Accelerated trace eyeblink conditioning after cortisol IV-infusion.
Identifieur interne : 000523 ( PubMed/Corpus ); précédent : 000522; suivant : 000524Accelerated trace eyeblink conditioning after cortisol IV-infusion.
Auteurs : Linn K. Kuehl ; Johanna Lass-Hennemann ; Steffen Richter ; Terry D. Blumenthal ; Melly Oitzl ; Hartmut SchachingerSource :
- Neurobiology of learning and memory [ 1095-9564 ] ; 2010.
English descriptors
- KwdEn :
- Adaptation, Physiological, Adult, Conditioning, Classical (drug effects), Conditioning, Classical (physiology), Conditioning, Eyelid (drug effects), Conditioning, Eyelid (physiology), Hormones (administration & dosage), Humans, Hydrocortisone (administration & dosage), Hydrocortisone (physiology), Infusions, Intravenous, Male, Reaction Time (drug effects), Reaction Time (physiology), Reference Values, Time Factors, Young Adult.
- MESH :
- chemical , administration & dosage : Hormones, Hydrocortisone.
- drug effects : Conditioning, Classical, Conditioning, Eyelid, Reaction Time.
- physiology : Conditioning, Classical, Conditioning, Eyelid, Hydrocortisone, Reaction Time.
- Adaptation, Physiological, Adult, Humans, Infusions, Intravenous, Male, Reference Values, Time Factors, Young Adult.
Abstract
Impairing effects of cortisol on learning performance have been shown in human trace eyeblink conditioning. As the effect is observed from 30 min to hours after administration, a genomic action of cortisol is assumed. Here we report rapid cortisol effects that were observed during the first 10 min after cortisol administration in humans. Young healthy males (n=24) received the cortisol synthesis inhibitor metyrapone (1.5 g per os) to avoid interference of the endogenous pulsatile secretion of cortisol. Next, 2mg cortisol or placebo was infused intravenously, immediately before the trace conditioning task. The probability of the conditioned eyeblink responses was assessed electromyographically during the trace eyeblink conditioning task (unconditioned stimulus: corneal air puff, 10 psi, 50 ms; conditioned stimulus: binaural pure tone, 7 dB, 1000 Hz, 400 ms; empty interval between CS and US: 550 ms). Cortisol resulted in a faster increase of conditioning (p=.02), reaching a comparable level to placebo later on. This result extends the well-known effects of stress on the quality and amount of learning by showing that cortisol also affects the speed of learning. We propose that cortisol accelerates trace eyeblink conditioning via a fast, non-genomic mechanism. This fast action of cortisol is part of the adaptive strategy during the early stress response.
DOI: 10.1016/j.nlm.2010.09.007
PubMed: 20850556
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Blumenthal</name></author><author><name sortKey="Oitzl, Melly" sort="Oitzl, Melly" uniqKey="Oitzl M" first="Melly" last="Oitzl">Melly Oitzl</name></author><author><name sortKey="Schachinger, Hartmut" sort="Schachinger, Hartmut" uniqKey="Schachinger H" first="Hartmut" last="Schachinger">Hartmut Schachinger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20850556</idno><idno type="pmid">20850556</idno><idno type="doi">10.1016/j.nlm.2010.09.007</idno><idno type="wicri:Area/PubMed/Corpus">000523</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000523</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Accelerated trace eyeblink conditioning after cortisol IV-infusion.</title><author><name sortKey="Kuehl, Linn K" sort="Kuehl, Linn K" uniqKey="Kuehl L" first="Linn K" last="Kuehl">Linn K. Kuehl</name><affiliation><nlm:affiliation>Institute of Psychobiology, Department of Clinical Physiology, University of Trier, Germany. linnkuehl@gmail.com</nlm:affiliation></affiliation></author><author><name sortKey="Lass Hennemann, Johanna" sort="Lass Hennemann, Johanna" uniqKey="Lass Hennemann J" first="Johanna" last="Lass-Hennemann">Johanna Lass-Hennemann</name></author><author><name sortKey="Richter, Steffen" sort="Richter, Steffen" uniqKey="Richter S" first="Steffen" last="Richter">Steffen Richter</name></author><author><name sortKey="Blumenthal, Terry D" sort="Blumenthal, Terry D" uniqKey="Blumenthal T" first="Terry D" last="Blumenthal">Terry D. Blumenthal</name></author><author><name sortKey="Oitzl, Melly" sort="Oitzl, Melly" uniqKey="Oitzl M" first="Melly" last="Oitzl">Melly Oitzl</name></author><author><name sortKey="Schachinger, Hartmut" sort="Schachinger, Hartmut" uniqKey="Schachinger H" first="Hartmut" last="Schachinger">Hartmut Schachinger</name></author></analytic><series><title level="j">Neurobiology of learning and memory</title><idno type="eISSN">1095-9564</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological</term><term>Adult</term><term>Conditioning, Classical (drug effects)</term><term>Conditioning, Classical (physiology)</term><term>Conditioning, Eyelid (drug effects)</term><term>Conditioning, Eyelid (physiology)</term><term>Hormones (administration & dosage)</term><term>Humans</term><term>Hydrocortisone (administration & dosage)</term><term>Hydrocortisone (physiology)</term><term>Infusions, Intravenous</term><term>Male</term><term>Reaction Time (drug effects)</term><term>Reaction Time (physiology)</term><term>Reference Values</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hormones</term><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Conditioning, Classical</term><term>Conditioning, Eyelid</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Conditioning, Classical</term><term>Conditioning, Eyelid</term><term>Hydrocortisone</term><term>Reaction Time</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Physiological</term><term>Adult</term><term>Humans</term><term>Infusions, Intravenous</term><term>Male</term><term>Reference Values</term><term>Time