[The effect of flumazenil on the endocrine stress reaction following modified neuroleptanesthesia].
Identifieur interne : 000A24 ( PubMed/Corpus ); précédent : 000A23; suivant : 000A25[The effect of flumazenil on the endocrine stress reaction following modified neuroleptanesthesia].
Auteurs : H A Adams ; R. Schöfer ; B. Bachmann-M ; G. HempelmannSource :
- Anaesthesiologie und Reanimation [ 0323-4983 ] ; 1993.
English descriptors
- KwdEn :
- Adolescent, Adult, Endocrine Glands (drug effects), Endocrine Glands (physiology), Female, Flumazenil (pharmacology), Genital Diseases, Female (surgery), Hemodynamics (drug effects), Hemodynamics (physiology), Humans, Middle Aged, Neuroleptanalgesia, Prospective Studies, Stress, Physiological (physiopathology).
- MESH :
- chemical , pharmacology : Flumazenil.
- drug effects : Endocrine Glands, Hemodynamics.
- physiology : Endocrine Glands, Hemodynamics.
- physiopathology : Stress, Physiological.
- surgery : Genital Diseases, Female.
- Adolescent, Adult, Female, Humans, Middle Aged, Neuroleptanalgesia, Prospective Studies.
Abstract
This study was undertaken to investigate in a prospective randomized way the influence of the benzodiazepine antagonist flumazenil on endocrine stress response and haemodynamic parameters after modified neuroleptanaesthesia. A total of 24 patients (ASA scores I or II) aged between 18 and 60 who were scheduled for major gynaecological surgery, were investigated. For modified neuroleptanaesthesia, midazolam, fentanyl and vecuronium were administered in standardized doses. After extubation, patients of the flumazenil group received initial injections of 0.2 mg flumazenil to antagonize the residual effect of midazolam and additional doses of 0.1 mg per minute until the desired level of vigilance was reached (awareness of person, time and place). In the control group no flumazenil was used. Endocrine stress parameters and haemodynamic parameters were measured at 7 different times, from before induction of anaesthesia up to 60 minutes after the operation. In both groups, a marked increase in endocrine stress response was observed. Adrenaline, noradrenaline, antidiuretic hormone, adrenocorticotropic hormone, cortisol, glucose and lactate, however, were not additionally influenced by the antagonism. No influence of flumazenil on mean arterial pressure, heart rate and arterial oxygen saturation was observed. After modified neuroleptanaesthesia, a careful antagonism of midazolam with small doses of flumazenil is not disadvantageous with respect of endocrine stress response and haemodynamic reactions.
PubMed: 8240640
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pubmed:8240640Le document en format XML
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Hempelmann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:8240640</idno><idno type="pmid">8240640</idno><idno type="wicri:Area/PubMed/Corpus">000A24</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A24</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[The effect of flumazenil on the endocrine stress reaction following modified neuroleptanesthesia].</title><author><name sortKey="Adams, H A" sort="Adams, H A" uniqKey="Adams H" first="H A" last="Adams">H A Adams</name><affiliation><nlm:affiliation>Abteilung Anästhesie und Intensivmedizin, Marienkrankenhaus Trier-Ehrang.</nlm:affiliation></affiliation></author><author><name sortKey="Schofer, R" sort="Schofer, R" uniqKey="Schofer R" first="R" last="Schöfer">R. Schöfer</name></author><author><name sortKey="Bachmann M, B" sort="Bachmann M, B" uniqKey="Bachmann M B" first="B" last="Bachmann-M">B. Bachmann-M</name></author><author><name sortKey="Hempelmann, G" sort="Hempelmann, G" uniqKey="Hempelmann G" first="G" last="Hempelmann">G. Hempelmann</name></author></analytic><series><title level="j">Anaesthesiologie und Reanimation</title><idno type="ISSN">0323-4983</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Endocrine Glands (drug effects)</term><term>Endocrine Glands (physiology)</term><term>Female</term><term>Flumazenil (pharmacology)</term><term>Genital Diseases, Female (surgery)</term><term>Hemodynamics (drug effects)</term><term>Hemodynamics (physiology)</term><term>Humans</term><term>Middle Aged</term><term>Neuroleptanalgesia</term><term>Prospective Studies</term><term>Stress, Physiological (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Flumazenil</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Endocrine Glands</term><term>Hemodynamics</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endocrine Glands</term><term>Hemodynamics</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Stress, Physiological</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Genital Diseases, Female</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Neuroleptanalgesia</term><term>Prospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was undertaken to investigate in a prospective randomized way the influence of the benzodiazepine antagonist flumazenil on endocrine stress response and haemodynamic parameters after modified neuroleptanaesthesia. A total of 24 patients (ASA scores I or II) aged between 18 and 60 