Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed.
Identifieur interne : 000274 ( PubMed/Corpus ); précédent : 000273; suivant : 000275Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed.
Auteurs : Katja K. Schneider ; Lilian Hüle ; Andrea B. Schote ; Jobst Meyer ; Christian FringsSource :
- Neuroreport [ 1473-558X ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Nerve Tissue Proteins, Receptors, Nicotinic.
- genetics : Reaction Time.
- Adolescent, Adult, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Sex Factors, Stroop Test, Young Adult.
Abstract
Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene that encodes the nicotinic acetylcholine receptor α5-subunit (CHRNA5). Male carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were faster than male carriers of at least one L allele or one A allele. In contrast, female carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were slower than female carriers of at least one L allele or one A allele. These results indicate that the minor alleles of both polymorphisms modulate response speed in a sex-dependent, diametrically opposed manner.
DOI: 10.1097/WNR.0000000000000313
PubMed: 25674902
Links to Exploration step
pubmed:25674902Le document en format XML
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<affiliation><nlm:affiliation>Departments of aCognitive Psychology bNeurobehavioral Genetics, University of Trier, Trier, Germany.</nlm:affiliation>
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<author><name sortKey="Hule, Lilian" sort="Hule, Lilian" uniqKey="Hule L" first="Lilian" last="Hüle">Lilian Hüle</name>
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<author><name sortKey="Schote, Andrea B" sort="Schote, Andrea B" uniqKey="Schote A" first="Andrea B" last="Schote">Andrea B. Schote</name>
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<author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name>
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<author><name sortKey="Frings, Christian" sort="Frings, Christian" uniqKey="Frings C" first="Christian" last="Frings">Christian Frings</name>
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<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Reaction Time (genetics)</term>
<term>Receptors, Nicotinic (genetics)</term>
<term>Sex Factors</term>
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<term>Female</term>
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<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene that encodes the nicotinic acetylcholine receptor α5-subunit (CHRNA5). Male carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were faster than male carriers of at least one L allele or one A allele. In contrast, female carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were slower than female carriers of at least one L allele or one A allele. These results indicate that the minor alleles of both polymorphisms modulate response speed in a sex-dependent, diametrically opposed manner.</div>
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<Abstract><AbstractText>Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene that encodes the nicotinic acetylcholine receptor α5-subunit (CHRNA5). Male carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were faster than male carriers of at least one L allele or one A allele. In contrast, female carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were slower than female carriers of at least one L allele or one A allele. These results indicate that the minor alleles of both polymorphisms modulate response speed in a sex-dependent, diametrically opposed manner.</AbstractText>
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