UnivTrevesV1, PubMed, Corpus, bibRecord, 000615

Inhibition of cortisol production by metyrapone enhances trace, but not delay, eyeblink conditioning.

Identifieur interne : 000615 ( PubMed/Corpus ); précédent : 000614; suivant : 000616

Inhibition of cortisol production by metyrapone enhances trace, but not delay, eyeblink conditioning.

Auteurs : Frauke Nees ; Steffen Richter ; Johanna Lass-Hennemann ; Terry D. Blumenthal ; Hartmut Sch Chinger

Source :

Psychopharmacology [ 0033-3158 ] ; 2008.

RBID : pubmed:18478206

English descriptors

KwdEn :
- Adult, Antimetabolites (pharmacology), Cerebellum (physiology), Circadian Rhythm (drug effects), Conditioning, Eyelid (drug effects), Electromyography, Female, Humans, Hydrocortisone (antagonists & inhibitors), Hydrocortisone (metabolism), Male, Metyrapone (pharmacology), Patch-Clamp Techniques, Saliva (metabolism), Young Adult.
MESH :
- chemical , antagonists & inhibitors : Hydrocortisone.
- chemical , metabolism : Hydrocortisone.
- chemical , pharmacology : Antimetabolites, Metyrapone.
- drug effects : Circadian Rhythm, Conditioning, Eyelid.
- metabolism : Saliva.
- physiology : Cerebellum.
- Adult, Electromyography, Female, Humans, Male, Patch-Clamp Techniques, Young Adult.

Abstract

Hypercortisolism [ corrected] impairs trace classical conditioning of the eyeblink response to an air puff but does not affect delay conditioning.

