Revised histopathological consensus classification of joint implant related pathology.
Identifieur interne : 000309 ( PubMed/Corpus ); précédent : 000308; suivant : 000310Revised histopathological consensus classification of joint implant related pathology.
Auteurs : V. Krenn ; L. Morawietz ; G. Perino ; H. Kienapfel ; R. Ascherl ; G J Hassenpflug ; M. Thomsen ; P. Thomas ; M. Huber ; D. Kendoff ; D. Baumhoer ; M G Krukemeyer ; S. Natu ; F. Boettner ; J. Zustin ; B. Kölbel ; W. Rüther ; J P Kretzer ; A. Tiemann ; A. Trampuz ; L. Frommelt ; R. Tichilow ; S. Söder ; S. Müller ; J. Parvizi ; U. Illgner ; T. GehrkeSource :
- Pathology, research and practice [ 1618-0631 ] ; 2014.
English descriptors
- KwdEn :
- Arthroplasty, Replacement (adverse effects), Arthroplasty, Replacement (instrumentation), Biomarkers (analysis), Biopsy, Consensus, Humans, Immunohistochemistry, Joint Prosthesis (adverse effects), Joints (chemistry), Joints (pathology), Joints (surgery), Predictive Value of Tests, Prosthesis Design, Prosthesis Failure, Prosthesis-Related Infections (classification), Prosthesis-Related Infections (metabolism), Prosthesis-Related Infections (pathology), Terminology as Topic, Treatment Outcome.
- MESH :
- chemical , analysis : Biomarkers.
- adverse effects : Arthroplasty, Replacement, Joint Prosthesis.
- chemistry : Joints.
- classification : Prosthesis-Related Infections.
- instrumentation : Arthroplasty, Replacement.
- metabolism : Prosthesis-Related Infections.
- pathology : Joints, Prosthesis-Related Infections.
- surgery : Joints.
- Biopsy, Consensus, Humans, Immunohistochemistry, Predictive Value of Tests, Prosthesis Design, Prosthesis Failure, Terminology as Topic, Treatment Outcome.
Abstract
This extended classification of joint implant related pathology is a practical histopathologic classification based on defined morphological criteria covering the complete spectrum of pathohistologic changes in periprosthetic tissues. These changes may occur as a consequence of endoprosthetic replacement of large joints and may lead to a reduction in the prosthesis survival rate. We describe the established consensus classification of the periprosthetic membrane, in which aseptic and septic prosthetic loosening can be subdivided into four histological types, as well as histopathological criteria for additional significant pathologies including endoprosthetic-associated arthrofibrosis, particle-induced immunological, inflammatory and toxic mechanisms (adverse reactions), and bone tissue pathologies. These characteristic tissue alterations and their relationships are summarized in the extended classification. Since particle heterogeneity in periprosthetic tissue is high and particle identification is a necessary part of diagnosis, the identification of different types of particles is described in the histopathological particle algorithm. The morphological qualities of prosthetic material particles and the demarcation between abrasion and non-abrasion endogenous particles are also summarized. This feasible classification which is based on low cost standard tissue processing and examination and on well-defined diagnostic criteria is a solid platform for the histological diagnosis of implant associated pathologies providing a stable and reproducible tool for the surgical pathologist. Since this classification is suitable for standardized histopathological diagnostics, it might also provide a useful data set for joint arthroplasty registers, particularly for registers based on so-called routine data.
