patients without metal sensitization, 12 OA patients before arthroplasty, and 8 PT patients without arthroplasty. Lymphocytic infiltrates were seen and fibrotic (Type IV membrane) tissue response was most frequent in the metal sensitive patients, for example, in 81% of the PT positive patients. The latter also had marked periprosthetic IFNγ expression. 8/9 patients with revision surgery using Ti-coated/oxinium based implants reported symptom relief. Our findings demonstrate that combining allergy diagnostics with histopathology and periprosthetic cytokine assessment could allow us to design better diagnostic strategies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25866822</PMID><DateCreated><Year>2015</Year><Month>04</Month><Day>13</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>28</Day></DateCompleted><DateRevised><Year>2015</Year><Month>04</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2314-6141</ISSN><JournalIssue CitedMedium="Internet"><Volume>2015</Volume><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>BioMed research international</Title><ISOAbbreviation>Biomed Res Int</ISOAbbreviation></Journal><ArticleTitle>Patients with intolerance reactions to total knee replacement: combined assessment of allergy diagnostics, periprosthetic histology, and peri-implant cytokine expression pattern.</ArticleTitle><Pagination><MedlinePgn>910156</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2015/910156</ELocationID><Abstract><AbstractText>We performed a combined approach to identify suspected allergy to knee arthroplasty (TKR): patch test (PT), lymphocyte transformation test (LTT), histopathology (overall grading; T- and B-lymphocytes, macrophages, and neutrophils), and semiquantitative Real-time-PCR-based periprosthetic inflammatory mediator analysis (IFNγ, TNFα, IL1-β, IL-2, IL-6, IL-8, IL-10, IL17, and TGFβ). We analyzed 25 TKR patients with yet unexplained complications like pain, effusion, and reduced range of motion. They consisted of 20 patients with proven metal sensitization (11 with PT reactions; 9 with only LTT reactivity). Control specimens were from 5 complicated TKR patients without metal sensitization, 12 OA patients before arthroplasty, and 8 PT patients without arthroplasty. Lymphocytic infiltrates were seen and fibrotic (Type IV membrane) tissue response was most frequent in the metal sensitive patients, for example, in 81% of the PT positive patients. The latter also had marked periprosthetic IFNγ expression. 8/9 patients with revision surgery using Ti-coated/oxinium based implants reported symptom relief. Our findings demonstrate that combining allergy diagnostics with histopathology and periprosthetic cytokine assessment could allow us to design better diagnostic strategies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von der Helm</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schopf</LastName><ForeName>Christoph</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Klinik und Poliklinik für Orthopädie der LMU, Marchioninistraße 15, 81377 München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mazoochian</LastName><ForeName>Farhad</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Klinik und Poliklinik für Orthopädie der LMU, Marchioninistraße 15, 81377 München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frommelt</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Endoklinik, Abteilung für Mikrobiologie, Holstenstraße 2, 22767 Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gollwitzer</LastName><ForeName>Hans</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Klinik für Orthopädie und Sportorthopädie der Technischen Universität München (TU), Ismaninger Straße 22, 81675 München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>Josef</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flaig</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krenn</LastName><ForeName>Veit</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institut für Pathologie, Max-Planck-Straße 5, 54296 Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Summer</LastName><ForeName>Burkhard</ForeName><Initials>B</Initials><Identifier Source="ORCID">0000-0002-8136-7335</Identifier><AffiliationInfo><Affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität (LMU), Frauenlobstraße 9-11, 80337 München, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biomed Res Int</MedlineTA><NlmUniqueID>101600173</NlmUniqueID></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Orthop Res. 2014 Sep;32(9):1241-6</RefSource><PMID Version="1">24897980</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Orthop Sports Phys Ther. 1998 Aug;28(2):88-96</RefSource><PMID Version="1">9699158</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Anal Biochem. 2001 Dec 1;299(1):63-70</RefSource><PMID Version="1">11726185</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Allergy. 2009 Aug;64(8):1157-65</RefSource><PMID Version="1">19220218</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Orthop Res. 2010 Apr;28(4):444-50</RefSource><PMID Version="1">19834954</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Bone Joint Surg Am. 2005 Jan;87(1):18-27</RefSource><PMID Version="1">15634811</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Bone Joint Surg Am. 2005 Jan;87(1):28-36</RefSource><PMID Version="1">15637030</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Rheumatol. 