Endocrine testicular function in HIV-infected outpatients.
Identifieur interne : 000928 ( PubMed/Corpus ); précédent : 000927; suivant : 000929Endocrine testicular function in HIV-infected outpatients.
Auteurs : T H Schürmeyer ; V. Müller ; A. Von Zur Mühlen ; R E SchmidtSource :
- European journal of medical research [ 0949-2321 ] ; 1997.
English descriptors
- KwdEn :
- Adult, Aldosterone (urine), Analysis of Variance, CD4 Lymphocyte Count, Chi-Square Distribution, Dehydroepiandrosterone Sulfate (blood), Estradiol (blood), Follicle Stimulating Hormone (blood), HIV Infections (blood), HIV Infections (immunology), HIV Infections (physiopathology), Humans, Hydrocortisone (urine), Male, Regression Analysis, Sex Hormone-Binding Globulin (analysis), Testis (secretion), Testosterone (blood), Thyroxine (blood), Triiodothyronine (blood).
- MESH :
- chemical , analysis : Sex Hormone-Binding Globulin.
- chemical , blood : Dehydroepiandrosterone Sulfate, Estradiol, Follicle Stimulating Hormone, Testosterone, Thyroxine, Triiodothyronine.
- chemical , urine : Aldosterone, Hydrocortisone.
- blood : HIV Infections.
- immunology : HIV Infections.
- physiopathology : HIV Infections.
- secretion : Testis.
- Adult, Analysis of Variance, CD4 Lymphocyte Count, Chi-Square Distribution, Humans, Male, Regression Analysis.
Abstract
We investigated endocrine testicular function in 100 HIV-infected men who were grouped according to the CDC criteria. Progression of the disease was associated with a 27% decrease in plasma oestradiol, which was the only parameter that was weakly correlated with CD4 cell count (r = 0.312, p <0.05). Individual data showed a decreased plasma concentration of total and free testosterone in 35% and 26% of the subjects, respectively, but we could not demonstrate an increased frequency of hypogonadism going along with a progression of the stage of disease. There was no significant correlation between androgen, SHBG or FSH levels and duration of HIV-infection, BMI or CD4 cell count. Hypergonadotropic hypogonadism was associated with an euthyroid sick state in a 15% subgroup of patients reporting a decrease in libido. Plasma T3 was significantly correlated with testosterone (r = 0.419, p <0.01) and mean plasma T3 was significantly decreased in 8 subjects suffering from erectile impotence. Thus, hypogonadism occurs frequently in HIV-infected outpatients. Like euthyroid sickness it does not seem to be a predictor for progression of the disease but an indicator of actual state of health.
PubMed: 9233899
Links to Exploration step
pubmed:9233899Le document en format XML
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<author><name sortKey="Muller, V" sort="Muller, V" uniqKey="Muller V" first="V" last="Müller">V. Müller</name>
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<author><name sortKey="Von Zur Muhlen, A" sort="Von Zur Muhlen, A" uniqKey="Von Zur Muhlen A" first="A" last="Von Zur Mühlen">A. Von Zur Mühlen</name>
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<author><name sortKey="Schmidt, R E" sort="Schmidt, R E" uniqKey="Schmidt R" first="R E" last="Schmidt">R E Schmidt</name>
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<front><div type="abstract" xml:lang="en">We investigated endocrine testicular function in 100 HIV-infected men who were grouped according to the CDC criteria. Progression of the disease was associated with a 27% decrease in plasma oestradiol, which was the only parameter that was weakly correlated with CD4 cell count (r = 0.312, p <0.05). Individual data showed a decreased plasma concentration of total and free testosterone in 35% and 26% of the subjects, respectively, but we could not demonstrate an increased frequency of hypogonadism going along with a progression of the stage of disease. There was no significant correlation between androgen, SHBG or FSH levels and duration of HIV-infection, BMI or CD4 cell count. Hypergonadotropic hypogonadism was associated with an euthyroid sick state in a 15% subgroup of patients reporting a decrease in libido. Plasma T3 was significantly correlated with testosterone (r = 0.419, p <0.01) and mean plasma T3 was significantly decreased in 8 subjects suffering from erectile impotence. Thus, hypogonadism occurs frequently in HIV-infected outpatients. Like euthyroid sickness it does not seem to be a predictor for progression of the disease but an indicator of actual state of health.</div>
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<Abstract><AbstractText>We investigated endocrine testicular function in 100 HIV-infected men who were grouped according to the CDC criteria. Progression of the disease was associated with a 27% decrease in plasma oestradiol, which was the only parameter that was weakly correlated with CD4 cell count (r = 0.312, p <0.05). Individual data showed a decreased plasma concentration of total and free testosterone in 35% and 26% of the subjects, respectively, but we could not demonstrate an increased frequency of hypogonadism going along with a progression of the stage of disease. There was no significant correlation between androgen, SHBG or FSH levels and duration of HIV-infection, BMI or CD4 cell count. Hypergonadotropic hypogonadism was associated with an euthyroid sick state in a 15% subgroup of patients reporting a decrease in libido. Plasma T3 was significantly correlated with testosterone (r = 0.419, p <0.01) and mean plasma T3 was significantly decreased in 8 subjects suffering from erectile impotence. Thus, hypogonadism occurs frequently in HIV-infected outpatients. Like euthyroid sickness it does not seem to be a predictor for progression of the disease but an indicator of actual state of health.</AbstractText>
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