Association between TNFA-308 G/A polymorphism and sensitization to para-phenylenediamine: a case-control study.
Identifieur interne : 000593 ( PubMed/Corpus ); précédent : 000592; suivant : 000594Association between TNFA-308 G/A polymorphism and sensitization to para-phenylenediamine: a case-control study.
Auteurs : B. Blömeke ; R. Brans ; H. Dickel ; T. Bruckner ; S. Erdmann ; M. Heesen ; H F Merk ; P-J CoenraadsSource :
- Allergy [ 1398-9995 ] ; 2009.
English descriptors
- KwdEn :
- Adult, Alleles, Case-Control Studies, Coloring Agents (adverse effects), Dermatitis, Allergic Contact (etiology), Dermatitis, Allergic Contact (genetics), Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Logistic Models, Male, Middle Aged, Phenylenediamines (adverse effects), Phenylenediamines (immunology), Polymorphism, Genetic, Tumor Necrosis Factor-alpha (genetics).
- MESH :
- chemical , adverse effects : Coloring Agents, Phenylenediamines.
- etiology : Dermatitis, Allergic Contact.
- genetics : Dermatitis, Allergic Contact, Tumor Necrosis Factor-alpha.
- chemical , immunology : Phenylenediamines.
- Adult, Alleles, Case-Control Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Logistic Models, Male, Middle Aged, Polymorphism, Genetic.
Abstract
Para-phenylenediamine (PPD) and related chemicals are common contact sensitizers, frequently causing allergic contact dermatitis (ACD). The cytokine tumor necrosis factor-alpha (TNF-alpha) plays a key role in contact sensitization.
DOI: 10.1111/j.1398-9995.2008.01704.x
PubMed: 18384449
Links to Exploration step
pubmed:18384449Le document en format XML
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<author><name sortKey="Blomeke, B" sort="Blomeke, B" uniqKey="Blomeke B" first="B" last="Blömeke">B. Blömeke</name>
<affiliation><nlm:affiliation>Department of Ecotoxicology and Toxicology, University of Trier, Trier, Germany.</nlm:affiliation>
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<author><name sortKey="Brans, R" sort="Brans, R" uniqKey="Brans R" first="R" last="Brans">R. Brans</name>
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<author><name sortKey="Dickel, H" sort="Dickel, H" uniqKey="Dickel H" first="H" last="Dickel">H. Dickel</name>
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<author><name sortKey="Bruckner, T" sort="Bruckner, T" uniqKey="Bruckner T" first="T" last="Bruckner">T. Bruckner</name>
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<author><name sortKey="Erdmann, S" sort="Erdmann, S" uniqKey="Erdmann S" first="S" last="Erdmann">S. Erdmann</name>
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<author><name sortKey="Heesen, M" sort="Heesen, M" uniqKey="Heesen M" first="M" last="Heesen">M. Heesen</name>
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<author><name sortKey="Merk, H F" sort="Merk, H F" uniqKey="Merk H" first="H F" last="Merk">H F Merk</name>
</author>
<author><name sortKey="Coenraads, P J" sort="Coenraads, P J" uniqKey="Coenraads P" first="P-J" last="Coenraads">P-J Coenraads</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Association between TNFA-308 G/A polymorphism and sensitization to para-phenylenediamine: a case-control study.</title>
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<affiliation><nlm:affiliation>Department of Ecotoxicology and Toxicology, University of Trier, Trier, Germany.</nlm:affiliation>
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<author><name sortKey="Dickel, H" sort="Dickel, H" uniqKey="Dickel H" first="H" last="Dickel">H. Dickel</name>
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<author><name sortKey="Bruckner, T" sort="Bruckner, T" uniqKey="Bruckner T" first="T" last="Bruckner">T. Bruckner</name>
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<author><name sortKey="Erdmann, S" sort="Erdmann, S" uniqKey="Erdmann S" first="S" last="Erdmann">S. Erdmann</name>
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<author><name sortKey="Heesen, M" sort="Heesen, M" uniqKey="Heesen M" first="M" last="Heesen">M. Heesen</name>
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<author><name sortKey="Merk, H F" sort="Merk, H F" uniqKey="Merk H" first="H F" last="Merk">H F Merk</name>
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<author><name sortKey="Coenraads, P J" sort="Coenraads, P J" uniqKey="Coenraads P" first="P-J" last="Coenraads">P-J Coenraads</name>
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<series><title level="j">Allergy</title>
<idno type="eISSN">1398-9995</idno>
