Cortisol rapidly disrupts prepulse inhibition in healthy men.
Identifieur interne : 000514 ( PubMed/Corpus ); précédent : 000513; suivant : 000515Cortisol rapidly disrupts prepulse inhibition in healthy men.
Auteurs : Steffen Richter ; André Schulz ; Carina M. Zech ; Melly S. Oitzl ; Nikolaos P. Daskalakis ; Terry D. Blumenthal ; Hartmut Sch ChingerSource :
- Psychoneuroendocrinology [ 1873-3360 ] ; 2011.
English descriptors
- KwdEn :
- Adult, Arousal (drug effects), Arousal (physiology), Health, Humans, Hydrocortisone (administration & dosage), Hydrocortisone (pharmacology), Male, Neural Inhibition (drug effects), Placebos, Reflex, Startle (drug effects), Reflex, Startle (physiology), Sensory Gating (drug effects), Single-Blind Method, Time Factors.
- MESH :
- chemical , administration & dosage : Hydrocortisone.
- drug effects : Arousal, Neural Inhibition, Reflex, Startle, Sensory Gating.
- chemical , pharmacology : Hydrocortisone.
- physiology : Arousal, Reflex, Startle.
- Adult, Health, Humans, Male, Placebos, Single-Blind Method, Time Factors.
Abstract
Stress is known to affect sensorimotor gating (measured with prepulse inhibition of startle, or PPI), possibly improving perception of threat signals at the expense of other input during states of arousal. Stress also induces a variety of autonomic nervous system and endocrine responses, such as an activation of the hypothalamic-pituitary-adrenal axis. The latter will result in the release of the stress hormone cortisol which is known to exert rapid and sustained action on several CNS processes. Since previous studies have not clarified whether and which stress response components may mediate effects on sensorimotor gating, this study asked whether a link may exist between cortisol and sensorimotor gating. We tested whether cortisol may affect PPI by assessing PPI before, during, and after non-stressful, covert 1mg IV cortisol infusions in 27 healthy men in a single-blind and placebo-controlled within-subject design. Cortisol induced a rapid reduction of PPI, with its maximum at 20 min after administration, and PPI returned to baseline after another 20 min. Startle magnitude in the absence of a prepulse was not affected. This rapid effect of the IV cortisol infusions is probably mediated by a non-genomic mechanism. We conclude that stress effects on sensorimotor gating may be mediated by glucocorticoids. The disruption of sensorimotor gating by the stress hormone cortisol may serve the processing of intense and potentially dangerous startling stimuli.
DOI: 10.1016/j.psyneuen.2010.07.002
PubMed: 20685043
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Oitzl</name></author><author><name sortKey="Daskalakis, Nikolaos P" sort="Daskalakis, Nikolaos P" uniqKey="Daskalakis N" first="Nikolaos P" last="Daskalakis">Nikolaos P. Daskalakis</name></author><author><name sortKey="Blumenthal, Terry D" sort="Blumenthal, Terry D" uniqKey="Blumenthal T" first="Terry D" last="Blumenthal">Terry D. Blumenthal</name></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:20685043</idno><idno type="pmid">20685043</idno><idno type="doi">10.1016/j.psyneuen.2010.07.002</idno><idno type="wicri:Area/PubMed/Corpus">000514</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000514</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cortisol rapidly disrupts prepulse inhibition in healthy men.</title><author><name sortKey="Richter, Steffen" sort="Richter, Steffen" uniqKey="Richter S" first="Steffen" last="Richter">Steffen Richter</name><affiliation><nlm:affiliation>Division of Clinical Physiology, Institute of Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier, Germany. richters@uni-trier.de</nlm:affiliation></affiliation></author><author><name sortKey="Schulz, Andre" sort="Schulz, Andre" uniqKey="Schulz A" first="André" last="Schulz">André Schulz</name></author><author><name sortKey="Zech, Carina M" sort="Zech, Carina M" uniqKey="Zech C" first="Carina M" last="Zech">Carina M. Zech</name></author><author><name sortKey="Oitzl, Melly S" sort="Oitzl, Melly S" uniqKey="Oitzl M" first="Melly S" last="Oitzl">Melly S. Oitzl</name></author><author><name sortKey="Daskalakis, Nikolaos P" sort="Daskalakis, Nikolaos P" uniqKey="Daskalakis N" first="Nikolaos P" last="Daskalakis">Nikolaos P. Daskalakis</name></author><author><name sortKey="Blumenthal, Terry D" sort="Blumenthal, Terry D" uniqKey="Blumenthal T" first="Terry D" last="Blumenthal">Terry D. Blumenthal</name></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name></author></analytic><series><title level="j">Psychoneuroendocrinology</title><idno type="eISSN">1873-3360</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Arousal (drug effects)</term><term>Arousal (physiology)</term><term>Health</term><term>Humans</term><term>Hydrocortisone (administration & dosage)</term><term>Hydrocortisone (pharmacology)</term><term>Male</term><term>Neural Inhibition (drug effects)</term><term>Placebos</term><term>Reflex, Startle (drug effects)</term><term>Reflex, Startle (physiology)</term><term>Sensory Gating (drug effects)</term><term>Single-Blind Method</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Arousal</term><term>Neural Inhibition</term><term>Reflex, Startle</term><term>Sensory Gating</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Arousal</term><term>Reflex, Startle</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Health</term><term>Humans</term><term>Male</term><term>Placebos</term><term>Single-Blind Method</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Stress is known to affect sensorimotor gating (measured with prepulse inhibition of startle, or PPI), possibly improving perception of threat signals at the expense of other input during states of arousal. Stress also induces a variety