DOI: 10.1016/j.prp.2014.09.017
PubMed: 25454771
Links to Exploration step
pubmed:25454771Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Revised histopathological consensus classification of joint implant related pathology.</title><author><name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. Krenn</name><affiliation><nlm:affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany. Electronic address: krenn@patho-trier.de.</nlm:affiliation></affiliation></author><author><name sortKey="Morawietz, L" sort="Morawietz, L" uniqKey="Morawietz L" first="L" last="Morawietz">L. Morawietz</name><affiliation><nlm:affiliation>Diagnostik Ernst von Bergmann GmbH, Institute of Pathology, Potsdam, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Perino, G" sort="Perino, G" uniqKey="Perino G" first="G" last="Perino">G. Perino</name><affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kienapfel, H" sort="Kienapfel, H" uniqKey="Kienapfel H" first="H" last="Kienapfel">H. Kienapfel</name><affiliation><nlm:affiliation>Klinik für Spez. Orthopädische Chirurgie und Unfallchirurgie, Auguste Viktoria Klinikum, Vivantes Netzwerk, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ascherl, R" sort="Ascherl, R" uniqKey="Ascherl R" first="R" last="Ascherl">R. Ascherl</name><affiliation><nlm:affiliation>Zentrum für Spezial- und Wechselendoprothetik und chirurgische Infektiologie, Zeisigwaldkliniken Bethanien, Chemnitz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hassenpflug, G J" sort="Hassenpflug, G J" uniqKey="Hassenpflug G" first="G J" last="Hassenpflug">G J Hassenpflug</name><affiliation><nlm:affiliation>Klinik für Orthopädie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Thomsen, M" sort="Thomsen, M" uniqKey="Thomsen M" first="M" last="Thomsen">M. Thomsen</name><affiliation><nlm:affiliation>Klinik für Orthopädie, DRK Klinik, Baden-Baden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, P" sort="Thomas, P" uniqKey="Thomas P" first="P" last="Thomas">P. Thomas</name><affiliation><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der LMU, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Huber, M" sort="Huber, M" uniqKey="Huber M" first="M" last="Huber">M. Huber</name><affiliation><nlm:affiliation>Pathologisch-bakteriologisches Institut, Otto Wagner Spital, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Kendoff, D" sort="Kendoff, D" uniqKey="Kendoff D" first="D" last="Kendoff">D. Kendoff</name><affiliation><nlm:affiliation>Helios Endo-Klinik, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Baumhoer, D" sort="Baumhoer, D" uniqKey="Baumhoer D" first="D" last="Baumhoer">D. Baumhoer</name><affiliation><nlm:affiliation>Bone Tumor Reference Center at the Institut of Pathology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Krukemeyer, M G" sort="Krukemeyer, M G" uniqKey="Krukemeyer M" first="M G" last="Krukemeyer">M G Krukemeyer</name><affiliation><nlm:affiliation>Paracelsus-Kliniken Deutschland Gmbh, Osnabrück, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Natu, S" sort="Natu, S" uniqKey="Natu S" first="S" last="Natu">S. Natu</name><affiliation><nlm:affiliation>Department of Pathology, University hospital of North Tees and Hartlepool NHS Foundation Trust, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Boettner, F" sort="Boettner, F" uniqKey="Boettner F" first="F" last="Boettner">F. Boettner</name><affiliation><nlm:affiliation>Adult Reconstruction and Joint Replacement Division, Hospital for Special Surgery, New York, NYC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zustin, J" sort="Zustin, J" uniqKey="Zustin J" first="J" last="Zustin">J. Zustin</name><affiliation><nlm:affiliation>Gerhard Domagk Institute of Pathology, University of Münster, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kolbel, B" sort="Kolbel, B" uniqKey="Kolbel B" first="B" last="Kölbel">B. Kölbel</name><affiliation><nlm:affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ruther, W" sort="Ruther, W" uniqKey="Ruther W" first="W" last="Rüther">W. Rüther</name><affiliation><nlm:affiliation>Universitätsklinikum Hamburg-Eppendorf Zentrum für Operative Medizin, Klinik für Orthopädie, Hamburg-Eppendorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kretzer, J P" sort="Kretzer, J P" uniqKey="Kretzer J" first="J P" last="Kretzer">J P Kretzer</name><affiliation><nlm:affiliation>Labor für Biomechanik und Implantatforschung, Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tiemann, A" sort="Tiemann, A" uniqKey="Tiemann A" first="A" last="Tiemann">A. Tiemann</name><affiliation><nlm:affiliation>Klinik für Orthopädie und Unfallchirurgie, SRH Zentralklinikum Suhl, Suhl, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Trampuz, A" sort="Trampuz, A" uniqKey="Trampuz A" first="A" last="Trampuz">A. Trampuz</name><affiliation><nlm:affiliation>Klinik für Orthopädie, Center für Muskuloskeletale Chirurgie, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Frommelt, L" sort="Frommelt, L" uniqKey="Frommelt L" first="L" last="Frommelt">L. Frommelt</name><affiliation><nlm:affiliation>Mikrobiologie und Infektionsepidemiologie in Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tichilow, R" sort="Tichilow, R" uniqKey="Tichilow R" first="R" last="Tichilow">R. Tichilow</name><affiliation><nlm:affiliation>R.R. