[Studies using S-(+)-ketamine on probands. Endocrine and circulatory reactions, recovery and dream experiences].
Identifieur interne : 000A32 ( PubMed/Corpus ); précédent : 000A31; suivant : 000A33[Studies using S-(+)-ketamine on probands. Endocrine and circulatory reactions, recovery and dream experiences].
Auteurs : H A Adams ; A. Thiel ; A. Jung ; G. Fengler ; G. HempelmannSource :
- Der Anaesthesist [ 0003-2417 ] ; 1992.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Adrenocorticotropic Hormone, Epinephrine, Hydrocortisone, Norepinephrine, Vasopressins.
- drug effects : Hemodynamics.
- chemical , pharmacology : Ketamine.
- Adult, Double-Blind Method, Female, Humans, Male, Stereoisomerism.
Abstract
Clinically used ketamine is a racemic mixture of two isomers, S(+)- and R(-)-ketamine. The anaesthetic potency of S(+)-ketamine was found to be three times higher than that of R(-)-ketamine. It was the aim of this study to compare the effects of racemic ketamine and S(+)-ketamine on endocrine and cardiovascular parameters, recovery and psychomimetic reactions in young healthy volunteers.
PubMed: 1332529
Links to Exploration step
pubmed:1332529Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Studies using S-(+)-ketamine on probands. Endocrine and circulatory reactions, recovery and dream experiences].</title><author><name sortKey="Adams, H A" sort="Adams, H A" uniqKey="Adams H" first="H A" last="Adams">H A Adams</name><affiliation><nlm:affiliation>Abteilung für Anaesthesie und Intensivmedizin, Marienkrankenhaus Trier-Ehrang.</nlm:affiliation></affiliation></author><author><name sortKey="Thiel, A" sort="Thiel, A" uniqKey="Thiel A" first="A" last="Thiel">A. Thiel</name></author><author><name sortKey="Jung, A" sort="Jung, A" uniqKey="Jung A" first="A" last="Jung">A. Jung</name></author><author><name sortKey="Fengler, G" sort="Fengler, G" uniqKey="Fengler G" first="G" last="Fengler">G. Fengler</name></author><author><name sortKey="Hempelmann, G" sort="Hempelmann, G" uniqKey="Hempelmann G" first="G" last="Hempelmann">G. Hempelmann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1332529</idno><idno type="pmid">1332529</idno><idno type="wicri:Area/PubMed/Corpus">000A32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Studies using S-(+)-ketamine on probands. Endocrine and circulatory reactions, recovery and dream experiences].</title><author><name sortKey="Adams, H A" sort="Adams, H A" uniqKey="Adams H" first="H A" last="Adams">H A Adams</name><affiliation><nlm:affiliation>Abteilung für Anaesthesie und Intensivmedizin, Marienkrankenhaus Trier-Ehrang.</nlm:affiliation></affiliation></author><author><name sortKey="Thiel, A" sort="Thiel, A" uniqKey="Thiel A" first="A" last="Thiel">A. Thiel</name></author><author><name sortKey="Jung, A" sort="Jung, A" uniqKey="Jung A" first="A" last="Jung">A. Jung</name></author><author><name sortKey="Fengler, G" sort="Fengler, G" uniqKey="Fengler G" first="G" last="Fengler">G. Fengler</name></author><author><name sortKey="Hempelmann, G" sort="Hempelmann, G" uniqKey="Hempelmann G" first="G" last="Hempelmann">G. Hempelmann</name></author></analytic><series><title level="j">Der Anaesthesist</title><idno type="ISSN">0003-2417</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenocorticotropic Hormone (blood)</term><term>Adult</term><term>Double-Blind Method</term><term>Epinephrine (blood)</term><term>Female</term><term>Hemodynamics (drug effects)</term><term>Humans</term><term>Hydrocortisone (blood)</term><term>Ketamine (pharmacology)</term><term>Male</term><term>Norepinephrine (blood)</term><term>Stereoisomerism</term><term>Vasopressins (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term><term>Epinephrine</term><term>Hydrocortisone</term><term>Norepinephrine</term><term>Vasopressins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hemodynamics</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Ketamine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Stereoisomerism</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clinically used ketamine is a racemic mixture of two isomers, S(+)- and R(-)-ketamine. The anaesthetic potency of S(+)-ketamine was found to be three times higher than that of R(-)-ketamine. It was the aim of this study to compare the effects of racemic ketamine and S(+)-ketamine on endocrine and cardiovascular parameters, recovery and psychomimetic reactions in young healthy volunteers.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1332529</PMID><DateCreated><Year>1992</Year><Month>12</Month><Day>18</Day></DateCreated><DateCompleted><Year>1992</Year><Month>12</Month><Day>18</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0003-2417</ISSN><JournalIssue CitedMedium="Print"><Volume>41</Volume><Issue>10</Issue><PubDate><Year>1992</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Der Anaesthesist</Title><ISOAbbreviation>Anaesthesist</ISOAbbreviation></Journal><ArticleTitle>[Studies using S-(+)-ketamine on probands. Endocrine and circulatory reactions, recovery and dream experiences].</ArticleTitle><Pagination><MedlinePgn>588-96</MedlinePgn></Pagination><Abstract><AbstractText Label="UNLABELLED">Clinically used ketamine is a racemic mixture of two isomers, S(+)- and R(-)-ketamine. The anaesthetic potency of S(+)-ketamine was found to be three times higher than that of R(-)-ketamine. It was the aim of this study to compare the effects of racemic ketamine and S(+)-ketamine on endocrine and cardiovascular parameters, recovery and psychomimetic reactions in young healthy volunteers.