Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, or L-ornithine.
Identifieur interne : 000868 ( PubMed/Corpus ); précédent : 000867; suivant : 000869Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, or L-ornithine.
Auteurs : K. Trier ; E B Olsen ; T. Kobayashi ; S M Ribel-MadsenSource :
- The British journal of ophthalmology [ 0007-1161 ] ; 1999.
English descriptors
- KwdEn :
- Acetazolamide (pharmacology), Amino Acids (metabolism), Animals, Collagen (metabolism), Female, Glycosaminoglycans (metabolism), Ornithine (pharmacology), Proteoglycans (metabolism), Rabbits, Sclera (drug effects), Sclera (metabolism), Sclera (ultrastructure), Theobromine (pharmacology), Uronic Acids (metabolism), Vasodilator Agents (pharmacology), Xanthines (pharmacology).
- MESH :
- chemical , metabolism : Amino Acids, Collagen, Glycosaminoglycans, Proteoglycans, Uronic Acids.
- chemical , pharmacology : Acetazolamide, Ornithine, Theobromine, Vasodilator Agents, Xanthines.
- drug effects : Sclera.
- metabolism : Sclera.
- ultrastructure : Sclera.
- Animals, Female, Rabbits.
Abstract
To examine a possible effect of 7-methylxanthine, theobromine, acetazolamide, or L-ornithine on the ultrastructure and biochemical composition of rabbit sclera.
PubMed: 10574816
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pubmed:10574816Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, or L-ornithine.</title><author><name sortKey="Trier, K" sort="Trier, K" uniqKey="Trier K" first="K" last="Trier">K. Trier</name><affiliation><nlm:affiliation>Trier Eye Clinic and Research Laboratories, Hellerup, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Olsen, E B" sort="Olsen, E B" uniqKey="Olsen E" first="E B" last="Olsen">E B Olsen</name></author><author><name sortKey="Kobayashi, T" sort="Kobayashi, T" uniqKey="Kobayashi T" first="T" last="Kobayashi">T. Kobayashi</name></author><author><name sortKey="Ribel Madsen, S M" sort="Ribel Madsen, S M" uniqKey="Ribel Madsen S" first="S M" last="Ribel-Madsen">S M Ribel-Madsen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10574816</idno><idno type="pmid">10574816</idno><idno type="wicri:Area/PubMed/Corpus">000868</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000868</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, or L-ornithine.</title><author><name sortKey="Trier, K" sort="Trier, K" uniqKey="Trier K" first="K" last="Trier">K. Trier</name><affiliation><nlm:affiliation>Trier Eye Clinic and Research Laboratories, Hellerup, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Olsen, E B" sort="Olsen, E B" uniqKey="Olsen E" first="E B" last="Olsen">E B Olsen</name></author><author><name sortKey="Kobayashi, T" sort="Kobayashi, T" uniqKey="Kobayashi T" first="T" last="Kobayashi">T. Kobayashi</name></author><author><name sortKey="Ribel Madsen, S M" sort="Ribel Madsen, S M" uniqKey="Ribel Madsen S" first="S M" last="Ribel-Madsen">S M Ribel-Madsen</name></author></analytic><series><title level="j">The British journal of ophthalmology</title><idno type="ISSN">0007-1161</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetazolamide (pharmacology)</term><term>Amino Acids (metabolism)</term><term>Animals</term><term>Collagen (metabolism)</term><term>Female</term><term>Glycosaminoglycans (metabolism)</term><term>Ornithine (pharmacology)</term><term>Proteoglycans (metabolism)</term><term>Rabbits</term><term>Sclera (drug effects)</term><term>Sclera (metabolism)</term><term>Sclera (ultrastructure)</term><term>Theobromine (pharmacology)</term><term>Uronic Acids (metabolism)</term><term>Vasodilator Agents (pharmacology)</term><term>Xanthines (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amino Acids</term><term>Collagen</term><term>Glycosaminoglycans</term><term>Proteoglycans</term><term>Uronic Acids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acetazolamide</term><term>Ornithine</term><term>Theobromine</term><term>Vasodilator Agents</term><term>Xanthines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Sclera</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Sclera</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Sclera</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Rabbits</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To examine a possible effect of 7-methylxanthine, theobromine, acetazolamide, or L-ornithine on the ultrastructure and biochemical composition of rabbit sclera.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10574816</PMID><DateCreated><Year>2000</Year><Month>01</Month><Day>28</Day></DateCreated><DateCompleted><Year>2000</Year><Month>01</Month><Day>28</Day></DateCompleted><DateRevised><Year>2014</Year><Month>06</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0007-1161</ISSN><JournalIssue CitedMedium="Print"><Volume>83</Volume><Issue>12</Issue><PubDate><Year>1999</Year><Month>Dec</Month></PubDate></JournalIssue><Title>The British journal of ophthalmology</Title><ISOAbbreviation>Br J Ophthalmol</ISOAbbreviation></Journal><ArticleTitle>Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, or L-ornithine.</ArticleTitle><Pagination><MedlinePgn>1370-5</MedlinePgn></Pagination><Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">To examine a possible effect of 7-methylxanthine, theobromine, acetazolamide, or L-ornithine on the ultrastructure and biochemical composition of rabbit sclera.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Groups of pigmented rabbits, six in each group, were dosed during 10 weeks with one of the substances under investigation, and one untreated group was the control. Samples of anterior and posterior sclera were taken for determination of hydroxyproline, hydroxylysine, proline, proteoglycans, uronic acids and dermatan sulphate, chondroitin sulphate, and hyaluronic acid. Sections were examined with electron microscopy, and the diameter of the individual collagen fibrils was measured.