Chronic stress modulates the use of spatial and stimulus-response learning strategies in mice and man.
Identifieur interne : 000611 ( PubMed/Corpus ); précédent : 000610; suivant : 000612Chronic stress modulates the use of spatial and stimulus-response learning strategies in mice and man.
Auteurs : Lars Schwabe ; Sergiu Dalm ; Hartmut Sch Chinger ; Melly S. OitzlSource :
- Neurobiology of learning and memory [ 1095-9564 ] ; 2008.
English descriptors
- KwdEn :
- Adaptation, Psychological, Adult, Analysis of Variance, Animals, Association Learning (physiology), Caudate Nucleus (physiology), Chi-Square Distribution, Chronic Disease, Discrimination Learning (physiology), Female, Hippocampus (physiology), Humans, Male, Mice, Mice, Inbred C57BL, Rats, Reaction Time (physiology), Reference Values, Retention (Psychology) (physiology), Self-Assessment, Spatial Behavior (physiology), Stress, Psychological (psychology), Young Adult.
- MESH :
- physiology : Association Learning, Caudate Nucleus, Discrimination Learning, Hippocampus, Reaction Time, Retention (Psychology), Spatial Behavior.
- psychology : Stress, Psychological.
- Adaptation, Psychological, Adult, Analysis of Variance, Animals, Chi-Square Distribution, Chronic Disease, Female, Humans, Male, Mice, Mice, Inbred C57BL, Rats, Reference Values, Self-Assessment, Young Adult.
Abstract
Acute stress modulates multiple memory systems in favor of caudate nucleus-dependent stimulus-response and at the expense of hippocampus-dependent spatial learning and memory. We examined in mice and humans whether chronic stress has similar consequences. Male C57BL/6J mice that had been repeatedly exposed to rats ("rat stress") used in a circular hole board task significantly more often a stimulus-response strategy (33%) than control mice (0%). While velocity was increased, differences in latency to exit hole, distance moved or number of holes visited were not observed. Increased velocity and performance during retention trials one day later indicates altered emotionality and motivation to explore in rat stressed mice. Forty healthy young men and women were split into "high chronic stress" and "low chronic stress" groups based on their answers in a chronic stress questionnaire ("Trier Inventory of Chronic Stress"-TICS) and trained in a 2D task. A test trial immediately after training revealed that participants of the "high chronic stress" group used the S-R strategy significantly more often (94%) than participants of the "low chronic stress" group (52%). Verbal self-reports confirmed the strategy derived from participants' choice in the test trial. Learning performance was unaffected by the chronic stress level. We conclude that one consequence of chronic stress is the shift to more rigid stimulus-response learning, that is accompanied by changes in motivational factors in mice.
DOI: 10.1016/j.nlm.2008.07.015
PubMed: 18707011
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pubmed:18707011Le document en format XML
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Oitzl</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18707011</idno><idno type="pmid">18707011</idno><idno type="doi">10.1016/j.nlm.2008.07.015</idno><idno type="wicri:Area/PubMed/Corpus">000611</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000611</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chronic stress modulates the use of spatial and stimulus-response learning strategies in mice and man.</title><author><name sortKey="Schwabe, Lars" sort="Schwabe, Lars" uniqKey="Schwabe L" first="Lars" last="Schwabe">Lars Schwabe</name><affiliation><nlm:affiliation>Division of Clinical Physiology, Institute of Psychobiology, University of Trier, Germany. Lars.Schwabe@ruhr-uni-bochum.de</nlm:affiliation></affiliation></author><author><name sortKey="Dalm, Sergiu" sort="Dalm, Sergiu" uniqKey="Dalm S" first="Sergiu" last="Dalm">Sergiu Dalm</name></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name></author><author><name sortKey="Oitzl, Melly S" sort="Oitzl, Melly S" uniqKey="Oitzl M" first="Melly S" last="Oitzl">Melly S. Oitzl</name></author></analytic><series><title level="j">Neurobiology of learning and memory</title><idno type="eISSN">1095-9564</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Psychological</term><term>Adult</term><term>Analysis of Variance</term><term>Animals</term><term>Association Learning (physiology)</term><term>Caudate Nucleus (physiology)</term><term>Chi-Square Distribution</term><term>Chronic Disease</term><term>Discrimination Learning (physiology)</term><term>Female</term><term>Hippocampus (physiology)</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Rats</term><term>Reaction Time (physiology)</term><term>Reference Values</term><term>Retention (Psychology) (physiology)</term><term>Self-Assessment</term><term>Spatial Behavior (physiology)</term><term>Stress, Psychological (psychology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Association Learning</term><term>Caudate Nucleus</term><term>Discrimination Learning</term><term>Hippocampus</term><term>Reaction Time</term><term>Retention (Psychology)</term><term>Spatial Behavior</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Stress, Psychological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Psychological</term><term>Adult</term><term>Analysis of Variance</term><term>Animals</term><term>Chi-Square Distribution</term><term>Chronic Disease</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Rats</term><term>Reference Values</term><term>Self-Assessment</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acute