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics, Saint Petersburg, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Soder, S" sort="Soder, S" uniqKey="Soder S" first="S" last="Söder">S. Söder</name><affiliation><nlm:affiliation>Pathologisches Institut, Universitätsklinikum Erlangen, Erlangen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Muller, S" sort="Muller, S" uniqKey="Muller S" first="S" last="Müller">S. Müller</name><affiliation><nlm:affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Parvizi, J" sort="Parvizi, J" uniqKey="Parvizi J" first="J" last="Parvizi">J. Parvizi</name><affiliation><nlm:affiliation>The Rothman Institute at Thomas Jefferson University, Sheridan Building, Philadelphia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Illgner, U" sort="Illgner, U" uniqKey="Illgner U" first="U" last="Illgner">U. Illgner</name><affiliation><nlm:affiliation>St. Josef-Stift Sendenhorst, Klinik für Orthopädie, Unfall- und Handchirurgie, Sendenhorst, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gehrke, T" sort="Gehrke, T" uniqKey="Gehrke T" first="T" last="Gehrke">T. Gehrke</name><affiliation><nlm:affiliation>Helios Endo-Klinik, Hamburg, Germany.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25454771</idno><idno type="pmid">25454771</idno><idno type="doi">10.1016/j.prp.2014.09.017</idno><idno type="wicri:Area/PubMed/Corpus">000309</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000309</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Revised histopathological consensus classification of joint implant related pathology.</title><author><name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. Krenn</name><affiliation><nlm:affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany. Electronic address: krenn@patho-trier.de.</nlm:affiliation></affiliation></author><author><name sortKey="Morawietz, L" sort="Morawietz, L" uniqKey="Morawietz L" first="L" last="Morawietz">L. Morawietz</name><affiliation><nlm:affiliation>Diagnostik Ernst von Bergmann GmbH, Institute of Pathology, Potsdam, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Perino, G" sort="Perino, G" uniqKey="Perino G" first="G" last="Perino">G. Perino</name><affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kienapfel, H" sort="Kienapfel, H" uniqKey="Kienapfel H" first="H" last="Kienapfel">H. Kienapfel</name><affiliation><nlm:affiliation>Klinik für Spez. Orthopädische Chirurgie und Unfallchirurgie, Auguste Viktoria Klinikum, Vivantes Netzwerk, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ascherl, R" sort="Ascherl, R" uniqKey="Ascherl R" first="R" last="Ascherl">R. Ascherl</name><affiliation><nlm:affiliation>Zentrum für Spezial- und Wechselendoprothetik und chirurgische Infektiologie, Zeisigwaldkliniken Bethanien, Chemnitz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hassenpflug, G J" sort="Hassenpflug, G J" uniqKey="Hassenpflug G" first="G J" last="Hassenpflug">G J Hassenpflug</name><affiliation><nlm:affiliation>Klinik für Orthopädie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Thomsen, M" sort="Thomsen, M" uniqKey="Thomsen M" first="M" last="Thomsen">M. Thomsen</name><affiliation><nlm:affiliation>Klinik für Orthopädie, DRK Klinik, Baden-Baden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, P" sort="Thomas, P" uniqKey="Thomas P" first="P" last="Thomas">P. Thomas</name><affiliation><nlm:affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der LMU, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Huber, M" sort="Huber, M" uniqKey="Huber M" first="M" last="Huber">M. Huber</name><affiliation><nlm:affiliation>Pathologisch-bakteriologisches Institut, Otto Wagner Spital, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Kendoff, D" sort="Kendoff, D" uniqKey="Kendoff D" first="D" last="Kendoff">D. Kendoff</name><affiliation><nlm:affiliation>Helios Endo-Klinik, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Baumhoer, D" sort="Baumhoer, D" uniqKey="Baumhoer D" first="D" last="Baumhoer">D. Baumhoer</name><affiliation><nlm:affiliation>Bone Tumor Reference Center at the Institut of Pathology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Krukemeyer, M G" sort="Krukemeyer, M G" uniqKey="Krukemeyer M" first="M G" last="Krukemeyer">M G Krukemeyer</name><affiliation><nlm:affiliation>Paracelsus-Kliniken Deutschland Gmbh, Osnabrück, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Natu, S" sort="Natu, S" uniqKey="Natu S" first="S" last="Natu">S. Natu</name><affiliation><nlm:affiliation>Department of Pathology, University hospital of North Tees and Hartlepool NHS Foundation Trust, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Boettner, F" sort="Boettner, F" uniqKey="Boettner F" first="F" last="Boettner">F. Boettner</name><affiliation><nlm:affiliation>Adult Reconstruction and Joint Replacement Division, Hospital for Special Surgery, New York, NYC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zustin, J" sort="Zustin, J" uniqKey="Zustin J" first="J" last="Zustin">J. Zustin</name><affiliation><nlm:affiliation>Gerhard Domagk Institute of Pathology, University