DOI: 10.1007/s00213-008-1155-2
PubMed: 18478206

Links to Exploration step

pubmed:18478206

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inhibition of cortisol production by metyrapone enhances trace, but not delay, eyeblink conditioning.</title>
<author><name sortKey="Nees, Frauke" sort="Nees, Frauke" uniqKey="Nees F" first="Frauke" last="Nees">Frauke Nees</name>
<affiliation><nlm:affiliation>Institute of Psychobiology, University of Trier, Trier, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Richter, Steffen" sort="Richter, Steffen" uniqKey="Richter S" first="Steffen" last="Richter">Steffen Richter</name>
</author>
<author><name sortKey="Lass Hennemann, Johanna" sort="Lass Hennemann, Johanna" uniqKey="Lass Hennemann J" first="Johanna" last="Lass-Hennemann">Johanna Lass-Hennemann</name>
</author>
<author><name sortKey="Blumenthal, Terry D" sort="Blumenthal, Terry D" uniqKey="Blumenthal T" first="Terry D" last="Blumenthal">Terry D. Blumenthal</name>
</author>
<author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name>
</author>
</titleStmt>
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<date when="2008">2008</date>
<idno type="RBID">pubmed:18478206</idno>
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<idno type="doi">10.1007/s00213-008-1155-2</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Inhibition of cortisol production by metyrapone enhances trace, but not delay, eyeblink conditioning.</title>
<author><name sortKey="Nees, Frauke" sort="Nees, Frauke" uniqKey="Nees F" first="Frauke" last="Nees">Frauke Nees</name>
<affiliation><nlm:affiliation>Institute of Psychobiology, University of Trier, Trier, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Richter, Steffen" sort="Richter, Steffen" uniqKey="Richter S" first="Steffen" last="Richter">Steffen Richter</name>
</author>
<author><name sortKey="Lass Hennemann, Johanna" sort="Lass Hennemann, Johanna" uniqKey="Lass Hennemann J" first="Johanna" last="Lass-Hennemann">Johanna Lass-Hennemann</name>
</author>
<author><name sortKey="Blumenthal, Terry D" sort="Blumenthal, Terry D" uniqKey="Blumenthal T" first="Terry D" last="Blumenthal">Terry D. Blumenthal</name>
</author>
<author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name>
</author>
</analytic>
<series><title level="j">Psychopharmacology</title>
<idno type="ISSN">0033-3158</idno>
<imprint><date when="2008" type="published">2008</date>
</imprint>
</series>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Antimetabolites (pharmacology)</term>
<term>Cerebellum (physiology)</term>
<term>Circadian Rhythm (drug effects)</term>
<term>Conditioning, Eyelid (drug effects)</term>
<term>Electromyography</term>
<term>Female</term>
<term>Humans</term>
<term>Hydrocortisone (antagonists & inhibitors)</term>
<term>Hydrocortisone (metabolism)</term>
<term>Male</term>
<term>Metyrapone (pharmacology)</term>
<term>Patch-Clamp Techniques</term>
<term>Saliva (metabolism)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimetabolites</term>
<term>Metyrapone</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Circadian Rhythm</term>
<term>Conditioning, Eyelid</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saliva</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebellum</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Electromyography</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Patch-Clamp Techniques</term>
<term>Young Adult</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Hypercortisolism [ corrected] impairs trace classical conditioning of the eyeblink response to an air puff but does not affect delay conditioning.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18478206</PMID>
<DateCreated><Year>2008</Year>
<Month>07</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted><Year>2008</Year>
<Month>12</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0033-3158</ISSN>
<JournalIssue CitedMedium="Print"><Volume>199</Volume>
<Issue>2</Issue>
<PubDate><Year>2008</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Psychopharmacology</Title>
<ISOAbbreviation>Psychopharmacology (Berl.)</ISOAbbreviation>
</Journal>
<ArticleTitle>Inhibition of cortisol production by metyrapone enhances trace, but not delay, eyeblink conditioning.</ArticleTitle>
<Pagination><MedlinePgn>183-90</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00213-008-1155-2</ELocationID>
<Abstract><AbstractText Label="RATIONALE" NlmCategory="BACKGROUND">Hypercortisolism [ corrected] impairs trace classical conditioning of the eyeblink response to an air puff but does not affect delay conditioning.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The opposite neurohormonal condition, hypocortisolism, may facilitate trace classical conditioning, which might be informative in understanding the role of classical conditioning in stress-sensitive syndromes such as fibromyalgia.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Volunteers (n = 82) were randomized to receive either an inhibitor of cortisol production (metyrapone, 1500 mg) or placebo and to complete a delay or a trace eyeblink conditioning protocol (unconditioned stimulus: corneal air puff, 10 psi, 50 ms; conditioned stimulus: binaural pure tone, 75 dB, 1000 Hz, 400 ms; empty interval in trace conditioning: 600 ms), where conditioned eyeblink response probability was assessed electromyographically.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Metyrapone induced hypocortisolism, reflected by a 30% decrease of salivary cortisol levels (p < 0.01), and facilitated trace eyeblink conditioning (p < 0.001), while delay eyeblink conditioning remained unaffected. Moreover, extinction of delay-conditioned eyeblink responses was impaired (p = 0.023), but extinction of trace-conditioned responses remained unaffected.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We conclude that acute mild metyrapone-induced hypocortisolism facilitates hippocampus-mediated classical trace eyeblink conditioning but suppresses the extinction of cerebellum-based delay-conditioned responses. Both results may be of theoretical and clinical significance for the generation and persistence of psychosomatic symptoms in patient groups characterized by relative hypocortisolism (e.g., fibromyalgia and chronic fatigue).</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nees</LastName>
<ForeName>Frauke</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Institute of Psychobiology, University of Trier, Trier, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Richter</LastName>
<ForeName>Steffen</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lass-Hennemann</LastName>
<ForeName>Johanna</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Blumenthal</LastName>
<ForeName>Terry D</ForeName>
<Initials>TD</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schächinger</LastName>
<ForeName>Hartmut</ForeName>
<Initials>H</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2008</Year>
<Month>05</Month>
<Day>14</Day>
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</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Psychopharmacology (Berl)</MedlineTA>
<NlmUniqueID>7608025</NlmUniqueID>
<ISSNLinking>0033-3158</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000963">Antimetabolites</NameOfSubstance>
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<Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber>
<NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance>
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<NameOfSubstance UI="D008797">Metyrapone</NameOfSubstance>
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<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Psychopharmacology (Berl). 2008 Nov;200(4):613</RefSource>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000963" MajorTopicYN="N">Antimetabolites</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002531" MajorTopicYN="N">Cerebellum</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002940" MajorTopicYN="N">Circadian Rhythm</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003215" MajorTopicYN="N">Conditioning, Eyelid</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004576" MajorTopicYN="N">Electromyography</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008797" MajorTopicYN="N">Metyrapone</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018408" MajorTopicYN="N">Patch-Clamp Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2008</Year>
<Month>03</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2008</Year>
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Inhibition of cortisol production by metyrapone enhances trace, but not delay, eyeblink conditioning.

Inhibition of cortisol production by metyrapone enhances trace, but not delay, eyeblink conditioning.

Source :

English descriptors

Abstract

Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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