[Meniscal degeneration score and NITEGE expression : immunohistochemical detection of NITEGE in advanced meniscal degeneration].
Identifieur interne : 000536 ( PubMed/Corpus ); précédent : 000535; suivant : 000537[Meniscal degeneration score and NITEGE expression : immunohistochemical detection of NITEGE in advanced meniscal degeneration].
Auteurs : V. Krenn ; P. Knöss ; W. Rüther ; M. Jakobs ; M. Otto ; M G Krukemeyer ; A. Heine ; G. Möllenhoff ; B. KurzSource :
- Der Orthopade [ 1433-0431 ] ; 2010.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Aged, Biomarkers (analysis), Cell Count, Cell Size, Chondrocytes (pathology), Disease Progression, Endopeptidases (analysis), Extracellular Matrix (pathology), Female, Humans, Knee Injuries (pathology), Knee Injuries (surgery), Male, Menisci, Tibial (pathology), Menisci, Tibial (surgery), Middle Aged, Osteoarthritis, Knee (classification), Osteoarthritis, Knee (diagnosis), Osteoarthritis, Knee (pathology), Predictive Value of Tests, Regeneration (physiology), Synovial Membrane (pathology), Tibial Meniscus Injuries, Young Adult.
- MESH :
- chemical , analysis : Biomarkers, Endopeptidases.
- classification : Osteoarthritis, Knee.
- diagnosis : Osteoarthritis, Knee.
- pathology : Chondrocytes, Extracellular Matrix, Knee Injuries, Menisci, Tibial, Osteoarthritis, Knee, Synovial Membrane.
- physiology : Regeneration.
- surgery : Knee Injuries, Menisci, Tibial.
- Adolescent, Adult, Age Factors, Aged, Cell Count, Cell Size, Disease Progression, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Tibial Meniscus Injuries, Young Adult.
Abstract
Meniscal degeneration (MD) is a structural change of fibrous cartilage that is common in orthopaedic diagnostics and relevant for health insurance matters. So far, there has been neither a standardised scoring system nor an immunohistochemical marker for MD.
DOI: 10.1007/s00132-010-1606-4
PubMed: 20221825
Links to Exploration step
pubmed:20221825Le document en format XML
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Otto</name></author><author><name sortKey="Krukemeyer, M G" sort="Krukemeyer, M G" uniqKey="Krukemeyer M" first="M G" last="Krukemeyer">M G Krukemeyer</name></author><author><name sortKey="Heine, A" sort="Heine, A" uniqKey="Heine A" first="A" last="Heine">A. Heine</name></author><author><name sortKey="Mollenhoff, G" sort="Mollenhoff, G" uniqKey="Mollenhoff G" first="G" last="Möllenhoff">G. Möllenhoff</name></author><author><name sortKey="Kurz, B" sort="Kurz, B" uniqKey="Kurz B" first="B" last="Kurz">B. Kurz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20221825</idno><idno type="pmid">20221825</idno><idno type="doi">10.1007/s00132-010-1606-4</idno><idno type="wicri:Area/PubMed/Corpus">000536</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000536</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Meniscal degeneration score and NITEGE expression : immunohistochemical detection of NITEGE in advanced meniscal degeneration].</title><author><name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. Krenn</name><affiliation><nlm:affiliation>Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max-Planck-Strasse 18+20, 54296, Trier, Deutschland. krenn@patho-trier.de</nlm:affiliation></affiliation></author><author><name sortKey="Knoss, P" sort="Knoss, P" uniqKey="Knoss P" first="P" last="Knöss">P. Knöss</name></author><author><name sortKey="Ruther, W" sort="Ruther, W" uniqKey="Ruther W" first="W" last="Rüther">W. Rüther</name></author><author><name sortKey="Jakobs, M" sort="Jakobs, M" uniqKey="Jakobs M" first="M" last="Jakobs">M. Jakobs</name></author><author><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M" last="Otto">M. Otto</name></author><author><name sortKey="Krukemeyer, M G" sort="Krukemeyer, M G" uniqKey="Krukemeyer M" first="M G" last="Krukemeyer">M G Krukemeyer</name></author><author><name sortKey="Heine, A" sort="Heine, A" uniqKey="Heine A" first="A" last="Heine">A. Heine</name></author><author><name sortKey="Mollenhoff, G" sort="Mollenhoff, G" uniqKey="Mollenhoff G" first="G" last="Möllenhoff">G. Möllenhoff</name></author><author><name sortKey="Kurz, B" sort="Kurz, B" uniqKey="Kurz B" first="B" last="Kurz">B. Kurz</name></author></analytic><series><title level="j">Der Orthopade</title><idno type="eISSN">1433-0431</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Biomarkers (analysis)</term><term>Cell Count</term><term>Cell Size</term><term>Chondrocytes (pathology)</term><term>Disease Progression</term><term>Endopeptidases (analysis)</term><term>Extracellular Matrix (pathology)</term><term>Female</term><term>Humans</term><term>Knee Injuries (pathology)</term><term>Knee Injuries (surgery)</term><term>Male</term><term>Menisci, Tibial (pathology)</term><term>Menisci, Tibial (surgery)</term><term>Middle Aged</term><term>Osteoarthritis, Knee (classification)</term><term>Osteoarthritis, Knee (diagnosis)</term><term>Osteoarthritis, Knee (pathology)</term><term>Predictive Value of Tests</term><term>Regeneration (physiology)</term><term>Synovial Membrane (pathology)</term><term>Tibial Meniscus Injuries</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term><term>Endopeptidases</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Osteoarthritis, Knee</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Osteoarthritis, Knee</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Chondrocytes</term><term>Extracellular Matrix</term><term>Knee Injuries</term><term>Menisci, Tibial</term><term>Osteoarthritis, Knee</term><term>Synovial Membrane</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Regeneration</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Knee Injuries</term><term>Menisci, Tibial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Cell Count</term><term>Cell Size</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Tibial Meniscus Injuries</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Meniscal degeneration (MD) is a structural change of fibrous cartilage that is common in orthopaedic diagnostics and relevant for health insurance matters. So far, there has been neither a standardised scoring system nor an immunohistochemical marker for MD.