of Münster, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kolbel, B" sort="Kolbel, B" uniqKey="Kolbel B" first="B" last="Kölbel">B. Kölbel</name><affiliation><nlm:affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ruther, W" sort="Ruther, W" uniqKey="Ruther W" first="W" last="Rüther">W. Rüther</name><affiliation><nlm:affiliation>Universitätsklinikum Hamburg-Eppendorf Zentrum für Operative Medizin, Klinik für Orthopädie, Hamburg-Eppendorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kretzer, J P" sort="Kretzer, J P" uniqKey="Kretzer J" first="J P" last="Kretzer">J P Kretzer</name><affiliation><nlm:affiliation>Labor für Biomechanik und Implantatforschung, Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tiemann, A" sort="Tiemann, A" uniqKey="Tiemann A" first="A" last="Tiemann">A. Tiemann</name><affiliation><nlm:affiliation>Klinik für Orthopädie und Unfallchirurgie, SRH Zentralklinikum Suhl, Suhl, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Trampuz, A" sort="Trampuz, A" uniqKey="Trampuz A" first="A" last="Trampuz">A. Trampuz</name><affiliation><nlm:affiliation>Klinik für Orthopädie, Center für Muskuloskeletale Chirurgie, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Frommelt, L" sort="Frommelt, L" uniqKey="Frommelt L" first="L" last="Frommelt">L. Frommelt</name><affiliation><nlm:affiliation>Mikrobiologie und Infektionsepidemiologie in Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tichilow, R" sort="Tichilow, R" uniqKey="Tichilow R" first="R" last="Tichilow">R. Tichilow</name><affiliation><nlm:affiliation>R.R. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics, Saint Petersburg, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Soder, S" sort="Soder, S" uniqKey="Soder S" first="S" last="Söder">S. Söder</name><affiliation><nlm:affiliation>Pathologisches Institut, Universitätsklinikum Erlangen, Erlangen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Muller, S" sort="Muller, S" uniqKey="Muller S" first="S" last="Müller">S. Müller</name><affiliation><nlm:affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Parvizi, J" sort="Parvizi, J" uniqKey="Parvizi J" first="J" last="Parvizi">J. Parvizi</name><affiliation><nlm:affiliation>The Rothman Institute at Thomas Jefferson University, Sheridan Building, Philadelphia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Illgner, U" sort="Illgner, U" uniqKey="Illgner U" first="U" last="Illgner">U. Illgner</name><affiliation><nlm:affiliation>St. Josef-Stift Sendenhorst, Klinik für Orthopädie, Unfall- und Handchirurgie, Sendenhorst, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gehrke, T" sort="Gehrke, T" uniqKey="Gehrke T" first="T" last="Gehrke">T. Gehrke</name><affiliation><nlm:affiliation>Helios Endo-Klinik, Hamburg, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Pathology, research and practice</title><idno type="eISSN">1618-0631</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arthroplasty, Replacement (adverse effects)</term><term>Arthroplasty, Replacement (instrumentation)</term><term>Biomarkers (analysis)</term><term>Biopsy</term><term>Consensus</term><term>Humans</term><term>Immunohistochemistry</term><term>Joint Prosthesis (adverse effects)</term><term>Joints (chemistry)</term><term>Joints (pathology)</term><term>Joints (surgery)</term><term>Predictive Value of Tests</term><term>Prosthesis Design</term><term>Prosthesis Failure</term><term>Prosthesis-Related Infections (classification)</term><term>Prosthesis-Related Infections (metabolism)</term><term>Prosthesis-Related Infections (pathology)</term><term>Terminology as Topic</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Arthroplasty, Replacement</term><term>Joint Prosthesis</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Joints</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Prosthesis-Related Infections</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Arthroplasty, Replacement</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Prosthesis-Related Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Joints</term><term>Prosthesis-Related Infections</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Joints</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biopsy</term><term>Consensus</term><term>Humans</term><term>Immunohistochemistry</term><term>Predictive Value of Tests</term><term>Prosthesis Design</term><term>Prosthesis Failure</term><term>Terminology as Topic</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This extended classification of joint implant related pathology is a practical histopathologic classification based on defined morphological criteria covering the complete spectrum of pathohistologic changes in periprosthetic tissues. These changes may occur as a consequence of endoprosthetic replacement of large joints and may lead to a reduction in the prosthesis survival rate. We describe the established consensus classification of the periprosthetic membrane, in which aseptic and septic prosthetic loosening can be subdivided into four histological types, as well as histopathological criteria for additional significant pathologies including endoprosthetic-associated arthrofibrosis, particle-induced