Sex differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress.
Identifieur interne : 000818 ( PubMed/Corpus ); précédent : 000817; suivant : 000819Sex differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress.
Auteurs : N. Rohleder ; N C Schommer ; D H Hellhammer ; R. Engel ; C. KirschbaumSource :
- Psychosomatic medicine [ 0033-3174 ]
English descriptors
- KwdEn :
- Adult, Anti-Inflammatory Agents (pharmacokinetics), Body Mass Index, Cytokines (biosynthesis), Cytokines (immunology), Dexamethasone (pharmacokinetics), Female, Humans, Hydrocortisone (metabolism), Hypothalamo-Hypophyseal System (metabolism), Male, Pituitary-Adrenal System (metabolism), Sex Factors, Stress Disorders, Post-Traumatic (immunology), Stress Disorders, Post-Traumatic (metabolism).
- MESH :
- chemical , biosynthesis : Cytokines.
- chemical , immunology : Cytokines.
- chemical , metabolism : Hydrocortisone.
- chemical , pharmacokinetics : Anti-Inflammatory Agents, Dexamethasone.
- immunology : Stress Disorders, Post-Traumatic.
- metabolism : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress Disorders, Post-Traumatic.
- Adult, Body Mass Index, Female, Humans, Male, Sex Factors.
Abstract
Men and women show marked differences in susceptibility to disorders related to the immune system. These gender differences have been proposed to be mediated by functional interactions of the hypothalamus-pituitary-adrenal (HPA) and hypothalamus-pituitary-gonadal (HPG) axes. A potential mechanism involved in this interaction is the glucocorticoid (GC) sensitivity of relevant target tissues for GC. Therefore, the aim of the study reported here was to investigate the impact of psychosocial stress and HPA axis activation on the GC sensitivity of proinflammatory cytokine production in men and women.
PubMed: 11719636
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pubmed:11719636Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sex differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress.</title><author><name sortKey="Rohleder, N" sort="Rohleder, N" uniqKey="Rohleder N" first="N" last="Rohleder">N. Rohleder</name><affiliation><nlm:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schommer, N C" sort="Schommer, N C" uniqKey="Schommer N" first="N C" last="Schommer">N C Schommer</name></author><author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D H" last="Hellhammer">D H Hellhammer</name></author><author><name sortKey="Engel, R" sort="Engel, R" uniqKey="Engel R" first="R" last="Engel">R. Engel</name></author><author><name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C" last="Kirschbaum">C. Kirschbaum</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2001 Nov-Dec</MedlineDate></PubDate></date><idno type="RBID">pubmed:11719636</idno><idno type="pmid">11719636</idno><idno type="wicri:Area/PubMed/Corpus">000818</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000818</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Sex differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress.</title><author><name sortKey="Rohleder, N" sort="Rohleder, N" uniqKey="Rohleder N" first="N" last="Rohleder">N. Rohleder</name><affiliation><nlm:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schommer, N C" sort="Schommer, N C" uniqKey="Schommer N" first="N C" last="Schommer">N C Schommer</name></author><author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D H" last="Hellhammer">D H Hellhammer</name></author><author><name sortKey="Engel, R" sort="Engel, R" uniqKey="Engel R" first="R" last="Engel">R. Engel</name></author><author><name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C" last="Kirschbaum">C. Kirschbaum</name></author></analytic><series><title level="j">Psychosomatic medicine</title><idno type="ISSN">0033-3174</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anti-Inflammatory Agents (pharmacokinetics)</term><term>Body Mass Index</term><term>Cytokines (biosynthesis)</term><term>Cytokines (immunology)</term><term>Dexamethasone (pharmacokinetics)</term><term>Female</term><term>Humans</term><term>Hydrocortisone (metabolism)</term><term>Hypothalamo-Hypophyseal System (metabolism)</term><term>Male</term><term>Pituitary-Adrenal System (metabolism)</term><term>Sex Factors</term><term>Stress Disorders, Post-Traumatic (immunology)</term><term>Stress Disorders, Post-Traumatic (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Dexamethasone</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Stress Disorders, Post-Traumatic</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term><term>Stress Disorders, Post-Traumatic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Body Mass Index</term><term>Female</term><term>Humans</term><term>Male</term><term>Sex Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Men and women show marked differences in susceptibility to disorders related to the immune system. These gender differences have been proposed to be mediated by functional interactions of the hypothalamus-pituitary-adrenal (HPA) and hypothalamus-pituitary-gonadal (HPG) axes. A potential mechanism involved in this interaction is the glucocorticoid (GC) sensitivity of relevant target tissues for GC. Therefore, the aim of the study reported here was to investigate the impact of psychosocial stress and HPA axis activation on the GC sensitivity of proinflammatory cytokine production in men and women.