Endocrine testicular function in HIV-infected outpatients.
Identifieur interne : 000928 ( PubMed/Corpus ); précédent : 000927; suivant : 000929Endocrine testicular function in HIV-infected outpatients.
Auteurs : T H Schürmeyer ; V. Müller ; A. Von Zur Mühlen ; R E SchmidtSource :
- European journal of medical research [ 0949-2321 ] ; 1997.
English descriptors
- KwdEn :
- Adult, Aldosterone (urine), Analysis of Variance, CD4 Lymphocyte Count, Chi-Square Distribution, Dehydroepiandrosterone Sulfate (blood), Estradiol (blood), Follicle Stimulating Hormone (blood), HIV Infections (blood), HIV Infections (immunology), HIV Infections (physiopathology), Humans, Hydrocortisone (urine), Male, Regression Analysis, Sex Hormone-Binding Globulin (analysis), Testis (secretion), Testosterone (blood), Thyroxine (blood), Triiodothyronine (blood).
- MESH :
- chemical , analysis : Sex Hormone-Binding Globulin.
- chemical , blood : Dehydroepiandrosterone Sulfate, Estradiol, Follicle Stimulating Hormone, Testosterone, Thyroxine, Triiodothyronine.
- chemical , urine : Aldosterone, Hydrocortisone.
- blood : HIV Infections.
- immunology : HIV Infections.
- physiopathology : HIV Infections.
- secretion : Testis.
- Adult, Analysis of Variance, CD4 Lymphocyte Count, Chi-Square Distribution, Humans, Male, Regression Analysis.
Abstract
We investigated endocrine testicular function in 100 HIV-infected men who were grouped according to the CDC criteria. Progression of the disease was associated with a 27% decrease in plasma oestradiol, which was the only parameter that was weakly correlated with CD4 cell count (r = 0.312, p <0.05). Individual data showed a decreased plasma concentration of total and free testosterone in 35% and 26% of the subjects, respectively, but we could not demonstrate an increased frequency of hypogonadism going along with a progression of the stage of disease. There was no significant correlation between androgen, SHBG or FSH levels and duration of HIV-infection, BMI or CD4 cell count. Hypergonadotropic hypogonadism was associated with an euthyroid sick state in a 15% subgroup of patients reporting a decrease in libido. Plasma T3 was significantly correlated with testosterone (r = 0.419, p <0.01) and mean plasma T3 was significantly decreased in 8 subjects suffering from erectile impotence. Thus, hypogonadism occurs frequently in HIV-infected outpatients. Like euthyroid sickness it does not seem to be a predictor for progression of the disease but an indicator of actual state of health.
PubMed: 9233899
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pubmed:9233899Le document en format XML
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Von Zur Mühlen</name></author><author><name sortKey="Schmidt, R E" sort="Schmidt, R E" uniqKey="Schmidt R" first="R E" last="Schmidt">R E Schmidt</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9233899</idno><idno type="pmid">9233899</idno><idno type="wicri:Area/PubMed/Corpus">000928</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000928</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Endocrine testicular function in HIV-infected outpatients.</title><author><name sortKey="Schurmeyer, T H" sort="Schurmeyer, T H" uniqKey="Schurmeyer T" first="T H" last="Schürmeyer">T H Schürmeyer</name><affiliation><nlm:affiliation>Herz-Jesu-Krankenhaus, Friedrich Wilhelm Str. 29, Trier D-54290, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Muller, V" sort="Muller, V" uniqKey="Muller V" first="V" last="Müller">V. Müller</name></author><author><name sortKey="Von Zur Muhlen, A" sort="Von Zur Muhlen, A" uniqKey="Von Zur Muhlen A" first="A" last="Von Zur Mühlen">A. Von Zur Mühlen</name></author><author><name sortKey="Schmidt, R E" sort="Schmidt, R E" uniqKey="Schmidt R" first="R E" last="Schmidt">R E Schmidt</name></author></analytic><series><title level="j">European journal of medical research</title><idno type="ISSN">0949-2321</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aldosterone (urine)</term><term>Analysis of Variance</term><term>CD4 Lymphocyte Count</term><term>Chi-Square Distribution</term><term>Dehydroepiandrosterone Sulfate (blood)</term><term>Estradiol (blood)</term><term>Follicle Stimulating Hormone (blood)</term><term>HIV Infections (blood)</term><term>HIV Infections (immunology)</term><term>HIV Infections (physiopathology)</term><term>Humans</term><term>Hydrocortisone (urine)</term><term>Male</term><term>Regression Analysis</term><term>Sex Hormone-Binding Globulin (analysis)</term><term>Testis (secretion)</term><term>Testosterone (blood)</term><term>Thyroxine (blood)</term><term>Triiodothyronine (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Sex Hormone-Binding Globulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Dehydroepiandrosterone Sulfate</term><term>Estradiol</term><term>Follicle Stimulating Hormone</term><term>Testosterone</term><term>Thyroxine</term><term>Triiodothyronine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Aldosterone</term><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="secretion" xml:lang="en"><term>Testis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>CD4 Lymphocyte Count</term><term>Chi-Square Distribution</term><term>Humans</term><term>Male</term><term>Regression Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated endocrine testicular function in 100 HIV-infected men who were grouped according to the CDC criteria. Progression of the disease was associated with a 27% decrease in plasma oestradiol, which was the only parameter that was weakly correlated with CD4 cell count (r = 0.312, p <0.05). Individual data showed a decreased plasma concentration of total and free testosterone in 35% and 26% of the subjects, respectively, but we could not demonstrate an increased frequency of hypogonadism going along with a progression of the stage of disease. There was no significant correlation between androgen, SHBG or FSH levels and duration of HIV-infection, BMI or CD4 cell count. Hypergonadotropic hypogonadism was associated with an euthyroid sick state in a 15% subgroup of patients reporting a decrease in libido. Plasma T3 was significantly correlated with testosterone (r = 0.419, p <0.01) and mean plasma T3 was significantly decreased in 8 subjects suffering from erectile impotence. Thus, hypogonadism occurs frequently in HIV-infected outpatients. Like euthyroid sickness it does not seem to be a predictor for progression of the disease but an indicator of actual state of health.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9233899</PMID><DateCreated><Year>1997</Year><Month>09</Month><Day>25</Day></DateCreated><DateCompleted><Year>1997</Year><Month>09</Month><Day>25</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0949-2321</ISSN><JournalIssue CitedMedium="Print"><Volume>2</Volume><Issue>7</Issue><PubDate><Year>1997</Year><Month>Jul</Month><Day>28</Day></PubDate></JournalIssue><Title>European journal of medical research</Title><ISOAbbreviation>Eur. J. Med. Res.</ISOAbbreviation></Journal><ArticleTitle>Endocrine testicular function in HIV-infected outpatients.</ArticleTitle><Pagination><MedlinePgn>275-81</MedlinePgn></Pagination><Abstract><AbstractText>We investigated endocrine testicular function in 100 HIV-infected men who were grouped according to the CDC criteria. Progression of the disease was associated with a 27% decrease in plasma oestradiol, which was the only parameter that was weakly correlated with CD4 cell count (r = 0.312, p <0.05). Individual data showed a decreased plasma concentration of total and free testosterone in 35% and 26% of the subjects, respectively, but we could not demonstrate an increased frequency of hypogonadism going along with a progression of the stage of disease. There was no significant correlation between androgen, SHBG or FSH levels and duration of HIV-infection, BMI or CD4 cell count. Hypergonadotropic hypogonadism was associated with an euthyroid sick state in a 15% subgroup of patients reporting a decrease in libido. Plasma T3 was significantly correlated with testosterone (r = 0.419, p <0.01) and mean plasma T3 was significantly decreased in 8 subjects suffering from erectile impotence. Thus, hypogonadism occurs frequently in HIV-infected outpatients. 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