Habituation of cortisol responses to repeated psychosocial stress-further characterization and impact of genetic factors.
Identifieur interne : 000719 ( PubMed/Corpus ); précédent : 000718; suivant : 000720Habituation of cortisol responses to repeated psychosocial stress-further characterization and impact of genetic factors.
Auteurs : Stefan Wüst ; Ilona S. Federenko ; Elisabeth F C. Van Rossum ; Jan W. Koper ; Dirk H. HellhammerSource :
- Psychoneuroendocrinology [ 0306-4530 ] ; 2005.
English descriptors
- KwdEn :
- Adaptation, Physiological (genetics), Adolescent, Adrenocorticotropic Hormone (blood), Adult, Area Under Curve, Habituation, Psychophysiologic (physiology), Humans, Hydrocortisone (analysis), Hydrocortisone (blood), Hypothalamo-Hypophyseal System (physiology), Individuality, Male, Pituitary-Adrenal System (physiology), Polymorphism, Genetic, Receptors, Glucocorticoid (genetics), Saliva (chemistry), Stimulation, Chemical, Stress, Psychological (blood), Stress, Psychological (genetics), Twins, Dizygotic, Twins, Monozygotic.
- MESH :
- chemical , analysis : Hydrocortisone.
- chemical , blood : Adrenocorticotropic Hormone, Hydrocortisone.
- blood : Stress, Psychological.
- chemistry : Saliva.
- genetics : Adaptation, Physiological, Receptors, Glucocorticoid, Stress, Psychological.
- physiology : Habituation, Psychophysiologic, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- Adolescent, Adult, Area Under Curve, Humans, Individuality, Male, Polymorphism, Genetic, Stimulation, Chemical, Twins, Dizygotic, Twins, Monozygotic.
Abstract
Although a rapid response habituation to repeated stress exposure is a key characteristic of the hypothalamus-pituitary-adrenal (HPA) axis, several studies document a substantial inter-individual variability of such HPA response patterns. In order to further investigate the individual differences in the habituation of this important neuroendocrine system to psychosocial stress, 54 male twin pairs were exposed to moderate psychosocial stress on three occasions, each exposure separated by a 1-week interval. Additionally, an ACTH(1-24) stimulation test (1 microg) and a dexamethasone suppression test (0.5mg) were performed. Although on average the expected decrease of mean cortisol and ACTH responses across stress exposures was observed, only 52% of the subjects showed this well-documented general decline and almost 16% of the participants even showed a response sensitization across sessions. Furthermore, a weak habituation was related to low cortisol responses to both the first stress exposure as well as the ACTH challenge. Moreover, genetic analyses did not reveal any evidence for a substantial heritability of the individual cortisol response habituation or an association between this habituation and two common polymorphisms in the glucocorticoid receptor gene.
DOI: 10.1016/j.psyneuen.2004.07.002
PubMed: 15471617
Links to Exploration step
pubmed:15471617Le document en format XML
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Koper</name></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15471617</idno><idno type="pmid">15471617</idno><idno type="doi">10.1016/j.psyneuen.2004.07.002</idno><idno type="wicri:Area/PubMed/Corpus">000719</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000719</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Habituation of cortisol responses to repeated psychosocial stress-further characterization and impact of genetic factors.</title><author><name sortKey="Wust, Stefan" sort="Wust, Stefan" uniqKey="Wust S" first="Stefan" last="Wüst">Stefan Wüst</name><affiliation><nlm:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany. wuest@uni.tri.de</nlm:affiliation></affiliation></author><author><name sortKey="Federenko, Ilona S" sort="Federenko, Ilona S" uniqKey="Federenko I" first="Ilona S" last="Federenko">Ilona S. Federenko</name></author><author><name sortKey="Van Rossum, Elisabeth F C" sort="Van Rossum, Elisabeth F C" uniqKey="Van Rossum E" first="Elisabeth F C" last="Van Rossum">Elisabeth F C. Van Rossum</name></author><author><name sortKey="Koper, Jan W" sort="Koper, Jan W" uniqKey="Koper J" first="Jan W" last="Koper">Jan W. Koper</name></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name></author></analytic><series><title level="j">Psychoneuroendocrinology</title><idno type="ISSN">0306-4530</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (genetics)</term><term>Adolescent</term><term>Adrenocorticotropic Hormone (blood)</term><term>Adult</term><term>Area Under Curve</term><term>Habituation, Psychophysiologic (physiology)</term><term>Humans</term><term>Hydrocortisone (analysis)</term><term>Hydrocortisone (blood)</term><term>Hypothalamo-Hypophyseal System (physiology)</term><term>Individuality</term><term>Male</term><term>Pituitary-Adrenal System (physiology)</term><term>Polymorphism, Genetic</term><term>Receptors, Glucocorticoid (genetics)</term><term>Saliva (chemistry)</term><term>Stimulation, Chemical</term><term>Stress, Psychological (blood)</term><term>Stress, Psychological (genetics)</term><term>Twins, Dizygotic</term><term>Twins, Monozygotic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adaptation, Physiological</term><term>Receptors, Glucocorticoid</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Habituation, Psychophysiologic</term><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Area Under Curve</term><term>Humans</term><term>Individuality</term><term>Male</term><term>Polymorphism, Genetic</term><term>Stimulation, Chemical</term><term>Twins, Dizygotic</term><term>Twins, Monozygotic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although a rapid response habituation to repeated stress exposure is a key characteristic of the hypothalamus-pituitary-adrenal (HPA) axis, several studies document a substantial inter-individual variability of such HPA response patterns. In order to further investigate the individual differences in the habituation of this important neuroendocrine system to psychosocial stress, 54 male twin pairs were exposed to moderate psychosocial stress on three occasions, each exposure separated by a 1-week interval. Additionally, an ACTH(1-24) stimulation test (1 microg) and a dexamethasone suppression test (0.5mg) were performed. Although on average the expected decrease of mean cortisol and ACTH responses across stress exposures was observed, only 52% of the subjects showed this well-documented general decline and almost 16% of the participants even showed a response sensitization across sessions. Furthermore, a weak habituation was related to low cortisol responses to both the first stress exposure as well as the ACTH challenge. Moreover, genetic analyses did not reveal any evidence for a substantial heritability of the individual cortisol response habituation or an association between this habituation and two common polymorphisms in the glucocorticoid receptor gene.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15471617</PMID><DateCreated><Year>2004</Year><Month>10</Month><Day>08</Day></DateCreated><DateCompleted><Year>2005</Year><Month>01</Month><Day>25</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0306-4530</ISSN><JournalIssue CitedMedium="Print"><Volume>30</Volume><Issue>2</Issue><PubDate><Year>2005</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Psychoneuroendocrinology</Title><ISOAbbreviation>Psychoneuroendocrinology</ISOAbbreviation></Journal><ArticleTitle>Habituation of cortisol responses to repeated psychosocial stress-further characterization and impact of genetic factors.</ArticleTitle><Pagination><MedlinePgn>199-211</MedlinePgn></Pagination><Abstract><AbstractText>Although a rapid response habituation to repeated stress exposure is a key characteristic of the hypothalamus-pituitary-adrenal (HPA) axis, several studies document a substantial inter-individual variability of such HPA response patterns. In order to further investigate the individual differences in the habituation of this important neuroendocrine system to psychosocial stress, 54 male twin pairs were exposed to moderate psychosocial stress on three occasions, each exposure separated by a 1-week interval. Additionally, an ACTH(1-24) stimulation test (1 microg) and a dexamethasone suppression test (0.5mg) were performed. Although on average the expected decrease of mean cortisol and ACTH responses across stress exposures was observed, only 52% of the subjects showed this well-documented general decline and almost 16% of the participants even showed a response sensitization across sessions. Furthermore, a weak habituation was related to low cortisol responses to both the first stress exposure as well as the ACTH challenge. Moreover, genetic analyses did not reveal any evidence for a substantial heritability of the individual cortisol response habituation or an association between this habituation and two common polymorphisms in the glucocorticoid receptor gene.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wüst</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany. wuest@uni.tri.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Federenko</LastName><ForeName>Ilona S</ForeName><Initials>IS</Initials></Author><Author ValidYN="Y"><LastName>van Rossum</LastName><ForeName>Elisabeth F C</ForeName><Initials>EF</Initials></Author><Author ValidYN="Y"><LastName>Koper</LastName><ForeName>Jan W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Hellhammer</LastName><ForeName>Dirk 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