[Endocrine stress response in cataract operations with local anesthesia].
Identifieur interne : 000A36 ( PubMed/Corpus ); précédent : 000A35; suivant : 000A37[Endocrine stress response in cataract operations with local anesthesia].
Auteurs : H A Adams ; V. Hessemer ; G. Hempelmann ; K W JacobiSource :
- Klinische Monatsblatter fur Augenheilkunde [ 0023-2165 ] ; 1992.
English descriptors
- KwdEn :
- Adrenocorticotropic Hormone (blood), Aged, Aged, 80 and over, Anesthesia, Local, Blood Pressure (drug effects), Cataract Extraction, Epinephrine (blood), Female, Heart Rate (drug effects), Hormones (blood), Humans, Hydrocortisone (blood), Male, Midazolam (administration & dosage), Middle Aged, Norepinephrine (blood), Preanesthetic Medication, Stress, Physiological (blood), Vasopressins (blood).
- MESH :
- chemical , administration & dosage : Midazolam.
- chemical , blood : Adrenocorticotropic Hormone, Epinephrine, Hormones, Hydrocortisone, Norepinephrine, Vasopressins.
- blood : Stress, Physiological.
- drug effects : Blood Pressure, Heart Rate.
- Aged, Aged, 80 and over, Anesthesia, Local, Cataract Extraction, Female, Humans, Male, Middle Aged, Preanesthetic Medication.
Abstract
This study was undertaken to investigate the endocrine stress response during cataract surgery in local anaesthesia (LA) with or without additional sedation with midazolam (Dormicum). 20 patients for cataract surgery in LA were randomly allocated to the midazolam-group (before injection of LA, sedation with single doses of 1 mg midazolam until the patient was sleeping, but awakeable), and to the control-group without sedation. Premedication and LA were standardized. The investigation was performed at 7 measuring points starting at the arrival in the preparation room up to 30 min after surgery. Adrenaline in plasma was significantly lower in the midazolam-group. Intraoperatively, adrenaline increased in the control-group and decreased in the midazolam-group. In time course, noradrenaline in plasma decreased in the midazolam-group, in contrast to the control-group. With respect to ADH, ACTH and cortisol, no significant differences were found in group levels or time course, and concentrations remained within normal range. In contrast to the control-group, mean arterial pressure decreased in the midazolam-group during the course of time. There were no differences in heart rate or arterial oxygen saturation between the two groups. Local anaesthesia and premedication were sufficient to prevent psychic and surgical stressors. The slight sympathoadrenergic response in the control-group was significantly reduced by small doses of midazolam. Thus, a careful supplementation of local anaesthesia with midazolam appears advantageous for patients with cardiovascular disorders.
DOI: 10.1055/s-2008-1045751
PubMed: 1319523
Links to Exploration step
pubmed:1319523Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Endocrine stress response in cataract operations with local anesthesia].</title><author><name sortKey="Adams, H A" sort="Adams, H A" uniqKey="Adams H" first="H A" last="Adams">H A Adams</name><affiliation><nlm:affiliation>Abteilung für Anaesthesie und Intensivmedizin Marienkrankenhaus Trier-Ehrang.</nlm:affiliation></affiliation></author><author><name sortKey="Hessemer, V" sort="Hessemer, V" uniqKey="Hessemer V" first="V" last="Hessemer">V. Hessemer</name></author><author><name sortKey="Hempelmann, G" sort="Hempelmann, G" uniqKey="Hempelmann G" first="G" last="Hempelmann">G. Hempelmann</name></author><author><name sortKey="Jacobi, K W" sort="Jacobi, K W" uniqKey="Jacobi K" first="K W" last="Jacobi">K W Jacobi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1319523</idno><idno type="pmid">1319523</idno><idno type="doi">10.1055/s-2008-1045751</idno><idno type="wicri:Area/PubMed/Corpus">000A36</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A36</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Endocrine stress response in cataract operations with local anesthesia].</title><author><name sortKey="Adams, H A" sort="Adams, H A" uniqKey="Adams H" first="H A" last="Adams">H A Adams</name><affiliation><nlm:affiliation>Abteilung für Anaesthesie und Intensivmedizin Marienkrankenhaus Trier-Ehrang.</nlm:affiliation></affiliation></author><author><name sortKey="Hessemer, V" sort="Hessemer, V" uniqKey="Hessemer V" first="V" last="Hessemer">V. Hessemer</name></author><author><name sortKey="Hempelmann, G" sort="Hempelmann, G" uniqKey="Hempelmann G" first="G" last="Hempelmann">G. Hempelmann</name></author><author><name sortKey="Jacobi, K W" sort="Jacobi, K W" uniqKey="Jacobi K" first="K W" last="Jacobi">K W Jacobi</name></author></analytic><series><title level="j">Klinische Monatsblatter fur Augenheilkunde</title><idno type="ISSN">0023-2165</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenocorticotropic Hormone (blood)</term><term>Aged</term><term>Aged, 80 and over</term><term>Anesthesia, Local</term><term>Blood Pressure (drug effects)</term><term>Cataract Extraction</term><term>Epinephrine (blood)</term><term>Female</term><term>Heart Rate (drug effects)</term><term>Hormones (blood)</term><term>Humans</term><term>Hydrocortisone (blood)</term><term>Male</term><term>Midazolam (administration & dosage)</term><term>Middle Aged</term><term>Norepinephrine (blood)</term><term>Preanesthetic Medication</term><term>Stress, Physiological (blood)</term><term>Vasopressins (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Midazolam</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term><term>Epinephrine</term><term>Hormones</term><term>Hydrocortisone</term><term>Norepinephrine</term><term>Vasopressins</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Stress, Physiological</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Pressure</term><term>Heart Rate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Anesthesia, Local</term><term>Cataract Extraction</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Preanesthetic Medication</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was undertaken to investigate the endocrine stress response during cataract surgery in local anaesthesia (LA) with or without additional sedation with midazolam (Dormicum). 