The low-dose dexamethasone suppression test in fibromyalgia.
Identifieur interne : 000659 ( PubMed/Corpus ); précédent : 000658; suivant : 000660The low-dose dexamethasone suppression test in fibromyalgia.
Auteurs : Katja Wingenfeld ; Dieter Wagner ; Iris Schmidt ; Gunther Meinlschmidt ; Dirk H. Hellhammer ; Christine HeimSource :
- Journal of psychosomatic research [ 0022-3999 ] ; 2007.
English descriptors
- KwdEn :
- Adrenocorticotropic Hormone (blood), Adult, Anxiety (blood), Anxiety (psychology), Biofeedback, Psychology (physiology), Depression (blood), Depression (psychology), Dexamethasone (administration & dosage), Dose-Response Relationship, Drug, Fatigue (blood), Fatigue (psychology), Female, Fibromyalgia (blood), Fibromyalgia (psychology), Humans, Hydrocortisone (blood), Hypothalamo-Hypophyseal System (physiopathology), Middle Aged, Pain (blood), Pain (psychology), Pituitary-Adrenal System (physiopathology).
- MESH :
- chemical , administration & dosage : Dexamethasone.
- chemical , blood : Adrenocorticotropic Hormone, Hydrocortisone.
- blood : Anxiety, Depression, Fatigue, Fibromyalgia, Pain.
- physiology : Biofeedback, Psychology.
- physiopathology : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- psychology : Anxiety, Depression, Fatigue, Fibromyalgia, Pain.
- Adult, Dose-Response Relationship, Drug, Female, Humans, Middle Aged.
Abstract
Fibromyalgia syndrome (FMS) has been associated with decreased cortisol secretion. Patients with posttraumatic stress disorder (PTSD) exhibit similar hypocortisolism in the context of increased negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis. Because trauma and PTSD have been associated with fibromyalgia, we evaluated whether patients with fibromyalgia demonstrate increased HPA feedback sensitivity.
DOI: 10.1016/j.jpsychores.2006.06.006
PubMed: 17188125
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pubmed:17188125Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The low-dose dexamethasone suppression test in fibromyalgia.</title><author><name sortKey="Wingenfeld, Katja" sort="Wingenfeld, Katja" uniqKey="Wingenfeld K" first="Katja" last="Wingenfeld">Katja Wingenfeld</name><affiliation><nlm:affiliation>Department of Psychobiology, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wagner, Dieter" sort="Wagner, Dieter" uniqKey="Wagner D" first="Dieter" last="Wagner">Dieter Wagner</name></author><author><name sortKey="Schmidt, Iris" sort="Schmidt, Iris" uniqKey="Schmidt I" first="Iris" last="Schmidt">Iris Schmidt</name></author><author><name sortKey="Meinlschmidt, Gunther" sort="Meinlschmidt, Gunther" uniqKey="Meinlschmidt G" first="Gunther" last="Meinlschmidt">Gunther Meinlschmidt</name></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name></author><author><name sortKey="Heim, Christine" sort="Heim, Christine" uniqKey="Heim C" first="Christine" last="Heim">Christine Heim</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17188125</idno><idno type="pmid">17188125</idno><idno type="doi">10.1016/j.jpsychores.2006.06.006</idno><idno type="wicri:Area/PubMed/Corpus">000659</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000659</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The low-dose dexamethasone suppression test in fibromyalgia.</title><author><name sortKey="Wingenfeld, Katja" sort="Wingenfeld, Katja" uniqKey="Wingenfeld K" first="Katja" last="Wingenfeld">Katja Wingenfeld</name><affiliation><nlm:affiliation>Department of Psychobiology, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wagner, Dieter" sort="Wagner, Dieter" uniqKey="Wagner D" first="Dieter" last="Wagner">Dieter Wagner</name></author><author><name sortKey="Schmidt, Iris" sort="Schmidt, Iris" uniqKey="Schmidt I" first="Iris" last="Schmidt">Iris Schmidt</name></author><author><name sortKey="Meinlschmidt, Gunther" sort="Meinlschmidt, Gunther" uniqKey="Meinlschmidt G" first="Gunther" last="Meinlschmidt">Gunther Meinlschmidt</name></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name></author><author><name sortKey="Heim, Christine" sort="Heim, Christine" uniqKey="Heim C" first="Christine" last="Heim">Christine Heim</name></author></analytic><series><title level="j">Journal of psychosomatic research</title><idno type="ISSN">0022-3999</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenocorticotropic Hormone (blood)</term><term>Adult</term><term>Anxiety (blood)</term><term>Anxiety (psychology)</term><term>Biofeedback, Psychology (physiology)</term><term>Depression (blood)</term><term>Depression (psychology)</term><term>Dexamethasone (administration & dosage)</term><term>Dose-Response Relationship, Drug</term><term>Fatigue (blood)</term><term>Fatigue (psychology)</term><term>Female</term><term>Fibromyalgia (blood)</term><term>Fibromyalgia (psychology)</term><term>Humans</term><term>Hydrocortisone (blood)</term><term>Hypothalamo-Hypophyseal System (physiopathology)</term><term>Middle Aged</term><term>Pain (blood)</term><term>Pain (psychology)</term><term>Pituitary-Adrenal System (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Dexamethasone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Anxiety</term><term>Depression</term><term>Fatigue</term><term>Fibromyalgia</term><term>Pain</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Biofeedback, Psychology</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Anxiety</term><term>Depression</term><term>Fatigue</term><term>Fibromyalgia</term><term>Pain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Humans</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fibromyalgia syndrome (FMS) has been associated with decreased cortisol secretion. Patients with posttraumatic stress disorder (PTSD) exhibit similar hypocortisolism in the context of increased negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis. Because trauma and PTSD have been associated with fibromyalgia, we evaluated whether patients with fibromyalgia demonstrate increased HPA feedback sensitivity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17188125</PMID><DateCreated><Year>2006</Year><Month>12</Month><Day>25</Day></DateCreated><DateCompleted><Year>2007</Year><Month>03</Month><Day>14</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3999</ISSN><JournalIssue CitedMedium="Print"><Volume>62</Volume><Issue>1</Issue><PubDate><Year>2007</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Journal of psychosomatic research</Title><ISOAbbreviation>J Psychosom Res</ISOAbbreviation></Journal><ArticleTitle>The low-dose dexamethasone suppression test in fibromyalgia.</ArticleTitle><Pagination><MedlinePgn>85-91</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Fibromyalgia syndrome (FMS) has been associated with decreased cortisol secretion. Patients with posttraumatic stress disorder (PTSD) exhibit similar hypocortisolism in the context of increased negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis. Because trauma and PTSD have been associated with fibromyalgia, we evaluated whether patients with fibromyalgia demonstrate increased HPA feedback sensitivity.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">Baseline blood samples were obtained at 0800 h, and 0.5 mg of dexamethasone was administered to 15 female patients with FMS and 20 normal controls at 2300 h. Adrenocorticotropin (ACTH), cortisol, and dexamethasone levels were measured at 0800 h after dexamethasone intake.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There were no group differences in mean ACTH or cortisol levels or in ACTH/cortisol ratio at baseline. After dexamethasone intake, patients with FMS exhibited more pronounced suppression of cortisol but not of ACTH, as well as increased ACTH/cortisol ratios compared with controls. Percent cortisol suppression was associated with pain and fatigue, while ACTH/cortisol ratio and dexamethasone availability were associated with stress and anxiety measures.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our results suggest increased sensitivity to glucocorticoid feedback, manifested at the adrenal level, in FMS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wingenfeld</LastName><ForeName>Katja</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Psychobiology, University of Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wagner</LastName><ForeName>Dieter</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Iris</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Meinlschmidt</LastName><ForeName>Gunther</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Hellhammer</LastName><ForeName>Dirk H</ForeName><Initials>DH</Initials></Author><Author ValidYN="Y"><LastName>Heim</LastName><ForeName>Christine</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Psychosom Res</MedlineTA><NlmUniqueID>0376333</NlmUniqueID><ISSNLinking>0022-3999</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>7S5I7G3JQL</RegistryNumber><NameOfSubstance UI="D003907">Dexamethasone</NameOfSubstance></Chemical><Chemical><RegistryNumber>9002-60-2</RegistryNumber><NameOfSubstance UI="D000324">Adrenocorticotropic Hormone</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000324" MajorTopicYN="N">Adrenocorticotropic Hormone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001007" MajorTopicYN="N">Anxiety</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001676" MajorTopicYN="N">Biofeedback, Psychology</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003907" MajorTopicYN="Y">Dexamethasone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005221" MajorTopicYN="N">Fatigue</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005356" MajorTopicYN="N">Fibromyalgia</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007030" MajorTopicYN="N">Hypothalamo-Hypophyseal System</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010146" MajorTopicYN="N">Pain</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010913" MajorTopicYN="N">Pituitary-Adrenal System</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>10</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2006</Year><Month>04</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2006</Year><Month>06</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>12</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>3</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>12</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17188125</ArticleId><ArticleId IdType="pii">S0022-3999(06)00329-1</ArticleId><ArticleId 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