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[Low-grade-/high-grade-synovitis: synovitis-score as a gold standard?].

Identifieur interne : 000677 ( PubMed/Corpus ); précédent : 000676; suivant : 000678

[Low-grade-/high-grade-synovitis: synovitis-score as a gold standard?].

Auteurs : V. Krenn ; L. Morawietz ; B. König ; M. Otto ; J. Kriegsmann ; A. Köpenik ; T. Böhme ; T. H Upl

Source :

RBID : pubmed:16819616

English descriptors

Abstract

Synovectomy specimens represent important material submitted from the orthopedist to the pathologist. However, no consistent histopathological grading system for chronic synovitis has been established so far.

DOI: 10.1007/s00132-006-0987-x
PubMed: 16819616

Links to Exploration step

pubmed:16819616

Le document en format XML

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<name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. Krenn</name>
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<nlm:affiliation>Institut für Pathologie, Moltkestrasse 32, 54292 Trier. krenn@patho-trier.de</nlm:affiliation>
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<name sortKey="Morawietz, L" sort="Morawietz, L" uniqKey="Morawietz L" first="L" last="Morawietz">L. Morawietz</name>
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<name sortKey="Konig, B" sort="Konig, B" uniqKey="Konig B" first="B" last="König">B. König</name>
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<name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M" last="Otto">M. Otto</name>
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<name sortKey="Kriegsmann, J" sort="Kriegsmann, J" uniqKey="Kriegsmann J" first="J" last="Kriegsmann">J. Kriegsmann</name>
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<name sortKey="H Upl, T" sort="H Upl, T" uniqKey="H Upl T" first="T" last="H Upl">T. H Upl</name>
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<div type="abstract" xml:lang="en">Synovectomy specimens represent important material submitted from the orthopedist to the pathologist. However, no consistent histopathological grading system for chronic synovitis has been established so far.</div>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Synovectomy specimens represent important material submitted from the orthopedist to the pathologist. However, no consistent histopathological grading system for chronic synovitis has been established so far.</AbstractText>
<AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">The three compartments of chronic synovitis (enlargement of lining cell layer, density of synovial stroma cells, leukocytic infiltrate) are graded semiquantitatively (from 0=absent to 3=strong), and the points for each compartment add up to the synovitis score: 0-1 = no synovitis, 2-4 = low-grade synovitis, 5-9 = high-grade synovitis. A total of 618 synovial specimens (resections n=559, biopsies n=59) from degenerative and inflammatory joint diseases were graded by two independent observers.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Median synovitis scores when correlated to clinical diagnoses were: 1, control; 2, osteoarthritis and post-traumatic arthritis; 3, psoriatic arthritis; 5, reactive and rheumatoid arthritis. The differences between rheumatic and non-rheumatic diseases were significant (p<0.001). The correlation between the two observers was high (p<0.001).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The proposed synovitis score enables stratification of chronic synovitis into low-grade (score 2-4) and high-grade (score >4), which is correlated to the nature of the disease (low-grade to non-rheumatic, high-grade to rheumatic), and it therefore contributes to the diagnosis of rheumatic and non-rheumatic joint diseases.</AbstractText>
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