Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress.
Identifieur interne : 000606 ( PubMed/Corpus ); précédent : 000605; suivant : 000607Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress.
Auteurs : Andreas Bohringer ; Lars Schwabe ; Steffen Richter ; Hartmut SchachingerSource :
- Psychoneuroendocrinology [ 0306-4530 ] ; 2008.
English descriptors
- KwdEn :
- Administration, Intranasal, Adult, Blood Glucose (metabolism), Blood Pressure (physiology), Electrocardiography, Heart Rate (physiology), Hormones (blood), Hormones (metabolism), Humans, Hydrocortisone (blood), Hydrocortisone (metabolism), Hypoglycemic Agents (adverse effects), Hypoglycemic Agents (blood), Hypoglycemic Agents (therapeutic use), Hypothalamo-Hypophyseal System (physiopathology), Insulin (administration & dosage), Insulin (blood), Insulin (therapeutic use), Male, Neuropsychological Tests, Pituitary-Adrenal System (physiopathology), Saliva (chemistry), Social Environment, Stress, Psychological (drug therapy), Stress, Psychological (psychology), Young Adult.
- MESH :
- chemical , administration & dosage : Insulin.
- chemical , adverse effects : Hypoglycemic Agents.
- chemical , blood : Hormones, Hydrocortisone, Hypoglycemic Agents, Insulin.
- chemical , metabolism : Blood Glucose, Hormones, Hydrocortisone.
- chemistry : Saliva.
- drug therapy : Stress, Psychological.
- physiology : Blood Pressure, Heart Rate.
- physiopathology : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- psychology : Stress, Psychological.
- chemical , therapeutic use : Hypoglycemic Agents, Insulin.
- Administration, Intranasal, Adult, Electrocardiography, Humans, Male, Neuropsychological Tests, Social Environment, Young Adult.
Abstract
Previous studies have shown that intranasally administered insulin exerts an inhibitory influence on the basal hypothalamic-pituitary-adrenal (HPA) axis activity. To date, however, it remains unclear as to whether intranasal insulin does furthermore affect HPA axis responsiveness in situations of stress. Here, we tested whether intranasally administered insulin attenuates the HPA axis response to psychosocial stress. Fifty minutes before being exposed to the Trier Social Stress Test (TSST), 26 healthy young male participants received a single intranasal dose of human insulin (40 I.U.) or placebo in a placebo controlled, double-blind between-subject design. Plasma cortisol, saliva cortisol, heart rate, and blood pressure were measured at resting baseline and in response to the TSST. Plasma cortisol (P<.001) and saliva cortisol (P<.001) increased in response to stress, as did heart rate (P<.001) and blood pressure (P<.001). Intranasal insulin did not influence plasma or saliva cortisol, heart rate, blood pressure, blood glucose, and plasma insulin levels at baseline. However, intranasal insulin diminished the saliva cortisol (two-way ANOVA; treatment by time interaction: P=.05) and plasma cortisol (two-way ANOVA; treatment by time interaction: P=.05) response to the TSST without affecting heart rate, and blood pressure stress reactivity. Our data show that a single intranasal insulin administration effectively lowers stress-induced HPA axis responsiveness. Intranasal insulin may offer a therapeutic potential to prevent hyperactivity of the HPA system.
DOI: 10.1016/j.psyneuen.2008.08.002
PubMed: 18804330
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pubmed:18804330Le document en format XML
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type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18804330</idno><idno type="pmid">18804330</idno><idno type="doi">10.1016/j.psyneuen.2008.08.002</idno><idno type="wicri:Area/PubMed/Corpus">000606</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000606</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress.</title><author><name sortKey="Bohringer, Andreas" sort="Bohringer, Andreas" uniqKey="Bohringer A" first="Andreas" last="Bohringer">Andreas Bohringer</name><affiliation><nlm:affiliation>Department of Clinical Physiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany. boeh1303@uni-trier.de</nlm:affiliation></affiliation></author><author><name sortKey="Schwabe, Lars" sort="Schwabe, Lars" uniqKey="Schwabe L" first="Lars" last="Schwabe">Lars Schwabe</name></author><author><name sortKey="Richter, Steffen" sort="Richter, Steffen" uniqKey="Richter S" first="Steffen" last="Richter">Steffen Richter</name></author><author><name sortKey="Schachinger, Hartmut" sort="Schachinger, Hartmut" uniqKey="Schachinger H" first="Hartmut" last="Schachinger">Hartmut Schachinger</name></author></analytic><series><title level="j">Psychoneuroendocrinology</title><idno type="ISSN">0306-4530</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intranasal</term><term>Adult</term><term>Blood Glucose (metabolism)</term><term>Blood Pressure (physiology)</term><term>Electrocardiography</term><term>Heart Rate (physiology)</term><term>Hormones (blood)</term><term>Hormones (metabolism)</term><term>Humans</term><term>Hydrocortisone (blood)</term><term>Hydrocortisone (metabolism)</term><term>Hypoglycemic Agents (adverse effects)</term><term>Hypoglycemic Agents (blood)</term><term>Hypoglycemic Agents (therapeutic use)</term><term>Hypothalamo-Hypophyseal System (physiopathology)</term><term>Insulin (administration & dosage)</term><term>Insulin (blood)</term><term>Insulin (therapeutic use)</term><term>Male</term><term>Neuropsychological Tests</term><term>Pituitary-Adrenal System (physiopathology)</term><term>Saliva (chemistry)</term><term>Social Environment</term><term>Stress, Psychological (drug therapy)</term><term>Stress, Psychological (psychology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Insulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Hypoglycemic Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Hormones</term><term>Hydrocortisone</term><term>Hypoglycemic