2006 Jan;18(1):80-7</RefSource><PMID Version="1">16344623</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biomed Mater Res B Appl Biomater. 2006 May;77(2):257-64</RefSource><PMID Version="1">16265661</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Pathol. 2006 Jun;59(6):591-7</RefSource><PMID Version="1">16731601</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Sarcoidosis Vasc Diffuse Lung Dis. 2006 Mar;23(1):38-50</RefSource><PMID Version="1">16933469</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Orthop. 2007 Apr;78(2):211-20</RefSource><PMID Version="1">17464609</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Orthopedics. 2007 Sep;30(9):760-1</RefSource><PMID Version="1">17899927</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2007 Oct 27;370(9597):1508-19</RefSource><PMID Version="1">17964352</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Orthopade. 2008 Jan;37(1):75-88</RefSource><PMID Version="1">18210082</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biomaterials. 2008 Apr;29(10):1494-500</RefSource><PMID Version="1">18155140</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Protoc. 2008;3(6):1101-8</RefSource><PMID Version="1">18546601</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Dtsch Dermatol Ges. 2009 May;7(5):410-3</RefSource><PMID Version="1">19192161</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bull NYU Hosp Jt Dis. 2009;67(2):182-8</RefSource><PMID Version="1">19583551</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Pathol. 2012 May;65(5):409-18</RefSource><PMID Version="1">22422805</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Bone Joint Surg Br. 2012 Aug;94(8):1126-34</RefSource><PMID Version="1">22844057</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Knee Surg Sports Traumatol Arthrosc. 2013 Mar;21(3):636-40</RefSource><PMID Version="1">22488014</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Z Rheumatol. 2013 May;72(4):383-92</RefSource><PMID Version="1">23446461</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dermatitis. 2013 May-Jun;24(3):106-7</RefSource><PMID Version="1">23665835</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Chir Belg. 2013 Mar-Apr;113(2):123-8</RefSource><PMID Version="1">23741931</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Orthopade. 2013 Aug;42(8):602-6</RefSource><PMID Version="1">23835642</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Orthopade. 2013 Aug;42(8):607-13</RefSource><PMID Version="1">23907451</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Bone Joint Surg Am. 2013 Sep 4;95(17):1561-8</RefSource><PMID Version="1">24005196</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Orthop Clin North Am. 2014 Jan;45(1):9-18</RefSource><PMID Version="1">24267203</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int Orthop. 2014 Feb;38(2):335-40</RefSource><PMID Version="1">24218115</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheumatol. 2014 Mar;66(3):647-56</RefSource><PMID Version="1">24574225</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dtsch Arztebl Int. 2014 Jun 9;111(23-24):407-16</RefSource><PMID Version="1">24980673</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Dermatol. 2011 Mar;164(3):473-8</RefSource><PMID Version="1">21087227</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Allergy Clin Immunol. 2011 Mar;127(3):701-21.e1-70</RefSource><PMID Version="1">21377040</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Orthop. 2011 Jun;82(3):386-8</RefSource><PMID Version="1">21504368</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Orthop. 2011 Oct;82(5):596-601</RefSource><PMID Version="1">22112191</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Allergy. 2001 Dec;56(12):1192-6</RefSource><PMID Version="1">11736749</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Orthop Relat Res. 2002 Nov;(404):7-13</RefSource><PMID Version="1">12439231</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Orthop Relat Res. 1996 Aug;(329 Suppl):S233-43</RefSource><PMID Version="1">8769337</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Bone Joint Surg Am. 2001 Mar;83-A(3):428-36</RefSource><PMID Version="1">11263649</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019645" MajorTopicYN="Y">Arthroplasty, Replacement, Knee</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="Y">Gene Expression Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006967" MajorTopicYN="Y">Hypersensitivity</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007962" MajorTopicYN="Y">Leukocytes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4383474</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>07</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>09</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25866822</ArticleId><ArticleId IdType="doi">10.1155/2015/910156</ArticleId><ArticleId IdType="pmc">PMC4383474</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000287 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000287 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Rhénanie
|area= UnivTrevesV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:25866822
|texte= Patients with intolerance reactions to total knee replacement: combined assessment of allergy diagnostics, periprosthetic histology, and peri-implant cytokine expression pattern.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:25866822" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a UnivTrevesV1
| This area was generated with Dilib version V0.6.31. |  |