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">6 women and 4 men between 23 and 38 years were investigated twice in a randomized double blind cross-over design receiving injections of 2 mg/kg BW racemic ketamine or 1 mg/kg BW S(+)-ketamine at an interval of at least 7 days. Samples were taken from a central venous catheter before and 1, 3, 5, 10, 15, 30, 60 and 120 min after injection for analysis of adrenaline, noradrenaline (by high pressure liquid chromatography with electrochemical detection), ADH, ACTH, cortisol (by radio immuno assay), glucose, lactate and free glycerol. In addition, SAP, HR, and arterial oxygen saturation were measured, and return of consciousness and orientation were protocoled. Incidence and assessment of dreams were reported by the volunteers.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Adrenaline, noradrenaline, ACTH, cortisol, lactate and free glycerol in plasma as well as SAP and HR increased significantly after injection of both racemic ketamine and S(+)-ketamine. The influence on ADH and glucose was not significant. There were no differences between racemic ketamine and S(+)-ketamine in these parameters. Recovery was significantly improved after administration of S(+)-ketamine. Simple orders were followed after 7.9 +/- 1.1 vs. 9.2 +/- 1.2 min (P = 0.004). Orientation with respect to the person returned after 9.0 +/- 1.8 vs. 11.5 +/- 2.5 min (P = 0.004); with respect to time and location after 10.1 +/- 2.1 min vs. 13.4 +/- 4.0 min (P = 0.007). 18 dreams were reported; assessment was positive in 13 cases and indifferent in 5 cases, none was negative. In 7 of 10 cases, the investigators were able to identify that S(+)-ketamine had been injected.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">With respect to endocrine and cardiovascular parameters, the pharmacodynamic effects of racemic and S(+)-ketamine were comparable. Because of the significant improvement in recovery and the reduced quantitative drug load, S(+)-ketamine offers a clear clinical advantage compared with currently used racemic ketamine.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Adams</LastName><ForeName>H A</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Abteilung für Anaesthesie und Intensivmedizin, Marienkrankenhaus Trier-Ehrang.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thiel</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Jung</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Fengler</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Hempelmann</LastName><ForeName>G</ForeName><Initials>G</Initials></Author></AuthorList><Language>ger</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><VernacularTitle>Untersuchungen mit S-(+)-Ketamin an Probanden. Endokrine- und Kreislaufreaktionen, Aufwachverhalten und Traumerlebnisse.</VernacularTitle></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Anaesthesist</MedlineTA><NlmUniqueID>0370525</NlmUniqueID><ISSNLinking>0003-2417</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>11000-17-2</RegistryNumber><NameOfSubstance UI="D014667">Vasopressins</NameOfSubstance></Chemical><Chemical><RegistryNumber>690G0D6V8H</RegistryNumber><NameOfSubstance UI="D007649">Ketamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>9002-60-2</RegistryNumber><NameOfSubstance UI="D000324">Adrenocorticotropic Hormone</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical><Chemical><RegistryNumber>X4W3ENH1CV</RegistryNumber><NameOfSubstance UI="D009638">Norepinephrine</NameOfSubstance></Chemical><Chemical><RegistryNumber>YKH834O4BH</RegistryNumber><NameOfSubstance UI="D004837">Epinephrine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Anaesthesist. 1992 Oct;41(10):585-7</RefSource><PMID Version="1">1443506</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000324" MajorTopicYN="N">Adrenocorticotropic Hormone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004837" MajorTopicYN="N">Epinephrine</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006439" MajorTopicYN="N">Hemodynamics</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007649" MajorTopicYN="N">Ketamine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009638" MajorTopicYN="N">Norepinephrine</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013237" MajorTopicYN="N">Stereoisomerism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014667" MajorTopicYN="N">Vasopressins</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1992</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1992</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1992</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1332529</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A32 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000A32 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Rhénanie
|area= UnivTrevesV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:1332529
|texte= [Studies using S-(+)-ketamine on probands. Endocrine and circulatory reactions, recovery and dream experiences].
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:1332529" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a UnivTrevesV1
| This area was generated with Dilib version V0.6.31. |  |