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20221825</PMID><DateCreated><Year>2010</Year><Month>05</Month><Day>04</Day></DateCreated><DateCompleted><Year>2010</Year><Month>08</Month><Day>17</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1433-0431</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><Issue>5</Issue><PubDate><Year>2010</Year><Month>May</Month></PubDate></JournalIssue><Title>Der Orthopade</Title><ISOAbbreviation>Orthopade</ISOAbbreviation></Journal><ArticleTitle>[Meniscal degeneration score and NITEGE expression : immunohistochemical detection of NITEGE in advanced meniscal degeneration].</ArticleTitle><Pagination><MedlinePgn>475-85</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00132-010-1606-4</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Meniscal degeneration (MD) is a structural change of fibrous cartilage that is common in orthopaedic diagnostics and relevant for health insurance matters. So far, there has been neither a standardised scoring system nor an immunohistochemical marker for MD.</AbstractText><AbstractText Label="MATERIAL AND METHOD" NlmCategory="METHODS">In this retrospective trial, the meniscal tissue of 60 patients was assessed immunohistochemically for NITEGE (G1 fragment of the proteoglycan aggrecan) expression. NITEGE expression was correlated with defined grades of MD: little (grade 0/1), medium (grade 2), or severe (grade 3).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Detection of extracellular NITEGE deposits in grade 2 or 3 MD had a positive predictive value and specificity of 100%, whereas no deposits were found in grade 0/1 MD. Sensitivity in advanced MD was 55%. Detection of extracellular NITEGE correlated positively with the grade of degeneration, as did patient age and the grade of degeneration. The patient age of those with grade 0/1 MD was significantly lower than for grade 3 (p<0.0001).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The thoroughly defined degeneration score (grade 1 - grade 3 MD) is suitable to assess the severity of degeneration. Extracellular NITEGE deposits can be regarded as an immunohistochemical marker for advanced (grades 2 and 3) MD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krenn</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max-Planck-Strasse 18+20, 54296, Trier, Deutschland. krenn@patho-trier.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Knöss</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Rüther</LastName><ForeName>W</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Jakobs</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Otto</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Krukemeyer</LastName><ForeName>M G</ForeName><Initials>MG</Initials></Author><Author ValidYN="Y"><LastName>Heine</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Möllenhoff</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Kurz</LastName><ForeName>B</ForeName><Initials>B</Initials></Author></AuthorList><Language>ger</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Meniskusdegenerationsscore und NITEGE-Expression : Immunhistochemischer NITEGE-Nachweis in der schwergradigen Meniskusdegeneration.</VernacularTitle></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Orthopade</MedlineTA><NlmUniqueID>0331266</NlmUniqueID><ISSNLinking>0085-4530</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.-</RegistryNumber><NameOfSubstance UI="D010450">Endopeptidases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.99.-</RegistryNumber><NameOfSubstance UI="C083641">aggrecanase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002452" MajorTopicYN="N">Cell Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D048429" MajorTopicYN="N">Cell Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019902" MajorTopicYN="N">Chondrocytes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010450" MajorTopicYN="N">Endopeptidases</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005109" MajorTopicYN="N">Extracellular Matrix</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007718" MajorTopicYN="N">Knee Injuries</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008592" MajorTopicYN="N">Menisci, Tibial</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020370" MajorTopicYN="N">Osteoarthritis, Knee</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012038" MajorTopicYN="N">Regeneration</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013583" MajorTopicYN="N">Synovial Membrane</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000070600" MajorTopicYN="Y">Tibial Meniscus Injuries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>3</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>3</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20221825</ArticleId><ArticleId IdType="doi">10.1007/s00132-010-1606-4</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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