immunological, inflammatory and toxic mechanisms (adverse reactions), and bone tissue pathologies. These characteristic tissue alterations and their relationships are summarized in the extended classification. Since particle heterogeneity in periprosthetic tissue is high and particle identification is a necessary part of diagnosis, the identification of different types of particles is described in the histopathological particle algorithm. The morphological qualities of prosthetic material particles and the demarcation between abrasion and non-abrasion endogenous particles are also summarized. This feasible classification which is based on low cost standard tissue processing and examination and on well-defined diagnostic criteria is a solid platform for the histological diagnosis of implant associated pathologies providing a stable and reproducible tool for the surgical pathologist. Since this classification is suitable for standardized histopathological diagnostics, it might also provide a useful data set for joint arthroplasty registers, particularly for registers based on so-called routine data.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25454771</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>03</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>14</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1618-0631</ISSN><JournalIssue CitedMedium="Internet"><Volume>210</Volume><Issue>12</Issue><PubDate><Year>2014</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Pathology, research and practice</Title><ISOAbbreviation>Pathol. Res. Pract.</ISOAbbreviation></Journal><ArticleTitle>Revised histopathological consensus classification of joint implant related pathology.</ArticleTitle><Pagination><MedlinePgn>779-86</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.prp.2014.09.017</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0344-0338(14)00282-9</ELocationID><Abstract><AbstractText>This extended classification of joint implant related pathology is a practical histopathologic classification based on defined morphological criteria covering the complete spectrum of pathohistologic changes in periprosthetic tissues. These changes may occur as a consequence of endoprosthetic replacement of large joints and may lead to a reduction in the prosthesis survival rate. We describe the established consensus classification of the periprosthetic membrane, in which aseptic and septic prosthetic loosening can be subdivided into four histological types, as well as histopathological criteria for additional significant pathologies including endoprosthetic-associated arthrofibrosis, particle-induced immunological, inflammatory and toxic mechanisms (adverse reactions), and bone tissue pathologies. These characteristic tissue alterations and their relationships are summarized in the extended classification. Since particle heterogeneity in periprosthetic tissue is high and particle identification is a necessary part of diagnosis, the identification of different types of particles is described in the histopathological particle algorithm. The morphological qualities of prosthetic material particles and the demarcation between abrasion and non-abrasion endogenous particles are also summarized. This feasible classification which is based on low cost standard tissue processing and examination and on well-defined diagnostic criteria is a solid platform for the histological diagnosis of implant associated pathologies providing a stable and reproducible tool for the surgical pathologist. Since this classification is suitable for standardized histopathological diagnostics, it might also provide a useful data set for joint arthroplasty registers, particularly for registers based on so-called routine data.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier GmbH. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krenn</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany. Electronic address: krenn@patho-trier.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morawietz</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Diagnostik Ernst von Bergmann GmbH, Institute of Pathology, Potsdam, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perino</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kienapfel</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Klinik für Spez. Orthopädische Chirurgie und Unfallchirurgie, Auguste Viktoria Klinikum, Vivantes Netzwerk, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ascherl</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Zentrum für Spezial- und Wechselendoprothetik und chirurgische Infektiologie, Zeisigwaldkliniken Bethanien, Chemnitz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hassenpflug</LastName><ForeName>G J</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>Klinik für Orthopädie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomsen</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Klinik für Orthopädie, DRK Klinik, Baden-Baden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Klinik und Poliklinik für Dermatologie und Allergologie der