of autonomic nervous system and endocrine responses, such as an activation of the hypothalamic-pituitary-adrenal axis. The latter will result in the release of the stress hormone cortisol which is known to exert rapid and sustained action on several CNS processes. Since previous studies have not clarified whether and which stress response components may mediate effects on sensorimotor gating, this study asked whether a link may exist between cortisol and sensorimotor gating. We tested whether cortisol may affect PPI by assessing PPI before, during, and after non-stressful, covert 1mg IV cortisol infusions in 27 healthy men in a single-blind and placebo-controlled within-subject design. Cortisol induced a rapid reduction of PPI, with its maximum at 20 min after administration, and PPI returned to baseline after another 20 min. Startle magnitude in the absence of a prepulse was not affected. This rapid effect of the IV cortisol infusions is probably mediated by a non-genomic mechanism. We conclude that stress effects on sensorimotor gating may be mediated by glucocorticoids. The disruption of sensorimotor gating by the stress hormone cortisol may serve the processing of intense and potentially dangerous startling stimuli.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20685043</PMID><DateCreated><Year>2010</Year><Month>12</Month><Day>06</Day></DateCreated><DateCompleted><Year>2011</Year><Month>03</Month><Day>31</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-3360</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>1</Issue><PubDate><Year>2011</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Psychoneuroendocrinology</Title><ISOAbbreviation>Psychoneuroendocrinology</ISOAbbreviation></Journal><ArticleTitle>Cortisol rapidly disrupts prepulse inhibition in healthy men.</ArticleTitle><Pagination><MedlinePgn>109-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.psyneuen.2010.07.002</ELocationID><Abstract><AbstractText>Stress is known to affect sensorimotor gating (measured with prepulse inhibition of startle, or PPI), possibly improving perception of threat signals at the expense of other input during states of arousal. Stress also induces a variety of autonomic nervous system and endocrine responses, such as an activation of the hypothalamic-pituitary-adrenal axis. The latter will result in the release of the stress hormone cortisol which is known to exert rapid and sustained action on several CNS processes. Since previous studies have not clarified whether and which stress response components may mediate effects on sensorimotor gating, this study asked whether a link may exist between cortisol and sensorimotor gating. We tested whether cortisol may affect PPI by assessing PPI before, during, and after non-stressful, covert 1mg IV cortisol infusions in 27 healthy men in a single-blind and placebo-controlled within-subject design. Cortisol induced a rapid reduction of PPI, with its maximum at 20 min after administration, and PPI returned to baseline after another 20 min. Startle magnitude in the absence of a prepulse was not affected. This rapid effect of the IV cortisol infusions is probably mediated by a non-genomic mechanism. We conclude that stress effects on sensorimotor gating may be mediated by glucocorticoids. The disruption of sensorimotor gating by the stress hormone cortisol may serve the processing of intense and potentially dangerous startling stimuli.</AbstractText><CopyrightInformation>Copyright © 2010 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Richter</LastName><ForeName>Steffen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Clinical Physiology, Institute of Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier, Germany. richters@uni-trier.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schulz</LastName><ForeName>André</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Zech</LastName><ForeName>Carina M</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Oitzl</LastName><ForeName>Melly S</ForeName><Initials>MS</Initials></Author><Author ValidYN="Y"><LastName>Daskalakis</LastName><ForeName>Nikolaos P</ForeName><Initials>NP</Initials></Author><Author ValidYN="Y"><LastName>Blumenthal</LastName><ForeName>Terry D</ForeName><Initials>TD</Initials></Author><Author ValidYN="Y"><LastName>Schächinger</LastName><ForeName>Hartmut</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>08</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Psychoneuroendocrinology</MedlineTA><NlmUniqueID>7612148</NlmUniqueID><ISSNLinking>0306-4530</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010919">Placebos</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001143" MajorTopicYN="N">Arousal</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006262" MajorTopicYN="N">Health</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009433" MajorTopicYN="N">Neural Inhibition</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010919" MajorTopicYN="N">Placebos</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013216" MajorTopicYN="N">Reflex, Startle</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055139" MajorTopicYN="N">Sensory Gating</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016037" MajorTopicYN="N">Single-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year><Month>12</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>06</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>07</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>4</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20685043</ArticleId><ArticleId IdType="pii">S0306-4530(10)00156-3</ArticleId><ArticleId IdType="doi">10.1016/j.psyneuen.2010.07.002</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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