Altered patterns of heartbeat-evoked potentials in depersonalization/derealization disorder: neurophysiological evidence for impaired cortical representation of bodily signals.
Identifieur interne : 000258 ( PubMed/Corpus ); précédent : 000257; suivant : 000259Altered patterns of heartbeat-evoked potentials in depersonalization/derealization disorder: neurophysiological evidence for impaired cortical representation of bodily signals.
Auteurs : André Schulz ; Susann Köster ; Manfred E. Beutel ; Hartmut Sch Chinger ; Claus Vögele ; Silke Rost ; Manfred Rauh ; Matthias MichalSource :
- Psychosomatic medicine [ 1534-7796 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- methods : Neurophysiology.
- physiology : Afferent Pathways, Evoked Potentials, Heart Rate, Interoception.
- physiopathology : Depersonalization.
- Adult, Female, Humans, Male, Young Adult.
Abstract
Core features of depersonalization/derealization disorder (DPD) are emotional numbing and feelings of disembodiment. Although there are several neurophysiological findings supporting subjective emotional numbing, the psychobiology of disembodiment remains unclear.
DOI: 10.1097/PSY.0000000000000195
PubMed: 25984819
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Altered patterns of heartbeat-evoked potentials in depersonalization/derealization disorder: neurophysiological evidence for impaired cortical representation of bodily signals.</title><author><name sortKey="Schulz, Andre" sort="Schulz, Andre" uniqKey="Schulz A" first="André" last="Schulz">André Schulz</name><affiliation><nlm:affiliation>From the Institute for Health and Behaviour (Schulz, Vögele, Rost), Research Unit INSIDE, University of Luxembourg, Walferdange, Luxembourg; Division of Clinical Psychophysiology (Schulz, Schächinger), Institute of Psychobiology, University of Trier, Trier, Germany; Department of Psychosomatic Medicine and Psychotherapy (Köster, Beutel, Michal), University Medical Center Mainz, Mainz, Germany; and Department of Pediatrics (Rauh), University Medical Center Erlangen, Erlangen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Koster, Susann" sort="Koster, Susann" uniqKey="Koster S" first="Susann" last="Köster">Susann Köster</name></author><author><name sortKey="Beutel, Manfred E" sort="Beutel, Manfred E" uniqKey="Beutel M" first="Manfred E" last="Beutel">Manfred E. Beutel</name></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name></author><author><name sortKey="Vogele, Claus" sort="Vogele, Claus" uniqKey="Vogele C" first="Claus" last="Vögele">Claus Vögele</name></author><author><name sortKey="Rost, Silke" sort="Rost, Silke" uniqKey="Rost S" first="Silke" last="Rost">Silke Rost</name></author><author><name sortKey="Rauh, Manfred" sort="Rauh, Manfred" uniqKey="Rauh M" first="Manfred" last="Rauh">Manfred Rauh</name></author><author><name sortKey="Michal, Matthias" sort="Michal, Matthias" uniqKey="Michal M" first="Matthias" last="Michal">Matthias Michal</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25984819</idno><idno type="pmid">25984819</idno><idno type="doi">10.1097/PSY.0000000000000195</idno><idno type="wicri:Area/PubMed/Corpus">000258</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000258</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Altered patterns of heartbeat-evoked potentials in depersonalization/derealization disorder: neurophysiological evidence for impaired cortical representation of bodily signals.</title><author><name sortKey="Schulz, Andre" sort="Schulz, Andre" uniqKey="Schulz A" first="André" last="Schulz">André Schulz</name><affiliation><nlm:affiliation>From the Institute for Health and Behaviour (Schulz, Vögele, Rost), Research Unit INSIDE, University of Luxembourg, Walferdange, Luxembourg; Division of Clinical Psychophysiology (Schulz, Schächinger), Institute of Psychobiology, University of Trier, Trier, Germany; Department of Psychosomatic Medicine and Psychotherapy (Köster, Beutel, Michal), University Medical Center Mainz, Mainz, Germany; and Department of Pediatrics (Rauh), University Medical Center Erlangen, Erlangen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Koster, Susann" sort="Koster, Susann" uniqKey="Koster S" first="Susann" last="Köster">Susann Köster</name></author><author><name sortKey="Beutel, Manfred E" sort="Beutel, Manfred E" uniqKey="Beutel M" first="Manfred E" last="Beutel">Manfred E. Beutel</name></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name></author><author><name sortKey="Vogele, Claus" sort="Vogele, Claus" uniqKey="Vogele C" first="Claus" last="Vögele">Claus Vögele</name></author><author><name sortKey="Rost, Silke" sort="Rost, Silke" uniqKey="Rost S" first="Silke" last="Rost">Silke Rost</name></author><author><name sortKey="Rauh, Manfred" sort="Rauh, Manfred" uniqKey="Rauh M" first="Manfred" last="Rauh">Manfred Rauh</name></author><author><name sortKey="Michal, Matthias" sort="Michal, Matthias" uniqKey="Michal M" first="Matthias" last="Michal">Matthias Michal</name></author></analytic><series><title level="j">Psychosomatic medicine</title><idno type="eISSN">1534-7796</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Afferent Pathways (physiology)</term><term>Depersonalization (physiopathology)</term><term>Evoked Potentials (physiology)</term><term>Female</term><term>Heart Rate (physiology)</term><term>Humans</term><term>Interoception (physiology)</term><term>Male</term><term>Neurophysiology (methods)</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neurophysiology</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Afferent Pathways</term><term>Evoked Potentials</term><term>Heart Rate</term><term>Interoception</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Depersonalization</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Core features of depersonalization/derealization disorder (DPD) are emotional numbing and feelings of disembodiment. Although there are several neurophysiological findings supporting subjective emotional numbing, the psychobiology of disembodiment remains unclear.