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11719636</PMID><DateCreated><Year>2001</Year><Month>11</Month><Day>23</Day></DateCreated><DateCompleted><Year>2002</Year><Month>04</Month><Day>18</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0033-3174</ISSN><JournalIssue CitedMedium="Print"><Volume>63</Volume><Issue>6</Issue><PubDate><MedlineDate>2001 Nov-Dec</MedlineDate></PubDate></JournalIssue><Title>Psychosomatic medicine</Title><ISOAbbreviation>Psychosom Med</ISOAbbreviation></Journal><ArticleTitle>Sex differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress.</ArticleTitle><Pagination><MedlinePgn>966-72</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Men and women show marked differences in susceptibility to disorders related to the immune system. These gender differences have been proposed to be mediated by functional interactions of the hypothalamus-pituitary-adrenal (HPA) and hypothalamus-pituitary-gonadal (HPG) axes. A potential mechanism involved in this interaction is the glucocorticoid (GC) sensitivity of relevant target tissues for GC. Therefore, the aim of the study reported here was to investigate the impact of psychosocial stress and HPA axis activation on the GC sensitivity of proinflammatory cytokine production in men and women.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A total of 45 healthy subjects were investigated. Eighteen women in the luteal phase of their menstrual cycle and 27 men were exposed to a psychosocial stress test (Trier Social Stress Test). Salivary free cortisol levels were measured repeatedly after exposure to the stressor. GC sensitivity was assessed in vitro by dexamethasone inhibition of lipopolysaccharide-stimulated production of interleukin-6 and tumor necrosis factor-alpha.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The stress test induced significant increases in salivary free cortisol with no significant differences between men and women. In contrast, GC sensitivity and lipopolysaccharide-stimulated cytokine production showed large gender differences. In men GC sensitivity was markedly increased 1 hour after stress, whereas GC sensitivity decreased significantly in women. Similarly, lipopolysaccharide-induced cytokine production decreased in response to stress in men but increased in women.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results demonstrate that despite similar free cortisol responses of men and women (studied in the luteal phase) to psychosocial stress, gender may exert differential effects on the immune system by modulating GC sensitivity of proinflammatory cytokine production.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rohleder</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schommer</LastName><ForeName>N C</ForeName><Initials>NC</Initials></Author><Author ValidYN="Y"><LastName>Hellhammer</LastName><ForeName>D H</ForeName><Initials>DH</Initials></Author><Author ValidYN="Y"><LastName>Engel</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Kirschbaum</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Psychosom Med</MedlineTA><NlmUniqueID>0376505</NlmUniqueID><ISSNLinking>0033-3174</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>7S5I7G3JQL</RegistryNumber><NameOfSubstance UI="D003907">Dexamethasone</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015992" MajorTopicYN="N">Body Mass Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003907" MajorTopicYN="N">Dexamethasone</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007030" MajorTopicYN="N">Hypothalamo-Hypophyseal System</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010913" MajorTopicYN="N">Pituitary-Adrenal System</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013313" MajorTopicYN="N">Stress Disorders, Post-Traumatic</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>11</Month><Day>24</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>4</Month><Day>19</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>11</Month><Day>24</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11719636</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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