Factors</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Impairing effects of cortisol on learning performance have been shown in human trace eyeblink conditioning. As the effect is observed from 30 min to hours after administration, a genomic action of cortisol is assumed. Here we report rapid cortisol effects that were observed during the first 10 min after cortisol administration in humans. Young healthy males (n=24) received the cortisol synthesis inhibitor metyrapone (1.5 g per os) to avoid interference of the endogenous pulsatile secretion of cortisol. Next, 2mg cortisol or placebo was infused intravenously, immediately before the trace conditioning task. The probability of the conditioned eyeblink responses was assessed electromyographically during the trace eyeblink conditioning task (unconditioned stimulus: corneal air puff, 10 psi, 50 ms; conditioned stimulus: binaural pure tone, 7 dB, 1000 Hz, 400 ms; empty interval between CS and US: 550 ms). Cortisol resulted in a faster increase of conditioning (p=.02), reaching a comparable level to placebo later on. This result extends the well-known effects of stress on the quality and amount of learning by showing that cortisol also affects the speed of learning. We propose that cortisol accelerates trace eyeblink conditioning via a fast, non-genomic mechanism. This fast action of cortisol is part of the adaptive strategy during the early stress response.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20850556</PMID><DateCreated><Year>2010</Year><Month>11</Month><Day>08</Day></DateCreated><DateCompleted><Year>2011</Year><Month>02</Month><Day>28</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9564</ISSN><JournalIssue CitedMedium="Internet"><Volume>94</Volume><Issue>4</Issue><PubDate><Year>2010</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Neurobiology of learning and memory</Title><ISOAbbreviation>Neurobiol Learn Mem</ISOAbbreviation></Journal><ArticleTitle>Accelerated trace eyeblink conditioning after cortisol IV-infusion.</ArticleTitle><Pagination><MedlinePgn>547-53</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nlm.2010.09.007</ELocationID><Abstract><AbstractText>Impairing effects of cortisol on learning performance have been shown in human trace eyeblink conditioning. As the effect is observed from 30 min to hours after administration, a genomic action of cortisol is assumed. Here we report rapid cortisol effects that were observed during the first 10 min after cortisol administration in humans. Young healthy males (n=24) received the cortisol synthesis inhibitor metyrapone (1.5 g per os) to avoid interference of the endogenous pulsatile secretion of cortisol. Next, 2mg cortisol or placebo was infused intravenously, immediately before the trace conditioning task. The probability of the conditioned eyeblink responses was assessed electromyographically during the trace eyeblink conditioning task (unconditioned stimulus: corneal air puff, 10 psi, 50 ms; conditioned stimulus: binaural pure tone, 7 dB, 1000 Hz, 400 ms; empty interval between CS and US: 550 ms). Cortisol resulted in a faster increase of conditioning (p=.02), reaching a comparable level to placebo later on. This result extends the well-known effects of stress on the quality and amount of learning by showing that cortisol also affects the speed of learning. We propose that cortisol accelerates trace eyeblink conditioning via a fast, non-genomic mechanism. This fast action of cortisol is part of the adaptive strategy during the early stress response.</AbstractText><CopyrightInformation>Copyright © 2010 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kuehl</LastName><ForeName>Linn K</ForeName><Initials>LK</Initials><AffiliationInfo><Affiliation>Institute of Psychobiology, Department of Clinical Physiology, University of Trier, Germany. linnkuehl@gmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lass-Hennemann</LastName><ForeName>Johanna</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Richter</LastName><ForeName>Steffen</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Blumenthal</LastName><ForeName>Terry D</ForeName><Initials>TD</Initials></Author><Author ValidYN="Y"><LastName>Oitzl</LastName><ForeName>Melly</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Schachinger</LastName><ForeName>Hartmut</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>09</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurobiol Learn Mem</MedlineTA><NlmUniqueID>9508166</NlmUniqueID><ISSNLinking>1074-7427</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006728">Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000222" MajorTopicYN="N">Adaptation, Physiological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003214" MajorTopicYN="N">Conditioning, Classical</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003215" MajorTopicYN="N">Conditioning, Eyelid</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006728" MajorTopicYN="N">Hormones</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007262" MajorTopicYN="N">Infusions, Intravenous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011930" MajorTopicYN="N">Reaction Time</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>04</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>07</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>09</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>9</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>9</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>3</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20850556</ArticleId><ArticleId IdType="pii">S1074-7427(10)00149-8</ArticleId><ArticleId IdType="doi">10.1016/j.nlm.2010.09.007</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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