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25984819</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>08</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>04</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1534-7796</ISSN><JournalIssue CitedMedium="Internet"><Volume>77</Volume><Issue>5</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Psychosomatic medicine</Title><ISOAbbreviation>Psychosom Med</ISOAbbreviation></Journal><ArticleTitle>Altered patterns of heartbeat-evoked potentials in depersonalization/derealization disorder: neurophysiological evidence for impaired cortical representation of bodily signals.</ArticleTitle><Pagination><MedlinePgn>506-16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/PSY.0000000000000195</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Core features of depersonalization/derealization disorder (DPD) are emotional numbing and feelings of disembodiment. Although there are several neurophysiological findings supporting subjective emotional numbing, the psychobiology of disembodiment remains unclear.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Heartbeat-evoked potentials (HEPs), which are considered psychophysiological indicators for the cortical representation of afferent signals originating from the cardiovascular system, were assessed in 23 patients with DPD and 24 healthy control individuals during rest and while performing a heartbeat perception task.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Absolute HEP amplitudes did not differ between groups. Nevertheless, healthy individuals showed higher HEPs during the heartbeat perception task than during rest, whereas no such effect was found in patients with DPD (p = .031). Patients with DPD had higher total levels of salivary α-amylase than did healthy individuals (9626.6 [8200.0] versus 5344.3 [3745.8] kU min/l; p = .029), but there were no group differences in cardiovascular measures (heart rate = 76.2 [10.1] versus 74.3 [7.5] beats/min, p = .60; normalized low-frequency heart rate variability = 0.63 [0.15] versus 0.56 [0.15] normalized units, p = .099; low frequency/high frequency ratio = 249.3 [242.7] versus 164.8 [108.8], p = .10), salivary cortisol (57.5 [46.7] versus 55.1 [43.6] nmol min/l, p = .86), or cortisone levels (593.2 [260.3] versus 543.8 [257.1] nmol min/l, p = .52).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results suggest altered cortical representation of afferent signals originating from the cardiovascular system in patients with DPD, which may be associated with higher sympathetic tone. These findings may reflect difficulties of patients with DPD to attend to their actual bodily experiences.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schulz</LastName><ForeName>André</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>From the Institute for Health and Behaviour (Schulz, Vögele, Rost), Research Unit INSIDE, University of Luxembourg, Walferdange, Luxembourg; Division of Clinical Psychophysiology (Schulz, Schächinger), Institute of Psychobiology, University of Trier, Trier, Germany; Department of Psychosomatic Medicine and Psychotherapy (Köster, Beutel, Michal), University Medical Center Mainz, Mainz, Germany; and Department of Pediatrics (Rauh), University Medical Center Erlangen, Erlangen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Köster</LastName><ForeName>Susann</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Beutel</LastName><ForeName>Manfred E</ForeName><Initials>ME</Initials></Author><Author ValidYN="Y"><LastName>Schächinger</LastName><ForeName>Hartmut</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Vögele</LastName><ForeName>Claus</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Rost</LastName><ForeName>Silke</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Rauh</LastName><ForeName>Manfred</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Michal</LastName><ForeName>Matthias</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Psychosom Med</MedlineTA><NlmUniqueID>0376505</NlmUniqueID><ISSNLinking>0033-3174</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000344" MajorTopicYN="N">Afferent Pathways</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003861" MajorTopicYN="N">Depersonalization</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005071" MajorTopicYN="N">Evoked Potentials</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006339" MajorTopicYN="N">Heart Rate</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065812" MajorTopicYN="N">Interoception</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009482" MajorTopicYN="N">Neurophysiology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25984819</ArticleId><ArticleId IdType="doi">10.1097/PSY.0000000000000195</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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