Agents</term><term>Insulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term><term>Hormones</term><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term><term>Heart Rate</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Stress, Psychological</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hypoglycemic Agents</term><term>Insulin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Adult</term><term>Electrocardiography</term><term>Humans</term><term>Male</term><term>Neuropsychological Tests</term><term>Social Environment</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies have shown that intranasally administered insulin exerts an inhibitory influence on the basal hypothalamic-pituitary-adrenal (HPA) axis activity. To date, however, it remains unclear as to whether intranasal insulin does furthermore affect HPA axis responsiveness in situations of stress. Here, we tested whether intranasally administered insulin attenuates the HPA axis response to psychosocial stress. Fifty minutes before being exposed to the Trier Social Stress Test (TSST), 26 healthy young male participants received a single intranasal dose of human insulin (40 I.U.) or placebo in a placebo controlled, double-blind between-subject design. Plasma cortisol, saliva cortisol, heart rate, and blood pressure were measured at resting baseline and in response to the TSST. Plasma cortisol (P<.001) and saliva cortisol (P<.001) increased in response to stress, as did heart rate (P<.001) and blood pressure (P<.001). Intranasal insulin did not influence plasma or saliva cortisol, heart rate, blood pressure, blood glucose, and plasma insulin levels at baseline. However, intranasal insulin diminished the saliva cortisol (two-way ANOVA; treatment by time interaction: P=.05) and plasma cortisol (two-way ANOVA; treatment by time interaction: P=.05) response to the TSST without affecting heart rate, and blood pressure stress reactivity. Our data show that a single intranasal insulin administration effectively lowers stress-induced HPA axis responsiveness. Intranasal insulin may offer a therapeutic potential to prevent hyperactivity of the HPA system.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18804330</PMID><DateCreated><Year>2008</Year><Month>11</Month><Day>25</Day></DateCreated><DateCompleted><Year>2009</Year><Month>02</Month><Day>06</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0306-4530</ISSN><JournalIssue CitedMedium="Print"><Volume>33</Volume><Issue>10</Issue><PubDate><Year>2008</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Psychoneuroendocrinology</Title><ISOAbbreviation>Psychoneuroendocrinology</ISOAbbreviation></Journal><ArticleTitle>Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress.</ArticleTitle><Pagination><MedlinePgn>1394-400</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.psyneuen.2008.08.002</ELocationID><Abstract><AbstractText>Previous studies have shown that intranasally administered insulin exerts an inhibitory influence on the basal hypothalamic-pituitary-adrenal (HPA) axis activity. To date, however, it remains unclear as to whether intranasal insulin does furthermore affect HPA axis responsiveness in situations of stress. Here, we tested whether intranasally administered insulin attenuates the HPA axis response to psychosocial stress. Fifty minutes before being exposed to the Trier Social Stress Test (TSST), 26 healthy young male participants received a single intranasal dose of human insulin (40 I.U.) or placebo in a placebo controlled, double-blind between-subject design. Plasma cortisol, saliva cortisol, heart rate, and blood pressure were measured at resting baseline and in response to the TSST. Plasma cortisol (P<.001) and saliva cortisol (P<.001) increased in response to stress, as did heart rate (P<.001) and blood pressure (P<.001). Intranasal insulin did not influence plasma or saliva cortisol, heart rate, blood pressure, blood glucose, and plasma insulin levels at baseline. However, intranasal insulin diminished the saliva cortisol (two-way ANOVA; treatment by time interaction: P=.05) and plasma cortisol (two-way ANOVA; treatment by time interaction: P=.05) response to the TSST without affecting heart rate, and blood pressure stress reactivity. Our data show that a single intranasal insulin administration effectively lowers stress-induced HPA axis responsiveness. Intranasal insulin may offer a therapeutic potential to prevent hyperactivity of the HPA system.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bohringer</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Clinical Physiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany. boeh1303@uni-trier.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwabe</LastName><ForeName>Lars</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Richter</LastName><ForeName>Steffen</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Schachinger</LastName><ForeName>Hartmut</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>09</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Psychoneuroendocrinology</MedlineTA><NlmUniqueID>7612148</NlmUniqueID><ISSNLinking>0306-4530</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001786">Blood Glucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006728">Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007004">Hypoglycemic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007328">Insulin</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000281" MajorTopicYN="N">Administration, Intranasal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001786" MajorTopicYN="N">Blood Glucose</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004562" MajorTopicYN="N">Electrocardiography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006339" MajorTopicYN="N">Heart Rate</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName 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