LMU, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huber</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Pathologisch-bakteriologisches Institut, Otto Wagner Spital, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kendoff</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Helios Endo-Klinik, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baumhoer</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Bone Tumor Reference Center at the Institut of Pathology, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krukemeyer</LastName><ForeName>M G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Paracelsus-Kliniken Deutschland Gmbh, Osnabrück, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Natu</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, University hospital of North Tees and Hartlepool NHS Foundation Trust, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boettner</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Adult Reconstruction and Joint Replacement Division, Hospital for Special Surgery, New York, NYC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zustin</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Gerhard Domagk Institute of Pathology, University of Münster, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kölbel</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rüther</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Universitätsklinikum Hamburg-Eppendorf Zentrum für Operative Medizin, Klinik für Orthopädie, Hamburg-Eppendorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kretzer</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Labor für Biomechanik und Implantatforschung, Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tiemann</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Klinik für Orthopädie und Unfallchirurgie, SRH Zentralklinikum Suhl, Suhl, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trampuz</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Klinik für Orthopädie, Center für Muskuloskeletale Chirurgie, Charité Universitätsmedizin Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frommelt</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Mikrobiologie und Infektionsepidemiologie in Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tichilow</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>R.R. Vreden Russian Scientific Research Institute of Traumatology and Orthopedics, Saint Petersburg, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Söder</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Pathologisches Institut, Universitätsklinikum Erlangen, Erlangen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parvizi</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The Rothman Institute at Thomas Jefferson University, Sheridan Building, Philadelphia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Illgner</LastName><ForeName>U</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>St. Josef-Stift Sendenhorst, Klinik für Orthopädie, Unfall- und Handchirurgie, Sendenhorst, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gehrke</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Helios Endo-Klinik, Hamburg, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>10</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Pathol Res Pract</MedlineTA><NlmUniqueID>7806109</NlmUniqueID><ISSNLinking>0344-0338</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D019643" MajorTopicYN="N">Arthroplasty, Replacement</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000295" MajorTopicYN="N">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032921" MajorTopicYN="N">Consensus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007595" MajorTopicYN="N">Joint Prosthesis</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007596" MajorTopicYN="N">Joints</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011474" MajorTopicYN="N">Prosthesis Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011475" MajorTopicYN="Y">Prosthesis Failure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016459" MajorTopicYN="N">Prosthesis-Related Infections</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009626" MajorTopicYN="Y">Terminology as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Adverse reactions</Keyword><Keyword MajorTopicYN="N">Arthrofibrosis</Keyword><Keyword MajorTopicYN="N">Endoprosthesis material</Keyword><Keyword MajorTopicYN="N">Joint arthroplasty registers</Keyword><Keyword MajorTopicYN="N">Joint implant failure</Keyword><Keyword MajorTopicYN="N">Neo-synovium</Keyword><Keyword MajorTopicYN="N">Particle disease</Keyword><Keyword MajorTopicYN="N">Particle identification</Keyword><Keyword MajorTopicYN="N">Periprosthetic infection</Keyword><Keyword MajorTopicYN="N">Periprosthetic membrane</Keyword><Keyword MajorTopicYN="N">SLIM</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>08</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>09</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25454771</ArticleId><ArticleId IdType="pii">S0344-0338(14)00282-9</ArticleId><ArticleId IdType="doi">10.1016/j.prp.2014.09.017</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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