20 patients for cataract surgery in LA were randomly allocated to the midazolam-group (before injection of LA, sedation with single doses of 1 mg midazolam until the patient was sleeping, but awakeable), and to the control-group without sedation. Premedication and LA were standardized. The investigation was performed at 7 measuring points starting at the arrival in the preparation room up to 30 min after surgery. Adrenaline in plasma was significantly lower in the midazolam-group. Intraoperatively, adrenaline increased in the control-group and decreased in the midazolam-group. In time course, noradrenaline in plasma decreased in the midazolam-group, in contrast to the control-group. With respect to ADH, ACTH and cortisol, no significant differences were found in group levels or time course, and concentrations remained within normal range. In contrast to the control-group, mean arterial pressure decreased in the midazolam-group during the course of time. There were no differences in heart rate or arterial oxygen saturation between the two groups. Local anaesthesia and premedication were sufficient to prevent psychic and surgical stressors. The slight sympathoadrenergic response in the control-group was significantly reduced by small doses of midazolam. Thus, a careful supplementation of local anaesthesia with midazolam appears advantageous for patients with cardiovascular disorders.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1319523</PMID><DateCreated><Year>1992</Year><Month>07</Month><Day>28</Day></DateCreated><DateCompleted><Year>1992</Year><Month>07</Month><Day>28</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0023-2165</ISSN><JournalIssue CitedMedium="Print"><Volume>200</Volume><Issue>4</Issue><PubDate><Year>1992</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Klinische Monatsblatter fur Augenheilkunde</Title><ISOAbbreviation>Klin Monbl Augenheilkd</ISOAbbreviation></Journal><ArticleTitle>[Endocrine stress response in cataract operations with local anesthesia].</ArticleTitle><Pagination><MedlinePgn>273-7</MedlinePgn></Pagination><Abstract><AbstractText>This study was undertaken to investigate the endocrine stress response during cataract surgery in local anaesthesia (LA) with or without additional sedation with midazolam (Dormicum). 20 patients for cataract surgery in LA were randomly allocated to the midazolam-group (before injection of LA, sedation with single doses of 1 mg midazolam until the patient was sleeping, but awakeable), and to the control-group without sedation. Premedication and LA were standardized. The investigation was performed at 7 measuring points starting at the arrival in the preparation room up to 30 min after surgery. Adrenaline in plasma was significantly lower in the midazolam-group. Intraoperatively, adrenaline increased in the control-group and decreased in the midazolam-group. In time course, noradrenaline in plasma decreased in the midazolam-group, in contrast to the control-group. With respect to ADH, ACTH and cortisol, no significant differences were found in group levels or time course, and concentrations remained within normal range. In contrast to the control-group, mean arterial pressure decreased in the midazolam-group during the course of time. There were no differences in heart rate or arterial oxygen saturation between the two groups. Local anaesthesia and premedication were sufficient to prevent psychic and surgical stressors. The slight sympathoadrenergic response in the control-group was significantly reduced by small doses of midazolam. Thus, a careful supplementation of local anaesthesia with midazolam appears advantageous for patients with cardiovascular disorders.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Adams</LastName><ForeName>H A</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Abteilung für Anaesthesie und Intensivmedizin Marienkrankenhaus Trier-Ehrang.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hessemer</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Hempelmann</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Jacobi</LastName><ForeName>K W</ForeName><Initials>KW</Initials></Author></AuthorList><Language>ger</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><VernacularTitle>Die endokrine Stressantwort bei Kataraktoperationen in Lokalanaesthesie.</VernacularTitle></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Klin Monbl Augenheilkd</MedlineTA><NlmUniqueID>0014133</NlmUniqueID><ISSNLinking>0023-2165</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006728">Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>11000-17-2</RegistryNumber><NameOfSubstance UI="D014667">Vasopressins</NameOfSubstance></Chemical><Chemical><RegistryNumber>9002-60-2</RegistryNumber><NameOfSubstance UI="D000324">Adrenocorticotropic Hormone</NameOfSubstance></Chemical><Chemical><RegistryNumber>R60L0SM5BC</RegistryNumber><NameOfSubstance UI="D008874">Midazolam</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical><Chemical><RegistryNumber>X4W3ENH1CV</RegistryNumber><NameOfSubstance UI="D009638">Norepinephrine</NameOfSubstance></Chemical><Chemical><RegistryNumber>YKH834O4BH</RegistryNumber><NameOfSubstance UI="D004837">Epinephrine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000324" MajorTopicYN="N">Adrenocorticotropic Hormone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000772" MajorTopicYN="Y">Anesthesia, Local</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002387" MajorTopicYN="Y">Cataract Extraction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004837" MajorTopicYN="N">Epinephrine</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006339" MajorTopicYN="N">Heart Rate</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006728" MajorTopicYN="N">Hormones</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008874" MajorTopicYN="N">Midazolam</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009638" MajorTopicYN="N">Norepinephrine</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011229" MajorTopicYN="Y">Preanesthetic Medication</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013312" MajorTopicYN="N">Stress, Physiological</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014667" MajorTopicYN="N">Vasopressins</DescriptorName><QualifierName 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