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Treatment with theobromine produced a significant increase in the contents of hydroxylysine, hydroxyproline, and proline in both anterior and posterior sclera, while 7-methylxanthine increased the contents of hydroxyproline and proline selectively in posterior sclera. Acetazolamide, on the other hand, significantly decreased the contents of hydroxyproline and proline in samples from anterior sclera. Uronic acids in both anterior and posterior sclera were significantly reduced by treatment with 7-methylxanthine, and L-ornithine significantly reduced uronic acids in posterior sclera. An inverse correlation between contents of hydroxyproline and uronic acids was found. The mean diameter of collagen fibrils was significantly higher in the posterior sclera from rabbits treated with 7-methylxanthine or theobromine, and significantly lower in rabbits treated with acetazolamide or L-ornithine compared with controls. In the anterior sclera, fibril diameter was significantly reduced in all treatment groups compared with controls. A positive, significant correlation between fibril diameter and content of hydroxyproline and proline was found in posterior sclera.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">7-Methylxanthine, a metabolite of caffeine, increases collagen concentration and the diameter of collagen fibrils in the posterior sclera, and may be useful for treatment or prevention of conditions associated with low level and/or inferior quality of scleral collagen, such as axial myopia, chronic open angle glaucoma, and possibly neovascular age related macular degeneration. The apparent loss of collagen induced by chronic treatment with acetazolamide should be taken into consideration as a potentially harmful side effect. These results may indicate that scleral biochemistry and ultrastructure are influenced by the retinal pigment epithelium. One possible explanation is that the scleral fibroblasts which produce the collagen are sensitive to changes in the physiological electric field created by the retinal pigment epithelium.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Trier</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Trier Eye Clinic and Research Laboratories, Hellerup, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsen</LastName><ForeName>E B</ForeName><Initials>EB</Initials></Author><Author ValidYN="Y"><LastName>Kobayashi</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Ribel-Madsen</LastName><ForeName>S M</ForeName><Initials>SM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br J Ophthalmol</MedlineTA><NlmUniqueID>0421041</NlmUniqueID><ISSNLinking>0007-1161</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000596">Amino Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006025">Glycosaminoglycans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011509">Proteoglycans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014574">Uronic Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014665">Vasodilator Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014970">Xanthines</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-34-5</RegistryNumber><NameOfSubstance UI="D003094">Collagen</NameOfSubstance></Chemical><Chemical><RegistryNumber>E524N2IXA3</RegistryNumber><NameOfSubstance UI="D009952">Ornithine</NameOfSubstance></Chemical><Chemical><RegistryNumber>E9M81NJM6G</RegistryNumber><NameOfSubstance UI="C064273">7-methylxanthine</NameOfSubstance></Chemical><Chemical><RegistryNumber>O3FX965V0I</RegistryNumber><NameOfSubstance UI="D000086">Acetazolamide</NameOfSubstance></Chemical><Chemical><RegistryNumber>OBD445WZ5P</RegistryNumber><NameOfSubstance UI="D013805">Theobromine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Anal Biochem. 1973 Aug;54(2):484-9</RefSource><PMID Version="1">4269305</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gen Pharmacol. 1997 Aug;29(2):181-96</RefSource><PMID Version="1">9251897</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Sci. 1985 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MajorTopicYN="N">Acetazolamide</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000596" MajorTopicYN="N">Amino Acids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003094" MajorTopicYN="N">Collagen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006025" MajorTopicYN="N">Glycosaminoglycans</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009952" MajorTopicYN="N">Ornithine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011509" MajorTopicYN="N">Proteoglycans</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012590" MajorTopicYN="N">Sclera</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013805" MajorTopicYN="N">Theobromine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014574" MajorTopicYN="N">Uronic Acids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014665" MajorTopicYN="N">Vasodilator Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014970" MajorTopicYN="N">Xanthines</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1722904</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>11</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>11</Month><Day>27</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>11</Month><Day>27</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10574816</ArticleId><ArticleId 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