who were scheduled for major gynaecological surgery, were investigated. For modified neuroleptanaesthesia, midazolam, fentanyl and vecuronium were administered in standardized doses. After extubation, patients of the flumazenil group received initial injections of 0.2 mg flumazenil to antagonize the residual effect of midazolam and additional doses of 0.1 mg per minute until the desired level of vigilance was reached (awareness of person, time and place). In the control group no flumazenil was used. Endocrine stress parameters and haemodynamic parameters were measured at 7 different times, from before induction of anaesthesia up to 60 minutes after the operation. In both groups, a marked increase in endocrine stress response was observed. Adrenaline, noradrenaline, antidiuretic hormone, adrenocorticotropic hormone, cortisol, glucose and lactate, however, were not additionally influenced by the antagonism. No influence of flumazenil on mean arterial pressure, heart rate and arterial oxygen saturation was observed. After modified neuroleptanaesthesia, a careful antagonism of midazolam with small doses of flumazenil is not disadvantageous with respect of endocrine stress response and haemodynamic reactions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8240640</PMID><DateCreated><Year>1994</Year><Month>01</Month><Day>06</Day></DateCreated><DateCompleted><Year>1994</Year><Month>01</Month><Day>06</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0323-4983</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>4</Issue><PubDate><Year>1993</Year></PubDate></JournalIssue><Title>Anaesthesiologie und Reanimation</Title><ISOAbbreviation>Anaesthesiol Reanim</ISOAbbreviation></Journal><ArticleTitle>[The effect of flumazenil on the endocrine stress reaction following modified neuroleptanesthesia].</ArticleTitle><Pagination><MedlinePgn>100-4</MedlinePgn></Pagination><Abstract><AbstractText>This study was undertaken to investigate in a prospective randomized way the influence of the benzodiazepine antagonist flumazenil on endocrine stress response and haemodynamic parameters after modified neuroleptanaesthesia. A total of 24 patients (ASA scores I or II) aged between 18 and 60 who were scheduled for major gynaecological surgery, were investigated. For modified neuroleptanaesthesia, midazolam, fentanyl and vecuronium were administered in standardized doses. After extubation, patients of the flumazenil group received initial injections of 0.2 mg flumazenil to antagonize the residual effect of midazolam and additional doses of 0.1 mg per minute until the desired level of vigilance was reached (awareness of person, time and place). In the control group no flumazenil was used. Endocrine stress parameters and haemodynamic parameters were measured at 7 different times, from before induction of anaesthesia up to 60 minutes after the operation. In both groups, a marked increase in endocrine stress response was observed. Adrenaline, noradrenaline, antidiuretic hormone, adrenocorticotropic hormone, cortisol, glucose and lactate, however, were not additionally influenced by the antagonism. No influence of flumazenil on mean arterial pressure, heart rate and arterial oxygen saturation was observed. After modified neuroleptanaesthesia, a careful antagonism of midazolam with small doses of flumazenil is not disadvantageous with respect of endocrine stress response and haemodynamic reactions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Adams</LastName><ForeName>H A</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Abteilung Anästhesie und Intensivmedizin, Marienkrankenhaus Trier-Ehrang.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schöfer</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Bachmann-M</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Hempelmann</LastName><ForeName>G</ForeName><Initials>G</Initials></Author></AuthorList><Language>ger</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><VernacularTitle>Der Einfluss von Flumazenil auf die endokrine Stressreaktion nach modifizierten Neuroleptanästhesien.</VernacularTitle></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Anaesthesiol Reanim</MedlineTA><NlmUniqueID>7611455</NlmUniqueID><ISSNLinking>0323-4983</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>40P7XK9392</RegistryNumber><NameOfSubstance UI="D005442">Flumazenil</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004702" MajorTopicYN="N">Endocrine Glands</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005442" MajorTopicYN="N">Flumazenil</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005831" MajorTopicYN="N">Genital Diseases, Female</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006439" MajorTopicYN="N">Hemodynamics</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009458" MajorTopicYN="Y">Neuroleptanalgesia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013312" MajorTopicYN="N">Stress, Physiological</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1993</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8240640</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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