UnivTrevesV1, PubMed, Corpus, bibRecord, 000274

Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed.

Identifieur interne : 000274 ( PubMed/Corpus ); précédent : 000273; suivant : 000275

Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed.

Auteurs : Katja K. Schneider ; Lilian Hüle ; Andrea B. Schote ; Jobst Meyer ; Christian Frings

Source :

Neuroreport [ 1473-558X ] ; 2015.

RBID : pubmed:25674902

English descriptors

KwdEn :
- Adolescent, Adult, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Nerve Tissue Proteins (genetics), Polymorphism, Single Nucleotide, Reaction Time (genetics), Receptors, Nicotinic (genetics), Sex Factors, Stroop Test, Young Adult.
MESH :
- chemical , genetics : Nerve Tissue Proteins, Receptors, Nicotinic.
- genetics : Reaction Time.
- Adolescent, Adult, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Sex Factors, Stroop Test, Young Adult.

Abstract

Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene that encodes the nicotinic acetylcholine receptor α5-subunit (CHRNA5). Male carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were faster than male carriers of at least one L allele or one A allele. In contrast, female carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were slower than female carriers of at least one L allele or one A allele. These results indicate that the minor alleles of both polymorphisms modulate response speed in a sex-dependent, diametrically opposed manner.

DOI: 10.1097/WNR.0000000000000313
PubMed: 25674902

Links to Exploration step

pubmed:25674902

Le document en format XML

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<author><name sortKey="Schneider, Katja K" sort="Schneider, Katja K" uniqKey="Schneider K" first="Katja K" last="Schneider">Katja K. Schneider</name>
<affiliation><nlm:affiliation>Departments of aCognitive Psychology bNeurobehavioral Genetics, University of Trier, Trier, Germany.</nlm:affiliation>
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<author><name sortKey="Hule, Lilian" sort="Hule, Lilian" uniqKey="Hule L" first="Lilian" last="Hüle">Lilian Hüle</name>
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<author><name sortKey="Schote, Andrea B" sort="Schote, Andrea B" uniqKey="Schote A" first="Andrea B" last="Schote">Andrea B. Schote</name>
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<author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name>
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<author><name sortKey="Frings, Christian" sort="Frings, Christian" uniqKey="Frings C" first="Christian" last="Frings">Christian Frings</name>
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<author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name>
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<author><name sortKey="Frings, Christian" sort="Frings, Christian" uniqKey="Frings C" first="Christian" last="Frings">Christian Frings</name>
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<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Reaction Time (genetics)</term>
<term>Receptors, Nicotinic (genetics)</term>
<term>Sex Factors</term>
<term>Stroop Test</term>
<term>Young Adult</term>
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<front><div type="abstract" xml:lang="en">Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene that encodes the nicotinic acetylcholine receptor α5-subunit (CHRNA5). Male carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were faster than male carriers of at least one L allele or one A allele. In contrast, female carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were slower than female carriers of at least one L allele or one A allele. These results indicate that the minor alleles of both polymorphisms modulate response speed in a sex-dependent, diametrically opposed manner.</div>
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<Abstract><AbstractText>Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene that encodes the nicotinic acetylcholine receptor α5-subunit (CHRNA5). Male carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were faster than male carriers of at least one L allele or one A allele. In contrast, female carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were slower than female carriers of at least one L allele or one A allele. These results indicate that the minor alleles of both polymorphisms modulate response speed in a sex-dependent, diametrically opposed manner.</AbstractText>
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<MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057190" MajorTopicYN="Y">Stroop Test</DescriptorName>
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Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed.

Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki