Synovitis score: discrimination between chronic low-grade and high-grade synovitis.
Identifieur interne : 000673 ( PubMed/Corpus ); précédent : 000672; suivant : 000674Synovitis score: discrimination between chronic low-grade and high-grade synovitis.
Auteurs : V. Krenn ; L. Morawietz ; G-R Burmester ; R W Kinne ; U. Mueller-Ladner ; B. Muller ; T. HauplSource :
- Histopathology [ 0309-0167 ] ; 2006.
English descriptors
- KwdEn :
- MESH :
- classification : Synovitis.
- diagnosis : Joint Diseases.
- immunology : Synovial Membrane.
- pathology : Synovial Membrane, Synovitis.
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity.
Abstract
To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non-rheumatic joint diseases.
DOI: 10.1111/j.1365-2559.2006.02508.x
PubMed: 16978198
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Mueller-Ladner</name></author><author><name sortKey="Muller, B" sort="Muller, B" uniqKey="Muller B" first="B" last="Muller">B. Muller</name></author><author><name sortKey="Haupl, T" sort="Haupl, T" uniqKey="Haupl T" first="T" last="Haupl">T. Haupl</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16978198</idno><idno type="pmid">16978198</idno><idno type="doi">10.1111/j.1365-2559.2006.02508.x</idno><idno type="wicri:Area/PubMed/Corpus">000673</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000673</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Synovitis score: discrimination between chronic low-grade and high-grade synovitis.</title><author><name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. Krenn</name><affiliation><nlm:affiliation>Institute for Pathology, Trier, and Department for Rheumatology, Charité University Hospital, Berlin, Germany. krenn@patho-trier.de</nlm:affiliation></affiliation></author><author><name sortKey="Morawietz, L" sort="Morawietz, L" uniqKey="Morawietz L" first="L" last="Morawietz">L. Morawietz</name></author><author><name sortKey="Burmester, G R" sort="Burmester, G R" uniqKey="Burmester G" first="G-R" last="Burmester">G-R Burmester</name></author><author><name sortKey="Kinne, R W" sort="Kinne, R W" uniqKey="Kinne R" first="R W" last="Kinne">R W Kinne</name></author><author><name sortKey="Mueller Ladner, U" sort="Mueller Ladner, U" uniqKey="Mueller Ladner U" first="U" last="Mueller-Ladner">U. Mueller-Ladner</name></author><author><name sortKey="Muller, B" sort="Muller, B" uniqKey="Muller B" first="B" last="Muller">B. Muller</name></author><author><name sortKey="Haupl, T" sort="Haupl, T" uniqKey="Haupl T" first="T" last="Haupl">T. Haupl</name></author></analytic><series><title level="j">Histopathology</title><idno type="ISSN">0309-0167</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Joint Diseases (diagnosis)</term><term>Male</term><term>Middle Aged</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Synovial Membrane (immunology)</term><term>Synovial Membrane (pathology)</term><term>Synovitis (classification)</term><term>Synovitis (pathology)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Synovitis</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Joint Diseases</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Synovial Membrane</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Synovial Membrane</term><term>Synovitis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non-rheumatic joint diseases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16978198</PMID><DateCreated><Year>2006</Year><Month>09</Month><Day>18</Day></DateCreated><DateCompleted><Year>2006</Year><Month>11</Month><Day>14</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0309-0167</ISSN><JournalIssue CitedMedium="Print"><Volume>49</Volume><Issue>4</Issue><PubDate><Year>2006</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Histopathology</Title><ISOAbbreviation>Histopathology</ISOAbbreviation></Journal><ArticleTitle>Synovitis score: discrimination between chronic low-grade and high-grade synovitis.</ArticleTitle><Pagination><MedlinePgn>358-64</MedlinePgn></Pagination><Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non-rheumatic joint diseases.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Three features of chronic synovitis (enlargement of lining cell layer, cellular density of synovial stroma, leukocytic infiltrate) were semiquantitatively evaluated (from 0, absent to 3, strong) and each feature was graded separately. The sum provided the synovitis score, which was interpreted as follows: 0-1, no synovitis; 2-4, low-grade synovitis; 5-9, high-grade synovitis. Five hundred and fifty-nine synovectomy specimens were graded by two independent observers. Clinical diagnoses were osteoarthrosis (n=212), post-traumatic arthritis (n=21), rheumatoid arthritis (n=246), psoriatic arthritis (n=22), reactive arthritis (n=9), as well as controls (n=49) from autopsies of patients without joint damage. Median synovitis scores when correlated with clinical diagnoses were: controls 1.0, osteoarthritis 2.0, post-traumatic arthritis 2.0, psoriatic arthritis 3.5, reactive arthritis 5.0 and rheumatoid arthritis 5.0. The scores differed significantly between most disease groups, especially between degenerative and rheumatic diseases. A high-grade synovitis was strongly associated with rheumatic joint diseases (P<0.001, sensitivity 61.7%, specificity 96.1%). The correlation between the two observers was high (r=0.941).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The proposed synovitis score is based on well-defined, reproducible histopathological criteria and may contribute to diagnosis in rheumatic and non-rheumatic joint diseases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krenn</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institute for Pathology, Trier, and Department for Rheumatology, Charité University Hospital, Berlin, Germany. krenn@patho-trier.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morawietz</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Burmester</LastName><ForeName>G-R</ForeName><Initials>GR</Initials></Author><Author ValidYN="Y"><LastName>Kinne</LastName><ForeName>R W</ForeName><Initials>RW</Initials></Author><Author ValidYN="Y"><LastName>Mueller-Ladner</LastName><ForeName>U</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Muller</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Haupl</LastName><ForeName>T</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Histopathology</MedlineTA><NlmUniqueID>7704136</NlmUniqueID><ISSNLinking>0309-0167</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007592" MajorTopicYN="N">Joint Diseases</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013583" MajorTopicYN="N">Synovial Membrane</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013585" MajorTopicYN="N">Synovitis</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>9</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>11</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>9</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16978198</ArticleId><ArticleId IdType="pii">HIS2508</ArticleId><ArticleId IdType="doi">10.1111/j.1365-2559.2006.02508.x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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