<imprint><date when="2009" type="published">2009</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Alleles</term>
<term>Case-Control Studies</term>
<term>Coloring Agents (adverse effects)</term>
<term>Dermatitis, Allergic Contact (etiology)</term>
<term>Dermatitis, Allergic Contact (genetics)</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Phenylenediamines (adverse effects)</term>
<term>Phenylenediamines (immunology)</term>
<term>Polymorphism, Genetic</term>
<term>Tumor Necrosis Factor-alpha (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Coloring Agents</term>
<term>Phenylenediamines</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dermatitis, Allergic Contact</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dermatitis, Allergic Contact</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Phenylenediamines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Alleles</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Genetic</term>
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<front><div type="abstract" xml:lang="en">Para-phenylenediamine (PPD) and related chemicals are common contact sensitizers, frequently causing allergic contact dermatitis (ACD). The cytokine tumor necrosis factor-alpha (TNF-alpha) plays a key role in contact sensitization.</div>
</front>
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<DateCreated><Year>2009</Year>
<Month>01</Month>
<Day>30</Day>
</DateCreated>
<DateCompleted><Year>2009</Year>
<Month>04</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2012</Year>
<Month>11</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1398-9995</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>64</Volume>
<Issue>2</Issue>
<PubDate><Year>2009</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Allergy</Title>
<ISOAbbreviation>Allergy</ISOAbbreviation>
</Journal>
<ArticleTitle>Association between TNFA-308 G/A polymorphism and sensitization to para-phenylenediamine: a case-control study.</ArticleTitle>
<Pagination><MedlinePgn>279-83</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1398-9995.2008.01704.x</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Para-phenylenediamine (PPD) and related chemicals are common contact sensitizers, frequently causing allergic contact dermatitis (ACD). The cytokine tumor necrosis factor-alpha (TNF-alpha) plays a key role in contact sensitization.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In this case-control study, we evaluated the distribution of variations in the regulatory region of the gene for TNF-alpha (TNFA-308 G/A) in 181 Caucasian individuals with a history of ACD and sensitization to PPD and 161 individuals with no history of sensitization to PPD.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The frequency of GA or AA TNFA genotypes was significantly higher in individuals sensitized to PPD than in age- and gender-matched controls giving an odds ratio (OR) of 2.16 (95% confidence interval, CI: 1.35-3.47; P = 0.0016). This relation was even more pronounced when restricting cases to females over 45 years (OR = 3.71; 95% CI: 1.65-8.31; P = 0.0017) vs younger females (less than or equal to 45 years; OR = 2.41; 95% CI: 1.03-5.65; P = 0.044) or males (OR = 1.05; 95% CI: 0.449-2.47; P = 1.0). In addition, a logistic regression model revealed a significant effect for TNFA-308 AA and AG vs GG genotype (point estimate = 2.152; 95% Wald CI: 1.332-3.477).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings suggest a possible role for the TNFA-308 genetic polymorphism as a susceptibility factor for chemically induced ACD.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Blömeke</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Ecotoxicology and Toxicology, University of Trier, Trier, Germany.</Affiliation>
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<MeshHeading><DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName>
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<MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
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<MeshHeading><DescriptorName UI="D004396" MajorTopicYN="N">Coloring Agents</DescriptorName>
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<MeshHeading><DescriptorName UI="D017449" MajorTopicYN="N">Dermatitis, Allergic Contact</DescriptorName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName>
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<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName>
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