stress modulates multiple memory systems in favor of caudate nucleus-dependent stimulus-response and at the expense of hippocampus-dependent spatial learning and memory. We examined in mice and humans whether chronic stress has similar consequences. Male C57BL/6J mice that had been repeatedly exposed to rats ("rat stress") used in a circular hole board task significantly more often a stimulus-response strategy (33%) than control mice (0%). While velocity was increased, differences in latency to exit hole, distance moved or number of holes visited were not observed. Increased velocity and performance during retention trials one day later indicates altered emotionality and motivation to explore in rat stressed mice. Forty healthy young men and women were split into "high chronic stress" and "low chronic stress" groups based on their answers in a chronic stress questionnaire ("Trier Inventory of Chronic Stress"-TICS) and trained in a 2D task. A test trial immediately after training revealed that participants of the "high chronic stress" group used the S-R strategy significantly more often (94%) than participants of the "low chronic stress" group (52%). Verbal self-reports confirmed the strategy derived from participants' choice in the test trial. Learning performance was unaffected by the chronic stress level. We conclude that one consequence of chronic stress is the shift to more rigid stimulus-response learning, that is accompanied by changes in motivational factors in mice.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18707011</PMID><DateCreated><Year>2008</Year><Month>09</Month><Day>16</Day></DateCreated><DateCompleted><Year>2009</Year><Month>01</Month><Day>16</Day></DateCompleted><DateRevised><Year>2010</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9564</ISSN><JournalIssue CitedMedium="Internet"><Volume>90</Volume><Issue>3</Issue><PubDate><Year>2008</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Neurobiology of learning and memory</Title><ISOAbbreviation>Neurobiol Learn Mem</ISOAbbreviation></Journal><ArticleTitle>Chronic stress modulates the use of spatial and stimulus-response learning strategies in mice and man.</ArticleTitle><Pagination><MedlinePgn>495-503</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nlm.2008.07.015</ELocationID><Abstract><AbstractText>Acute stress modulates multiple memory systems in favor of caudate nucleus-dependent stimulus-response and at the expense of hippocampus-dependent spatial learning and memory. We examined in mice and humans whether chronic stress has similar consequences. Male C57BL/6J mice that had been repeatedly exposed to rats ("rat stress") used in a circular hole board task significantly more often a stimulus-response strategy (33%) than control mice (0%). While velocity was increased, differences in latency to exit hole, distance moved or number of holes visited were not observed. Increased velocity and performance during retention trials one day later indicates altered emotionality and motivation to explore in rat stressed mice. Forty healthy young men and women were split into "high chronic stress" and "low chronic stress" groups based on their answers in a chronic stress questionnaire ("Trier Inventory of Chronic Stress"-TICS) and trained in a 2D task. A test trial immediately after training revealed that participants of the "high chronic stress" group used the S-R strategy significantly more often (94%) than participants of the "low chronic stress" group (52%). Verbal self-reports confirmed the strategy derived from participants' choice in the test trial. Learning performance was unaffected by the chronic stress level. We conclude that one consequence of chronic stress is the shift to more rigid stimulus-response learning, that is accompanied by changes in motivational factors in mice.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schwabe</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Clinical Physiology, Institute of Psychobiology, University of Trier, Germany. Lars.Schwabe@ruhr-uni-bochum.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dalm</LastName><ForeName>Sergiu</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Schächinger</LastName><ForeName>Hartmut</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Oitzl</LastName><ForeName>Melly S</ForeName><Initials>MS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>08</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurobiol Learn Mem</MedlineTA><NlmUniqueID>9508166</NlmUniqueID><ISSNLinking>1074-7427</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000223" MajorTopicYN="N">Adaptation, Psychological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001245" MajorTopicYN="N">Association Learning</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002421" MajorTopicYN="N">Caudate Nucleus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016009" MajorTopicYN="N">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004193" MajorTopicYN="N">Discrimination Learning</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006624" MajorTopicYN="N">Hippocampus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011930" MajorTopicYN="N">Reaction Time</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012153" MajorTopicYN="N">Retention (Psychology)</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012647" MajorTopicYN="N">Self-Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013037" MajorTopicYN="N">Spatial Behavior</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000523" 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