Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes.
Identifieur interne : 000609 ( PubMed/Corpus ); précédent : 000608; suivant : 000610Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes.
Auteurs : R. Kumsta ; S. Entringer ; J W Koper ; E F C. Van Rossum ; D H Hellhammer ; S. WüstSource :
- Biological psychology [ 1873-6246 ] ; 2008.
English descriptors
- KwdEn :
- Adult, Blood Vessels (drug effects), Dexamethasone (pharmacology), Dose-Response Relationship, Drug, Enzyme-Linked Immunosorbent Assay (methods), Female, Genotype, Glucocorticoids (pharmacology), Humans, Interleukin-6 (metabolism), Leukocytes (drug effects), Leukocytes (metabolism), Male, Polymorphism, Genetic, Receptors, Glucocorticoid (genetics), Skin, Statistics, Nonparametric, Vasoconstriction (drug effects), Vasoconstriction (genetics), Young Adult.
- MESH :
- chemical , genetics : Receptors, Glucocorticoid.
- chemical , metabolism : Interleukin-6.
- chemical , pharmacology : Dexamethasone, Glucocorticoids.
- drug effects : Blood Vessels, Leukocytes, Vasoconstriction.
- genetics : Vasoconstriction.
- metabolism : Leukocytes.
- methods : Enzyme-Linked Immunosorbent Assay.
- Adult, Dose-Response Relationship, Drug, Female, Genotype, Humans, Male, Polymorphism, Genetic, Skin, Statistics, Nonparametric, Young Adult.
Abstract
A considerable variability in the sensitivity to glucocorticoids (GCs) exists between individuals and these differences have been implicated in the etiology of psychiatric diseases such as depression. Glucocorticoid receptor (GR) gene polymorphisms might account in part for variability in GC responsiveness. We assessed the association between four common GR gene (NR3C1) polymorphisms (ER22/23EK, N363S, BclI, 9beta) and markers of glucocorticoid sensitivity in two target tissues (subdermal blood vessels, peripheral leukocytes) in 206 healthy individuals. The BclI GG genotype group showed the least degree of skin blanching, reflecting a lower GC sensitivity of subdermal blood vessels (p=.01). No association between GR genotype and GC sensitivity of peripheral leukocytes was observed. In the same subjects we previously observed an association between GR genotype and GC sensitivity of the pituitary. Polymorphism of the GR gene might constitute a vulnerability or protection factor for stress related disorders and altered GC sensitivity.
DOI: 10.1016/j.biopsycho.2008.04.007
PubMed: 18502562
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pubmed:18502562Le document en format XML
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Van Rossum</name></author><author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D H" last="Hellhammer">D H Hellhammer</name></author><author><name sortKey="Wust, S" sort="Wust, S" uniqKey="Wust S" first="S" last="Wüst">S. Wüst</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18502562</idno><idno type="pmid">18502562</idno><idno type="doi">10.1016/j.biopsycho.2008.04.007</idno><idno type="wicri:Area/PubMed/Corpus">000609</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000609</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes.</title><author><name sortKey="Kumsta, R" sort="Kumsta, R" uniqKey="Kumsta R" first="R" last="Kumsta">R. Kumsta</name><affiliation><nlm:affiliation>Department of Theoretical and Clinical Psychobiology, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Entringer, S" sort="Entringer, S" uniqKey="Entringer S" first="S" last="Entringer">S. Entringer</name></author><author><name sortKey="Koper, J W" sort="Koper, J W" uniqKey="Koper J" first="J W" last="Koper">J W Koper</name></author><author><name sortKey="Van Rossum, E F C" sort="Van Rossum, E F C" uniqKey="Van Rossum E" first="E F C" last="Van Rossum">E F C. Van Rossum</name></author><author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D H" last="Hellhammer">D H Hellhammer</name></author><author><name sortKey="Wust, S" sort="Wust, S" uniqKey="Wust S" first="S" last="Wüst">S. Wüst</name></author></analytic><series><title level="j">Biological psychology</title><idno type="eISSN">1873-6246</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Blood Vessels (drug effects)</term><term>Dexamethasone (pharmacology)</term><term>Dose-Response Relationship, Drug</term><term>Enzyme-Linked Immunosorbent Assay (methods)</term><term>Female</term><term>Genotype</term><term>Glucocorticoids (pharmacology)</term><term>Humans</term><term>Interleukin-6 (metabolism)</term><term>Leukocytes (drug effects)</term><term>Leukocytes (metabolism)</term><term>Male</term><term>Polymorphism, Genetic</term><term>Receptors, Glucocorticoid (genetics)</term><term>Skin</term><term>Statistics, Nonparametric</term><term>Vasoconstriction (drug effects)</term><term>Vasoconstriction (genetics)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Glucocorticoid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dexamethasone</term><term>Glucocorticoids</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Vessels</term><term>Leukocytes</term><term>Vasoconstriction</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Vasoconstriction</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Polymorphism, Genetic</term><term>Skin</term><term>Statistics, Nonparametric</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A considerable variability in the sensitivity to glucocorticoids (GCs) exists between individuals and these differences have been implicated in the etiology of psychiatric diseases such as depression. Glucocorticoid receptor (GR) gene polymorphisms might account in part for variability in GC responsiveness. We assessed the association between four common GR gene (NR3C1) polymorphisms (ER22/23EK, N363S, BclI, 9beta) and markers of glucocorticoid sensitivity in two target tissues (subdermal blood vessels, peripheral leukocytes) in 206 healthy individuals. The BclI GG genotype group showed the least degree of skin blanching, reflecting a lower GC sensitivity of subdermal blood vessels (p=.01). No association between GR genotype and GC sensitivity of peripheral leukocytes was observed. In the same subjects we previously observed an association between GR genotype and GC sensitivity of the pituitary. Polymorphism of the GR gene might constitute a vulnerability or protection factor for stress related disorders and altered GC sensitivity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18502562</PMID><DateCreated><Year>2008</Year><Month>09</Month><Day>10</Day></DateCreated><DateCompleted><Year>2009</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-6246</ISSN><JournalIssue CitedMedium="Internet"><Volume>79</Volume><Issue>2</Issue><PubDate><Year>2008</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Biological psychology</Title><ISOAbbreviation>Biol Psychol</ISOAbbreviation></Journal><ArticleTitle>Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes.</ArticleTitle><Pagination><MedlinePgn>179-84</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biopsycho.2008.04.007</ELocationID><Abstract><AbstractText>A considerable variability in the sensitivity to glucocorticoids (GCs) exists between individuals and these differences have been implicated in the etiology of psychiatric diseases such as depression. Glucocorticoid receptor (GR) gene polymorphisms might account in part for variability in GC responsiveness. We assessed the association between four common GR gene (NR3C1) polymorphisms (ER22/23EK, N363S, BclI, 9beta) and markers of glucocorticoid sensitivity in two target tissues (subdermal blood vessels, peripheral leukocytes) in 206 healthy individuals. The BclI GG genotype group showed the least degree of skin blanching, reflecting a lower GC sensitivity of subdermal blood vessels (p=.01). No association between GR genotype and GC sensitivity of peripheral leukocytes was observed. In the same subjects we previously observed an association between GR genotype and GC sensitivity of the pituitary. Polymorphism of the GR gene might constitute a vulnerability or protection factor for stress related disorders and altered GC sensitivity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kumsta</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Theoretical and Clinical Psychobiology, University of Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Entringer</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Koper</LastName><ForeName>J W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>van Rossum</LastName><ForeName>E F C</ForeName><Initials>EF</Initials></Author><Author ValidYN="Y"><LastName>Hellhammer</LastName><ForeName>D H</ForeName><Initials>DH</Initials></Author><Author ValidYN="Y"><LastName>Wüst</LastName><ForeName>S</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>04</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biol Psychol</MedlineTA><NlmUniqueID>0375566</NlmUniqueID><ISSNLinking>0301-0511</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005938">Glucocorticoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C497713">NR3C1 protein, 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Immunosorbent Assay</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005938" MajorTopicYN="N">Glucocorticoids</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007962" MajorTopicYN="N">Leukocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" 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Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2008</Year><Month>01</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2008</Year><Month>03</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2008</Year><Month>04</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>5</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>4</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>5</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18502562</ArticleId><ArticleId IdType="pii">S0301-0511(08)00096-3</ArticleId><ArticleId 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